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["Please note: Some rows in this table might have been deleted due to confidentiality reasons!"]
[null,null,"Item","Phase","Therapeutic area","Type of study","Sample size",null,null,null,null,"Randomisation",null,"Baseline characterization",null,"Blinded assessment",null,null,"Exclusion of data from analysis",null,"Controls",null,"Model choice",null,null,null,"Outcome choice",null,"Dose reponse \n(RATE ON IB LEVEL)",null,"Age matched to patients \n(RATE ON IB LEVEL)",null,"Mechanistic evidence \n(RATE ON IB LEVEL)","Replication of experiment \n(RATE ON IB LEVEL)",null,"Replication in different model \n(RATE ON IB LEVEL)","Replication in different species (RATE ON IB LEVEL)",null,"Citation of references",null,"Reporting on direction of results",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Dose reponse \n(RATE ON IB LEVEL)",null,"Age matched to patients \n(RATE ON IB LEVEL)",null,"Mechanistic evidence \n(RATE ON IB LEVEL)","Replication of experiment \n(RATE ON IB LEVEL)",null,"Replication in different model \n(RATE ON IB LEVEL)",null,"Replication in different species (RATE ON IB LEVEL)",null,"Citation of references",null,"Reporting on direction of results"]
[null,null,"Research questions",null,null,"Determine whether experiment listed in an efficacy study, Yes, no or unclear","Is sample size reported, Yes or no?","If yes, how many?",null,"group size","If yes, is sample size calculation reported, Yes or no?","Is randomisation reported, \nYes or no?","If yes, describe the method used to generate the randomization sequence.?","Is baseline characterization reported, \nYes or no?","If yes, what type?","Is blinded assessment  for treatment allocation reported, \nYes or no?","Is blinded assessment  for outcome assessment reported, \nYes or no?","If yes, when?","Is exclusion of data reported, Yes or no?","If yes, justification?","Is control group reported, Yes or no?","If yes, what type of control?","Is the species of animal reported?","If yes, what species?","Is the type of model reported?","Is the specifications of model reported?","Is the outcome choice reported, \nYes or no?","If yes, is the metric or time-course or both reported?","Is dose response reported? Yes or no?","If yes, is positive reponse reported, Yes or no? ","Is the age of animals reported, \nYes or no?","If yes, is it matched to patients?","Yes or no?","Is there replication of experiment, Yes or no?","If no, is there other similar study?","Is there replication in different model, \nYes or no?","Is there replication in different species, \nYes or no?","If yes, species type?","Is there references reported, \nYes or no?","If yes, what type of references?","Is effect size reported? Yes or no? \n(Step 1)","Is  significant value reported? Yes or no? \n(Step 2)","Was the investigation positive, inconclusive or negative?",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Is dose response reported? Yes or no?","If yes, is positive reponse reported, Yes or no? ","Is the age of animals reported, \nYes or no?","If yes, is it matched to patients?","Yes or no?","Is there replication of experiment, Yes or no?","If no, is there other similar study?","Is there replication in different model, \nYes or no?","If yes, model type?","Is there replication in different species, \nYes or no?","If yes, species type?","Is there references reported, \nYes or no?","If yes, what type of references?","Is effect size reported? Yes or no? \n(Step 1)","Is  significant value reported? Yes or no? \n(Step 2)","Was the investigation positive, inconclusive or negative?"]
["PCES","IB","Coding criteria",null,null,"■ In cases where drug are tested for efficacy in their respective therapeutic indications,  complete experiment level and IB level extraction. DO NOT PERFORM AN EXTRACTION for non-efficacy studies","■ Does the experiment report sample sizes for all extractable groups?\n■ Is information provided on the number of animal per treatment group or total number of animal for the whole experiment?","n = ?","group size",null,"■ Has a power calculation been performed a priori to determine sample size?\n■ Select no if there are no explicit statements about sample size determination.","■ Were animals randomly assigned to treatment?\n■ Select unclear if there are no explicit statements about allocation.","Group designation, Cage randomization,\nPermanent designation, Randomization to treatment","■ Was the emergence of confounding physiological variables monitored and addressed (e.g. blood pressure, body temperature)?\n■ Were the groups similar at baseline or were they adjusted for confounders in the analysis?\n■ Was the distribution of relevant baseline characteristics balanced for the intervention and control groups?\n■ If relevant, did the investigators adequately adjust for unequal distribution of some relevant baseline characteristics in the analysis?\n■ Was the timing of disease induction adequate? \n\n","Sex, age, immune status, weight, microbial status of the animal ","■ Was treatment allocation concealed from the investigators during the experiment?\n■ Select no if there are no explicit statements about blinding to treatment allocation.","■ Were investigators blinded to treatment allocation during outcome assessment? \n■ Select no if there are no explicit statements about blinding to outcome assessment."," ","■ Do studies explain the flow of animals from inclusion through to analysis?\n■ Has every animal been accounted for, from entry into experiment through treatment, outcome assessment, sacri ce and analysis? ","Animal death","■ Were appropriate controls used in all in vivo experiments (e.g. positive, negative)?","Positive control, negative control, sham, comparator arm","Mouse, rat, dog, monkey, etc.",null,"Induced or Experimental, spontaneous (xenograft, orthotopic), transgenic, type of disease","Tumor size, etc.","Endpoints, type of measurement (survival, tumor shrinkage, etc), time-course of measurement, mean survival ",null,"■ Was there a demonstration of dose-response relationship of  the adverse effect?\n■ Was there a time course (e.g., onset and duration of response) of the adverse effect?\n■ Was the doses eliciting the adverse effect compared to the doses eliciting the primary pharmacodynamic effect in the test species or the proposed therapeutic effect in humans?\n■ Minimum of 3 different doses",null,"■ Is age of animals mentioned?","■ Check inclusion criteria of patients",null,"■ Is it the same model?\n■ Is it the same drug? \n■ Is it measuring the same outcome?",null,"■ Whether efficacy studies were replicated in more than one model. \n■ Is it the same species?","■ Whether efficacy studies were replicated in more than one species.",null,"■ If there is internal study number, citation, … then it is a yes.","Peer-reviewed, in house data",null,"■ Is there a p-value reported in the figure description or in the experiment results?","■ If p value significant (typically ≤ 0.05), then it is positiv.e",null,null,null,null,null,"Mouse","Rat","Rabbit","Monkey/Primate","Hamster","Dog","chicken","guinea-pig","ferret","pig",null,null,"Anzahl Yes PCES","Anzahl No PCES","Prozent Yes PCES","Anzahl Yes IB","Anzahl No IB"]
[1,"IB1",null,2,null,"no efficacy","-","-",null,null,"-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","only positive PCES","any references reported","any peer-reviewed references reported",null,null,{"$f":"COUNTIFS(X6:X735,\"*mouse\")","v":492},{"$f":"COUNTIFS($X6:$X735,\"*rat\")","v":60},{"$f":"COUNTIFS($X6:$X735,\"*rabbit\")","v":9},{"$f":"COUNTIFS($X6:$X735,\"*monkey\")","v":3},{"$f":"COUNTIFS($X6:$X735,\"*hamster*\")","v":12},{"$f":"COUNTIFS($X6:$X735,\"*dog*\")","v":5},{"$f":"COUNTIFS($X6:$X735,\"*chick*\")","v":4},{"$f":"COUNTIFS($X6:$X735,\"*guin*\")","v":2},{"$f":"COUNTIFS($X6:$X735,\"*ferr*\")","v":1},{"$f":"COUNTIFS($X6:$X735,\"pig*\")","v":1},"yes",{"$f":"COUNTIFS(AH6,\"no\",AJ6,\"no\",AK6,\"no\")","v":0},{"$f":"COUNTIFS(A5:AB5,\"yes\")","v":0},{"$f":"COUNTIFS(A5:AP5,\"no\")","v":0},{"$f":"BI5/SUM(BI5:BJ5)","v":{"$error":"#DIV/0!"}},{"$f":"COUNTIFS(AC5:AL5,\"yes\")","v":0},{"$f":"COUNTIFS(AC5:AL5,\"no\")","v":0},{"$f":"BL5/SUM(BL5:BM5)","v":{"$error":"#DIV/0!"}}]
[{"$f":"A5+1","v":2},"IB2",null,2,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"no","no","-","no","-","no","no","-","no","-","yes","Positive control","yes","Mouse","yes","yes","yes","both","no","-","no","-","yes","no","no","yes","no","-","yes","In house","yes","no","positive","yes","yes","no","yes",null,{"$f":"COUNTIFS(X6:X735,\"*mice\")","v":21},null,null,{"$f":"COUNTIFS($X6:$X735,\"prima*\")","v":6},null,null,null,null,null,null,"no",0,{"$f":"SUM(G6=BG$5,L6=BG$5,N6=BG$5,P6=BG$5,Q6=BG$5,S6=BG$5,U6=BG$5,W6=BG$5,Y6=BG$5,Z6=BG$5,AA6=BG$5)","v":5},{"$f":"SUM(G6=BG$6,L6=BG$6,N6=BG$6,P6=BG$6,Q6=BG$6,S6=BG$6,U6=BG$6,W6=BG$6,Y6=BG$6,Z6=BG$6,AA6=BG$6)","v":6},{"$f":"BI6/SUM(BI6:BJ6)","v":0.45454545454545453},{"$f":"SUM(AC6=BG$5,AE6=BG$5,AG6=BG$5,AH6=BG$5,AJ6=BG$5,AK6=BG$5)","v":2},{"$f":"SUM(AC6=BG$6,AE6=BG$6,AG6=BG$6,AH6=BG$6,AJ6=BG$6,AK6=BG$6)","v":4},{"$f":"BL6/SUM(BL6:BM6)","v":0.33333333333333331},{"$f":"(AVERAGE(BK6:BK9)*11+BN6*6)/17","v":0.41176470588235292},{"$f":"SUM(BI6:BJ6,BL6:BM6)","v":17}]
[{"$f":"A6+1","v":3},"IB2",null,2,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"no","no","-","no","-","no","no","-","no","-","yes","Positive control","yes","Mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,"-","yes","In house","yes","no","positive",null,null,null,null,null,{"$f":"COUNTIFS(X6:X74,\"*mur*\")","v":6},null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,null,null,null,null,{"$f":"SUM(BI7:BJ7,BL7:BM7)","v":11}]
[4,"IB2",null,2,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"no","no","-","no","-","no","no","-","no","-","yes","Positive control","yes","Mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,"-","yes","In house","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,null,null,null,null,11]
[5,"IB2",null,2,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"no","no","-","no","-","no","no","-","no","-","yes","Positive control","yes","Mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,"-","yes","In house","yes","no","positive",null,null,null,null,null,{"$f":"SUM(AW5:AW7)","v":519},{"$f":"SUM(AX5:AX7)","v":60},9,9,12,5,4,{"$f":"SUM(BD5:BD7)","v":2},{"$f":"SUM(BE5:BE7)","v":1},1,null,1,5,6,0.45454545454545453,null,null,null,null,11]
[6,"IB3",null,1,"Blood product & biotech","efficacy","no","-",null,null,"no","no","-","yes","Bodyweight","no","no","-","no","-","yes","Positive control, negative control","yes","Mouse","yes","yes","yes","both","no","-","no","-","yes","no","no","no","no","-","no","-","yes","no","positive","yes","no","no","yes",null,{"$f":"AW9/$AW11","v":0.83440514469453375},{"$f":"AX9/$AW11","v":9.6463022508038579E-2},1.4469453376205787E-2,{"$f":"AZ9/$AW11","v":1.4469453376205787E-2},1.9292604501607719E-2,8.0385852090032149E-3,6.4308681672025723E-3,3.2154340836012861E-3,{"$f":"BE9/$AW11","v":1.6077170418006431E-3},{"$f":"BF9/$AW11","v":1.6077170418006431E-3},null,0,6,5,0.54545454545454541,{"$f":"SUM(AC10=BG$5,AE10=BG$5,AG10=BG$5,AH10=BG$5,AJ10=BG$5,AK10=BG$5)","v":1},{"$f":"SUM(AC10=BG$6,AE10=BG$6,AG10=BG$6,AH10=BG$6,AJ10=BG$6,AK10=BG$6)","v":5},{"$f":"BL10/SUM(BL10:BM10)","v":0.16666666666666666},{"$f":"(AVERAGE(BK10:BK11)+BN10)/2","v":0.37878787878787873},17]
[7,"IB3",null,1,"Blood product & biotech","efficacy","yes",48,12,12,"no","no","-","yes","Sex","no","no","-","no","-","yes","Positive control, negative control","yes","Mouse","yes","yes","yes","both",null,"-",null,null,null,null,null,null,null,null,"no","-","yes","no","positive",null,null,null,null,null,{"$f":"SUM(AW9:BF9)","v":622},null,null,null,null,null,null,null,null,null,null,0,7,4,0.63636363636363635,null,null,null,null,11]
[8,"IB4",null,2,"Respiratory system","efficacy","no","-",null,null,"no","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric","yes","yes","no","-","yes","no","no","yes","no","-","yes","in house","no","yes","positive","yes","yes","no","yes",null,{"$f":"AW11/708","v":0.87853107344632764},null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,{"$f":"SUM(AC12=BG$5,AE12=BG$5,AG12=BG$5,AH12=BG$5,AJ12=BG$5,AK12=BG$5)","v":3},{"$f":"SUM(AC12=BG$6,AE12=BG$6,AG12=BG$6,AH12=BG$6,AJ12=BG$6,AK12=BG$6)","v":3},0.5,{"$f":"(AVERAGE(BK12:BK32)*11+BN12*6)/17","v":0.29971988795518201},17]
[9,"IB4",null,2,"Respiratory system","efficacy","yes",38,"n=9-10, 4 groups",9,"no","no","-","no","-","no","no","-","no","-","yes","negative","no","-","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[10,"IB4",null,2,"Respiratory system","efficacy","no","-",null,null,"no","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[11,"IB4",null,2,"Respiratory system","efficacy","no","-",null,null,"no","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[12,"IB4",null,2,"Respiratory system","efficacy","no","-",null,null,"no","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","yes","positive",null,null,null,null,null,{"$f":"SUM(AW9:AX9)","v":579},{"$f":"SUM(AY9,BA9,BD9:BE9)","v":24},{"$f":"SUM(BB9,BC9,BF9)","v":10},9,{"$f":"SUM(AZ9,AW16:AY16)","v":622},"Unspecified","Total",null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[13,"IB4",null,2,"Respiratory system","efficacy","no","-",null,null,"no","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","yes","positive",null,null,null,null,null,{"$f":"AW16/AW11","v":0.93086816720257237},{"$f":"AX16/AW11","v":3.8585209003215437E-2},{"$f":"AY16/AW11","v":1.607717041800643E-2},{"$f":"AZ16/BA16","v":1.4469453376205787E-2},null,{"$f":"BC17-BA16","v":86},708,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[14,"IB4",null,2,"Respiratory system","efficacy","no","-",null,null,"no","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","yes","positive",null,null,null,null,null,{"$f":"AW16/$BC17","v":0.81779661016949157},{"$f":"AX16/$BC17","v":3.3898305084745763E-2},{"$f":"AY16/$BC17","v":1.4124293785310734E-2},{"$f":"AZ16/$BC17","v":1.2711864406779662E-2},{"$f":"BA16/$BC17","v":0.87853107344632764},{"$f":"BB17/$BC17","v":0.12146892655367232},{"$f":"BC17/$BC17","v":1},null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[15,"IB4",null,2,"Respiratory system","efficacy","yes",36,"5-7 size per group, 9 groups",5,"no","no","-","no","-","no","no","-","no","-","yes","negative","yes","murine","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,0,0,null,null,11]
[16,"IB4",null,2,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","murine","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in house","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[17,"IB4",null,2,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","murine","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","inconclusive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[18,"IB4",null,2,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","murine","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","inconclusive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[19,"IB4",null,2,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","murine","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","inconclusive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[20,"IB4",null,2,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","inconclusive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,1,10,9.0909090909090912E-2,0,0,null,null,11]
[21,"IB4",null,2,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","murine","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","inconclusive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[22,"IB4",null,2,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","inconclusive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,1,10,9.0909090909090912E-2,0,0,null,null,11]
[23,"IB4",null,2,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","inconclusive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,1,10,9.0909090909090912E-2,0,0,null,null,11]
[24,"IB4",null,2,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","positive","no","-","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","inconclusive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[25,"IB4",null,2,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","positive","no","-","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","inconclusive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[26,"IB4",null,2,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","positive","no","-","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","inconclusive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[27,"IB4",null,2,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","inconclusive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,1,10,9.0909090909090912E-2,0,0,null,null,11]
[28,"IB4",null,2,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","inconclusive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,1,1,10,9.0909090909090912E-2,0,0,null,null,11]
[29,"IB5",null,null,"Respiratory system","efficacy","no","-",null,null,"no","no","-","no","-","no","no","-","no","-","no","-","yes","Dog","yes","no","no","-","no","-","yes","yes","no","no","no","no","no","-","yes","In house","no","no","inconclusive","no","yes","no","no",null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,1,5,0.16666666666666666,{"$f":"(AVERAGE(BK33:BK34)*11+BN33*6)/17","v":0.17647058823529413},17]
[30,"IB5",null,null,"Respiratory system","efficacy","no","-",null,null,"no","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,"-",null,null,null,null,null,null,null,null,"yes","In house","no","no","inconclusive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[31,"IB6",null,null,"Blood product & biotech","efficacy","no","-",null,null,"no","no","-","yes","Nude","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric","yes","yes","no","-","yes","no","yes","yes","no","-","yes","In house","no","no","positive","yes","yes","no","yes",null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,3,3,0.5,{"$f":"(AVERAGE(BK35:BK45)*11+BN35*6)/17","v":0.43850267379679142},17]
[32,"IB6",null,null,"Blood product & biotech","efficacy","no","-",null,null,"no","no","-","yes","Nude","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","In house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[33,"IB6",null,null,"Blood product & biotech","efficacy","no","-",null,null,"no","no","-","yes","Nude","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","In house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[34,"IB6",null,null,"Blood product & biotech","efficacy","no","-",null,null,"no","no","-","yes","Nude","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,"yes",null,null,"-","yes","In house","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[35,"IB6",null,null,"Blood product & biotech","efficacy","no","-",null,null,"no","no","-","yes","Nude","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,"-","yes","In house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[36,"IB6",null,null,"Blood product & biotech","efficacy","no","-",null,null,"no","no","-","yes","Nude","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,"-","yes","In house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[37,"IB6",null,null,"Blood product & biotech","efficacy","no","-",null,null,"no","no","-","yes","Nude","no","no","-","no","-","yes","Postive control","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,"-","yes","In house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[38,"IB6",null,null,"Blood product & biotech","efficacy","no","-",null,null,"no","no","-","yes","Nude","no","no","-","no","-","yes","Postive control","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,"-","yes","In house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[39,"IB6",null,null,"Blood product & biotech","efficacy","no","-",null,null,"no","no","-","yes","Nude","no","no","-","no","-","yes","Postive control","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,"-","yes","In house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[40,"IB6",null,null,"Blood product & biotech","efficacy","no","-",null,null,"no","no","-","yes","Nude","no","no","-","no","-","yes","Postive control","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,"-","yes","In house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[41,"IB6",null,null,"Blood product & biotech","efficacy","no","-",null,null,"no","no","-","yes","Nude","no","no","-","no","-","yes","Postive control","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,"-","yes","In house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[42,"IB7",null,null,"Blood product & biotech","efficacy","no","-",null,null,"no","no","-","yes","nude","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-","yes","yes","no","-","yes","no","yes","yes","no","-","yes","In house","no","no","positive","no","yes","yes","yes",null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,3,3,0.5,{"$f":"(AVERAGE(BK46:BK60)*11+BN46*6)/17","v":0.37647058823529411},17]
[43,"IB7",null,null,"Blood product & biotech","efficacy","no","-",null,null,"no","no","-","yes","nude","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","In house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[44,"IB7",null,null,"Blood product & biotech","efficacy","no","-",null,null,"no","no","-","yes","nude","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","In house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[45,"IB7",null,null,"Blood product & biotech","efficacy","no","-",null,null,"no","no","-","yes","nude","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[46,"IB7",null,null,"Blood product & biotech","efficacy","no","-",null,null,"no","no","-","yes","Nude","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,"-","yes","In house","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[47,"IB7",null,null,"Blood product & biotech","efficacy","no","-",null,null,"no","no","-","yes","Nude","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,"-","yes","In house","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[48,"IB7",null,null,"Blood product & biotech","efficacy","no","-",null,null,"no","no","-","yes","Nude","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,"-","yes","In house","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[49,"IB7",null,null,"Blood product & biotech","efficacy","no","-",null,null,"no","no","-","yes","Nude","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,"-","yes","In house","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[50,"IB7",null,null,"Blood product & biotech","efficacy","no","-",null,null,"no","no","-","yes","Nude","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,"-","yes","In house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[51,"IB7",null,null,"Blood product & biotech","efficacy","no","-",null,null,"no","no","-","yes","Nude","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,"-","yes","In house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[52,"IB7",null,null,"Blood product & biotech","efficacy","no","-",null,null,"no","no","-","yes","Nude","no","no","-","no","-","yes","Postive control","yes","mouse","yes","no","no","no",null,null,null,null,null,null,null,null,null,"-","yes","In house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[53,"IB7",null,null,"Blood product & biotech","efficacy","no","-",null,null,"no","no","-","yes","Nude","no","no","-","no","-","yes","Postive control","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,"-","yes","In house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[54,"IB7",null,null,"Blood product & biotech","efficacy","no","-",null,null,"no","no","-","yes","Nude","no","no","-","no","-","yes","Postive control","yes","mouse","yes","no","no","no",null,null,null,null,null,null,null,null,null,"-","yes","In house","no","no","negative",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[55,"IB7",null,null,"Blood product & biotech","efficacy","no","-",null,null,"no","no","-","yes","Nude","no","no","-","no","-","yes","Postive control","yes","mouse","yes","no","no","no",null,null,null,null,null,null,null,null,null,"-","yes","In house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[56,"IB7",null,null,"Blood product & biotech","efficacy","no","-",null,null,"no","no","-","yes","Nude","no","no","-","no","-","yes","Postive control","yes","mouse","yes","no","no","no",null,null,null,null,null,null,null,null,null,"-","yes","In house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,1,4,7,0.36363636363636365,0,0,null,null,11]
[57,"IB8",null,null,"Respiratory system","efficacy","no","-",null,null,"no","no","-","yes","Wistar","no","no","-","no","-","yes","negative, positive","yes","rat","yes","yes","yes","both","yes","yes","no","-","yes","no","no","no","no","-","yes","In house","yes","no","positive","yes","yes","no","yes",null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,2,4,0.33333333333333331,{"$f":"(AVERAGE(BK61:BK62)*11+BN61*6)/17","v":0.47058823529411764},17]
[58,"IB8",null,null,"Respiratory system","efficacy","no","-",null,null,"no","no","-","yes","Wistar","no","no","-","no","-","yes","Negative","yes","rat","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","In house","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,0,0,null,null,11]
[59,"IB9",null,null,"Rheumatology","efficacy","yes",48,null,12,"no","no","-","no","-","no","no","-","no","-","yes","Positive","yes","Rat","no","no","no","-","yes","yes","yes","yes","yes","yes","yes","no","no","-","yes","In house","no","no","positive","yes","yes","no","no",null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,4,2,0.66666666666666663,{"$f":"(AVERAGE(BK63:BK66)*11+BN63*6)/17","v":0.52941176470588236},17]
[60,"IB9",null,null,"Rheumatology","efficacy","yes",70,null,10,"no","no","-","no","-","no","no","-","no","-","yes","Positive, Negative","yes","Rat","no","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","In house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[61,"IB9",null,null,"Rheumatology","efficacy","yes",50,null,10,"no","no","-","yes","Sex, young adult","no","no","-","no","-","yes","Negative","yes","Rat","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","In house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,7,4,0.63636363636363635,0,0,null,null,11]
[62,"IB9",null,null,"Rheumatology","efficacy","yes",48,null,12,"no","no","-","no","-","no","no","-","yes","yes","yes","Negative","yes","Rat","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","In house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,1,7,4,0.63636363636363635,0,0,null,null,11]
[63,"IB13",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","yes","yes","yes","Negative, positive","yes","mouse","yes","no","yes","metric","no","-","yes","yes","yes","no","no","no","no","-","yes","Peer-reviewed","yes","yes","positive","yes","yes","yes","yes",null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,2,4,0.33333333333333331,{"$f":"(AVERAGE(BK67:BK70)*11+BN67*6)/17","v":0.39705882352941174},17]
[64,"IB13",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",25,null,6,"no","no","-","no","-","no","no","-","yes","yes","yes","Negative, positive","yes","mouse","yes","no","yes","both",null,"-",null,null,null,null,null,null,null,null,"yes","Peer-reviewed","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,0,0,null,null,11]
[65,"IB13",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","yes","ARCaPM cells were injected into the tibiae of nude mice on Day 1, and on Day 31 \nanimals with established bone lesions were randomized to receive cabozantinib or vehicle \nqd for 7 weeks of treatment","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","no",null,null,null,null,null,null,null,null,null,null,"yes","Peer-reviewed","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"COUNTIFS(AH70,\"no\",AJ70,\"no\",AK70,\"no\")","v":0},5,6,0.45454545454545453,0,0,null,null,11]
[66,"IB13",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","Peer-reviewed","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,{"$f":"SUM(G70=BG$5,L70=BG$5,N70=BG$5,P70=BG$5,Q70=BG$5,S70=BG$5,U70=BG$5,W70=BG$5,Y70=BG$5,Z70=BG$5,AA70=BG$5)","v":3},{"$f":"SUM(G70=BG$6,L70=BG$6,N70=BG$6,P70=BG$6,Q70=BG$6,S70=BG$6,U70=BG$6,W70=BG$6,Y70=BG$6,Z70=BG$6,AA70=BG$6)","v":8},{"$f":"BI70/SUM(BI70:BJ70)","v":0.27272727272727271},0,0,null,null,11]
[{"$f":"A70+1","v":67},"IB10",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",6,null,2,"no","no","-","yes","sex","no","no","-","no","-","yes","unclear","yes","mouse","yes","no","yes","metric","yes","yes","no","-","yes","yes","-","yes","no","-","no","-","yes","no","positive","yes","no","no","yes",null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,4,2,{"$f":"BL71/SUM(BL71:BM71)","v":0.66666666666666663},{"$f":"(AVERAGE(BK71:BK74)*11+BN71*6)/17","v":0.47058823529411764},{"$f":"SUM(BI71:BJ71,BL71:BM71)","v":17}]
[68,"IB10",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",6,null,2,"no","no","-","yes","sex","no","no","-","no","-","yes","unclear","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,0,0,null,null,11]
[69,"IB10",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[70,"IB10",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[71,"IB10",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[72,"IB10",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",6,null,2,"no","no","-","yes","sex","no","no","-","no","-","yes","unclear","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,{"$f":"BI76/SUM(BI76:BJ76)","v":0.54545454545454541},{"$f":"SUM(AC76=BG$5,AE76=BG$5,AG76=BG$5,AH76=BG$5,AJ76=BG$5,AK76=BG$5)","v":0},{"$f":"SUM(AC76=BG$6,AE76=BG$6,AG76=BG$6,AH76=BG$6,AJ76=BG$6,AK76=BG$6)","v":0},null,null,11]
[73,"IB11",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",21,null,7,"no","no","-","yes","sex","no","no","-","no","-","yes","negative","yes","rat","yes","yes","yes","both","yes","yes","no","-","yes","no","yes","yes","no","-","yes","In house","yes","yes","positive","yes","yes","no","yes",null,null,null,null,null,null,null,null,null,null,null,null,0,7,4,0.63636363636363635,3,3,{"$f":"BL77/SUM(BL77:BM77)","v":0.5},{"$f":"(AVERAGE(BK77:BK84)*11+BN77*6)/17","v":0.44117647058823534},17]
