F-Seq: a feature density estimator for high-throughput sequence tags

AP Boyle, J Guinney, GE Crawford, TS Furey - Bioinformatics, 2008 - academic.oup.com
Bioinformatics, 2008academic.oup.com
Tag sequencing using high-throughput sequencing technologies are now regularly
employed to identify specific sequence features, such as transcription factor binding sites
(ChIP-seq) or regions of open chromatin (DNase-seq). To intuitively summarize and display
individual sequence data as an accurate and interpretable signal, we developed F-Seq, a
software package that generates a continuous tag sequence density estimation allowing
identification of biologically meaningful sites whose output can be displayed directly in the …
Abstract
Summary: Tag sequencing using high-throughput sequencing technologies are now regularly employed to identify specific sequence features, such as transcription factor binding sites (ChIP-seq) or regions of open chromatin (DNase-seq). To intuitively summarize and display individual sequence data as an accurate and interpretable signal, we developed F-Seq, a software package that generates a continuous tag sequence density estimation allowing identification of biologically meaningful sites whose output can be displayed directly in the UCSC Genome Browser.
Availability: The software is written in the Java language and is available on all major computing platforms for download at http://www.genome.duke.edu/labs/furey/software/fseq.
Contact:  terry.furey@duke.edu
Oxford University Press
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