SOPHiA GENETICS

The Blood Cancers group in our newly launched SOPHiA GENETICS Community is already becoming a meeting point for healthcare leaders worldwide. Inside, conversations are unfolding on the toughest challenges in oncohematology - from complex workflows to breakthrough applications of AI. Here’s a taste of what’s being discussed: 🔬 Why detecting gene fusions with DNA-based NGS is so challenging, and what solutions are there. 💬 Expert answers from our Product Manager, José María “Chema” Belloso, who’s in the group to respond directly to your questions. 📚 Access to new content, insights, and real-world experiences advancing the field. This is where the future of blood cancer research is being debated, tested, and shaped. The discussions are live. The experts are here. Will you be part of it? 👉 Join the Blood Cancers group within the SOPHiA GENETICS Community today: https://loom.ly/YvtdNAw #BloodCancer #Leukemia #Lymphoma #Oncohematology #SOPHiADDM #HealthcareInnovation

💙 At SOPHiA GENETICS, our bold mission is powered by people. This week, our Boston Social Committee showed what that looks like in action. A group of SOPHiAN volunteers rolled up their sleeves at The Boston House, preparing dinner for families of children receiving cancer care at Dana-Farber Cancer Institute and Boston Children's Hospital. The Boston House is a home away from home for families facing some of the hardest days of their lives. Sharing a meal together reminded us why we do what we do. Behind every dataset, every workflow, and every innovation, there are real people, families, and their stories. We’re proud of our colleagues who gave their time and energy, and grateful to be part of a culture where #WeDo has purpose, everyday. #LifeAtSOPHiA #TeamCulture #TeamSOPHiA

🌍 Join SOPHiA GENETICS & Platomics at ECP 2025 in Vienna and learn more how we simplify genetic analysis and IVDR compliance for our users! Stop by our booth, meet our experts and learn more about the key benefits of our partnership with Platomics! 💻 Digital test compliance workflow ⏱️ Faster turnaround with automation 🔒Scalable, secure IVDR solutions Join our demo sessions daily at ECP 2025 at the SOPHiA GENETICS booth #129: • Sept 7: 14:30-15:30 CET • Sept 8: 13:00-14:00 CET • Sept 9: 11:00-12:00 CET Don't miss the chance to meet us and explore how genomic analyses meet seamless regulatory compliance! European Society of Pathology #ECP2025 #IVDR #compliance #genomics #datadrivenmedicine

🌎 How can we expand access to precision medicine globally? Explore how the comprehensive SOPHiA DDM™ Platform can increase equity in access to care by expediting the implementation and adoption of accurate genomics testing in diverse, global populations. The SOPHiA DDM™ decentralized approach is accelerating precision medicine by helping pharma successfully implement their post-market strategies. 👉🏼Read our article on Sponsored Testing: https://loom.ly/47lGHgs #DataDrivenMedicine #PrecisionMedicine #Genomics #HealthEquity

Glad to continue my #ResearchSpotlight series with a study recently published in Nature Communications that puts the SOPHiA DDM™ platform at the center of new insights into how targeted therapies can reshape the evolution of #cancer.    In 143 patients with myeloproliferative neoplasms (MPN) analyzed on the SOPHiA DDM™ platform, the authors uncovered striking dynamics:    · Patients treated with the JAK2 inhibitor ruxolitinib accumulated more mutations, especially in the RAS pathway.  · These mutations correlated with worse outcomes under treatment.  · Lab experiments confirmed that JAK2 inhibition can select resistant clones.    The message is clear: cancer adapts, and therapies can drive that evolution in unexpected ways. For clinicians, it may mean that screening for RAS mutations becomes essential when treating MPN with JAK inhibitors. While ruxolitinib offers great benefits for a subset of patients, it may drive negative clinical outcomes in some other patients. This kind of longitudinal, real-world genomic insight is exactly what’s needed to stay ahead, and why we built our solutions at SOPHiA GENETICS: to help decode complexity so clinicians and researchers can adapt strategies and improve outcomes.     I’m particularly proud to see our platform supporting leading centers such as Gustave Roussy, and Hôpital Saint-Louis in Paris - where Dr. Bruno Cassinat and colleagues are advancing the study of myeloid disorders and contributing to this important progress.    Authored by Nabih Maslah, Nina Kaci, Blandine ROUX, Gabriela Alexe, Raphael Marie, Helene Pasquer, Emmanuelle VERGER, Rafael Daltro De Oliveira, Cécile Culeux, Bochra MLAYAH, Nicolas Gauthier, Fanny Gonzalez-de-Chavez, Lin-Pierre Zhao, Saravanan Ganesan, Panhong Gou, Frank Ling, Juliette Soret-DULPHY, Nathalie Parquet, William Vainchenker, Emmanuel Raffoux, Rose Ann P., Stephane Giraudier, Caroline Marty, Isabelle Plo, Camille Lobry, Kimberly Stegmaier, Alexandre Puissant, Jean-Jacques Kiladjian, bruno cassinat & Lina Benajiba. Link to the full study: https://lnkd.in/eZ3GvB2U Springer Nature