[74,"IB11",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","negative","no","-","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","In house","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[75,"IB11",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","negative","no","-","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","In house","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[76,"IB11",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","yes","yes","yes","negative, positive","no","-","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","In house","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[77,"IB11",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","negative, positive","no","-","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","In house","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[78,"IB11",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","Negative, positive","no","-","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","In house","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[79,"IB11",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","Negative, positive","no","-","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","In house","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[80,"IB11",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","Negative, positive","no","-","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","In house","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[81,"IB12",null,null,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric","yes","yes","no","-","yes","yes","-","yes","no","-","yes","In house","no","no","positive","no","yes","no","yes",null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,4,2,0.66666666666666663,{"$f":"(AVERAGE(BK85:BK104)*11+BN85*6)/17","v":0.37941176470588234},17]
[82,"IB12",null,null,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","In house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[83,"IB12",null,null,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","no",null,null,null,null,null,null,null,null,null,null,"yes","In house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[84,"IB12",null,null,"Respiratory system","efficacy","no","-",null,null,"-","no","-","yes","sex, nude mice","no","no","-","no","-","no","-","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","In house","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[85,"IB12",null,null,"Respiratory system","efficacy","yes",26,"12-14",12,"no","yes","To determine the histologic effect of vismodegib treatment on SC LS180 xenografts in CD-1 nude mice, 26 mice with a mean LS180 tumor volume of 75 mm\n3 were grouped  randomly into two groups of 12–14 mice each.  ","yes","nude","no","no","-","yes","no","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","In house","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,9,2,0.81818181818181823,0,0,null,null,11]
[86,"IB12",null,null,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","In house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,1,10,9.0909090909090912E-2,0,0,null,null,11]
[87,"IB12",null,null,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","In house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,1,10,9.0909090909090912E-2,0,0,null,null,11]
[88,"IB12",null,null,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","In house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,1,10,9.0909090909090912E-2,0,0,null,null,11]
[89,"IB12",null,null,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","In house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,1,10,9.0909090909090912E-2,0,0,null,null,11]
[90,"IB12",null,null,"Respiratory system","efficacy","yes",45,"5-7",5,"no","no",null,"no","-","no","no","-","yes","no","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","In house","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,7,4,0.63636363636363635,0,0,null,null,11]
[91,"IB12",null,null,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","In house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[92,"IB12",null,null,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","In house","no","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,1,10,9.0909090909090912E-2,0,0,null,null,11]
[93,"IB12",null,null,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","In house","no","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,1,10,9.0909090909090912E-2,0,0,null,null,11]
[94,"IB12",null,null,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","In house","no","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,1,10,9.0909090909090912E-2,0,0,null,null,11]
[95,"IB12",null,null,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","In house","no","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,1,10,9.0909090909090912E-2,0,0,null,null,11]
[96,"IB12",null,null,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","In house","no","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,1,10,9.0909090909090912E-2,0,0,null,null,11]
[97,"IB12",null,null,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","In house","no","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,1,10,9.0909090909090912E-2,0,0,null,null,11]
[98,"IB12",null,null,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no",null,"no","-","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","In house","no","no","negative",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,1,10,9.0909090909090912E-2,0,0,null,null,11]
[99,"IB12",null,null,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","In house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[100,"IB12",null,null,"Respiratory system","efficacy","no","-",null,null,"-","no","-","yes","Nude","no","no","-","no","-","no",null,"no","-","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","In house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[101,"IB14",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no",null,"yes","rat","yes","no","yes","metric","no","-","no","-","yes","no","no","yes","no","-","yes","peer revieweded","no","no","positive","yes","yes","yes","no",null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,2,4,0.33333333333333331,{"$f":"(AVERAGE(BK105:BK106)*11+BN105*6)/17","v":0.29411764705882354},17]
[102,"IB14",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no",null,"yes","rat","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[103,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","rat","yes","no","no","-","yes","yes","no","-","yes","no","yes","yes","yes","rat, mice","yes","peer revieweded","no","no","positive","no","yes","yes","yes",null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,4,2,0.66666666666666663,{"$f":"(AVERAGE(BK107:BK122)*11+BN107*6)/17","v":0.4154411764705882},17]
[104,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[105,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[106,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","In house","no","no","negative",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[107,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",30,null,10,"no","no","-","no","-","no","no","-","no","-","yes","Negative, positive","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[108,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",30,null,10,"no","no","-","no","-","no","no","-","no","-","yes","Negative, positive","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[109,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","Postive control","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[110,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","Postive control","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[111,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","no","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,1,10,9.0909090909090912E-2,0,0,null,null,11]
[112,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","no","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,1,10,9.0909090909090912E-2,0,0,null,null,11]
[113,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[114,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[115,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","yes","sex, female","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[116,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[117,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","rat","no","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,1,10,9.0909090909090912E-2,0,0,null,null,11]
[118,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","Postive control","yes","rat","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[119,"IB16",null,2,null,"no efficacy",null,null,null,null,null,"-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,0,0,{"$error":"#DIV/0!"},0,0,null,null,0]
[120,"IB17",null,null,"Anti-infectives","efficacy","yes",31,"7-8",7,"no","no","-","yes","bodyweight at day 0","no","no","-","yes","no","yes","negative","yes","mouse","yes","no","yes","both","yes","yes","no",null,"yes","no","yes","yes","yes","mouse, dog","no","-","no","yes","positive","yes","no","no","no",null,null,null,null,null,null,null,null,null,null,null,null,0,7,4,0.63636363636363635,4,2,0.66666666666666663,{"$f":"(AVERAGE(BK124:BK130)*11+BN124*6)/17","v":0.57983193277310929},17]
[121,"IB17",null,null,"Anti-infectives","efficacy","yes",16,null,8,"no","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"no","-","no","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[122,"IB17",null,null,"Anti-infectives","efficacy","yes",56,null,8,"no","no","-","yes","sex, age","no","no","-","no","-","yes","negative","yes","rat","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"no","-","no","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,0,0,null,null,11]
[123,"IB17",null,null,"Anti-infectives","efficacy","yes",40,null,8,"no","no","-","yes","sex","no","no","-","no","-","yes","negative","yes","dog","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"no","-","no","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,0,0,null,null,11]
[124,"IB17",null,null,"Anti-infectives","efficacy","yes",3,null,3,"no","no","-","yes","sex, age","no","no","-","no","-","yes","cross over","yes","monkey","no","no","yes","both",null,null,null,null,null,null,null,null,null,null,"no","-","no","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[125,"IB17",null,null,"Anti-infectives","efficacy","yes",40,null,8,"no","no","-","yes","sex","no","no","-","no","-","yes","negative","yes","hamster","no","no","yes","both",null,null,null,null,null,null,null,null,null,null,"no","-","no","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[126,"IB17",null,null,"Anti-infectives","efficacy","yes",24,null,8,"no","no","-","yes","sex","no","no","-","no","-","yes","negative","yes","guinea pigs","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"no","-","no","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,7,4,0.63636363636363635,0,0,null,null,11]
[127,"IB18",null,null,"Alimentary tract & metabolism","efficacy","yes",60,null,10,"no","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","both","yes","yes","yes","yes","no","yes","-","yes","yes","mice, rat, monkey","yes","in house","yes","yes","positive","yes","yes","no","yes",null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,5,1,0.83333333333333337,{"$f":"(AVERAGE(BK131:BK141)*11+BN131*6)/17","v":0.63636363636363635},17]
[128,"IB18",null,null,"Alimentary tract & metabolism","efficacy","yes",36,null,6,"no","no","-","no","-","no","no","-","no","-","yes","negative","yes","rat","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in house","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[129,"IB18",null,null,"Alimentary tract & metabolism","efficacy","yes",16,"5-6",5,"no","no","-","no","-","no","no","-","yes","no","no","-","yes","monkey","no","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in house","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"COUNTIFS(AH134,\"no\",AJ134,\"no\",AK134,\"no\")","v":0},4,7,0.36363636363636365,0,0,null,null,11]
[130,"IB18",null,null,"Alimentary tract & metabolism","efficacy","yes",96,null,12,"no","yes","yes","yes","sex","no","no","-","no","-","yes","Negative, positive","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in house","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,{"$f":"SUM(G134=BG$5,L134=BG$5,N134=BG$5,P134=BG$5,Q134=BG$5,S134=BG$5,U134=BG$5,W134=BG$5,Y134=BG$5,Z134=BG$5,AA134=BG$5)","v":8},{"$f":"SUM(G134=BG$6,L134=BG$6,N134=BG$6,P134=BG$6,Q134=BG$6,S134=BG$6,U134=BG$6,W134=BG$6,Y134=BG$6,Z134=BG$6,AA134=BG$6)","v":3},0.72727272727272729,0,0,null,null,11]
[{"$f":"A134+1","v":131},"IB18",null,null,"Alimentary tract & metabolism","efficacy","yes",72,null,12,"no","yes","yes","yes","sex","no","no","-","no","-","yes","Negative, positive","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,8,3,0.72727272727272729,0,0,null,null,{"$f":"SUM(BI135:BJ135,BL135:BM135)","v":11}]
[132,"IB18",null,null,"Alimentary tract & metabolism","efficacy","yes",40,null,8,"no","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","in house","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[133,"IB18",null,null,"Alimentary tract & metabolism","efficacy","yes",50,null,10,"no","no","-","no","-","no","no","-","no","-","yes","positive","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","in house","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[134,"IB18",null,null,"Alimentary tract & metabolism","efficacy","yes",90,null,10,"no","yes","yes","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in house","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,0,0,null,null,11]
[135,"IB18",null,null,"Alimentary tract & metabolism","efficacy","yes",90,null,10,"no","no","-","no","-","no","no","-","no","-","yes","Negative, positive","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in house","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[136,"IB18",null,null,"Alimentary tract & metabolism","efficacy","no","-",null,null,"-","yes","yes","yes","sex","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in house","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,{"$f":"BI140/SUM(BI140:BJ140)","v":0.54545454545454541},{"$f":"SUM(AC140=BG$5,AE140=BG$5,AG140=BG$5,AH140=BG$5,AJ140=BG$5,AK140=BG$5)","v":0},{"$f":"SUM(AC140=BG$6,AE140=BG$6,AG140=BG$6,AH140=BG$6,AJ140=BG$6,AK140=BG$6)","v":0},null,null,11]
[137,"IB18",null,null,"Alimentary tract & metabolism","efficacy","yes",56,null,14,"no","yes","yes","yes","sex, age","no","no","-","no","-","yes","Negative, positive","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in house","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,1,7,4,0.63636363636363635,0,0,null,null,11]
[138,"IB19",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",12,null,6,"no","yes","yes","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both","no","-","no","-","no","no","no","no","no","-","no",null,"yes","no","positive","yes","no","no","yes",null,null,null,null,null,null,null,null,null,null,null,null,0,7,4,0.63636363636363635,0,6,{"$f":"BL142/SUM(BL142:BM142)","v":0},{"$f":"(AVERAGE(BK142)*11+BN142*6)/17","v":0.41176470588235292},17]
[139,"IB20",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","no","no",null,"no","no","-","no","-","no","-","yes","rat","yes","yes","no","-","yes","yes","no","-","yes","yes","-","yes","yes","rat, mice","yes","peer revieweded","yes","no","positive","yes","yes","yes","yes",null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,5,1,0.83333333333333337,{"$f":"(AVERAGE(BK143:BK158)*11+BN143*6)/17","v":0.49632352941176461},17]
[140,"IB20",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","no","yes","sex","no","no","-","no","-","yes","negative","yes","rat","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,0,0,null,null,11]
[141,"IB20",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","no","yes","sex","no","no","-","no","-","yes","negative","yes","rat","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,0,0,null,null,11]
[142,"IB20",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","no","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[143,"IB20",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","no","no","-","no","no","-","no","-","yes","Negative, positive","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[144,"IB20",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","no","no","-","no","no","-","no","-","yes","Negative, positive","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[145,"IB20",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","no","no","-","no","no","-","no","-","yes","positive","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[146,"IB20",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","no","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[147,"IB20",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","no","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[148,"IB20",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","no","yes","sex","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[149,"IB20",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","no","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[150,"IB20",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","no","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[151,"IB20",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","no","no","-","no","no","-","no","-","no","-","yes","rat","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[152,"IB20",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","no","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[153,"IB20",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","no","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[154,"IB20",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","no","no","-","no","no","-","no","-","yes","positive","yes","rat","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[155,"IB21",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","no","no","-","no","no","-","no","-","yes","positive","yes","mouse","yes","no","yes","both","yes","yes","no",null,"yes","yes",null,"yes","no","-","no","-","yes","no","positive","no","no","no","yes",null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,4,2,0.66666666666666663,{"$f":"(AVERAGE(BK159:BK176)*11+BN159*6)/17","v":0.45751633986928103},17]
[156,"IB21",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","no","no","-","no","no","-","no","-","yes","positive","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"no","-","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[157,"IB21",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","positive","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"no","-","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[158,"IB21",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","negative, positive","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"no","-","no","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[159,"IB21",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","negative, positive","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"no","-","no","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[160,"IB21",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","negative, positive","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"no","-","no","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[161,"IB21",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",40,null,10,"no","no","-","no","-","no","no","-","no","-","yes","negative, positive","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"no","-","no","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,0,0,null,null,11]
[162,"IB21",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",20,null,10,"no","no","-","no","-","no","no","-","no","-","yes","negative, positive","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"no","-","no","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,0,0,null,null,11]
[163,"IB21",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",20,null,5,"no","no","-","no","-","no","no","-","yes","no","yes","negative, positive","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,7,4,0.63636363636363635,0,0,null,null,11]
[164,"IB21",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",12,null,3,"no","no","-","no","-","no","no","-","yes","no","yes","negative, positive","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,7,4,0.63636363636363635,0,0,null,null,11]
[165,"IB21",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",20,null,5,"no","no","-","no","-","no","no","-","yes","no","yes","negative, positive","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,7,4,0.63636363636363635,0,0,null,null,11]
[166,"IB21",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"no","-","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,1,10,9.0909090909090912E-2,0,0,null,null,11]
[167,"IB21",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"no","-","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,1,10,9.0909090909090912E-2,0,0,null,null,11]
[168,"IB21",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"no","-","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,1,10,9.0909090909090912E-2,0,0,null,null,11]
[169,"IB21",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"no","-","yes","no","negative",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,1,10,9.0909090909090912E-2,0,0,null,null,11]
[170,"IB21",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"no","-","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,1,10,9.0909090909090912E-2,0,0,null,null,11]
[171,"IB21",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"no","-","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,1,10,9.0909090909090912E-2,0,0,null,null,11]
[172,"IB21",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,1,10,9.0909090909090912E-2,0,0,null,null,11]
[173,"IB22",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",24,null,8,"no","no","-","yes","sex","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","both","yes","yes","no",null,"yes","yes","-","yes","yes","mice, rat","no","-","yes","no","positive","no","no","no","yes",null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,5,1,0.83333333333333337,{"$f":"(AVERAGE(BK177:BK204)*11+BN177*6)/17","v":0.48319327731092421},17]
[174,"IB22",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","yes","sex","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"no","-","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[175,"IB22",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"no","-","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[176,"IB22",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","rat","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"no","-","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[177,"IB22",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","yes","sex","no","no","-","no","-","no","-","yes","rat","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"no","-","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[178,"IB22",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","yes","sex","no","no","-","no","-","no","-","yes","rat","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"no","-","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[179,"IB22",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","rabbit","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"no","-","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[180,"IB22",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","rabbit","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"no","-","yes","no","negative",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[181,"IB22",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[182,"IB22",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","negative",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[183,"IB22",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[184,"IB22",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[185,"IB22",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[186,"IB22",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[187,"IB22",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[188,"IB22",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","negative",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[189,"IB22",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","negative",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[190,"IB22",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","negative",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[191,"IB22",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","negative",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[192,"IB22",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","negative",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[193,"IB22",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"COUNTIFS(AH198,\"no\",AJ198,\"no\",AK198,\"no\")","v":0},3,8,0.27272727272727271,0,0,null,null,11]
[194,"IB22",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,{"$f":"SUM(G198=BG$5,L198=BG$5,N198=BG$5,P198=BG$5,Q198=BG$5,S198=BG$5,U198=BG$5,W198=BG$5,Y198=BG$5,Z198=BG$5,AA198=BG$5)","v":3},{"$f":"SUM(G198=BG$6,L198=BG$6,N198=BG$6,P198=BG$6,Q198=BG$6,S198=BG$6,U198=BG$6,W198=BG$6,Y198=BG$6,Z198=BG$6,AA198=BG$6)","v":8},0.27272727272727271,0,0,null,null,11]
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[196,"IB22",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","negative",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[197,"IB22",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","negative",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[198,"IB22",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[199,"IB22",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[200,"IB22",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,{"$f":"BI204/SUM(BI204:BJ204)","v":0.27272727272727271},{"$f":"SUM(AC204=BG$5,AE204=BG$5,AG204=BG$5,AH204=BG$5,AJ204=BG$5,AK204=BG$5)","v":0},{"$f":"SUM(AC204=BG$6,AE204=BG$6,AG204=BG$6,AH204=BG$6,AJ204=BG$6,AK204=BG$6)","v":0},null,null,11]
[201,"IB23",null,null,"Blood product & biotech","efficacy","yes",48,null,8,"no","no","-","yes","sex","no","no","-","yes","yes","yes","negative","yes","mouse","yes","yes","yes","metric","yes","yes","no","-","no","yes","-","yes","yes","mice, dogs","yes","in house","yes","yes","positive","yes","yes","yes","yes",null,null,null,null,null,null,null,null,null,null,null,null,0,8,3,0.72727272727272729,4,2,{"$f":"BL205/SUM(BL205:BM205)","v":0.66666666666666663},{"$f":"(AVERAGE(BK205:BK232)*11+BN205*6)/17","v":0.53361344537815114},17]
[202,"IB23",null,null,"Blood product & biotech","efficacy","yes",27,null,9,"no","no","-","yes","sex","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","both","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,0,0,null,null,11]
[203,"IB23",null,null,"Blood product & biotech","efficacy","yes",18,"5-8",5,"no","no","-","yes","sex","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in house","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,0,0,null,null,11]
[204,"IB23",null,null,"Blood product & biotech","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","in house","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[205,"IB23",null,null,"Blood product & biotech","efficacy","yes",16,null,8,"no","no","-","yes","sex","no","no","-","yes","yes","yes","negative","yes","mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","in house","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,8,3,0.72727272727272729,0,0,null,null,11]
[206,"IB23",null,null,"Blood product & biotech","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[207,"IB23",null,null,"Blood product & biotech","efficacy","yes",31,"5-7",5,"no","no","-","yes","sex","no","no","-","yes","yes","yes","negative","yes","mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,8,3,0.72727272727272729,0,0,null,null,11]
[208,"IB23",null,null,"Blood product & biotech","efficacy","yes",70,null,10,"no","no","-","no","-","no","no","-","yes","yes","yes","negative","yes","mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","both","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,7,4,0.63636363636363635,0,0,null,null,11]
[209,"IB23",null,null,"Blood product & biotech","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[210,"IB23",null,null,"Blood product & biotech","efficacy","yes",20,null,10,"no","no","-","yes","sex","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,7,4,0.63636363636363635,0,0,null,null,11]
[211,"IB23",null,null,"Blood product & biotech","efficacy","yes",30,null,10,"no","no","-","yes","sex","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,0,0,null,null,11]
[212,"IB23",null,null,"Blood product & biotech","efficacy","yes",50,null,10,"no","no","-","yes","sex","no","no","-","yes","yes","yes","negative, positive","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in house","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,7,4,0.63636363636363635,0,0,null,null,11]
[213,"IB23",null,null,"Blood product & biotech","efficacy","no","-",null,null,null,"no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[214,"IB23",null,null,"Blood product & biotech","efficacy","yes",40,null,10,"no","no","-","no","-","no","no","-","no","-","yes","negative, positive","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[215,"IB23",null,null,"Blood product & biotech","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[216,"IB23",null,null,"Blood product & biotech","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[217,"IB23",null,null,"Blood product & biotech","efficacy","yes",13,"5-8",5,"no","no","-","yes","sex","no","no","-","yes","yes","yes","negative","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","in house","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,7,4,0.63636363636363635,0,0,null,null,11]
