PROTEROS biostructures GmbH

Watch our webinar and learn about our new service, Crystallographic Fragment Screening combined with Fragment Evolution using Chemical Space Docking™ into Enamine REAL. Dr. Debora Konz Makino, Dr. Jan Wollenhaupt, and Dr. Martin Fleck, from Proteros Biostructures join Dr. Raphael Klein, from BioSolveIT, to highlight our integrated early drug discovery approach. The team demonstrate how to identify binding sites on WRN helicase, using Proteros heritage in Structural Biology and Protein Sciences, and expertise in biophysical validation. This webinar was hosted on June 5th 2025, with all research and findings up to date, accurate, and correct at time of recording. Request access to the material: https://lnkd.in/dXzP6spk

Explore Proteros Small Molecule Libraries for Accelerated Drug Discovery! Whether you're aiming for high-throughput screening (HTS), SAR insights, or drug repurposing opportunities, our libraries are curated to deliver quality, diversity, and speed. All collections are Ro5 compliant, carefully curated to exclude reactive compounds, PAINS, and unfavorable physicochemical properties. 🧪 Centroid-Based Small Molecule Library – High Diversity for HTS 186k structurally diverse compounds selected using a unique centroid-based approach. Available in pooled format for HTS by SPR and non-pooled format for all plate-based assays in either 384- or 1536-format. Enables rapid hit deconvolution from screening to hit list in 2 weeks! 🔗 Cluster-Based Small Molecule Library – Designed for Optimal Hit Discovery 150k high-quality compounds organized into 23,598 well-defined clusters for insights in the initial SAR. Additional cluster members are available by expansion into full range of Enamine compounds. 💊 Drug Repurposing Library – Unlock Hidden Potential Explore the library containing 3,577 clinically validated compounds (launched drugs and clinical candidates from Phase II on) to be screened by itself or in parallel with another Proteros library. Using this library, you can investigate how existing drugs act on a novel target, identify compounds for repurposing opportunities for novel targets or identify well-characterized tool compounds. #DrugDiscovery #SmallMoleculeLibraries #HTS #DrugRepurposing #PharmaceuticalResearch #Proteros Lear more: https://www.proteros.com/

Discover Proteros' Tailored Screening Libraries – Designed to Accelerate Your Drug Discovery Proteros offers a collection of three strategically designed fragments libraries, each crafted to meet your specific research needs. All collections are Ro3 or Ro5 compliant, carefully curated to exclude reactive compounds, PAINS, and unfavorable physicochemical properties. Sourced from different commercial vendors and designed to address any target class, these libraries are ready to support your hit discovery and optimization efforts. 🔍 Fragment Library – For Biophysical or High-Concentration Functional Assays A diverse collection of 3k Proteros-handpicked fragments – Proteros popular library for SPR based screening. Also available in d6-DMSO stocks for Ligand-based NMR screening. 🔬 19F-NMR Fragment Library This Enamine library contains 1,280 fluorinated fragments arranged in pools of 16 for rapid identification and sensitive detection of true hits. 💎 Crystallographic Fragment Library – Optimized for CFS Gain rapid structure-guided insights with 480 hand selected fragments tailored for crystallography-based fragment screening. Structural information of hits can be used to identify novel pockets and expand fragments rapidly into Enamine REAL space. #DrugDiscovery #FragmentScreening #StructuralBiology #Proteros #19FNMR Lear more: https://www.proteros.com/

🚀 Accelerating Drug Discovery via Crystallographic Fragment Screening (CFS) at Proteros We recently completed a focused and fast-paced Fragment-Based Drug Discovery campaign — delivering high-quality structural insights and validated chemical starting points in record time. 🔹 480 fragments screened individually by X-ray crystallography 🔹 9.4% hit rate, with an average resolution of 1.6 Å 🔹 40 of 45 compounds synthesized in just 4 weeks 🔹 10 molecules validated by crystallography 🔹 Binding confirmed via biophysical assays 🕒 Timeline: Project completed in just 3–4 months ✅ Outcome: Structurally diverse starting points at a known allosteric site — with 7 novel and 1 known allosteric sites identified This work highlights the power of integrating high-resolution structural biology, synthetic chemistry, and biophysical validation to rapidly generate tractable hits for challenging targets. Proud of the collaborative efforts that made this possible! #DrugDiscovery #FragmentScreening #CFS #StructuralBiology #AllostericSites #XrayCrystallography #MedicinalChemistry #Proteros #Enamine #BioSolveIT #InnovationInBiotech #Sandexis #FBBD #LibraryScreen

