Cobetter Filtration Group

LNP-mRNA Ultrafiltration Technology Showdown: TFF Cassette vs. Hollow Fiber Filter - A Case Study Efficient purification of lipid nanoparticles (LNPs) is critical for the development and manufacturing of mRNA-based therapeutics. As the "golden carrier" for nucleic acid delivery, LNPs require a robust downstream ultrafiltration process that preserves particle integrity while enabling high-purity concentration and buffer exchange. In this study, Cobetter evaluated two mainstream tangential flow filtration (TFF) formats—RC (regenerated cellulose) TFF cassettes and mPES (modified polyethersulfone) hollow fiber filters—for mRNA-LNP purification. Results showed that RC TFF cassettes outperformed in flux rate and overall processing efficiency, reducing membrane area and filtration time without compromising LNP attributes such as size, polydispersity (PDI), and encapsulation efficiency. In contrast, hollow fiber filters offered lower shear environments, making them suitable for shear-sensitive materials but exhibited relatively lower flux. Ultimately, both formats remain viable depending on specific material characteristics and process goals. Cobetter’s deep technical know-how ensures precise membrane-to-process matching, maintaining critical quality attributes across lab and GMP scales. This positions Cobetter as a reliable partner in advancing LNP-mRNA ultrafiltration technologies. To learn more, please click the below article. For direct inquires, please contact LTCsales@cobetter.com #bioprocessing #bioproduction #biopharmaceutical #biopharma #biologics #downstream #DSP #downstreamprocessing #LNP #mRNA

Visit Cobetter at BIO Asia-Taiwan Exhibition 2025 !!! 📅 July 24-28, 2025 📍 Booth L629 – Taipei Nangang Exhibition Center, Hall 1, 4F Cobetter is pleased to announce its participation at BIO Asia-Taiwan Exhibition 2025, the most professional pharmaceutical event in Taiwan, China. During the show, we will showcase our latest innovations in solutions for the pharmaceutical and life sciences industries, with a focus on advanced filtration, separation and purification technologies. As a global company committed to quality, innovation and sustainability, Cobetter invites you to explore new possibilities for collaboration and to drive the future of pharmaceutical development with us. Visit our booth and take the opportunity to: * See our R&D innovations * Discuss customized solutions for your filtration and purification challenges * Consult our technical experts for detailed insights Our team Crystal Lee, Colin Cui and Candy Chen are ready to welcome you. Send us a message to schedule a priority meeting: candy.chen@cobetterfilter.com  

Optimizing Small Nucleic Acid Drug Processes with Cobetter Ultrafiltration Small nucleic acid drugs—such as siRNA, miRNA, ASOs, and aptamers—are revolutionizing precision medicine by regulating gene expression with high specificity. Following the 2024 Nobel Prize awarded for miRNA discoveries, global interest in RNA-based therapies has surged. Yet, manufacturing these molecules poses unique challenges, particularly in purification, impurity control, and delivery system integration. Cobetter offers a robust ultrafiltration and membrane chromatography platform tailored for small nucleic acid manufacturing. Whether for concentration, diafiltration, desalting, or endotoxin removal, Cobetter's regenerated cellulose ultrafiltration cassettes (1–3KDH pore sizes) ensure high yield and process efficiency. Cobetter also addresses downstream needs such as LNP purification, endotoxin clearance, and enzyme-sensitive component handling with nuclease-free consumables and modular single-use systems. From solid-phase synthesis to high-throughput ultrafiltration, Cobetter supports the full development cycle of small nucleic acid therapeutics with validated, scalable, and GMP-compliant solutions. Click the below link for the full article: https://lnkd.in/g6V42STF For direct inquiries, please contact LTCsales@cobetter.com #bioprocessing #bioproduction #biopharmaceutical #biopharma #biologics #downstream #DSP #downstreamprocessing #RNA

Introducing Cobetter Pultrix XQ – High-Efficiency Anion Exchange Membrane Adsorber Cobetter’s Pultrix XQ membrane adsorber integrates membrane separation and ion-exchange chromatography to deliver fast, scalable, and cost-effective purification of negatively charged biomolecules such as plasmid DNA, mRNA, and viruses. Engineered with a high-density quaternary ammonium (Q) ligand and 2 μm pore size, it enables convective mass transfer for rapid, high-capacity binding at low pressure. With 30–50× faster throughput than traditional chromatography and compatibility across scales, Pultrix XQ supports everything from small-scale development (via 24-well plates) to large-scale GMP production. It offers superior impurity removal (HCP, endotoxin, etc.), strong reproducibility, and simplified operation—no column packing or cleaning validation needed. Pultrix XQ helps streamline plasmid purification and other critical bioprocessing workflows, providing a flexible, efficient alternative to traditional resins. 💡 To learn more about how this membrane can elevate your purification process, click the below link for the full article: https://lnkd.in/gWeB9NsH For direct inquiries, pleas contact LTCsales@cobetter.com #bioprocessing #bioproduction #biopharmaceutical #biopharma #biologics #downstream #DSP #downstreamprocessing

Empowering CGT Process Development with Cobetter's TFF Minilab System Tangential Flow Filtration (TFF) is essential in bioprocessing, particularly in cell and gene therapy (CGT). Manual TFF systems, while functional, lack real-time monitoring and precise control—often consuming valuable time and resources. To address this, Cobetter has introduced the TFF Minilab System, an automated solution offering constant flow/pressure control, real-time data logging, and intuitive human-machine interaction. The Minilab system supports applications like concentration, diafiltration, and purification of mRNA, plasmids, viral vectors, and exosomes. Case studies show yields up to 97–101% with excellent process control. With built-in recipe modes, graphing, and audit trails, the system ensures traceability, reproducibility, and process optimization—crucial for CGT scalability. Click the below link for the full article: https://lnkd.in/gTUPyUFY Cobetter’s TFF Minilab delivers both performance and efficiency. Contact us to explore how it can streamline your upstream or downstream development: LTCsales@cobetter.com #bioprocessing #bioproduction #biopharmaceutical #biopharma #biologics #downstream #DSP #downstreamprocessing #genetherapy #CGT