[218,"IB23",null,null,"Blood product & biotech","efficacy","yes",48,"8-1ß",8,"no","no","-","yes","sex","no","no","-","yes","yes","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","both","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,8,3,0.72727272727272729,0,0,null,null,11]
[219,"IB23",null,null,"Blood product & biotech","efficacy","yes",40,"8 per group",8,"no","no","-","yes","sex","no","no","-","yes","yes","yes","negative, positive","yes","mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","both","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,8,3,0.72727272727272729,0,0,null,null,11]
[220,"IB23",null,null,"Blood product & biotech","efficacy","yes",30,null,10,"no","no","-","yes","sex","no","no","-","yes","yes","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in house","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,8,3,0.72727272727272729,0,0,null,null,11]
[221,"IB23",null,null,"Blood product & biotech","efficacy","yes",13,"5-8",5,"no","no","-","yes","sex","no","no","-","yes","yes","yes","negative","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","in house","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,7,4,0.63636363636363635,0,0,null,null,11]
[222,"IB23",null,null,"Blood product & biotech","efficacy","yes",40,null,10,"no","no","-","yes","sex","no","no","-","yes","yes","yes","negative","yes","mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","in house","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,8,3,0.72727272727272729,0,0,null,null,11]
[223,"IB23",null,null,"Blood product & biotech","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","in house","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[224,"IB23",null,null,"Blood product & biotech","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[225,"IB23",null,null,"Blood product & biotech","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[226,"IB23",null,null,"Blood product & biotech","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[227,"IB23",null,null,"Blood product & biotech","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[228,"IB23",null,null,"Blood product & biotech","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[229,"IB24",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",24,null,8,"no","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","yes","yes","metric","yes","yes","no","-","yes","no","yes","yes","no","-","no","-","no","yes","positive","yes","no","no","yes",null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,3,3,0.5,{"$f":"(AVERAGE(BK233:BK236)*11+BN233*6)/17","v":0.51470588235294112},17]
[230,"IB24",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",48,"7-8",8,"no","no","-","no","-","no","no","-","yes","no","no","-","yes","mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","no","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,0,0,null,null,11]
[231,"IB24",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",16,"8 per group",8,"no","no","-","yes","sex","no","no","-","yes","no","no","-","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"no","-","no","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,7,4,0.63636363636363635,0,0,null,null,11]
[232,"IB24",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",64,null,8,"no","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[233,"IB25",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both","yes","yes","no","-","yes","yes","-","yes","no","-","no","-","no","yes","positive","yes","no","no","yes",null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,4,2,0.66666666666666663,{"$f":"(AVERAGE(BK237:BK247)*11+BN237*6)/17","v":0.42780748663101609},17]
[234,"IB25",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"no","-","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[235,"IB25",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[236,"IB25",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[237,"IB25",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[238,"IB25",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[239,"IB25",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[240,"IB25",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","negative, positive","no",null,"yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"no","-","no","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[241,"IB25",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","negative, positive","no",null,"yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[242,"IB25",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","negative, positive","no",null,"yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"no","-","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[243,"IB25",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","negative, positive","no",null,"yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"no","-","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[244,"IB26",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","negative, positive","yes","mouse","yes","yes","yes","both","yes","yes","no","-","yes","no","yes","yes","yes","mice, rats","yes","in house","no","yes","positive","yes","yes","yes","yes",null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,4,2,0.66666666666666663,{"$f":"(AVERAGE(BK248:BK251)*11+BN248*6)/17","v":0.55882352941176472},17]
[245,"IB26",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",36,null,12,"no","no","-","yes","sex","no","no","-","no","-","yes","negative, positive","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,7,4,0.63636363636363635,0,0,null,null,11]
[246,"IB26",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","yes","sex","no","no","-","no","-","no","-","yes","rat","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[247,"IB26",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",25,null,5,"no","no","-","yes","sex","no","no","-","no","-","yes","positive","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded ","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,1,6,5,0.54545454545454541,0,0,null,null,11]
[248,"IB27",null,null,"Allergy & Immunology","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","primate","yes","no","yes","metric","no","-","no","-","yes","no","no","no","no","Therefore, the majority of nonclinical \nefficacy studies with belatacept were performed on human or non-human primate cells in \nvitro or non-human primates in vivo. ","no","-","no","no","positive","yes","no","no","no",null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,1,5,0.16666666666666666,{"$f":"(AVERAGE(BK252:BK254)*11+BN252*6)/17","v":0.21568627450980393},17]
[249,"IB27",null,null,"Allergy & Immunology","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","primate","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[250,"IB27",null,null,"Allergy & Immunology","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","primate","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[251,"IB28",null,null,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","rat","yes","no","yes","metric","yes","yes","no","-","yes","yes","-","yes","yes","mice, rats, dogs","yes","in house","no","no","positive","yes","yes","yes","yes",null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,5,1,0.83333333333333337,{"$f":"(AVERAGE(BK255:BK261)*11+BN255*6)/17","v":0.49579831932773111},17]
[252,"IB28",null,null,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","rat","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in house","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[253,"IB28",null,null,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","rat","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[254,"IB28",null,null,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","dog","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","in house","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[255,"IB28",null,null,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[256,"IB28",null,null,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","negative","yes","rat","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[257,"IB28",null,null,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","negative","yes","rat","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded ","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"COUNTIFS(AH262,\"no\",AJ262,\"no\",AK262,\"no\")","v":0},4,7,0.36363636363636365,0,0,null,null,11]
[258,"IB29",null,null,"Blood product & biotech","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-","yes","yes","no","-","yes","yes","-","no","no","-","yes","in house","no","no","positive","no","yes","no","no",null,null,null,null,null,null,null,null,null,null,null,null,0,{"$f":"SUM(G262=BG$5,L262=BG$5,N262=BG$5,P262=BG$5,Q262=BG$5,S262=BG$5,U262=BG$5,W262=BG$5,Y262=BG$5,Z262=BG$5,AA262=BG$5)","v":2},{"$f":"SUM(G262=BG$6,L262=BG$6,N262=BG$6,P262=BG$6,Q262=BG$6,S262=BG$6,U262=BG$6,W262=BG$6,Y262=BG$6,Z262=BG$6,AA262=BG$6)","v":9},0.18181818181818182,3,3,0.5,{"$f":"(AVERAGE(BK262:BK275)*11+BN262*6)/17","v":0.29411764705882354},17]
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[260,"IB29",null,null,"Blood product & biotech","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[261,"IB29",null,null,"Blood product & biotech","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[262,"IB29",null,null,"Blood product & biotech","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[263,"IB29",null,null,"Blood product & biotech","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[264,"IB29",null,null,"Blood product & biotech","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,{"$f":"BI268/SUM(BI268:BJ268)","v":0.18181818181818182},{"$f":"SUM(AC268=BG$5,AE268=BG$5,AG268=BG$5,AH268=BG$5,AJ268=BG$5,AK268=BG$5)","v":0},{"$f":"SUM(AC268=BG$6,AE268=BG$6,AG268=BG$6,AH268=BG$6,AJ268=BG$6,AK268=BG$6)","v":0},null,null,11]
[265,"IB29",null,null,"Blood product & biotech","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[266,"IB29",null,null,"Blood product & biotech","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[267,"IB29",null,null,"Blood product & biotech","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[268,"IB29",null,null,"Blood product & biotech","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[269,"IB29",null,null,"Blood product & biotech","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","negative",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[270,"IB29",null,null,"Blood product & biotech","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[271,"IB29",null,null,"Blood product & biotech","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[272,"IB30",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","positive","yes","mouse","yes","yes","yes","both","yes","yes","no","-","yes","yes","-","yes","no","-","yes","in house","yes","no","positive","yes","yes","no","yes",null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,4,2,{"$f":"BL276/SUM(BL276:BM276)","v":0.66666666666666663},{"$f":"(AVERAGE(BK276:BK286)*11+BN276*6)/17","v":0.4331550802139037},17]
[273,"IB30",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","positive","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in house","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[274,"IB30",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","positive","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in house","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[275,"IB30",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","positive","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in house","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[276,"IB30",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","positive","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[277,"IB30",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","positive","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","in house","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[278,"IB30",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","positive","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[279,"IB30",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[280,"IB30",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[281,"IB30",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[282,"IB30",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,2,9,0.18181818181818182,0,0,null,null,11]
[283,"IB31",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",42,null,6,"no","no","-","no","-","no","no","-","no","-","yes","Positive, Negative","yes","mouse","yes","yes","yes","both","yes","yes","no","-","no","yes","-","yes","no","-","yes","in house","no","no","positive","no","yes","no","yes",null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,3,3,0.5,{"$f":"(AVERAGE(BK287:BK291)*11+BN287*6)/17","v":0.55294117647058816},17]
[284,"IB31",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",36,null,6,"no","no","-","no","-","no","no","-","no","-","yes","Positive, Negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in house","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,0,0,null,null,11]
[285,"IB31",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",18,null,6,"no","no","-","no","-","no","no","-","no","-","yes","Positive, Negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","yes","negative",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,0,0,null,null,11]
[286,"IB31",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",40,null,8,"no","no","-","yes","sex","no","no","-","yes","yes","yes","positive","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in house","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,8,3,0.72727272727272729,0,0,null,null,11]
[287,"IB31",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",16,null,8,"no","no","-","no","-","no","no","-","no","-","yes","positive","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in house","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,0,0,null,null,11]
[288,"IB32",null,2,null,"no efficacy","-","-",null,null,"-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,0,0,{"$error":"#DIV/0!"},0,0,null,null,0]
[289,"IB33",null,2,null,"no efficacy","-","-",null,null,"-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,1,0,0,{"$error":"#DIV/0!"},0,0,null,null,0]
[290,"IB34",null,null,"Allergy & Immunology","efficacy","no","-",null,null,"-","no","-","yes","sex","no","no","-","no","-","yes","negative","yes","mouse","yes","no","no","-","yes","yes","yes","yes","no","no","no","no","no","-","yes","in house","no","no","positive","yes","yes","no","no",null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,2,4,0.33333333333333331,{"$f":"(AVERAGE(BK294:BK297)*11+BN294*6)/17","v":0.3235294117647059},17]
[291,"IB35",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","yes","Positive, Negative","yes","rat","yes","no","yes","both","yes","yes","no",null,"no","yes","-","yes","no","-","yes","in house","no","no","positive","yes","yes","no","no",null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,3,3,0.5,{"$f":"(AVERAGE(BK295:BK302)*11+BN295*6)/17","v":0.36029411764705882},17]
[292,"IB35",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[293,"IB35",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[294,"IB35",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[295,"IB35",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[296,"IB35",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[297,"IB35",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[298,"IB35",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[299,"IB36",null,null,"Dermatologicals","efficacy","yes",30,"10 per group",10,"no","no","-","no","-","no","no","-","no","-","yes","positive","yes","mouse","yes","yes","yes","metric","yes","yes","no",null,"yes","no","yes","yes","yes","rat, mice","yes","in house","no","no","positive","yes","yes","yes","no",null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,4,2,0.66666666666666663,{"$f":"(AVERAGE(BK303:BK310)*11+BN303*6)/17","v":0.54411764705882348},17]
[300,"IB36",null,null,"Dermatologicals","efficacy","yes",24,"8-9 per group",8,"no","no","-","no","-","no","no","-","no","-","yes","positive","yes","rat","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,0,0,null,null,11]
[301,"IB36",null,null,"Dermatologicals","efficacy","yes",6,null,null,"no","no","-","no","-","no","no","-","no","-","yes","positive","yes","rat","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,0,0,null,null,11]
[302,"IB36",null,null,"Dermatologicals","efficacy","yes",5,"5 per group",5,"no","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewedd","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[303,"IB36",null,null,"Dermatologicals","efficacy","yes",10,"5-6 per group",5,"no","no","-","no","-","no","no","-","no","-","yes","positive","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[304,"IB36",null,null,"Dermatologicals","efficacy","yes",25,"7-10 per group",7,"no","no","-","no","-","no","no","-","no","-","yes","positive","yes","rat","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[305,"IB36",null,null,"Dermatologicals","efficacy","yes",30,"10 per group",10,"no","no","-","no","-","no","no","-","no","-","yes","positive","yes","rat","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[306,"IB36",null,null,"Dermatologicals","efficacy","yes",45,"15 per group",15,"no","no","-","no","-","no","no","-","no","-","yes","positive","yes","rat","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[{"$f":"#REF!+1","v":{"$error":"#REF!"}},"IB39",null,null,null,"no efficacy","-","-",null,null,"-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-","-",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,0,0,{"$error":"#DIV/0!"},0,0,null,null,0]
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[null,"IB5a",null,null,"Cardiovascular","efficacy","yes",16,"4 per group",4,"no","no",null,"no",null,"no","no",null,"no",null,"yes","negative","yes","dogs","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in-house","no","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,1,{"$f":"SUM(G710=BG$5,L710=BG$5,N710=BG$5,P710=BG$5,Q710=BG$5,S710=BG$5,U710=BG$5,W710=BG$5,Y710=BG$5,Z710=BG$5,AA710=BG$5)","v":6},{"$f":"SUM(G710=BG$6,L710=BG$6,N710=BG$6,P710=BG$6,Q710=BG$6,S710=BG$6,U710=BG$6,W710=BG$6,Y710=BG$6,Z710=BG$6,AA710=BG$6)","v":5},0.54545454545454541,0,0,null,null,11]
[null,"IB1b",null,"2a","Rheumatology","efficacy","no",null,null,null,null,"no",null,"yes"," sex","no","no",null,"no",null,"yes","negative","Yes","Rat","yes","no","yes","no","yes","yes","no",null,"yes","no",null,"no","no",null,"yes","in-house","no","no","positive","yes","yes","no","no",null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,2,4,0.33333333333333331,{"$f":"(AVERAGE(BK711)*11+BN711*6)/17","v":0.41176470588235292},{"$f":"SUM(BI711:BJ711,BL711:BM711)","v":17}]
[null,"IB2b",null,1,"Nervous system","efficacy","yes",null,"9-10 per group",9,"no","yes","no","no",null,"no","no",null,"no",null,"yes","negative","yes","mice","yes","yes","yes","both","yes","yes","no",null,"yes","no",null,"yes","yes","rats","no",null,"no","yes","positive","yes","no","no","yes",null,null,null,null,null,null,null,null,null,null,null,null,0,7,4,0.63636363636363635,4,2,0.66666666666666663,{"$f":"(AVERAGE(BK712:BK714)*11+BN712*6)/17","v":0.58823529411764708},17]
[null,"IB2b",null,null,"Nervous system","efficacy","no",null,null,null,null,"no",null,"no",null,"no","no",null,"no",null,"yes","negative","yes","rat","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"no",null,"no","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[null,"IB2b",null,null,"Nervous system","efficacy","no",null,null,null,null,"no",null,"yes","female","no","no",null,"no",null,"yes","negative","yes","mice","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"no",null,"no","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,0,0,null,null,11]
[null,"IB3b",null,"1/2","Anti-neoplastic & immune-modulating agents","efficacy","no",null,null,null,null,"yes","no","no",null,"no","no",null,"no",null,"yes","negative","yes","mice","yes","yes","yes","both","yes","yes","no",null,"yes","yes",null,"yes","no",null,"yes","in-house","yes","no","positive","yes","yes","no","yes",null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,4,2,0.66666666666666663,{"$f":"(AVERAGE(BK715:BK719)*11+BN715*6)/17","v":0.54117647058823526},17]
[null,"IB3b",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no",null,null,null,null,"no",null,"no",null,"no","no",null,"no",null,"yes","negative","yes","mice","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in-house","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,{"$f":"BI716/SUM(BI716:BJ716)","v":0.45454545454545453},{"$f":"SUM(AC716=BG$5,AE716=BG$5,AG716=BG$5,AH716=BG$5,AJ716=BG$5,AK716=BG$5)","v":0},{"$f":"SUM(AC716=BG$6,AE716=BG$6,AG716=BG$6,AH716=BG$6,AJ716=BG$6,AK716=BG$6)","v":0},null,null,11]
[null,"IB3b",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no",null,null,null,null,"no",null,"no",null,"no","no",null,"no",null,"yes","negative","yes","mice","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in-house","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[null,"IB3b",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no",null,null,null,null,"yes",null,"no",null,"no","no",null,"no",null,"yes","comparator (approved therapeutics)","yes","mice","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in-house","yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,0,0,null,null,11]
[null,"IB3b",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no",null,null,null,null,"no",null,"no",null,"no","no",null,"no",null,"yes","single substances","no",null,"yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"no",null,"yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,0,0,null,null,11]
[null,"IB4b",null,1,"Anti-neoplastic & immune-modulating agents","efficacy","no",null,null,null,null,"no",null,"yes","sex","no","no",null,"no",null,"yes","negative","yes","mice","yes","yes","yes","both","yes","yes","no",null,"yes","yes",null,"yes","yes","mouse, rat","yes","in-house","yes","yes","positive","yes","yes","no","yes",null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,5,1,{"$f":"BL720/SUM(BL720:BM720)","v":0.83333333333333337},{"$f":"(AVERAGE(BK720:BK727)*11+BN720*6)/17","v":0.65441176470588236},17]
[null,"IB4b",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no",null,null,null,null,"no",null,"yes","sex","no","no",null,"no",null,"yes","negative","yes","rat","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in-house","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,0,0,null,null,11]
[null,"IB4b",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no",null,null,null,null,"no",null,"yes","sex","no","no",null,"no",null,"yes","negative","yes","mice","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in-house","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,0,0,null,null,11]
[null,"IB4b",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no",null,null,null,null,"no",null,"yes","sex","no","no",null,"no",null,"yes","negative","yes","mice","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in-house","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,0,0,null,null,11]
[null,"IB4b",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no",null,null,null,null,"no",null,"yes","sex","no","no",null,"no",null,"yes","negative","yes","mice","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in-house","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,0,0,null,null,11]
[null,"IB4b",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",null,"8-10 per group",8,"no","no",null,"yes","sex","no","no",null,"no",null,"yes","negative","yes","mice","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in-house","no","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,7,4,0.63636363636363635,0,0,null,null,11]
[null,"IB4b",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no",null,null,null,null,"no",null,"yes","sex","no","no",null,"no",null,"yes","negative","yes","mice","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in-house","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,0,0,null,null,11]
[null,"IB4b",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no",null,null,null,null,"no",null,"yes","sex","no","no",null,"no",null,"yes","negative","yes","mice","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in-house","yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,0,0,null,null,11]
[null,"IB5b",null,"2a","Blood product & biotech","efficacy","no",null,null,null,null,"no",null,"no",null,"no","no",null,"no",null,"yes","negative","yes","mice","yes","yes","no","no","no",null,"no",null,"no","no",null,"yes","no",null,"no",null,"no","no","positive","yes","no","no","yes",null,null,null,null,null,null,null,null,null,null,null,null,0,4,7,0.36363636363636365,1,5,0.16666666666666666,{"$f":"(AVERAGE(BK728:BK731)*11+BN728*6)/17","v":0.30882352941176472},17]
[null,"IB5b",null,null,"Blood product & biotech","efficacy","no",null,null,null,null,"no",null,"no",null,"no","no",null,"no",null,"yes","comparator (human plasma/Ersatz)","yes","mice","yes","no","no","no",null,null,null,null,null,null,null,null,null,null,"no",null,"no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,3,8,0.27272727272727271,0,0,null,null,11]
[null,"IB5b",null,null,"Blood product & biotech","efficacy","no",null,null,null,null,"no",null,"no",null,"no","no",null,"no",null,"yes","negative","yes","mice","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"no",null,"yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[null,"IB5b",null,null,"Blood product & biotech","efficacy","no",null,null,null,null,"no",null,"no",null,"no","no",null,"no",null,"yes","negative","yes","mice","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"no",null,"no","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[null,"IB6b",null,"1/2","Alimentary tract & metabolism","efficacy","yes",null,"5-9 per group",5,"no","no",null,"yes","sex","no","no",null,"no",null,"yes","negative","yes","mice","yes","no","yes","both","yes","yes","no",null,"yes","no",null,"yes","no",null,"no",null,"yes","yes","positive","yes","no","no","yes",null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,3,3,0.5,{"$f":"(AVERAGE(BK732:BK735)*11+BN732*6)/17","v":0.52941176470588236},17]
[null,"IB6b",null,null,"Alimentary tract & metabolism","efficacy","yes",null,"6 per group",6,"no","no",null,"yes","sex","no","no",null,"no",null,"yes","negative","yes","mice","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"no",null,"yes","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,6,5,0.54545454545454541,0,0,null,null,11]
[null,"IB6b",null,null,"Alimentary tract & metabolism","efficacy","yes",null,"10-12 per group",10,"no","yes","no","yes","sex","no","no",null,"no",null,"yes","negative","yes","mice","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"no",null,"no","yes","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,7,4,0.63636363636363635,0,0,null,null,11]
[null,"IB6b",null,null,"Alimentary tract & metabolism","efficacy","no",null,null,null,null,"no",null,"yes","sex","no","no",null,"no",null,"yes","negative","yes","mice","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"no",null,"yes","no","positive",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,5,6,0.45454545454545453,0,0,null,null,11]
[]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"only positive PCES","any reference cited","any peer-reviewed reference cited"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"yes",{"$f":"COUNTIFS(AR2:AR732,\"yes\")","v":70},{"$f":"COUNTIFS(AS2:AS732,\"yes\")","v":68},{"$f":"COUNTIFS(AT2:AT732,\"yes\")","v":27},{"$f":"COUNTIFS(AU2:AU732,\"yes\")","v":69},"yes",null,null,null,null,null,null,null,null,null,null,null,{"$f":"SUM(BH5:BH735)","v":15}]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"no",{"$f":"COUNTIFS(AR2:AR734,\"no\")","v":21},{"$f":"COUNTIFS(AS2:AS734,\"no\")","v":23},{"$f":"COUNTIFS(AT2:AT734,\"no\")","v":64},{"$f":"COUNTIFS(AU2:AU734,\"no\")","v":22},"no"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"SUM(AR738:AR739)","v":91},{"$f":"SUM(AS738:AS739)","v":91},{"$f":"SUM(AT738:AT739)","v":91}]
[]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"yes",{"$f":"AR738/AR740","v":0.76923076923076927},{"$f":"AS738/AS740","v":0.74725274725274726},{"$f":"AT738/AT740","v":0.2967032967032967},null,"yes "]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"no",{"$f":"AR739/AR740","v":0.23076923076923078},{"$f":"AS739/AS740","v":0.25274725274725274},{"$f":"AT739/AT740","v":0.70329670329670335},null,"no"]
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[null,"IB99"]

{"sheet":"First in man trials","index":1,"n_rows":1046027,"n_cols":85,"rows_kept":4500,"cut":true,"hidden":false,"merged":[[26,33,33,33],[26,34,33,34],[26,35,33,35],[26,36,33,36],[26,27,33,27],[26,28,33,28],[26,29,33,29],[26,30,33,30],[26,31,33,31],[26,32,33,32],[23,33,25,33],[23,34,25,34],[23,35,25,35],[23,36,25,36],[23,27,25,27],[23,28,25,28],[23,29,25,29],[23,30,25,30],[23,31,25,31],[23,32,25,32],[21,33,22,33],[21,34,22,34],[21,35,22,35],[21,36,22,36],[21,27,22,27],[21,28,22,28],[21,29,22,29],[21,30,22,30],[21,31,22,31],[21,32,22,32],[18,33,20,33],[18,34,20,34],[18,35,20,35],[18,36,20,36],[18,27,20,27],[18,28,20,28],[18,29,20,29],[18,30,20,30],[18,31,20,31],[18,32,20,32],[11,27,17,27],[11,28,17,28],[11,29,17,29],[11,30,17,30],[11,31,17,31],[11,32,17,32],[11,33,17,33],[11,34,17,34],[11,35,17,35],[11,36,17,36],[6,27,10,27],[6,28,10,28],[6,29,10,29],[6,30,10,30],[6,31,10,31],[6,32,10,32],[6,33,10,33],[6,34,10,34],[6,35,10,35],[6,36,10,36],[4,33,5,33],[4,34,5,34],[4,35,5,35],[4,36,5,36],[4,27,5,27],[4,28,5,28],[4,29,5,29],[4,30,5,30],[4,31,5,31],[4,32,5,32],[1,82,1,84],[1,54,1,56],[1,57,1,58],[1,59,1,60],[1,61,1,66],[1,67,1,68],[1,69,1,70],[1,71,1,72],[1,74,1,75],[1,76,1,77],[1,78,1,79],[1,80,1,81],[1,50,1,51],[1,52,1,53],[1,21,1,24],[1,25,1,26],[1,27,1,28],[1,29,1,30],[1,32,1,33],[1,19,1,20],[1,35,1,36],[1,37,1,38],[1,39,1,41],[1,47,1,49],[1,5,1,9],[1,10,1,11],[1,12,1,13],[1,14,1,16],[1,17,1,18]],"bounds":{"rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0}}
["Please note: Some rows in this table might have been deleted due to confidentiality reasons!"]