🚀 High Throughput Screening with SPR: Accelerate your discovery with our robust SPR capabilities! Our powerful screening solution features one of the world's largest SPR facilities, equipped with multiple Cytiva Biacore 8K and 8K+ instruments. Our tailored service includes: ✅ High information density for deselection of false positive (sensogram shape, binding kinetics) ✅ Proteros 186K centroid based small molecule library can be screened in as little as 2 weeks Our proprietary compound pooling and hit deconvolution strategy maximizes efficiency, delivering you actionable insights quickly to accelerate your early-stage programs. Let’s unlock new possibilities together! https://www.proteros.com/

Are you a virtual AI company that needs data to build model sets and/or validate your findings? Proteros is trusted by the majority of the world’s top 20 pharmaceutical companies, empowering many virtual biotechs and Pharma innovators in the virtual space with unmatched expertise in protein and structural analysis. Our facility has been specifically designed to meet specific service execution demands, offering structural biology, cryo-EM, protein sciences, biologics and assays, biophysics and screening services all "under one roof". Success is in sight with our delivery of high quality libraries for HT and fragment screening, Providing the data and validation needed for any drug discovery project ✅. Inquire below to get started! https://lnkd.in/eZ_NKYhD

 if there was an integrated platform that combined world class Protein Sciences and Cryo-EM infrastructure? There is! We call it the Proteros Integrated Cryo-EM Workbench. Here's what you can expect when working with us: ✅ A dedicated team for protein construct design, expression, and purification ✅ Rigorous QC for Cryo-EM that routinely solves high resolution structures with defined ligand binding modes ✅ Cryo-EM condition optimization and structure determination platform ✅ Special target expertise for various target classes like GPCR, membrane proteins, Biologics, DNA and RNA bound proteins, and many more Find out how you can Reach Right Faster to obtain your Cryo-EM structures with us! https://lnkd.in/eNsENPwG

❄️ Cryo-EM Services at Proteros ❄️ Access our world-class integrated protein science and cryo-em solutions. Sub-divided into three major sections, you can make use of our recommended full service or pick and choose the elements you need for your project - 🧬 Protein Sciences Construct design Expression systems: E.coli, insect, mammalian, yeast Purification and rigorous analytics-driven QC 🧬 EM Feasibility Analysis Purity, homogeneity and stability testing Negative staining EM Ligand-Protein interaction analysis 🧬 Structural Determination Cryo-EM condition optimisation Low-resolution cryo-EM and/or High-resolution cryo-EM Ready to get started? Find out more about our cryo-EM services now https://lnkd.in/eNsENPwG #CryoEM #ProteinSciences #ConstructDesign #DrugDiscovery

Proteins are at the heart of everything we do. Finding the right protein, for the right experiment in drug discovery. Regardless of whether it’s for biophysical characterization of compounds, assays, screening, or structural biology, for us, finding the RIGHT protein is so much more than just a Purity % We’re all about knowing the protein in question has the RIGHT ✅Functionality ✅Construct ✅Homogeneity ✅Post-translational modifications ✅Complex Composition ✅Stability ✅Activity ✅Purity Getting it right isn’t easy, and it requires in-depth understanding of the downstream applications. Find out how we could help you find the right protein for your discovery projects today https://lnkd.in/gHH_nNBd

🔐 How can we help unlock your challenging drug discovery target? In addition to our current range of solutions, we will be launching: ⚙️ High Throughput Screening (HTS) ⚙️ Crystallographic Fragment Screening  ⚙️ 19-F High Throughput Screening via NMR We’re thrilled to be advancing our drug discovery capabilities and look forward to unveiling more about our latest innovations soon. Don't just take our word for it – we are trusted by most of the world's top 20 pharma companies. We have a proven track record of more than 200 pharma and biotech partners in the US, Europe, and Japan. Established close to 25 years ago, we know more than a thing or two about proteins. Get in touch to be the first to find out about the launch of our new offerings or explore our current drug discovery solutions here 👉 https://lnkd.in/ev33Ufs6