Join Us at PMEC & CPHI China! We are excited to invite you to one of the most prestigious events in the pharmaceutical industry—PMEC & CPHI China! This is the perfect opportunity to discover innovative solutions transforming the biopharmaceutical sector. 🗓️ Dates: June 24-26, 2025 🏢 Booth: N3B56 📍 Location: SNIEC, Shanghai, China Our team will be on-site to showcase the latest advancements in filtration technology. We’re eager to engage, share insights, and discuss how our cutting-edge solutions are making a difference in the industry. 💬 Don’t miss out—let’s connect! Visit our booth or schedule a meeting with us in advance. We’re here to answer any questions and explore potential collaborations. Looking forward to seeing you there!

Cobetter Activated Carbon for ADC Purification Processes Antibody-Drug Conjugates (ADCs) are transforming oncology by combining targeted antibodies with potent cytotoxins. As ADC development accelerates globally, efficient purification—especially the removal of free toxins—has become a critical challenge. Traditional methods like ultrafiltration and chromatography have limitations in cost, efficiency, and scalability. Activated carbon is emerging as a cost-effective and powerful alternative. With high adsorption capacity, chemical stability, and broad applicability, activated carbon depth filters can remove free toxins by orders of magnitude in a single step—making them a "dark horse" in ADC purification. Cobetter has validated activated carbon’s compatibility with key solvents (e.g., DMSO, DMF) and materials used in ADC manufacturing. These studies, conducted in accordance with USP 665, ensure reliable performance and safety across scales. As ADC demand rises, activated carbon presents a scalable, efficient solution to advance therapeutic innovation. Learn more: https://lnkd.in/g6nv6mgX For direct inquiris, please contact LTCsales@cobetter.com #pharma #pharmaproduction #bioproduction #biopharmaceutical #biopharma #ADC #antibody

Enhancing Blood Product Manufacturing with Cobetter Single-Use Systems Single‐use systems for blood product manufacturing offer robust foreign‐matter control and minimized liquid residues, enhancing both sterility assurance and process efficiency. By employing blow‐molding for co‐extrusion films, Cobetter’s single‐use bioprocessing bags achieve superior cleanliness, environmental‐stress resistance, tear and tensile strength, and chemical stability compared to conventional cast films. Stringent production‐process controls—ISO-classified cleanrooms (ISO 7 for accessory molding; ISO 4–8 for filling), WFI‐standard pre-rinsing lines, ultrasonic cleaning, and Class 100 drying ovens—together with comprehensive personnel and equipment protocols (double-gowning, dust and static removal) ensure consistent component hygiene. Moreover, single‐use redundant filtration and filling bag systems demonstrably reduce dead volumes versus stainless steel counterparts, yielding up to 883.8 mL additional product per batch and lowering costs for high‐value blood therapies. Real‐world drainage testing under process conditions is recommended to validate laboratory findings. Learn more: https://lnkd.in/gQWUVUPF For direct inquiris, please contact LTCsales@cobetter.com #pharma #pharmaproduction #bioproduction #biopharmaceutical #biopharma #singleuse #sus #liquidhandling #plasma #bloodproduct

Visit Cobetter at FCE Pharma 2025 – Brazil! 📅 June 10-12, 2025 📍 Booth G101 – São Paulo Expo Cobetter is pleased to announce its participation at FCE Pharma 2025, the largest pharmaceutical event in Brazil. During the show, we will showcase our latest innovations in solutions for the pharmaceutical and life sciences industries, with a focus on advanced filtration, separation and purification technologies. As a global company committed to quality, innovation and sustainability, Cobetter invites you to explore new possibilities for collaboration and to drive the future of pharmaceutical development with us. Visit our booth and take the opportunity to: * See our R&D innovations * Discuss customized solutions for your filtration and purification challenges * Consult our technical experts for detailed insights Our team Ervin Lee, Ariane Sharon Luzini, Kaia Zhu and Pablo Grigera are ready to welcome you. Send us a message to schedule a priority meeting: ervin@cobetter.com or ariane.luzini@cobetter.com Find us at: São Paulo Expo – Stand G101 Rodovia dos Imigrantes, 1.5 km – Vila Água Funda, São Paulo – SP, 04329-900

🌟 Cobetter Filtration Group is excited to invite you to TIDES 2025! 🌟 Join us at this premier event to explore innovative solutions for the pharmaceutical sector! 🗓️ Dates: May 19-22, 2025 🏢 Booth: 716, Level 1 📍 Location: Manchester Grand Hyatt, San Diego, CA Meet our dedicated team, Melody Xiaojiao Zhang, MIA GUO, Krystal Xu, and Vicky He, who will be on hand to discuss our latest advancements in filtration technology. We look forward to engaging with you and showcasing our cutting-edge solutions that are transforming the biopharmaceutical industry. 💬 Let’s connect! Feel free to stop by our booth, or schedule a meeting with us in advance. We’re here to answer any questions and explore potential collaborations. 📞 For inquiries or to arrange a meeting, don’t hesitate to reach out! 🔗 Learn more about our process solutions for the biopharm industry: https://cobetter.com/ See you there! #BIO #Biopharma #Biotechnology #Filtration #TIDES #Cobetter #Oligo