[null,"Item","Phase","Therapeutic area","Type of study","Sample size",null,null,null,null,"Randomisation",null,"Baseline characterization",null,"Blinded assessment",null,null,"Exclusion of data from analysis",null,"Controls",null,"Model choice",null,null,null,"Outcome choice",null,"Dose reponse \n(RATE ON IB LEVEL)",null,"Age matched to patients \n(RATE ON IB LEVEL)",null,"Mechanistic evidence \n(RATE ON IB LEVEL)","Replication of experiment \n(RATE ON IB LEVEL)",null,"Replication in different model \n(RATE ON IB LEVEL)","Replication in different species (RATE ON IB LEVEL)",null,"Citation of references",null,"Reporting on direction of results",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Dose reponse \n(RATE ON IB LEVEL)",null,"Age matched to patients \n(RATE ON IB LEVEL)",null,"Mechanistic evidence \n(RATE ON IB LEVEL)","Replication of experiment \n(RATE ON IB LEVEL)",null,"Replication in different model \n(RATE ON IB LEVEL)",null,"Replication in different species (RATE ON IB LEVEL)",null,"Citation of references",null,"Reporting on direction of results"]
[null,"Research questions",null,null,"Determine whether experiment listed in an efficacy study, Yes, no or unclear","Is sample size reported, Yes or no?","If yes, how many?",null,"group size","If yes, is sample size calculation reported, Yes or no?","Is randomisation reported, \nYes or no?","If yes, describe the method used to generate the randomization sequence.?","Is baseline characterization reported, \nYes or no?","If yes, what type?","Is blinded assessment  for treatment allocation reported, \nYes or no?","Is blinded assessment  for outcome assessment reported, \nYes or no?","If yes, when?","Is exclusion of data reported, Yes or no?","If yes, justification?","Is control group reported, Yes or no?","If yes, what type of control?","Is the species of animal reported?","If yes, what species?","Is the type of model reported?","Is the specifications of model reported?","Is the outcome choice reported, \nYes or no?","If yes, is the metric or time-course or both reported?","Is dose response reported? Yes or no?","If yes, is positive reponse reported, Yes or no? ","Is the age of animals reported, \nYes or no?","If yes, is it matched to patients?","Yes or no?","Is there replication of experiment, Yes or no?","If no, is there other similar study?","Is there replication in different model, \nYes or no?","Is there replication in different species, \nYes or no?","If yes, species type?","Is there references reported, \nYes or no?","If yes, what type of references?","Is effect size reported? Yes or no? \n(Step 1)","Is  significant value reported? Yes or no? \n(Step 2)","Was the investigation positive, inconclusive or negative?",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Is dose response reported? Yes or no?","If yes, is positive reponse reported, Yes or no? ","Is the age of animals reported, \nYes or no?","If yes, is it matched to patients?","Yes or no?","Is there replication of experiment, Yes or no?","If no, is there other similar study?","Is there replication in different model, \nYes or no?","If yes, model type?","Is there replication in different species, \nYes or no?","If yes, species type?","Is there references reported, \nYes or no?","If yes, what type of references?","Is effect size reported? Yes or no? \n(Step 1)","Is  significant value reported? Yes or no? \n(Step 2)","Was the investigation positive, inconclusive or negative?"]
["IB","Coding criteria",null,null,"■ In cases where drug are tested for efficacy in their respective therapeutic indications,  complete experiment level and IB level extraction. DO NOT PERFORM AN EXTRACTION for non-efficacy studies","■ Does the experiment report sample sizes for all extractable groups?\n■ Is information provided on the number of animal per treatment group or total number of animal for the whole experiment?","n = ?","group size",null,"■ Has a power calculation been performed a priori to determine sample size?\n■ Select no if there are no explicit statements about sample size determination.","■ Were animals randomly assigned to treatment?\n■ Select unclear if there are no explicit statements about allocation.","Group designation, Cage randomization,\nPermanent designation, Randomization to treatment","■ Was the emergence of confounding physiological variables monitored and addressed (e.g. blood pressure, body temperature)?\n■ Were the groups similar at baseline or were they adjusted for confounders in the analysis?\n■ Was the distribution of relevant baseline characteristics balanced for the intervention and control groups?\n■ If relevant, did the investigators adequately adjust for unequal distribution of some relevant baseline characteristics in the analysis?\n■ Was the timing of disease induction adequate? \n\n","Sex, age, immune status, weight, microbial status of the animal ","■ Was treatment allocation concealed from the investigators during the experiment?\n■ Select no if there are no explicit statements about blinding to treatment allocation.","■ Were investigators blinded to treatment allocation during outcome assessment? \n■ Select no if there are no explicit statements about blinding to outcome assessment."," ","■ Do studies explain the flow of animals from inclusion through to analysis?\n■ Has every animal been accounted for, from entry into experiment through treatment, outcome assessment, sacri ce and analysis? ","Animal death","■ Were appropriate controls used in all in vivo experiments (e.g. positive, negative)?","Positive control, negative control, sham, comparator arm","Mouse, rat, dog, monkey, etc.",null,"Induced or Experimental, spontaneous (xenograft, orthotopic), transgenic, type of disease","Tumor size, etc.","Endpoints, type of measurement (survival, tumor shrinkage, etc), time-course of measurement, mean survival ",null,"■ Was there a demonstration of dose-response relationship of  the adverse effect?\n■ Was there a time course (e.g., onset and duration of response) of the adverse effect?\n■ Was the doses eliciting the adverse effect compared to the doses eliciting the primary pharmacodynamic effect in the test species or the proposed therapeutic effect in humans?\n■ Minimum of 3 different doses",null,"■ Is age of animals mentioned?","■ Check inclusion criteria of patients",null,"■ Is it the same model?\n■ Is it the same drug? \n■ Is it measuring the same outcome?",null,"■ Whether efficacy studies were replicated in more than one model. \n■ Is it the same species?","■ Whether efficacy studies were replicated in more than one species.",null,"■ If there is internal study number, citation, … then it is a yes.","Peer-reviewed, in house data",null,"■ Is there a p-value reported in the figure description or in the experiment results?","■ If p value significant (typically ≤ 0.05), then it is positiv.e"]
["IB3",null,1,"Blood product & biotech","efficacy","no","-",null,null,"na","no","-","yes","Bodyweight","no","no","-","no","-","yes","Positive control, negative control","yes","Mouse","yes","yes","yes","both","no","-","no","-","yes","no","no","no","no","-","no","-","yes","no","positive"]
["IB3",null,1,"Blood product & biotech","efficacy","yes",48,12,12,"no","no","-","yes","Sex","no","no","-","no","-","yes","Positive control, negative control","yes","Mouse","yes","yes","yes","both",null,"-",null,null,null,null,null,null,null,null,"no","-","yes","no","positive"]
["IB43",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,null,"-","no","-","yes","amount of tumor cell, tumor size","no","no","-","no","-","yes","positive, negative","yes","mouse","yes","no","yes","both","yes","yes","yes","no","yes","yes",null,"yes","no",null,"yes","peer reviewed","yes","yes","positive"]
["IB43",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",20,null,10,"no","yes",null,"yes",null,"no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in house","yes","yes","positive"]
["IB43",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",102,null,23,"no","yes",null,"yes",null,"no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","yes","positive"]
["IB43",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",60,null,12,"no","yes",null,"yes",null,"no","no","-","yes","yes","yes","negative","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in house","yes","yes","positive"]
["IB43",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",32,"10-12",10,"no","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","in house","no","no","positive"]
["IB46",null,null,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-","no",null,"yes","yes","no","yes",null,"yes","yes",null,"no","-","no","no","positive"]
["IB46",null,null,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","ferrets","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive"]
["IB46",null,null,"Respiratory system","efficacy","no","-",null,null,"-","no","-","no","-","no","no","-","no","-","no","-","yes","rabbit","no","no","yes","time-course",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive"]
["IB46",null,null,"Respiratory system","efficacy","no","-",null,null,"-","no","-","yes","age","no","no","-","no","-","yes","negative","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive"]
["IB46",null,null,"Respiratory system","efficacy","no","-",null,null,"-","no","-","yes","age","no","no","-","no","-","yes","negative","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive"]
["IB46",null,null,"Respiratory system","efficacy","no","-",null,null,"-","no","-","yes","age","no","no","-","no","-","yes","negative","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive"]
["IB46",null,null,"Respiratory system","efficacy","no","-",null,null,"-","no","-","yes","age","no","no","-","no","-","yes","negative","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive"]
["IB50",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",48,null,12,"no","no","-","no","-","no","no","-","no","-","no","negative","yes","mouse","yes","no","yes","metric","no",null,"no",null,"yes","no",null,"no","no",null,"no","-","no","no","positive"]
["IB50",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",40,null,8,"no","no","-","no","-","no","no","-","no","-","no","negative","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive"]
["IB50",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",56,null,12,"no","no","-","no","-","no","no","-","no","-","no","negative","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"no","-","no","no","positive"]
["IB4a",null,1,"Anti-neoplastic & immune-modulating agents","efficacy","yes",20,"10 per group",10,"no","no",null,"no",null,"no","no",null,"no",null,"yes","negative","yes","Mouse","yes","yes","yes","metric","no",null,"no",null,"yes","yes",null,"no","no",null,"no",null,"yes","yes","positive"]
["IB4a",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",44,"11 per group",11,"no","no",null,"no",null,"no","no",null,"no",null,"yes","negative","yes","Mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"no",null,"yes","yes","positive"]
["IB2b",null,1,"Nervous system","efficacy","yes",null,"9-10 per group",9,"no","yes","no","no",null,"no","no",null,"no",null,"yes","negative","yes","mice","yes","yes","yes","both","yes","yes","no",null,"yes","no",null,"yes","yes","rats","no",null,"no","yes","positive"]
["IB2b",null,null,"Nervous system","efficacy","no",null,null,null,null,"no",null,"no",null,"no","no",null,"no",null,"yes","negative","yes","rat","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"no",null,"no","yes","positive"]
["IB2b",null,null,"Nervous system","efficacy","no",null,null,null,null,"no",null,"yes","female","no","no",null,"no",null,"yes","negative","yes","mice","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"no",null,"no","yes","positive"]
["IB4b",null,1,"Anti-neoplastic & immune-modulating agents","efficacy","no",null,null,null,null,"no",null,"yes","sex","no","no",null,"no",null,"yes","negative","yes","mice","yes","yes","yes","both","yes","yes","no",null,"yes","yes",null,"yes","yes","mouse, rat","yes","in-house","yes","yes","positive"]
["IB4b",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no",null,null,null,null,"no",null,"yes","sex","no","no",null,"no",null,"yes","negative","yes","rat","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in-house","yes","yes","positive"]
["IB4b",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no",null,null,null,null,"no",null,"yes","sex","no","no",null,"no",null,"yes","negative","yes","mice","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in-house","yes","yes","positive"]
["IB4b",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no",null,null,null,null,"no",null,"yes","sex","no","no",null,"no",null,"yes","negative","yes","mice","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in-house","yes","yes","positive"]
["IB4b",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no",null,null,null,null,"no",null,"yes","sex","no","no",null,"no",null,"yes","negative","yes","mice","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in-house","yes","yes","positive"]
["IB4b",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",null,"8-10 per group",8,"no","no",null,"yes","sex","no","no",null,"no",null,"yes","negative","yes","mice","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in-house","no","yes","positive"]
["IB4b",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no",null,null,null,null,"no",null,"yes","sex","no","no",null,"no",null,"yes","negative","yes","mice","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in-house","yes","yes","positive"]
["IB4b",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no",null,null,null,null,"no",null,"yes","sex","no","no",null,"no",null,"yes","negative","yes","mice","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","in-house","yes","yes","positive"]
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[null,null,null,null,null,null,"total sample size",null,"group size"]
[]
[null,null,null,null,null,null,{"$f":"AVERAGE(G5:G34)","v":47},"mean",{"$f":"AVERAGE(I5:I34)","v":11.416666666666666},{"$f":"COUNTIFS(G5:G34,\"*group*\")","v":0}]
[null,null,null,null,null,null,{"$f":"MEDIAN(G5:G34)","v":46},"median",{"$f":"MEDIAN(I5:I34)","v":10.5}]
[]
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[null,null,null,null,"Total","Mean","However, given that the mean sample size in the PCES of our sample was 35, even if the mean effect size for every study in our sample were d= 0.8 (a large effect), 37 % of studies should fail to demonstrate significance at a p value of .05. (power 0,632)"]
[null,null,null,null,"Berechnung?"]
[null,null,null,null,"Total","Median","However, given that the median sample size in the PCES of our sample was 32, even if the mean effect size for every study in our sample were d= 0.8 (a large effect), 41% of studies should fail to demonstrate significance at a p value of .05. (Power 0,591)"]
[]
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[]
[null,null,null,null,"Group size, t-test, two independent means","Median","However, given that the median group size in the PCES of our sample was 8, even if the mean effect size for every study in our sample were d= 0.8 (a large effect), 55% of studies should fail to demonstrate significance at a p value of .05. (Power 0,451)"]
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["IB99"]

{"sheet":"Results","index":2,"n_rows":1259,"n_cols":59,"rows_kept":1259,"cut":false,"hidden":false,"merged":[[30,0,31,0],[32,0,33,0],[34,0,35,0],[36,0,37,0],[38,0,40,0],[15,0,16,0],[23,0,24,0],[25,0,26,0],[27,0,28,0],[17,0,22,0],[3,0,5,0],[6,0,7,0],[8,0,9,0],[10,0,12,0],[13,0,14,0],[171,61,179,61],[182,61,194,61],[197,61,200,61],[202,61,204,61],[205,61,206,61]]}
["Please note: Some rows in this table might have been deleted due to confidentiality reasons!"]
