Comparison of two methods to detect publication bias in meta-analysis
ContextEgger's regression test is often used to help detect publication bias in meta-
analyses. However, the performance of this test and the usual funnel plot have been
challenged particularly when the summary estimate is the natural log of the odds ratio
(lnOR). ObjectiveTo compare the performance of Egger's regression test with a regression
test based on sample size (a modification of Macaskill's test) with lnOR as the summary
estimate. DesignSimulation of meta-analyses under a number of scenarios in the presence …
analyses. However, the performance of this test and the usual funnel plot have been
challenged particularly when the summary estimate is the natural log of the odds ratio
(lnOR). ObjectiveTo compare the performance of Egger's regression test with a regression
test based on sample size (a modification of Macaskill's test) with lnOR as the summary
estimate. DesignSimulation of meta-analyses under a number of scenarios in the presence …
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