✈️ Next stop...Vienna! 🇦🇹 We're thrilled to be back at ECP for another year! Don't miss the chance to stop by booth 129 – the hub for innovation, collaboration, and the future of data-driven medicine! 🚀 Here’s what’s waiting for you this year: 🧬 Joint symposium with AstraZeneca to discover MSK-ACCESS® powered with SOPHiA DDM™ across a pan-tumour landscape 🧬 Partner engagements with Illumina, Hamilton & Platomics - stay tuned for the details! 🧬 Meet the Experts session at our booth on September 8 @ 15:00-17:00) CET 🧬 …and much more to come! 💡Don’t miss the chance to discover our latest developments and groundbreaking projects pioneering the next era of data-driven medicine. Can't meet us in Vienna? Join our community now and explore exclusive insights and networking opportunities with our global community of users and experts! 🔗 Register here: https://loom.ly/YvtdNAw #ECP2025 #Pathology #DataDrivenMedicine #Innovation

🌍 From Boston's Fenway to Rolle, Bidart, Pessac, and beyond, today’s Town Hall brought together our global community of SOPHiANs. We got energized by the incredible momentum we're building, and celebrated the people who make it possible. What makes these moments special are not only the updates, but the culture we’ve built together. A culture rooted in curiosity, collaboration, and courage. A culture where innovation isn’t an abstract goal but something lived daily by people who push boundaries, support each other, and never lose sight of the patients we ultimately serve. We leave this Town Hall inspired, aligned, and ready to keep shaping the future of data-driven medicine. #LifeAtSOPHiA #GlobalTeam #Momentum #Townhall

🧬 Liquid biopsy promises global progress in oncology—but only if we address the barriers Join us on August 27th at 10AM EDT for a webinar where leaders from SOPHiA GENETICS, AstraZeneca, and Synnovis discuss how MSK-ACCESS® powered with SOPHiA DDM™ is helping make advanced liquid biopsy analysis a global reality. 💡 Key takeaways: ✅ Improve accuracy & reproducibility with a robust, decentralized approach ✅ See what real-world implementation looks like in a clinical research setting ✅ Learn how strategic collaboration is closing the access gap in cancer diagnostics 🌍 Turning innovation into impact—worldwide. 🎟️ Register now: https://loom.ly/KLJz5WI #LiquidBiopsy #OncologyInnovation #PrecisionMedicine #GlobalHealthEquity #MolecularDiagnostics #SOPHiAGENETICS

📣 LAST CHANCE TO REGISTER! 💡Don't miss our live webinar on August 20th, hosted by Precision Medicine Online “From data to discovery: Unlocking the potential of RNA with robust, in-house solutions” Join Professor Alexandre Harlé for an in-depth look at expertly designed RNA NGS solutions for advanced variant detection from solid tumors, including lung and sarcoma. Prof. Harlé will share his experience of co-developing and implementing in-house, sample-to-report solutions that address the current and future needs of the Cancer Institute of Lorraine, Nancy, France.  What You’ll Learn: ➡️ Discover an innovative RNA technology that detects novel (partner-agnostic) gene fusions  ➡️ Explore how decentralized sample-to-report help accelerate turnaround times and improve operational efficiency.    ➡️ Understand the value of combining targeted RNA and DNA insights to capture a more comprehensive molecular picture to support informed decision-making. 📅 Wednesday, August 20, 2025 🕑 16:00 CET | 10:00 EDT 🔗 Book your spot now:  https://loom.ly/PhEZ3ZU #Webinar #PrecisionMedicineOnline #Genomics #PrecisionMedicine #AI #RNAseq

🚀 Day 1 at #HGSA2025 is here! We’re thrilled to be in Sydney connecting with the genetics community at this prestigious congress. 🇦🇺 📍 Stop by Booth #5 to meet the SOPHiA GENETICS team and discover how our New Generation SOPHiA DDM™ Platform is transforming precision medicine. From Exome sequencing to advanced oncology applications like MSK-ACCESS® and MSK-IMPACT®, powered by SOPHiA DDM™, we’re pushing the boundaries of data-driven genomics. Let’s shape the future of healthcare together with multimodal, globally scalable solutions. See you at Booth #5! #Genomics #ExomeSequencing #HGSA2025 Niharika Anand Fiona Park Zhiliang Chen