[null,"ALL","x",null,"n",null,null,null,null,"only 1","x",null,"n",null,null,null,null,"only a","x",null,"n",null,null,null,null,"only b","x",null,"n",null,null,null,null,"1 - subset with publication check","x",null,"n",null,null,null,null,"1 - publication check","x",null,"n",null,null,null,null,"First in man studies","x",null,"n"]
[null,null,"Yes","No","Total","yes in %","no in %",null,null,null,"Yes","No","Total","yes in %","no in %",null,null,null,"Yes","No","Total","yes in %","no in %",null,null,null,"Yes","No","Total","yes in %","no in %",null,null,null,"Yes","No","Total","yes in %","no in %",null,null,null,"Yes","No","Total","yes in %","no in %",null,null,null,"Yes","No","Total","yes in %","no in %"]
["Sample size","Is sample size reported, Yes or no?",{"$f":"COUNTIF('Coding matrix'!G$5:G$735,\"yes\")","v":184},{"$f":"COUNTIF('Coding matrix'!G$5:G$735,\"no\")","v":524},{"$f":"SUM(C4:D4)","v":708},{"$f":"C4/E4","v":0.25988700564971751},{"$f":"D4/E4","v":0.74011299435028244},null,null,"Is sample size reported, Yes or no?",{"$f":"COUNTIF('Coding matrix'!G$5:G$695,\"yes\")","v":164},{"$f":"COUNTIF('Coding matrix'!G$5:G$695,\"no\")","v":504},{"$f":"SUM(K4:L4)","v":668},{"$f":"K4/M4","v":0.24550898203592814},{"$f":"L4/M4","v":0.75449101796407181},null,null,"Is sample size reported, Yes or no?",{"$f":"COUNTIF('Coding matrix'!G$696:G$710,\"yes\")","v":15},{"$f":"COUNTIF('Coding matrix'!X$696:X$710,\"no\")","v":0},{"$f":"SUM(S4:T4)","v":15},{"$f":"S4/U4","v":1},{"$f":"T4/U4","v":0},null,null,"Is sample size reported, Yes or no?",{"$f":"COUNTIF('Coding matrix'!G$711:G$735,\"yes\")","v":5},{"$f":"COUNTIF('Coding matrix'!G$711:G$735,\"no\")","v":20},{"$f":"SUM(AA4:AB4)","v":25},{"$f":"AA4/AC4","v":0.2},{"$f":"AB4/AC4","v":0.8},null,null,"Is sample size reported, Yes or no?",{"$f":"COUNTIF('peer-reviewed publications IB'!G$5:G$84,\"yes\")","v":8},{"$f":"COUNTIF('peer-reviewed publications IB'!G$5:G$84,\"no\")","v":72},{"$f":"SUM(AI4:AJ4)","v":80},{"$f":"AI4/AK4","v":0.1},{"$f":"AJ4/AK4","v":0.9},null,null,"Is sample size reported, Yes or no?",{"$f":"COUNTIF('peer-reviewed publications pub'!$G$5:$G$84,\"yes\")","v":73},{"$f":"COUNTIF('peer-reviewed publications pub'!$G$5:$G$84,\"no\")","v":7},{"$f":"SUM(AQ4:AR4)","v":80},{"$f":"AQ4/AS4","v":0.91249999999999998},{"$f":"AR4/AS4","v":8.7499999999999994E-2},null,null,"Is sample size reported, Yes or no?",{"$f":"COUNTIF('First in man trials'!F$5:F$695,\"yes\")","v":12},{"$f":"COUNTIF('First in man trials'!F$5:F$695,\"no\")","v":18},{"$f":"SUM(AY4:AZ4)","v":30},{"$f":"AY4/BA4","v":0.4},{"$f":"AZ4/BA4","v":0.6}]
[null,"If yes, how many?",null,null,{"$f":"SUM(C5:D5)","v":0},null,null,null,null,"If yes, how many?",null,null,{"$f":"SUM(K5:L5)","v":0},null,null,null,null,"If yes, how many?",null,null,{"$f":"SUM(S5:T5)","v":0},null,null,null,null,"If yes, how many?",null,null,{"$f":"SUM(AA5:AB5)","v":0},null,null,null,null,"If yes, how many?",{"$f":"COUNTIF('peer-reviewed publications IB'!H$5:H$84,\"yes\")","v":0},{"$f":"COUNTIF('peer-reviewed publications IB'!H$5:H$84,\"no\")","v":0},{"$f":"SUM(AI5:AJ5)","v":0},null,null,null,null,"If yes, how many?",{"$f":"COUNTIF('peer-reviewed publications pub'!$H$5:$H$84,\"yes\")","v":0},{"$f":"COUNTIF('peer-reviewed publications pub'!$H$5:$H$84,\"no\")","v":0},{"$f":"SUM(AQ5:AR5)","v":0},null,null,null,null,"If yes, how many?",null,null,{"$f":"SUM(AY5:AZ5)","v":0}]
[null,"If yes, is sample size calculation reported?",{"$f":"COUNTIF('Coding matrix'!$K$5:$K$735,\"yes\")","v":0},{"$f":"COUNTIF('Coding matrix'!$K$5:$K$735,\"no\")","v":225},225,{"$f":"C6/E6","v":0},{"$f":"D6/E6","v":1},null,null,"If yes, is sample size calculation reported?",{"$f":"COUNTIF('Coding matrix'!$K$5:$K$695,\"yes\")","v":0},{"$f":"COUNTIF('Coding matrix'!$K$5:$K$695,\"no\")","v":205},205,{"$f":"K6/M6","v":0},{"$f":"L6/M6","v":1},null,null,"If yes, is sample size calculation reported?",{"$f":"COUNTIF('Coding matrix'!$K$696:$K$710,\"yes\")","v":0},{"$f":"COUNTIF('Coding matrix'!$K$696:$K$710,\"no\")","v":15},{"$f":"SUM(S6:T6)","v":15},{"$f":"S6/U6","v":0},{"$f":"T6/U6","v":1},null,null,"If yes, is sample size calculation reported?",{"$f":"COUNTIF('Coding matrix'!$K$711:$K$735,\"yes\")","v":0},{"$f":"COUNTIF('Coding matrix'!$K$711:$K$735,\"no\")","v":5},5,{"$f":"AA6/AC6","v":0},{"$f":"AB6/AC6","v":1},null,null,"If yes, is sample size calculation reported?",{"$f":"COUNTIF('peer-reviewed publications IB'!I$5:I$84,\"yes\")","v":0},{"$f":"COUNTIF('peer-reviewed publications IB'!I$5:I$84,\"no\")","v":30},30,{"$f":"AI6/AK6","v":0},{"$f":"AJ6/AK6","v":1},null,null,"If yes, is sample size calculation reported?",{"$f":"COUNTIF('peer-reviewed publications pub'!$I$5:$I$84,\"yes\")","v":0},{"$f":"COUNTIF('peer-reviewed publications pub'!$I$5:$I$84,\"no\")","v":63},63,{"$f":"AQ6/AS6","v":0},{"$f":"AR6/AS6","v":1},null,null,"If yes, is sample size calculation reported?",{"$f":"COUNTIF('First in man trials'!$J$5:$J$695,\"yes\")","v":0},{"$f":"COUNTIF('First in man trials'!$J$5:$J$695,\"no\")","v":12},12,{"$f":"AY6/BA6","v":0},{"$f":"AZ6/BA6","v":1}]
["Randomisation","Is randomisation reported?",{"$f":"COUNTIF('Coding matrix'!$L$5:$L$735,\"yes\")","v":26},{"$f":"COUNTIF('Coding matrix'!$L$5:$L$735,\"no\")","v":682},708,3.6723163841807911E-2,0.96327683615819204,null,null,"Is randomisation reported?",{"$f":"COUNTIF('Coding matrix'!$L$5:$L$695,\"yes\")","v":22},{"$f":"COUNTIF('Coding matrix'!$L$5:$L$695,\"no\")","v":646},668,3.2934131736526949E-2,0.96706586826347307,null,null,"Is randomisation reported?",{"$f":"COUNTIF('Coding matrix'!$L$696:$L$710,\"yes\")","v":0},{"$f":"COUNTIF('Coding matrix'!$L$696:$L$710,\"no\")","v":15},15,0,1,null,null,"Is randomisation reported?",{"$f":"COUNTIF('Coding matrix'!$L$711:$L$735,\"yes\")","v":4},{"$f":"COUNTIF('Coding matrix'!$L$711:$L$735,\"no\")","v":21},25,0.16,0.84,null,null,"Is randomisation reported?",{"$f":"COUNTIF('peer-reviewed publications IB'!J$5:J$84,\"yes\")","v":1},{"$f":"COUNTIF('peer-reviewed publications IB'!J$5:J$84,\"no\")","v":79},80,1.2500000000000001E-2,0.98750000000000004,null,null,"Is randomisation reported?",{"$f":"COUNTIF('peer-reviewed publications pub'!$J$5:$J$84,\"yes\")","v":22},{"$f":"COUNTIF('peer-reviewed publications pub'!$J$5:$J$84,\"no\")","v":58},80,0.27500000000000002,0.72499999999999998,null,null,"Is randomisation reported?",{"$f":"COUNTIF('First in man trials'!$K$5:$K$695,\"yes\")","v":4},{"$f":"COUNTIF('First in man trials'!$K$5:$K$695,\"no\")","v":26},30,0.13333333333333333,0.8666666666666667]
[null,"If yes, describe the method used to generate the randomization sequence?",null,null,null,null,null,null,null,"If yes, describe the method used to generate the randomization sequence?",null,null,null,null,null,null,null,"If yes, describe the method used to generate the randomization sequence?",null,null,null,null,null,null,null,"If yes, describe the method used to generate the randomization sequence?",null,null,null,null,null,null,null,"If yes, describe the method used to generate the randomization sequence?",{"$f":"COUNTIF('peer-reviewed publications IB'!K$5:K$84,\"yes\")","v":0},{"$f":"COUNTIF('peer-reviewed publications IB'!K$5:K$84,\"no\")","v":1},null,null,null,null,null,"If yes, describe the method used to generate the randomization sequence?",{"$f":"COUNTIF('peer-reviewed publications pub'!$K$5:$K$84,\"yes\")","v":0},{"$f":"COUNTIF('peer-reviewed publications pub'!$K$5:$K$84,\"no\")","v":9},null,null,null,null,null,"If yes, describe the method used to generate the randomization sequence?"]
["Baseline characterization","Is baseline characterization reported?",{"$f":"COUNTIF('Coding matrix'!$N$5:$N$735,\"yes\")","v":127},{"$f":"COUNTIF('Coding matrix'!$N$5:$N$735,\"no\")","v":581},708,0.17937853107344634,0.82062146892655363,null,null,"Is baseline characterization reported?",{"$f":"COUNTIF('Coding matrix'!$N$5:$N$695,\"yes\")","v":109},{"$f":"COUNTIF('Coding matrix'!$N$5:$N$695,\"no\")","v":559},{"$f":"SUM(K9:L9)","v":668},{"$f":"K9/M9","v":0.16317365269461079},{"$f":"L9/M9","v":0.83682634730538918},null,null,"Is baseline characterization reported?",{"$f":"COUNTIF('Coding matrix'!$N$696:$N$710,\"yes\")","v":4},{"$f":"COUNTIF('Coding matrix'!$N$696:$N$710,\"no\")","v":11},{"$f":"SUM(S9:T9)","v":15},{"$f":"S9/U9","v":0.26666666666666666},{"$f":"T9/U9","v":0.73333333333333328},null,null,"Is baseline characterization reported?",{"$f":"COUNTIF('Coding matrix'!$N$711:$N$735,\"yes\")","v":14},{"$f":"COUNTIF('Coding matrix'!$N$711:$N$735,\"no\")","v":11},{"$f":"SUM(AA9:AB9)","v":25},{"$f":"AA9/AC9","v":0.56000000000000005},{"$f":"AB9/AC9","v":0.44},null,null,"Is baseline characterization reported?",{"$f":"COUNTIF('peer-reviewed publications IB'!L$5:L$84,\"yes\")","v":5},{"$f":"COUNTIF('peer-reviewed publications IB'!L$5:L$84,\"no\")","v":75},{"$f":"SUM(AI9:AJ9)","v":80},{"$f":"AI9/AK9","v":6.25E-2},{"$f":"AJ9/AK9","v":0.9375},null,null,"Is baseline characterization reported?",{"$f":"COUNTIF('peer-reviewed publications pub'!$L$5:$L$84,\"yes\")","v":61},{"$f":"COUNTIF('peer-reviewed publications pub'!$L$5:$L$84,\"no\")","v":19},{"$f":"SUM(AQ9:AR9)","v":80},{"$f":"AQ9/AS9","v":0.76249999999999996},{"$f":"AR9/AS9","v":0.23749999999999999},null,null,"Is baseline characterization reported?",{"$f":"COUNTIF('First in man trials'!$M$5:$M$695,\"yes\")","v":19},{"$f":"COUNTIF('First in man trials'!$M$5:$M$695,\"no\")","v":11},{"$f":"SUM(AY9:AZ9)","v":30},{"$f":"AY9/BA9","v":0.6333333333333333},{"$f":"AZ9/BA9","v":0.36666666666666664}]
[null,"If yes, what type?",null,null,null,null,null,null,null,"If yes, what type?",null,null,null,null,null,null,null,"If yes, what type?",null,null,null,null,null,null,null,"If yes, what type?",null,null,null,null,null,null,null,"If yes, what type?",{"$f":"COUNTIF('peer-reviewed publications IB'!M$5:M$84,\"yes\")","v":0},{"$f":"COUNTIF('peer-reviewed publications IB'!M$5:M$84,\"no\")","v":0},null,null,null,null,null,"If yes, what type?",{"$f":"COUNTIF('peer-reviewed publications pub'!$M$5:$M$84,\"yes\")","v":0},{"$f":"COUNTIF('peer-reviewed publications pub'!$M$5:$M$84,\"no\")","v":0},null,null,null,null,null,"If yes, what type?"]
["Blinded assessment","Is blinded assessment  for treatment allocation reported?",{"$f":"COUNTIF('Coding matrix'!$P$5:$P$6861,\"yes\")","v":0},{"$f":"COUNTIF('Coding matrix'!$P$5:$P$735,\"no\")","v":708},708,0,1,null,null,"Is blinded assessment  for treatment allocation reported?",{"$f":"COUNTIF('Coding matrix'!$P$5:$P$695,\"yes\")","v":0},{"$f":"COUNTIF('Coding matrix'!$P$5:$P$695,\"no\")","v":668},{"$f":"SUM(K11:L11)","v":668},{"$f":"K11/M11","v":0},{"$f":"L11/M11","v":1},null,null,"Is blinded assessment  for treatment allocation reported?",{"$f":"COUNTIF('Coding matrix'!$P$696:$P$6861,\"yes\")","v":0},{"$f":"COUNTIF('Coding matrix'!$P$696:$P$710,\"no\")","v":15},{"$f":"SUM(S11:T11)","v":15},{"$f":"S11/U11","v":0},{"$f":"T11/U11","v":1},null,null,"Is blinded assessment  for treatment allocation reported?",{"$f":"COUNTIF('Coding matrix'!$P$711:$P$6861,\"yes\")","v":0},{"$f":"COUNTIF('Coding matrix'!$P$711:$P$735,\"no\")","v":25},{"$f":"SUM(AA11:AB11)","v":25},{"$f":"AA11/AC11","v":0},{"$f":"AB11/AC11","v":1},null,null,"Is blinded assessment  for treatment allocation reported?",{"$f":"COUNTIF('peer-reviewed publications IB'!N$5:N$84,\"yes\")","v":0},{"$f":"COUNTIF('peer-reviewed publications IB'!N$5:N$84,\"no\")","v":80},{"$f":"SUM(AI11:AJ11)","v":80},{"$f":"AI11/AK11","v":0},{"$f":"AJ11/AK11","v":1},null,null,"Is blinded assessment  for treatment allocation reported?",{"$f":"COUNTIF('peer-reviewed publications pub'!$N$5:$N$84,\"yes\")","v":0},{"$f":"COUNTIF('peer-reviewed publications pub'!$N$5:$N$84,\"no\")","v":80},{"$f":"SUM(AQ11:AR11)","v":80},{"$f":"AQ11/AS11","v":0},{"$f":"AR11/AS11","v":1},null,null,"Is blinded assessment  for treatment allocation reported?",{"$f":"COUNTIF('First in man trials'!$O$5:$O$695,\"yes\")","v":0},{"$f":"COUNTIF('First in man trials'!$O$5:$O$695,\"no\")","v":30},{"$f":"SUM(AY11:AZ11)","v":30},{"$f":"AY11/BA11","v":0},{"$f":"AZ11/BA11","v":1}]
[null,"Is blinded assessment  for outcome assessment reported?",{"$f":"COUNTIF('Coding matrix'!$Q$5:$Q$735,\"yes\")","v":0},{"$f":"COUNTIF('Coding matrix'!$Q$5:$Q$735,\"no\")","v":708},708,0,1,null,null,"Is blinded assessment  for outcome assessment reported?",{"$f":"COUNTIF('Coding matrix'!$Q$5:$Q$695,\"yes\")","v":0},{"$f":"COUNTIF('Coding matrix'!$Q$5:$Q$695,\"no\")","v":668},668,0,1,null,null,"Is blinded assessment  for outcome assessment reported?",{"$f":"COUNTIF('Coding matrix'!$Q$696:$Q$710,\"yes\")","v":0},{"$f":"COUNTIF('Coding matrix'!$Q$696:$Q$710,\"no\")","v":15},15,0,1,null,null,"Is blinded assessment  for outcome assessment reported?",{"$f":"COUNTIF('Coding matrix'!$Q$711:$Q$735,\"yes\")","v":0},{"$f":"COUNTIF('Coding matrix'!$Q$711:$Q$735,\"no\")","v":25},25,0,1,null,null,"Is blinded assessment  for outcome assessment reported?",{"$f":"COUNTIF('peer-reviewed publications IB'!O$5:O$84,\"yes\")","v":0},{"$f":"COUNTIF('peer-reviewed publications IB'!O$5:O$84,\"no\")","v":80},80,0,1,null,null,"Is blinded assessment  for outcome assessment reported?",{"$f":"COUNTIF('peer-reviewed publications pub'!$O$5:$O$84,\"yes\")","v":4},{"$f":"COUNTIF('peer-reviewed publications pub'!$O$5:$O$84,\"no\")","v":76},80,0.05,0.95,null,null,"Is blinded assessment  for outcome assessment reported?",{"$f":"COUNTIF('First in man trials'!$P$5:$P$695,\"yes\")","v":0},{"$f":"COUNTIF('First in man trials'!$P$5:$P$695,\"no\")","v":30},30,0,1]
[null,"If yes, when?",null,null,null,null,null,null,null,"If yes, when?",null,null,null,null,null,null,null,"If yes, when?",null,null,null,null,null,null,null,"If yes, when?",null,null,null,null,null,null,null,"If yes, when?",{"$f":"COUNTIF('peer-reviewed publications IB'!P$5:P$84,\"yes\")","v":0},{"$f":"COUNTIF('peer-reviewed publications IB'!P$5:P$84,\"no\")","v":0},null,null,null,null,null,"If yes, when?",{"$f":"COUNTIF('peer-reviewed publications pub'!$P$5:$P$84,\"yes\")","v":0},{"$f":"COUNTIF('peer-reviewed publications pub'!$P$5:$P$84,\"no\")","v":0},null,null,null,null,null,"If yes, when?"]
["Exclusion of data from analysis","Is exclusion of data reported?",{"$f":"COUNTIF('Coding matrix'!$S$5:$S$735,\"yes\")","v":38},{"$f":"COUNTIF('Coding matrix'!$S$5:$S$735,\"no\")","v":670},708,5.3672316384180789E-2,0.9463276836158192,null,null,"Is exclusion of data reported?",{"$f":"COUNTIF('Coding matrix'!$S$5:$S$695,\"yes\")","v":38},{"$f":"COUNTIF('Coding matrix'!$S$5:$S$695,\"no\")","v":630},{"$f":"SUM(K14:L14)","v":668},{"$f":"K14/M14","v":5.6886227544910177E-2},{"$f":"L14/M14","v":0.94311377245508987},null,null,"Is exclusion of data reported?",{"$f":"COUNTIF('Coding matrix'!$S$696:$S$710,\"yes\")","v":0},{"$f":"COUNTIF('Coding matrix'!$S$696:$S$710,\"no\")","v":15},{"$f":"SUM(S14:T14)","v":15},{"$f":"S14/U14","v":0},{"$f":"T14/U14","v":1},null,null,"Is exclusion of data reported?",{"$f":"COUNTIF('Coding matrix'!$S$711:$S$735,\"yes\")","v":0},{"$f":"COUNTIF('Coding matrix'!$S$711:$S$735,\"no\")","v":25},{"$f":"SUM(AA14:AB14)","v":25},{"$f":"AA14/AC14","v":0},{"$f":"AB14/AC14","v":1},null,null,"Is exclusion of data reported?",{"$f":"COUNTIF('peer-reviewed publications IB'!Q$5:Q$84,\"yes\")","v":4},{"$f":"COUNTIF('peer-reviewed publications IB'!Q$5:Q$84,\"no\")","v":76},{"$f":"SUM(AI14:AJ14)","v":80},{"$f":"AI14/AK14","v":0.05},{"$f":"AJ14/AK14","v":0.95},null,null,"Is exclusion of data reported?",{"$f":"COUNTIF('peer-reviewed publications pub'!$Q$5:$Q$84,\"yes\")","v":11},{"$f":"COUNTIF('peer-reviewed publications pub'!$Q$5:$Q$84,\"no\")","v":69},{"$f":"SUM(AQ14:AR14)","v":80},{"$f":"AQ14/AS14","v":0.13750000000000001},{"$f":"AR14/AS14","v":0.86250000000000004},null,null,"Is exclusion of data reported?",{"$f":"COUNTIF('First in man trials'!$R$5:$R$695,\"yes\")","v":1},{"$f":"COUNTIF('First in man trials'!$R$5:$R$695,\"no\")","v":29},{"$f":"SUM(AY14:AZ14)","v":30},{"$f":"AY14/BA14","v":3.3333333333333333E-2},{"$f":"AZ14/BA14","v":0.96666666666666667}]
[null,"If yes, justification?",{"$f":"COUNTIF('Coding matrix'!$T$5:$T$735,\"yes\")","v":26},{"$f":"COUNTIF('Coding matrix'!$T$5:$T$735,\"no\")","v":12},38,0.68421052631578949,0.31578947368421051,null,null,"If yes, justification?",{"$f":"COUNTIF('Coding matrix'!$T$5:$T$695,\"yes\")","v":26},{"$f":"COUNTIF('Coding matrix'!$T$5:$T$695,\"no\")","v":12},38,0.68421052631578949,0.31578947368421051,null,null,"If yes, justification?",{"$f":"COUNTIF('Coding matrix'!$T$696:$T$710,\"yes\")","v":0},{"$f":"COUNTIF('Coding matrix'!$T$696:$T$710,\"no\")","v":0},{"$f":"SUM(S15:T15)","v":0},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},null,null,"If yes, justification?",{"$f":"COUNTIF('Coding matrix'!$T$711:$T$735,\"yes\")","v":0},{"$f":"COUNTIF('Coding matrix'!$T$711:$T$735,\"no\")","v":0},0,{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},null,null,"If yes, justification?",{"$f":"COUNTIF('peer-reviewed publications IB'!R$5:R$84,\"yes\")","v":4},{"$f":"COUNTIF('peer-reviewed publications IB'!R$5:R$84,\"no\")","v":0},4,1,0,null,null,"If yes, justification?",{"$f":"COUNTIF('peer-reviewed publications pub'!$R$5:$R$84,\"yes\")","v":8},{"$f":"COUNTIF('peer-reviewed publications pub'!$R$5:$R$84,\"no\")","v":1},9,0.88888888888888884,0.1111111111111111,null,null,"If yes, justification?",{"$f":"COUNTIF('First in man trials'!$S$5:$S$695,\"yes\")","v":1},{"$f":"COUNTIF('First in man trials'!$S$5:$S$695,\"no\")","v":0},1,1,0]
["Controls","Is control group reported?",{"$f":"COUNTIF('Coding matrix'!$U$5:$U$735,\"yes\")","v":329},{"$f":"COUNTIF('Coding matrix'!$U$5:$U$735,\"no\")","v":379},708,0.46468926553672318,0.53531073446327682,null,null,"Is control group reported?",{"$f":"COUNTIF('Coding matrix'!$U$5:$U$695,\"yes\")","v":290},{"$f":"COUNTIF('Coding matrix'!$U$5:$U$695,\"no\")","v":378},668,0.43413173652694609,0.56586826347305386,null,null,"Is control group reported?",{"$f":"COUNTIF('Coding matrix'!$U$696:$U$710,\"yes\")","v":14},{"$f":"COUNTIF('Coding matrix'!$U$696:$U$710,\"no\")","v":1},15,0.93333333333333335,6.6666666666666666E-2,null,null,"Is control group reported?",{"$f":"COUNTIF('Coding matrix'!$U$711:$U$735,\"yes\")","v":25},{"$f":"COUNTIF('Coding matrix'!$U$711:$U$735,\"no\")","v":0},25,1,0,null,null,"Is control group reported?",{"$f":"COUNTIF('peer-reviewed publications IB'!S$5:S$84,\"yes\")","v":30},{"$f":"COUNTIF('peer-reviewed publications IB'!S$5:S$84,\"no\")","v":50},{"$f":"SUM(AI16:AJ16)","v":80},0.375,0.625,null,null,"Is control group reported?",{"$f":"COUNTIF('peer-reviewed publications pub'!$S$5:$S$84,\"yes\")","v":78},{"$f":"COUNTIF('peer-reviewed publications pub'!$S$5:$S$84,\"no\")","v":2},80,0.97499999999999998,2.5000000000000001E-2,null,null,"Is control group reported?",{"$f":"COUNTIF('First in man trials'!$T$5:$T$695,\"yes\")","v":24},{"$f":"COUNTIF('First in man trials'!$T$5:$T$695,\"no\")","v":6},30,0.8,0.2]
[null,"If yes, what type of control?",null,null,null,null,null,null,null,"If yes, what type of control?",null,null,null,null,null,null,null,"If yes, what type of control?",null,null,null,null,null,null,null,"If yes, what type of control?",null,null,null,null,null,null,null,"If yes, what type of control?",{"$f":"COUNTIF('peer-reviewed publications IB'!T$5:T$84,\"yes\")","v":0},{"$f":"COUNTIF('peer-reviewed publications IB'!T$5:T$84,\"no\")","v":0},null,null,null,null,null,"If yes, what type of control?",{"$f":"COUNTIF('peer-reviewed publications pub'!$T$5:$T$84,\"yes\")","v":0},{"$f":"COUNTIF('peer-reviewed publications pub'!$T$5:$T$84,\"no\")","v":0},null,null,null,null,null,"If yes, what type of control?"]
["Model choice","Is the species of animal reported?",{"$f":"COUNTIF('Coding matrix'!$W$5:$W$735,\"yes\")","v":622},{"$f":"COUNTIF('Coding matrix'!$W$5:$W$735,\"no\")","v":86},{"$f":"SUM(C18:D18)","v":708},0.87853107344632764,0.12146892655367232,null,null,"Is the species of animal reported?",{"$f":"COUNTIF('Coding matrix'!$W$5:$W$695,\"yes\")","v":583},{"$f":"COUNTIF('Coding matrix'!$W$5:$W$695,\"no\")","v":85},{"$f":"SUM(K18:L18)","v":668},{"$f":"K18/M18","v":0.8727544910179641},{"$f":"L18/M18","v":0.12724550898203593},null,null,"Is the species of animal reported?",{"$f":"COUNTIF('Coding matrix'!$W$696:$W$710,\"yes\")","v":15},{"$f":"COUNTIF('Coding matrix'!$W$696:$W$710,\"no\")","v":0},{"$f":"SUM(S18:T18)","v":15},{"$f":"S18/U18","v":1},{"$f":"T18/U18","v":0},null,null,"Is the species of animal reported?",{"$f":"COUNTIF('Coding matrix'!$W$711:$W$735,\"yes\")","v":24},{"$f":"COUNTIF('Coding matrix'!$W$711:$W$735,\"no\")","v":1},{"$f":"SUM(AA18:AB18)","v":25},{"$f":"AA18/AC18","v":0.96},{"$f":"AB18/AC18","v":0.04},null,null,"Is the species of animal reported?",{"$f":"COUNTIF('peer-reviewed publications IB'!U$5:U$84,\"yes\")","v":69},{"$f":"COUNTIF('peer-reviewed publications IB'!U$5:U$84,\"no\")","v":11},{"$f":"SUM(AI18:AJ18)","v":80},{"$f":"AI18/AK18","v":0.86250000000000004},{"$f":"AJ18/AK18","v":0.13750000000000001},null,null,"Is the species of animal reported?",{"$f":"COUNTIF('peer-reviewed publications pub'!$U$5:$U$84,\"yes\")","v":80},{"$f":"COUNTIF('peer-reviewed publications pub'!$U$5:$U$84,\"no\")","v":0},{"$f":"SUM(AQ18:AR18)","v":80},{"$f":"AQ18/AS18","v":1},{"$f":"AR18/AS18","v":0},null,null,"Is the species of animal reported?",{"$f":"COUNTIF('First in man trials'!$V$5:$V$695,\"yes\")","v":30},{"$f":"COUNTIF('First in man trials'!$V$5:$V$695,\"no\")","v":0},{"$f":"SUM(AY18:AZ18)","v":30},{"$f":"AY18/BA18","v":1},{"$f":"AZ18/BA18","v":0}]
[null,"If yes, what species?",null,null,null,null,null,null,null,"If yes, what species?",null,null,null,null,null,null,null,"If yes, what species?",null,null,null,null,null,null,null,"If yes, what species?",null,null,null,null,null,null,null,"If yes, what species?",{"$f":"COUNTIF('peer-reviewed publications IB'!V$5:V$84,\"yes\")","v":0},{"$f":"COUNTIF('peer-reviewed publications IB'!V$5:V$84,\"no\")","v":0},null,null,null,null,null,"If yes, what species?",{"$f":"COUNTIF('peer-reviewed publications pub'!$V$5:$V$84,\"yes\")","v":0},{"$f":"COUNTIF('peer-reviewed publications pub'!$V$5:$V$84,\"no\")","v":0},null,null,null,null,null,"If yes, what species?"]
[null,"Is the type of model reported?",{"$f":"COUNTIF('Coding matrix'!$Y$5:$Y$735,\"yes\")","v":684},{"$f":"COUNTIF('Coding matrix'!$Y$5:$Y$735,\"no\")","v":24},708,0.96610169491525422,3.3898305084745763E-2,null,null,"Is the type of model reported?",{"$f":"COUNTIF('Coding matrix'!$Y$5:$Y$695,\"yes\")","v":644},{"$f":"COUNTIF('Coding matrix'!$Y$5:$Y$695,\"no\")","v":24},{"$f":"SUM(K20:L20)","v":668},{"$f":"K20/M20","v":0.9640718562874252},{"$f":"L20/M20","v":3.5928143712574849E-2},null,null,"Is the type of model reported?",{"$f":"COUNTIF('Coding matrix'!$Y$696:$Y$710,\"yes\")","v":15},{"$f":"COUNTIF('Coding matrix'!$Y$696:$Y$710,\"no\")","v":0},{"$f":"SUM(S20:T20)","v":15},{"$f":"S20/U20","v":1},{"$f":"T20/U20","v":0},null,null,"Is the type of model reported?",{"$f":"COUNTIF('Coding matrix'!$Y$711:$Y$735,\"yes\")","v":25},{"$f":"COUNTIF('Coding matrix'!$Y$711:$Y$735,\"no\")","v":0},{"$f":"SUM(AA20:AB20)","v":25},{"$f":"AA20/AC20","v":1},{"$f":"AB20/AC20","v":0},null,null,"Is the type of model reported?",{"$f":"COUNTIF('peer-reviewed publications IB'!W$5:W$84,\"yes\")","v":73},{"$f":"COUNTIF('peer-reviewed publications IB'!W$5:W$84,\"no\")","v":7},{"$f":"SUM(AI20:AJ20)","v":80},{"$f":"AI20/AK20","v":0.91249999999999998},{"$f":"AJ20/AK20","v":8.7499999999999994E-2},null,null,"Is the type of model reported?",{"$f":"COUNTIF('peer-reviewed publications pub'!$W$5:$W$84,\"yes\")","v":80},{"$f":"COUNTIF('peer-reviewed publications pub'!$W$5:$W$84,\"no\")","v":0},{"$f":"SUM(AQ20:AR20)","v":80},{"$f":"AQ20/AS20","v":1},{"$f":"AR20/AS20","v":0},null,null,"Is the type of model reported?",{"$f":"COUNTIF('First in man trials'!$X$5:$X$695,\"yes\")","v":29},{"$f":"COUNTIF('First in man trials'!$X$5:$X$695,\"no\")","v":1},{"$f":"SUM(AY20:AZ20)","v":30},{"$f":"AY20/BA20","v":0.96666666666666667},{"$f":"AZ20/BA20","v":3.3333333333333333E-2}]
[null,"If yes, what model?",null,null,null,null,null,null,null,"If yes, what model?",null,null,null,null,null,null,null,"If yes, what model?",null,null,null,null,null,null,null,"If yes, what model?",null,null,null,null,null,null,null,"If yes, what model?",{"$f":"COUNTIF('peer-reviewed publications IB'!#REF!,\"yes\")","v":{"$error":"#REF!"}},{"$f":"COUNTIF('peer-reviewed publications IB'!#REF!,\"no\")","v":{"$error":"#REF!"}},null,null,null,null,null,"If yes, what model?",{"$f":"COUNTIF('peer-reviewed publications pub'!#REF!,\"yes\")","v":{"$error":"#REF!"}},{"$f":"COUNTIF('peer-reviewed publications pub'!#REF!,\"no\")","v":{"$error":"#REF!"}},null,null,null,null,null,"If yes, what model?"]
[null,"Is the specifications of model reported?",{"$f":"COUNTIF('Coding matrix'!$Z$5:$Z$735,\"yes\")","v":193},{"$f":"COUNTIF('Coding matrix'!$Z$5:$Z$735,\"no\")","v":515},708,0.27259887005649719,0.72740112994350281,null,null,"Is the specifications of model reported?",{"$f":"COUNTIF('Coding matrix'!$Z$5:$Z$695,\"yes\")","v":166},{"$f":"COUNTIF('Coding matrix'!$Z$5:$Z$695,\"no\")","v":502},{"$f":"SUM(K22:L22)","v":668},{"$f":"K22/M22","v":0.24850299401197604},{"$f":"L22/M22","v":0.75149700598802394},null,null,"Is the specifications of model reported?",{"$f":"COUNTIF('Coding matrix'!$Z$696:$Z$710,\"yes\")","v":8},{"$f":"COUNTIF('Coding matrix'!$Z$696:$Z$710,\"no\")","v":7},{"$f":"SUM(S22:T22)","v":15},{"$f":"S22/U22","v":0.53333333333333333},{"$f":"T22/U22","v":0.46666666666666667},null,null,"Is the specifications of model reported?",{"$f":"COUNTIF('Coding matrix'!$Z$711:$Z$735,\"yes\")","v":19},{"$f":"COUNTIF('Coding matrix'!$Z$711:$Z$735,\"no\")","v":6},{"$f":"SUM(AA22:AB22)","v":25},{"$f":"AA22/AC22","v":0.76},{"$f":"AB22/AC22","v":0.24},null,null,"Is the specifications of model reported?",{"$f":"COUNTIF('peer-reviewed publications IB'!X$5:X$84,\"yes\")","v":12},{"$f":"COUNTIF('peer-reviewed publications IB'!X$5:X$84,\"no\")","v":68},{"$f":"SUM(AI22:AJ22)","v":80},{"$f":"AI22/AK22","v":0.15},{"$f":"AJ22/AK22","v":0.85},null,null,"Is the specifications of model reported?",{"$f":"COUNTIF('peer-reviewed publications pub'!$X$5:$X$84,\"yes\")","v":74},{"$f":"COUNTIF('peer-reviewed publications pub'!$X$5:$X$84,\"no\")","v":6},{"$f":"SUM(AQ22:AR22)","v":80},{"$f":"AQ22/AS22","v":0.92500000000000004},{"$f":"AR22/AS22","v":7.4999999999999997E-2},null,null,"Is the specifications of model reported?",{"$f":"COUNTIF('First in man trials'!$Y$5:$Y$695,\"yes\")","v":15},{"$f":"COUNTIF('First in man trials'!$Y$5:$Y$695,\"no\")","v":15},{"$f":"SUM(AY22:AZ22)","v":30},{"$f":"AY22/BA22","v":0.5},{"$f":"AZ22/BA22","v":0.5}]
[null,"If yes, details",null,null,null,null,null,null,null,"If yes, details",null,null,null,null,null,null,null,"If yes, details",null,null,null,null,null,null,null,"If yes, details",null,null,null,null,null,null,null,"If yes, details",{"$f":"COUNTIF('peer-reviewed publications IB'!#REF!,\"yes\")","v":{"$error":"#REF!"}},{"$f":"COUNTIF('peer-reviewed publications IB'!#REF!,\"no\")","v":{"$error":"#REF!"}},null,null,null,null,null,"If yes, details",{"$f":"COUNTIF('peer-reviewed publications pub'!#REF!,\"yes\")","v":{"$error":"#REF!"}},{"$f":"COUNTIF('peer-reviewed publications pub'!#REF!,\"no\")","v":{"$error":"#REF!"}},null,null,null,null,null,"If yes, details"]
["Outcome choice","Is the outcome choice reported?",{"$f":"COUNTIF('Coding matrix'!$AA$5:$AA$735,\"yes\")","v":575},{"$f":"COUNTIF('Coding matrix'!$AA$5:$AA$735,\"no\")","v":133},708,0.81214689265536721,0.18785310734463276,null,null,"Is the outcome choice reported?",{"$f":"COUNTIF('Coding matrix'!$AA$5:$AA$695,\"yes\")","v":537},{"$f":"COUNTIF('Coding matrix'!$AA$5:$AA$695,\"no\")","v":131},{"$f":"SUM(K24:L24)","v":668},{"$f":"K24/M24","v":0.80389221556886226},{"$f":"L24/M24","v":0.19610778443113772},null,null,"Is the outcome choice reported?",{"$f":"COUNTIF('Coding matrix'!$AA$696:$AA$710,\"yes\")","v":15},{"$f":"COUNTIF('Coding matrix'!$AA$696:$AA$710,\"no\")","v":0},{"$f":"SUM(S24:T24)","v":15},{"$f":"S24/U24","v":1},{"$f":"T24/U24","v":0},null,null,"Is the outcome choice reported?",{"$f":"COUNTIF('Coding matrix'!$AA$711:$AA$735,\"yes\")","v":23},{"$f":"COUNTIF('Coding matrix'!$AA$711:$AA$735,\"no\")","v":2},{"$f":"SUM(AA24:AB24)","v":25},{"$f":"AA24/AC24","v":0.92},{"$f":"AB24/AC24","v":0.08},null,null,"Is the outcome choice reported?",{"$f":"COUNTIF('peer-reviewed publications IB'!Y$5:Y$84,\"yes\")","v":67},{"$f":"COUNTIF('peer-reviewed publications IB'!Y$5:Y$84,\"no\")","v":13},{"$f":"SUM(AI24:AJ24)","v":80},{"$f":"AI24/AK24","v":0.83750000000000002},{"$f":"AJ24/AK24","v":0.16250000000000001},null,null,"Is the outcome choice reported?",{"$f":"COUNTIF('peer-reviewed publications pub'!$Y$5:$Y$84,\"yes\")","v":80},{"$f":"COUNTIF('peer-reviewed publications pub'!$Y$5:$Y$84,\"no\")","v":0},{"$f":"SUM(AQ24:AR24)","v":80},{"$f":"AQ24/AS24","v":1},{"$f":"AR24/AS24","v":0},null,null,"Is the outcome choice reported?",{"$f":"COUNTIF('First in man trials'!$Z$5:$Z$695,\"yes\")","v":24},{"$f":"COUNTIF('First in man trials'!$Z$5:$Z$695,\"no\")","v":6},{"$f":"SUM(AY24:AZ24)","v":30},{"$f":"AY24/BA24","v":0.8},{"$f":"AZ24/BA24","v":0.2}]
[null,"If yes, is the metric or time-course or both reported?",null,null,null,null,null,null,null,"If yes, is the metric or time-course or both reported?",null,null,null,null,null,null,null,"If yes, is the metric or time-course or both reported?",null,null,null,null,null,null,null,"If yes, is the metric or time-course or both reported?",null,null,null,null,null,null,null,"If yes, is the metric or time-course or both reported?",{"$f":"COUNTIF('peer-reviewed publications IB'!Z$5:Z$84,\"yes\")","v":0},{"$f":"COUNTIF('peer-reviewed publications IB'!Z$5:Z$84,\"no\")","v":1},null,null,null,null,null,"If yes, is the metric or time-course or both reported?",{"$f":"COUNTIF('peer-reviewed publications pub'!$Z$5:$Z$84,\"yes\")","v":0},{"$f":"COUNTIF('peer-reviewed publications pub'!$Z$5:$Z$84,\"no\")","v":0},null,null,null,null,null,"If yes, is the metric or time-course or both reported?"]
["Dose reponse \n(RATE ON IB LEVEL)","Is dose response reported?",{"$f":"COUNTIF('Coding matrix'!$AC$5:$AC$735,\"yes\")","v":67},{"$f":"COUNTIF('Coding matrix'!$AC$5:$AC$735,\"no\")","v":24},{"$f":"SUM(C26:D26)","v":91},0.73626373626373631,0.26373626373626374,null,null,"Is dose response reported?",{"$f":"COUNTIF('Coding matrix'!$AC$5:$AC$695,\"yes\")","v":58},{"$f":"COUNTIF('Coding matrix'!$AC$5:$AC$695,\"no\")","v":21},{"$f":"SUM(K26:L26)","v":79},{"$f":"K26/M26","v":0.73417721518987344},{"$f":"L26/M26","v":0.26582278481012656},null,null,"Is dose response reported?",{"$f":"COUNTIF('Coding matrix'!$AC$696:$AC$710,\"yes\")","v":4},{"$f":"COUNTIF('Coding matrix'!$AC$696:$AC$710,\"no\")","v":2},{"$f":"SUM(S26:T26)","v":6},{"$f":"S26/U26","v":0.66666666666666663},{"$f":"T26/U26","v":0.33333333333333331},null,null,"Is dose response reported?",{"$f":"COUNTIF('Coding matrix'!$AC$711:$AC$735,\"yes\")","v":5},{"$f":"COUNTIF('Coding matrix'!$AC$711:$AC$735,\"no\")","v":1},{"$f":"SUM(AA26:AB26)","v":6},{"$f":"AA26/AC26","v":0.83333333333333337},{"$f":"AB26/AC26","v":0.16666666666666666},null,null,"Is dose response reported?",{"$f":"COUNTIF('peer-reviewed publications IB'!AA$5:AA$84,\"yes\")","v":12},{"$f":"COUNTIF('peer-reviewed publications IB'!AA$5:AA$84,\"no\")","v":8},{"$f":"SUM(AI26:AJ26)","v":20},{"$f":"AI26/AK26","v":0.6},{"$f":"AJ26/AK26","v":0.4},null,null,"Is dose response reported?",{"$f":"COUNTIF('peer-reviewed publications pub'!$AA$5:$AA$84,\"yes\")","v":13},{"$f":"COUNTIF('peer-reviewed publications pub'!$AA$5:$AA$84,\"no\")","v":7},{"$f":"SUM(AQ26:AR26)","v":20},{"$f":"AQ26/AS26","v":0.65},{"$f":"AR26/AS26","v":0.35},null,null,"Is dose response reported?",{"$f":"COUNTIF('First in man trials'!$AB$5:$AB$695,\"yes\")","v":3},{"$f":"COUNTIF('First in man trials'!$AB$5:$AB$695,\"no\")","v":4},{"$f":"SUM(AY26:AZ26)","v":7},{"$f":"AY26/BA26","v":0.42857142857142855},{"$f":"AZ26/BA26","v":0.5714285714285714}]
[null,"If yes, is positive reponse reported? ",{"$f":"COUNTIF('Coding matrix'!$AD$5:$AD$735,\"yes\")","v":67},{"$f":"COUNTIF('Coding matrix'!$AD$5:$AD$735,\"no\")","v":0},67,{"$f":"C27/E27","v":1},0,null,null,"If yes, is positive reponse reported? ",{"$f":"COUNTIF('Coding matrix'!$AD$5:$AD$695,\"yes\")","v":58},{"$f":"COUNTIF('Coding matrix'!$AD$5:$AD$695,\"no\")","v":0},{"$f":"SUM(K27:L27)","v":58},{"$f":"K27/M27","v":1},0,null,null,"If yes, is positive reponse reported? ",{"$f":"COUNTIF('Coding matrix'!$AD$696:$AD$710,\"yes\")","v":4},{"$f":"COUNTIF('Coding matrix'!$AD$696:$AD$710,\"no\")","v":0},{"$f":"SUM(S27:T27)","v":4},{"$f":"S27/U27","v":1},0,null,null,"If yes, is positive reponse reported? ",{"$f":"COUNTIF('Coding matrix'!$AD$711:$AD$735,\"yes\")","v":5},{"$f":"COUNTIF('Coding matrix'!$AD$711:$AD$735,\"no\")","v":0},{"$f":"SUM(AA27:AB27)","v":5},{"$f":"AA27/AC27","v":1},0,null,null,"If yes, is positive reponse reported? ",{"$f":"COUNTIF('peer-reviewed publications IB'!AB$5:AB$84,\"yes\")","v":12},{"$f":"COUNTIF('peer-reviewed publications IB'!AB$5:AB$84,\"no\")","v":0},{"$f":"SUM(AI27:AJ27)","v":12},{"$f":"AI27/AK27","v":1},0,null,null,"If yes, is positive reponse reported? ",{"$f":"COUNTIF('peer-reviewed publications pub'!$AB$5:$AB$84,\"yes\")","v":13},{"$f":"COUNTIF('peer-reviewed publications pub'!$AB$5:$AB$84,\"no\")","v":0},{"$f":"SUM(AQ27:AR27)","v":13},{"$f":"AQ27/AS27","v":1},0,null,null,"If yes, is positive reponse reported? ",{"$f":"COUNTIF('First in man trials'!$AC$5:$AC$695,\"yes\")","v":3},{"$f":"COUNTIF('First in man trials'!$AC$5:$AC$695,\"no\")","v":0},{"$f":"SUM(AY27:AZ27)","v":3},{"$f":"AY27/BA27","v":1},0]
["Age matched to patients \n(RATE ON IB LEVEL)","Is the age of animals reported?",{"$f":"COUNTIF('Coding matrix'!$AE$5:$AE$735,\"yes\")","v":14},{"$f":"COUNTIF('Coding matrix'!$AE$5:$AE$735,\"no\")","v":77},91,0.15384615384615385,0.84615384615384615,null,null,"Is the age of animals reported?",{"$f":"COUNTIF('Coding matrix'!$AE$5:$AE$695,\"yes\")","v":13},{"$f":"COUNTIF('Coding matrix'!$AE$5:$AE$695,\"no\")","v":66},79,{"$f":"K28/M28","v":0.16455696202531644},0.83544303797468356,null,null,"Is the age of animals reported?",{"$f":"COUNTIF('Coding matrix'!$AE$696:$AE$710,\"yes\")","v":1},{"$f":"COUNTIF('Coding matrix'!$AE$696:$AE$710,\"no\")","v":5},6,{"$f":"S28/U28","v":0.16666666666666666},0.83333333333333337,null,null,"Is the age of animals reported?",{"$f":"COUNTIF('Coding matrix'!$AE$711:$AE$735,\"yes\")","v":0},{"$f":"COUNTIF('Coding matrix'!$AE$711:$AE$735,\"no\")","v":6},6,{"$f":"AA28/AC28","v":0},1,null,null,"Is the age of animals reported?",{"$f":"COUNTIF('peer-reviewed publications IB'!AC$5:AC$84,\"yes\")","v":3},{"$f":"COUNTIF('peer-reviewed publications IB'!AC$5:AC$84,\"no\")","v":17},20,{"$f":"AI28/AK28","v":0.15},0.85,null,null,"Is the age of animals reported?",{"$f":"COUNTIF('peer-reviewed publications pub'!$AC$5:$AC$84,\"yes\")","v":14},{"$f":"COUNTIF('peer-reviewed publications pub'!$AC$5:$AC$84,\"no\")","v":6},20,{"$f":"AQ28/AS28","v":0.7},0.3,null,null,"Is the age of animals reported?",{"$f":"COUNTIF('First in man trials'!$AD$5:$AD$695,\"yes\")","v":2},{"$f":"COUNTIF('First in man trials'!$AD$5:$AD$695,\"no\")","v":5},7,{"$f":"AY28/BA28","v":0.2857142857142857},0.7142857142857143]
[null,"Is the age of animals matched to patients?",{"$f":"COUNTIF('Coding matrix'!$AF$5:$AF$735,\"yes\")","v":8},{"$f":"COUNTIF('Coding matrix'!$AF$5:$AF$735,\"no\")","v":6},14,0.5714285714285714,0.42857142857142855,{"$f":"C29/E28","v":8.7912087912087919E-2},null,"Is the age of animals matched to patients?",{"$f":"COUNTIF('Coding matrix'!$AF$5:$AF$695,\"yes\")","v":8},{"$f":"COUNTIF('Coding matrix'!$AF$5:$AF$695,\"no\")","v":5},13,0.61538461538461542,0.38461538461538464,{"$f":"K29/M28","v":0.10126582278481013},null,"Is the age of animals matched to patients?",{"$f":"COUNTIF('Coding matrix'!$AF$696:$AF$710,\"yes\")","v":0},{"$f":"COUNTIF('Coding matrix'!$AF$696:$AF$710,\"no\")","v":1},1,0,1,{"$f":"S29/U28","v":0},null,"Is the age of animals matched to patients?",{"$f":"COUNTIF('Coding matrix'!$AF$711:$AF$735,\"yes\")","v":0},{"$f":"COUNTIF('Coding matrix'!$AF$711:$AF$735,\"no\")","v":0},0,{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$f":"AA29/AC28","v":0},null,"Is the age of animals matched to patients?",{"$f":"COUNTIF('peer-reviewed publications IB'!AD$5:AD$84,\"yes\")","v":1},{"$f":"COUNTIF('peer-reviewed publications IB'!AD$5:AD$84,\"no\")","v":2},3,0.33333333333333331,0.66666666666666663,{"$f":"AI29/AK28","v":0.05},null,"Is the age of animals matched to patients?",{"$f":"COUNTIF('peer-reviewed publications pub'!$AD$5:$AD$84,\"yes\")","v":1},{"$f":"COUNTIF('peer-reviewed publications pub'!$AD$5:$AD$84,\"no\")","v":13},14,{"$f":"AQ29/AS29","v":7.1428571428571425E-2},0.9285714285714286,{"$f":"AQ29/AS28","v":0.05},null,"Is the age of animals matched to patients?",{"$f":"COUNTIF('First in man trials'!$AE$5:$AE$695,\"yes\")","v":1},{"$f":"COUNTIF('First in man trials'!$AE$5:$AE$695,\"no\")","v":1},2,0.5,0.5,{"$f":"AY29/BA28","v":0.14285714285714285}]
["Mechanistic evidence \n(RATE ON IB LEVEL)","Yes or no?",{"$f":"COUNTIF('Coding matrix'!$AG$5:$AG$735,\"yes\")","v":64},{"$f":"COUNTIF('Coding matrix'!$AG$5:$AG$735,\"no\")","v":27},91,0.70329670329670335,0.2967032967032967,null,null,"Mechanistic evidence",{"$f":"COUNTIF('Coding matrix'!$AG$5:$AG$695,\"yes\")","v":54},{"$f":"COUNTIF('Coding matrix'!$AG$5:$AG$695,\"no\")","v":25},79,0.68354430379746833,0.31645569620253167,null,null,"Mechanistic evidence",{"$f":"COUNTIF('Coding matrix'!$AG$696:$AG$710,\"yes\")","v":5},{"$f":"COUNTIF('Coding matrix'!$AG$696:$AG$710,\"no\")","v":1},6,0.83333333333333337,0.16666666666666666,null,null,"Mechanistic evidence",{"$f":"COUNTIF('Coding matrix'!$AG$711:$AG$735,\"yes\")","v":5},{"$f":"COUNTIF('Coding matrix'!$AG$711:$AG$735,\"no\")","v":1},6,0.83333333333333337,0.16666666666666666,null,null,"Mechanistic evidence",{"$f":"COUNTIF('peer-reviewed publications IB'!AE$5:AE$84,\"yes\")","v":15},{"$f":"COUNTIF('peer-reviewed publications IB'!AE$5:AE$84,\"no\")","v":5},20,0.75,0.25,null,null,"Mechanistic evidence",{"$f":"COUNTIF('peer-reviewed publications pub'!$AE$5:$AE$84,\"yes\")","v":15},{"$f":"COUNTIF('peer-reviewed publications pub'!$AE$5:$AE$84,\"no\")","v":5},20,0.75,0.25,null,null,"Mechanistic evidence",{"$f":"COUNTIF('First in man trials'!$AF$5:$AF$695,\"yes\")","v":6},{"$f":"COUNTIF('First in man trials'!$AF$5:$AF$695,\"no\")","v":1},7,0.8571428571428571,0.14285714285714285]
["Replication of experiment \n(RATE ON IB LEVEL)","Is there replication of experiment?",{"$f":"COUNTIF('Coding matrix'!$AH$5:$AH$735,\"yes\")","v":27},{"$f":"COUNTIF('Coding matrix'!$AH$5:$AH$735,\"no\")","v":64},91,0.2967032967032967,0.70329670329670335,null,null,"Is there replication of experiment?",{"$f":"COUNTIF('Coding matrix'!$AH$5:$AH$695,\"yes\")","v":24},{"$f":"COUNTIF('Coding matrix'!$AH$5:$AH$695,\"no\")","v":55},79,0.30379746835443039,0.69620253164556967,null,null,"Is there replication of experiment?",{"$f":"COUNTIF('Coding matrix'!$AH$696:$AH$710,\"yes\")","v":1},{"$f":"COUNTIF('Coding matrix'!$AH$696:$AH$710,\"no\")","v":5},6,0.16666666666666666,0.83333333333333337,null,null,"Is there replication of experiment?",{"$f":"COUNTIF('Coding matrix'!$AH$711:$AH$735,\"yes\")","v":2},{"$f":"COUNTIF('Coding matrix'!$AH$711:$AH$735,\"no\")","v":4},6,0.33333333333333331,0.66666666666666663,null,null,"Is there replication of experiment?",{"$f":"COUNTIF('peer-reviewed publications IB'!AF$5:AF$84,\"yes\")","v":8},{"$f":"COUNTIF('peer-reviewed publications IB'!AF$5:AF$84,\"no\")","v":12},20,0.4,0.6,null,null,"Is there replication of experiment?",{"$f":"COUNTIF('peer-reviewed publications pub'!$AF$5:$AF$84,\"yes\")","v":8},{"$f":"COUNTIF('peer-reviewed publications pub'!$AF$5:$AF$84,\"no\")","v":12},20,0.4,0.6,null,null,"Is there replication of experiment?",{"$f":"COUNTIF('First in man trials'!$AG$5:$AG$695,\"yes\")","v":4},{"$f":"COUNTIF('First in man trials'!$AG$5:$AG$695,\"no\")","v":3},7,0.5714285714285714,0.42857142857142855]
[null,"If no, is there other similar study?",{"$f":"COUNTIF('Coding matrix'!$AI$5:$AI$735,\"yes\")","v":17},{"$f":"COUNTIF('Coding matrix'!$AI$5:$AI$735,\"no\")","v":12},29,0.58620689655172409,0.41379310344827586,null,null,"If no, is there other similar study?",{"$f":"COUNTIF('Coding matrix'!$AI$5:$AI$695,\"yes\")","v":17},{"$f":"COUNTIF('Coding matrix'!$AI$5:$AI$695,\"no\")","v":12},29,0.58620689655172409,0.41379310344827586,null,null,"If no, is there other similar study?",{"$f":"COUNTIF('Coding matrix'!$AI$696:$AI$710,\"yes\")","v":0},{"$f":"COUNTIF('Coding matrix'!$AI$696:$AI$710,\"no\")","v":0},0,{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},null,null,"If no, is there other similar study?",{"$f":"COUNTIF('Coding matrix'!$AI$711:$AI$735,\"yes\")","v":0},{"$f":"COUNTIF('Coding matrix'!$AI$711:$AI$735,\"no\")","v":0},0,{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},null,null,"If no, is there other similar study?",{"$f":"COUNTIF('peer-reviewed publications IB'!AG5:AG$84,\"yes\")","v":3},{"$f":"COUNTIF('peer-reviewed publications IB'!AG$5:AG$84,\"no\")","v":2},5,0.6,0.4,null,null,"If no, is there other similar study?",{"$f":"COUNTIF('peer-reviewed publications pub'!$AG$5:$AG$84,\"yes\")","v":3},{"$f":"COUNTIF('peer-reviewed publications pub'!$AG$5:$AG$84,\"no\")","v":2},5,0.6,0.4,null,null,"If no, is there other similar study?",{"$f":"COUNTIF('First in man trials'!$AH$5:$AH$695,\"yes\")","v":0},{"$f":"COUNTIF('First in man trials'!$AH$5:$AH$695,\"no\")","v":1},1,0,1]
["Replication in different model \n(RATE ON IB LEVEL)","Is there replication in different model?",{"$f":"COUNTIF('Coding matrix'!$AJ$5:$AJ$735,\"yes\")","v":70},{"$f":"COUNTIF('Coding matrix'!$AJ$5:$AJ$735,\"no\")","v":21},{"$f":"SUM(C33:D33)","v":91},{"$f":"C33/E33","v":0.76923076923076927},0.23076923076923078,null,null,"Is there replication in different model?",{"$f":"COUNTIF('Coding matrix'!$AJ$5:$AJ$695,\"yes\")","v":61},{"$f":"COUNTIF('Coding matrix'!$AJ$5:$AJ$695,\"no\")","v":18},{"$f":"SUM(K33:L33)","v":79},0.77215189873417722,0.22784810126582278,null,null,"Is there replication in different model?",{"$f":"COUNTIF('Coding matrix'!$AJ$696:$AJ$710,\"yes\")","v":4},{"$f":"COUNTIF('Coding matrix'!$AJ$696:$AJ$710,\"no\")","v":2},{"$f":"SUM(S33:T33)","v":6},0.66666666666666663,0.33333333333333331,null,null,"Is there replication in different model?",{"$f":"COUNTIF('Coding matrix'!$AJ$711:$AJ$735,\"yes\")","v":5},{"$f":"COUNTIF('Coding matrix'!$AJ$711:$AJ$735,\"no\")","v":1},{"$f":"SUM(AA33:AB33)","v":6},0.83333333333333337,0.16666666666666666,null,null,"Is there replication in different model?",{"$f":"COUNTIF('peer-reviewed publications IB'!AH$5:AH84,\"yes\")","v":18},{"$f":"COUNTIF('peer-reviewed publications IB'!AH$5:AH$84,\"no\")","v":2},{"$f":"SUM(AI33:AJ33)","v":20},0.9,0.1,null,null,"Is there replication in different model?",{"$f":"COUNTIF('peer-reviewed publications pub'!$AH$5:$AH$84,\"yes\")","v":19},{"$f":"COUNTIF('peer-reviewed publications pub'!$AH$5:$AH$84,\"no\")","v":1},{"$f":"SUM(AQ33:AR33)","v":20},0.95,0.05,null,null,"Is there replication in different model?",{"$f":"COUNTIF('First in man trials'!$AI$5:$AI$695,\"yes\")","v":4},{"$f":"COUNTIF('First in man trials'!$AI$5:$AI$695,\"no\")","v":3},{"$f":"SUM(AY33:AZ33)","v":7},0.5714285714285714,0.42857142857142855]
[null,"If yes, model type?",null,null,null,null,null,null,null,"If yes, model type?",null,null,null,null,null,null,null,"If yes, model type?",null,null,null,null,null,null,null,"If yes, model type?",null,null,null,null,null,null,null,"If yes, model type?",{"$f":"COUNTIF('peer-reviewed publications IB'!#REF!,\"yes\")","v":{"$error":"#REF!"}},{"$f":"COUNTIF('peer-reviewed publications IB'!#REF!,\"no\")","v":{"$error":"#REF!"}},null,null,null,null,null,"If yes, model type?",{"$f":"COUNTIF('peer-reviewed publications pub'!#REF!,\"yes\")","v":{"$error":"#REF!"}},{"$f":"COUNTIF('peer-reviewed publications pub'!#REF!,\"no\")","v":{"$error":"#REF!"}},null,null,null,null,null,"If yes, model type?"]
["Replication in different species (RATE ON IB LEVEL)","Is there replication in different species?",{"$f":"COUNTIF('Coding matrix'!$AK$5:$AK$735,\"yes\")","v":25},{"$f":"COUNTIF('Coding matrix'!$AK$5:$AK$735,\"no\")","v":66},91,0.27472527472527475,0.72527472527472525,null,null,"Is there replication in different species?",{"$f":"COUNTIF('Coding matrix'!$AK$5:$AK$695,\"yes\")","v":22},{"$f":"COUNTIF('Coding matrix'!$AK$5:$AK$695,\"no\")","v":57},{"$f":"SUM(K35:L35)","v":79},{"$f":"K35/M35","v":0.27848101265822783},{"$f":"L35/M35","v":0.72151898734177211},null,null,"Is there replication in different species?",{"$f":"COUNTIF('Coding matrix'!$AK$696:$AK$710,\"yes\")","v":1},{"$f":"COUNTIF('Coding matrix'!$AK$696:$AK$710,\"no\")","v":5},{"$f":"SUM(S35:T35)","v":6},{"$f":"S35/U35","v":0.16666666666666666},{"$f":"T35/U35","v":0.83333333333333337},null,null,"Is there replication in different species?",{"$f":"COUNTIF('Coding matrix'!$AK$711:$AK$735,\"yes\")","v":2},{"$f":"COUNTIF('Coding matrix'!$AK$711:$AK$735,\"no\")","v":4},{"$f":"SUM(AA35:AB35)","v":6},{"$f":"AA35/AC35","v":0.33333333333333331},{"$f":"AB35/AC35","v":0.66666666666666663},null,null,"Is there replication in different species?",{"$f":"COUNTIF('peer-reviewed publications IB'!AI$5:AI$84,\"yes\")","v":8},{"$f":"COUNTIF('peer-reviewed publications IB'!AI$5:AI$84,\"no\")","v":12},{"$f":"SUM(AI35:AJ35)","v":20},{"$f":"AI35/AK35","v":0.4},{"$f":"AJ35/AK35","v":0.6},null,null,"Is there replication in different species?",{"$f":"COUNTIF('peer-reviewed publications pub'!$AI$5:$AI$84,\"yes\")","v":8},{"$f":"COUNTIF('peer-reviewed publications pub'!$AI$5:$AI$84,\"no\")","v":12},{"$f":"SUM(AQ35:AR35)","v":20},{"$f":"AQ35/AS35","v":0.4},{"$f":"AR35/AS35","v":0.6},null,null,"Is there replication in different species?",{"$f":"COUNTIF('First in man trials'!$AJ$5:$AJ$695,\"yes\")","v":3},{"$f":"COUNTIF('First in man trials'!$AJ$5:$AJ$695,\"no\")","v":4},{"$f":"SUM(AY35:AZ35)","v":7},{"$f":"AY35/BA35","v":0.42857142857142855},{"$f":"AZ35/BA35","v":0.5714285714285714}]
[null,"If yes, species type?",null,null,null,null,null,null,null,"If yes, species type?",null,null,null,null,null,null,null,"If yes, species type?",null,null,null,null,null,null,null,"If yes, species type?",null,null,null,null,null,null,null,"If yes, species type?",{"$f":"COUNTIF('peer-reviewed publications IB'!AJ$5:AJ$84,\"yes\")","v":0},{"$f":"COUNTIF('peer-reviewed publications IB'!AJ$5:AJ$84,\"no\")","v":0},null,null,null,null,null,"If yes, species type?",{"$f":"COUNTIF('peer-reviewed publications pub'!$AJ$5:$AJ$84,\"yes\")","v":0},{"$f":"COUNTIF('peer-reviewed publications pub'!$AJ$5:$AJ$84,\"no\")","v":0},null,null,null,null,null,"If yes, species type?"]
["Citation of references","Is there references reported?",{"$f":"COUNTIF('Coding matrix'!$AM$5:$AM$735,\"yes\")","v":514},{"$f":"COUNTIF('Coding matrix'!$AM$5:$AM$735,\"no\")","v":194},708,0.72598870056497178,0.27401129943502822,null,null,"Is there references reported?",{"$f":"COUNTIF('Coding matrix'!$AM$5:$AM$695,\"yes\")","v":492},{"$f":"COUNTIF('Coding matrix'!$AM$5:$AM$695,\"no\")","v":176},{"$f":"SUM(K37:L37)","v":668},{"$f":"K37/M37","v":0.73652694610778446},{"$f":"L37/M37","v":0.26347305389221559},null,null,"Is there references reported?",{"$f":"COUNTIF('Coding matrix'!$AM$696:$AM$710,\"yes\")","v":9},{"$f":"COUNTIF('Coding matrix'!$AM$696:$AM$710,\"no\")","v":6},{"$f":"SUM(S37:T37)","v":15},{"$f":"S37/U37","v":0.6},{"$f":"T37/U37","v":0.4},null,null,"Is there references reported?",{"$f":"COUNTIF('Coding matrix'!$AM$711:$AM$735,\"yes\")","v":13},{"$f":"COUNTIF('Coding matrix'!$AM$711:$AM$735,\"no\")","v":12},{"$f":"SUM(AA37:AB37)","v":25},{"$f":"AA37/AC37","v":0.52},{"$f":"AB37/AC37","v":0.48},null,null,"Is there references reported?",{"$f":"COUNTIF('peer-reviewed publications IB'!AK$5:AK$84,\"yes\")","v":80},{"$f":"COUNTIF('peer-reviewed publications IB'!AK$5:AK$84,\"no\")","v":0},{"$f":"SUM(AI37:AJ37)","v":80},{"$f":"AI37/AK37","v":1},{"$f":"AJ37/AK37","v":0},null,null,"Is there references reported?",{"$f":"COUNTIF('peer-reviewed publications pub'!$AK$5:$AK$84,\"yes\")","v":80},{"$f":"COUNTIF('peer-reviewed publications pub'!$AK$5:$AK$84,\"no\")","v":0},{"$f":"SUM(AQ37:AR37)","v":80},{"$f":"AQ37/AS37","v":1},{"$f":"AR37/AS37","v":0},null,null,"Is there references reported?",{"$f":"COUNTIF('First in man trials'!$AL$5:$AL$695,\"yes\")","v":13},{"$f":"COUNTIF('First in man trials'!$AL$5:$AL$695,\"no\")","v":17},{"$f":"SUM(AY37:AZ37)","v":30},{"$f":"AY37/BA37","v":0.43333333333333335},{"$f":"AZ37/BA37","v":0.56666666666666665}]
[null,"If yes, what type of references?",null,null,null,null,null,null,null,"If yes, what type of references?",null,null,null,null,null,null,null,"If yes, what type of references?",null,null,null,null,null,null,null,"If yes, what type of references?",null,null,null,null,null,null,null,"If yes, what type of references?",{"$f":"COUNTIF('peer-reviewed publications IB'!AL$5:AL$84,\"yes\")","v":0},{"$f":"COUNTIF('peer-reviewed publications IB'!AL$5:AL$84,\"no\")","v":0},null,null,null,null,null,"If yes, what type of references?",{"$f":"COUNTIF('peer-reviewed publications pub'!$AL$5:$AL$84,\"yes\")","v":0},{"$f":"COUNTIF('peer-reviewed publications pub'!$AL$5:$AL$84,\"no\")","v":0},null,null,null,null,null,"If yes, what type of references?"]
["Inferential statistics","Is effect size reported?",{"$f":"COUNTIF('Coding matrix'!$AO$5:$AO$735,\"yes\")","v":211},{"$f":"COUNTIF('Coding matrix'!$AO$5:$AO$735,\"no\")","v":497},708,0.2980225988700565,0.70197740112994356,16,{"$f":"16/91","v":0.17582417582417584},"Is effect size reported?",{"$f":"COUNTIF('Coding matrix'!$AO$5:$AO$695,\"yes\")","v":188},{"$f":"COUNTIF('Coding matrix'!$AO$5:$AO$695,\"no\")","v":480},{"$f":"SUM(K39:L39)","v":668},{"$f":"K39/M39","v":0.28143712574850299},{"$f":"L39/M39","v":0.71856287425149701},16,{"$f":"16/91","v":0.17582417582417584},"Is effect size reported?",{"$f":"COUNTIF('Coding matrix'!$AO$696:$AO$710,\"yes\")","v":7},{"$f":"COUNTIF('Coding matrix'!$AO$696:$AO$710,\"no\")","v":8},{"$f":"SUM(S39:T39)","v":15},{"$f":"S39/U39","v":0.46666666666666667},{"$f":"T39/U39","v":0.53333333333333333},16,{"$f":"16/91","v":0.17582417582417584},"Is effect size reported?",{"$f":"COUNTIF('Coding matrix'!$AO$711:$AO$735,\"yes\")","v":16},{"$f":"COUNTIF('Coding matrix'!$AO$711:$AO$735,\"no\")","v":9},{"$f":"SUM(AA39:AB39)","v":25},{"$f":"AA39/AC39","v":0.64},{"$f":"AB39/AC39","v":0.36},16,{"$f":"16/91","v":0.17582417582417584},"Is effect size reported?",{"$f":"COUNTIF('peer-reviewed publications IB'!AM$5:AM$84,\"yes\")","v":13},{"$f":"COUNTIF('peer-reviewed publications IB'!AM$5:AM$84,\"no\")","v":67},{"$f":"SUM(AI39:AJ39)","v":80},{"$f":"AI39/AK39","v":0.16250000000000001},{"$f":"AJ39/AK39","v":0.83750000000000002},16,{"$f":"16/91","v":0.17582417582417584},"Is effect size reported?",{"$f":"COUNTIF('peer-reviewed publications pub'!$AM$5:$AM$84,\"yes\")","v":49},{"$f":"COUNTIF('peer-reviewed publications pub'!$AM$5:$AM$84,\"no\")","v":31},{"$f":"SUM(AQ39:AR39)","v":80},{"$f":"AQ39/AS39","v":0.61250000000000004},{"$f":"AR39/AS39","v":0.38750000000000001},16,{"$f":"16/91","v":0.17582417582417584},"Is effect size reported?",{"$f":"COUNTIF('First in man trials'!$AN$5:$AN$695,\"yes\")","v":14},{"$f":"COUNTIF('First in man trials'!$AN$5:$AN$695,\"no\")","v":16},{"$f":"SUM(AY39:AZ39)","v":30},{"$f":"AY39/BA39","v":0.46666666666666667},{"$f":"AZ39/BA39","v":0.53333333333333333},16,{"$f":"16/91","v":0.17582417582417584}]
[null,"Is  significant value reported? ",{"$f":"COUNTIF('Coding matrix'!$AP$5:$AP$735,\"yes\")","v":161},{"$f":"COUNTIF('Coding matrix'!$AP$5:$AP$735,\"no\")","v":547},708,0.22740112994350281,0.77259887005649719,{"$f":"91-H39","v":75},{"$f":"H40/91","v":0.82417582417582413},"Is  significant value reported? ",{"$f":"COUNTIF('Coding matrix'!$AP$5:$AP$695,\"yes\")","v":139},{"$f":"COUNTIF('Coding matrix'!$AP$5:$AP$695,\"no\")","v":529},668,0.20808383233532934,0.79191616766467066,{"$f":"91-P39","v":75},{"$f":"P40/91","v":0.82417582417582413},"Is  significant value reported? ",{"$f":"COUNTIF('Coding matrix'!$AP$696:$AP$710,\"yes\")","v":8},{"$f":"COUNTIF('Coding matrix'!$AP$696:$AP$710,\"no\")","v":7},15,0.53333333333333333,0.46666666666666667,{"$f":"91-X39","v":75},{"$f":"X40/91","v":0.82417582417582413},"Is  significant value reported? ",{"$f":"COUNTIF('Coding matrix'!$AP$711:$AP$735,\"yes\")","v":14},{"$f":"COUNTIF('Coding matrix'!$AP$711:$AP$735,\"no\")","v":11},25,0.56000000000000005,0.44,{"$f":"91-AF39","v":75},{"$f":"AF40/91","v":0.82417582417582413},"Is  significant value reported? ",{"$f":"COUNTIF('peer-reviewed publications IB'!AN$5:AN$84,\"yes\")","v":11},{"$f":"COUNTIF('peer-reviewed publications IB'!AN$5:AN$84,\"no\")","v":69},80,0.13750000000000001,0.86250000000000004,{"$f":"91-AN39","v":75},{"$f":"AN40/91","v":0.82417582417582413},"Is  significant value reported? ",{"$f":"COUNTIF('peer-reviewed publications pub'!$AN$5:$AN$84,\"yes\")","v":61},{"$f":"COUNTIF('peer-reviewed publications pub'!$AN$5:$AN$84,\"no\")","v":19},80,0.76249999999999996,0.23749999999999999,{"$f":"91-AV39","v":75},{"$f":"AV40/91","v":0.82417582417582413},"Is  significant value reported? ",{"$f":"COUNTIF('First in man trials'!$AO$5:$AO$695,\"yes\")","v":17},{"$f":"COUNTIF('First in man trials'!$AO$5:$AO$695,\"no\")","v":13},30,0.56666666666666665,0.43333333333333335,{"$f":"91-BD39","v":75},{"$f":"BD40/91","v":0.82417582417582413}]
[null,"Was the investigation positive, inconclusive or negative?",{"$f":"COUNTIF('Coding matrix'!AQ5:AQ735,\"positive\")","v":636},{"$f":"COUNTIF('Coding matrix'!AQ5:AQ735,\"negative\")","v":43},{"$f":"COUNTIF('Coding matrix'!AQ5:AQ695,\"inconclusive\")","v":29},{"$f":"SUM(C41:E41)","v":708},null,null,null,"Was the investigation positive, inconclusive or negative?",{"$f":"COUNTIF('Coding matrix'!$AQ$5:$AQ$695,\"positive\")","v":596},{"$f":"COUNTIF('Coding matrix'!$AQ$5:$AQ$695,\"inconclusive\")","v":29},{"$f":"COUNTIF('Coding matrix'!$AQ$5:$AQ$695,\"negative\")","v":43},{"$f":"SUM(K41:M41)","v":668},null,null,null,"Was the investigation positive, inconclusive or negative?",{"$f":"COUNTIF('Coding matrix'!$AQ$696:$AQ$710,\"positive\")","v":15},{"$f":"COUNTIF('Coding matrix'!$AQ$696:$AQ$710,\"negative\")","v":0},{"$f":"COUNTIF('Coding matrix'!$AQ$696:$AQ$710,\"inconclusive\")","v":0},{"$f":"SUM(S41:U41)","v":15},null,null,null,"Was the investigation positive, inconclusive or negative?",{"$f":"COUNTIF('Coding matrix'!$AQ$711:$AQ$735,\"positive\")","v":25},{"$f":"COUNTIF('Coding matrix'!$AQ$711:$AQ$735,\"negative\")","v":0},{"$f":"COUNTIF('Coding matrix'!$AQ$711:$AQ$735,\"inconclusive\")","v":0},{"$f":"SUM(AA41:AC41)","v":25},null,null,null,"Was the investigation positive, inconclusive or negative?",{"$f":"COUNTIF('peer-reviewed publications IB'!AO$5:AO$84,\"positive\")","v":78},{"$f":"COUNTIF('peer-reviewed publications IB'!AO$5:AO$84,\"negative\")","v":0},{"$f":"COUNTIF('peer-reviewed publications IB'!AO$5:AO$84,\"inconclusive\")","v":2},{"$f":"SUM(AI41:AK41)","v":80},null,null,null,"Was the investigation positive, inconclusive or negative?",{"$f":"COUNTIF('peer-reviewed publications pub'!$AO$5:$AO$84,\"positive\")","v":77},{"$f":"COUNTIF('peer-reviewed publications pub'!$AO$5:$AO$84,\"negative\")","v":0},{"$f":"COUNTIF('peer-reviewed publications pub'!$AO$5:$AO$84,\"inconclusive\")","v":3},{"$f":"SUM(AQ41:AS41)","v":80},null,null,null,"Was the investigation positive, inconclusive or negative?",{"$f":"COUNTIF('First in man trials'!$AP$5:$AP$695,\"positive\")","v":30},{"$f":"COUNTIF('First in man trials'!$AP$5:$AP$695,\"inconclusive\")","v":0},{"$f":"COUNTIF('First in man trials'!$AP$5:$AP$695,\"negative\")","v":0},{"$f":"SUM(AY41:BA41)","v":30}]
[null,null,"positive","negative","inconclusive",null,null,null,null,null,"positive","negative","inconclusive",null,null,null,null,null,"positive","negative","inconclusive",null,null,null,null,null,"positive","negative","inconclusive",null,null,null,null,null,"positive","negative","inconclusive",null,null,null,null,null,"positive","negative","inconclusive",null,null,null,null,null,"positive","negative","inconclusive"]
[null,null,{"$f":"C41/$F41","v":0.89830508474576276},{"$f":"D41/$F41","v":6.0734463276836161E-2},{"$f":"E41/$F41","v":4.0960451977401127E-2},null,null,null,null,null,{"$f":"K41/$N41","v":0.89221556886227549},{"$f":"L41/$N41","v":4.3413173652694613E-2},6.4371257485029934E-2,null,null,null,null,null,{"$f":"S41/$V41","v":1},{"$f":"T41/$F41","v":0},{"$f":"U41/$F41","v":0},null,null,null,null,null,{"$f":"AA41/$AD41","v":1},{"$f":"AB41/$AD41","v":0},{"$f":"AC41/$AD41","v":0},null,null,null,null,null,{"$f":"AI41/$AL41","v":0.97499999999999998},{"$f":"AJ41/$AL41","v":0},2.5000000000000001E-2,null,null,null,null,null,{"$f":"AQ41/$AL41","v":0.96250000000000002},{"$f":"AR41/$AL41","v":0},3.7499999999999999E-2,null,null,null,null,null,{"$f":"AY41/$N41","v":4.4910179640718563E-2},{"$f":"AZ41/$N41","v":0},0]
[null,"neither effect size nor significance value reported?",{"$f":"SUM(BH:BH)","v":0},{"$f":"C44/E40","v":0},{"$f":"COUNTIFS('Coding matrix'!AU5:AU732,\"no\")","v":22},{"$f":"E44/E35","v":0.24175824175824176},null,null,null,"neither effect size nor significance value reported?",{"$f":"SUM(BL:BL)","v":0},{"$f":"K44/M40","v":0},null,null,null,null,null,"neither effect size nor significance value reported?",{"$f":"SUM(BT:BT)","v":0},{"$f":"S44/U40","v":0},null,null,null,null,null,"neither effect size nor significance value reported?",{"$f":"SUM(CB:CB)","v":0},{"$f":"AA44/AC40","v":0},null,null,null,null,null,"neither effect size nor significance value reported?",{"$f":"SUM(CJ:CJ)","v":0},{"$f":"AI44/AK40","v":0},null,null,null,null,null,"neither effect size nor significance value reported?",{"$f":"SUM(CR:CR)","v":0},{"$f":"AQ44/AS40","v":0},null,null,null,null,null,"neither effect size nor significance value reported?",{"$f":"SUM(CZ:CZ)","v":0},{"$f":"AY44/BA40","v":0}]
[null,"effect size and/or significance value reported",{"$f":"E40-C44","v":708},{"$f":"C45/E40","v":1},{"$f":"91-E44","v":69},{"$f":"E45/E35","v":0.75824175824175821},null,null,null,"effect size and/or significance value reported",{"$f":"M40-K44","v":668},{"$f":"K45/M40","v":1},null,null,null,null,null,"effect size and/or significance value reported",{"$f":"U40-S44","v":15},{"$f":"S45/U40","v":1},null,null,null,null,null,"effect size and/or significance value reported",{"$f":"AC40-AA44","v":25},{"$f":"AA45/AC40","v":1},null,null,null,null,null,"effect size and/or significance value reported",{"$f":"AK40-AI44","v":80},{"$f":"AI45/AK40","v":1},null,null,null,null,null,"effect size and/or significance value reported",{"$f":"AS40-AQ44","v":80},{"$f":"AQ45/AS40","v":1},null,null,null,null,null,"effect size and/or significance value reported",{"$f":"BA40-AY44","v":30},{"$f":"AY45/BA40","v":1}]
[null,"\"positive\" without effect size or significance value",{"$f":"SUM(BI:BI)","v":0},{"$f":"C46/E40","v":0},null,null,null,null,null,"\"positive\" without effect size or significance value",{"$f":"SUM(BM:BM)","v":0},{"$f":"K46/M40","v":0},null,null,null,null,null,"\"positive\" without effect size or significance value",{"$f":"SUM(BU:BU)","v":0},{"$f":"S46/U40","v":0},null,null,null,null,null,"\"positive\" without effect size or significance value",{"$f":"SUM(CC:CC)","v":0},{"$f":"AA46/AC40","v":0},null,null,null,null,null,"\"positive\" without effect size or significance value",{"$f":"SUM(CK:CK)","v":0},{"$f":"AI46/AK40","v":0},null,null,null,null,null,"\"positive\" without effect size or significance value",{"$f":"SUM(CS:CS)","v":0},{"$f":"AQ46/AS40","v":0},null,null,null,null,null,"\"positive\" without effect size or significance value",{"$f":"SUM(DA:DA)","v":0},{"$f":"AY46/BA40","v":0}]
[null,"\"negative\" without effect size or significance value",{"$f":"SUM(BF:BF)","v":0},{"$f":"C47/E40","v":0},null,null,null,null,null,"\"negative\" without effect size or significance value",{"$f":"SUM(BN:BN)","v":0},{"$f":"K47/M40","v":0},null,null,null,null,null,"\"negative\" without effect size or significance value",{"$f":"SUM(BV:BV)","v":0},{"$f":"S47/U40","v":0},null,null,null,null,null,"\"negative\" without effect size or significance value",{"$f":"SUM(CD:CD)","v":0},{"$f":"AA47/AC40","v":0},null,null,null,null,null,"\"negative\" without effect size or significance value",{"$f":"SUM(CL:CL)","v":0},{"$f":"AI47/AK40","v":0},null,null,null,null,null,"\"negative\" without effect size or significance value",{"$f":"SUM(CT:CT)","v":0},{"$f":"AQ47/AS40","v":0},null,null,null,null,null,"\"negative\" without effect size or significance value",{"$f":"SUM(DB:DB)","v":0},{"$f":"AY47/BA40","v":0}]
[null,"\"unclear\" without effect size or significance value",{"$f":"SUM(BG:BG)","v":0},{"$f":"C48/E40","v":0},null,null,null,null,null,"\"unclear\" without effect size or significance value",{"$f":"SUM(BO:BO)","v":0},{"$f":"K48/M40","v":0},null,null,null,null,null,"\"unclear\" without effect size or significance value",{"$f":"SUM(BW:BW)","v":0},{"$f":"S48/U40","v":0},null,null,null,null,null,"\"unclear\" without effect size or significance value",{"$f":"SUM(CE:CE)","v":0},{"$f":"AA48/AC40","v":0},null,null,null,null,null,"\"unclear\" without effect size or significance value",{"$f":"SUM(CM:CM)","v":0},{"$f":"AI48/AK40","v":0},null,null,null,null,null,"\"unclear\" without effect size or significance value",{"$f":"SUM(CU:CU)","v":0},{"$f":"AQ48/AS40","v":0},null,null,null,null,null,"\"unclear\" without effect size or significance value",{"$f":"SUM(DC:DC)","v":0},{"$f":"AY48/BA40","v":0}]
[null,null,null,{"$f":"SUM(D46:D48)","v":0},null,null,null,null,null,null,null,{"$f":"SUM(L46:L48)","v":0},null,null,null,null,null,null,null,{"$f":"SUM(T46:T48)","v":0},null,null,null,null,null,null,null,{"$f":"SUM(AB46:AB48)","v":0},null,null,null,null,null,null,null,{"$f":"SUM(AJ46:AJ48)","v":0},null,null,null,null,null,null,null,{"$f":"SUM(AR46:AR48)","v":0},null,null,null,null,null,null,null,{"$f":"SUM(AZ46:AZ48)","v":0}]
[]
[]
[]
[null,null,{"$f":"SUM(C46:C47)","v":0},{"$f":"C53/E37","v":0}]
[]
[]
[]
[]
["Ibs",12,{"$f":"B58/E35","v":0.13186813186813187},null,{"$f":"E35-B58","v":79},{"$f":"E58/E35","v":0.86813186813186816}]
["PCES",40,{"$f":"B59/E39","v":5.6497175141242938E-2},null,{"$f":"E39-B59","v":668},{"$f":"E59/E40","v":0.94350282485875703}]
[]
[]
[]
[]
[]
[]
[]
["no replication (any type)",{"$f":"'Coding matrix'!$BH$738","v":15},{"$f":"B67/E35","v":0.16483516483516483}]
["any replication",{"$f":"E35-B67","v":76},{"$f":"B68/E35","v":0.8351648351648352}]
[]
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[]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"COUNTIFS('Coding matrix'!AO1234,\"no\",'Coding matrix'!AP1234,\"no\",'Coding matrix'!AQ1234,\"unclear\")","v":0}]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"COUNTIFS('Coding matrix'!AO1235,\"no\",'Coding matrix'!AP1235,\"no\",'Coding matrix'!AQ1235,\"unclear\")","v":0}]

{"sheet":"Distribution data","index":3,"n_rows":727,"n_cols":50,"rows_kept":727,"cut":false,"hidden":false,"merged":[[7,9,15,9],[18,9,30,9],[33,9,35,9],[37,9,39,9],[40,9,41,9]]}
["Please note: Some rows in this table might have been deleted due to confidentiality reasons!"]
["IB","Phase","Number of in vivo efficacy studies",null,null,"First in man?","First in man`?"]
["IB1","Phase 2",0,null,null,null,{"$f":"COUNTIFS(F3,\"Yes\")","v":0},{"$f":"COUNTIFS(F3,\"*\")","v":0},{"$f":"COUNTIFS(F3,\"No\")","v":0}]
["IB2","Phase 2",4,"a",0.41176470588235292,"No",0,1,1,"IB7",null,null,null,15,16,18,31,4,3,13,6,{"$f":"SUM(N4:U5)","v":213},{"$f":"668-V4","v":455},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Total",null,"Evaluated","Phase ","Number of PCES",1.96]
["IB3","Phase 1",2,"a",0.37878787878787873,"Yes",1,1,0,"IB12",null,null,null,20,28,14,5,8,32,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB001","Phase 2",null,null,0,"IB2",2,"Anti-neoplastic & immune-modulating agents","efficacy",{"$f":"COUNTIF(AT:AT,\"IB1\")","v":1}]
["IB4","Phase 2",21,"d",0.29971988795518201,"No",0,1,1,"IB15",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB002","Phase 2","IB002","Phase 2",4,"IB2",2,"Anti-neoplastic & immune-modulating agents","efficacy",{"$f":"COUNTIF(AT:AT,\"IB2\")","v":4}]
["IB5","Phase 1 b",2,"a",0.17647058823529413,"No",0,1,1,"IB21",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB003","Phase 1","IB003","Phase 1",2,"IB2",2,"Anti-neoplastic & immune-modulating agents","efficacy",{"$f":"COUNTIF(AT:AT,\"IB3\")","v":2}]
["IB6","Phase 1",11,"c",0.43850267379679142,"No",0,1,1,"IB22",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB004","Phase 2","IB004","Phase 2",21,"IB2",2,"Anti-neoplastic & immune-modulating agents","efficacy",{"$f":"COUNTIF(AT:AT,\"IB4\")","v":21}]
["IB7","Phase 1",15,"c",0.37647058823529411,"No",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB005","Phase 1 b","IB005","Phase 1 b",2,"IB3",1,"Blood product & biotech","efficacy",{"$f":"COUNTIF(AT:AT,\"IB5\")","v":2}]
["IB8","Phase 1",2,"a",0.47058823529411764,"No",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB006","Phase 1","IB006","Phase 1",11,"IB3",1,"Blood product & biotech","efficacy",{"$f":"COUNTIF(AT:AT,\"IB6\")","v":11}]
["IB9","Phase 1 / 2 a",4,"a",0.52941176470588236,"No",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB007","Phase 1","IB007","Phase 1",15,"IB4",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB7\")","v":15}]
["IB10","Phase 1 b",6,"b",0.39705882352941174,"No",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB008","Phase 1","IB008","Phase 1",2,"IB4",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB8\")","v":2}]
["IB11","Phase 1 b / 2",8,"b",0.47058823529411764,"No",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB009","Phase 1 / 2 a","IB009","Phase 1 / 2 a",4,"IB4",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB9\")","v":4}]
["IB12","Phase 2",20,"d",0.44117647058823534,"No",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB010","Phase 1 b","IB010","Phase 1 b",6,"IB4",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB10\")","v":6}]
["IB13","Phase 2",4,"a",0.37941176470588234,"No",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB011","Phase 1 b / 2","IB011","Phase 1 b / 2",8,"IB4",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB11\")","v":8}]
["IB14","Phase 2",2,"a",0.29411764705882354,"No",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB012","Phase 2","IB012","Phase 2",20,"IB4",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB12\")","v":20}]
["IB15","Phase 2",16,"d",0.4154411764705882,"No",0,1,1,"IB29",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB013","Phase 2","IB013","Phase 2",4,"IB4",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB13\")","v":4}]
["IB16","Phase 2",0,null,null,null,0,0,0,"IB31",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB014","Phase 2","IB014","Phase 2",2,"IB4",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB14\")","v":2}]
["IB17","Phase 2",7,"b",0.57983193277310929,"No",0,1,1,"IB49",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB015","Phase 2","IB015","Phase 2",16,"IB4",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB15\")","v":16}]
["IB18","Phase 2",11,"c",0.63636363636363635,"No",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB016","Phase 2",null,null,0,"IB4",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB16\")","v":1}]
["IB19","Phase 2",1,"a",0.41176470588235292,"No",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB017","Phase 2","IB017","Phase 2",7,"IB4",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB17\")","v":7}]
["IB20","Phase 2",16,"d",0.49632352941176461,"No",0,1,1,null,null,null,"Number of preclinical studies extracted from the IBs\n",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB018","Phase 2","IB018","Phase 2",11,"IB4",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB18\")","v":11}]
["IB21","Phase 2",18,"d",0.45751633986928103,"No",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB019","Phase 2","IB019","Phase 2",1,"IB4",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB19\")","v":1}]
["IB22","Phase 2",28,"d",0.48319327731092421,"No",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB020","Phase 2","IB020","Phase 2",16,"IB4",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB20\")","v":16}]
["IB23","Phase 2",28,"d",0.53361344537815114,"No",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB021","Phase 2","IB021","Phase 2",18,"IB4",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB21\")","v":18}]
["IB24","Phase 2",4,"a",0.51470588235294112,"No",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB022","Phase 2","IB022","Phase 2",28,"IB4",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB22\")","v":28}]
["IB25","Phase 2",11,"c",0.42780748663101609,"No",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB023","Phase 2","IB023","Phase 2",28,"IB4",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB23\")","v":28}]
["IB26","Phase 2",4,"a",0.55882352941176472,"No",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB024","Phase 2","IB024","Phase 2",4,"IB4",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB24\")","v":4}]
["IB27","Phase 2",3,"a",0.21568627450980393,"No",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB025","Phase 2","IB025","Phase 2",11,"IB4",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB25\")","v":11}]
["IB28","Phase 2",7,"b",0.49579831932773111,"No",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB026","Phase 2","IB026","Phase 2",4,"IB4",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB26\")","v":4}]
["IB29","Phase 2",14,"c",0.29411764705882354,"No",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB027","Phase 2","IB027","Phase 2",3,"IB4",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB27\")","v":3}]
["IB30","Phase 2",11,"c",0.4331550802139037,"No",0,1,1,"IB54",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB028","Phase 2","IB028","Phase 2",7,"IB5","1b","Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB28\")","v":7}]
["IB31","Phase 2",5,"a",0.55294117647058816,"No",0,1,1,"IB63",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB029","Phase 2","IB029","Phase 2",14,"IB5","1b","Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB29\")","v":14}]
["IB32","Phase 2",0,null,null,null,0,0,0,"IB77",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB030","Phase 2","IB030","Phase 2",11,"IB6",1,"Blood product & biotech","efficacy",{"$f":"COUNTIF(AT:AT,\"IB30\")","v":11}]
["IB33","Phase 2",0,null,null,null,{"$f":"COUNTIFS(F35,\"Yes\")","v":0},{"$f":"COUNTIFS(F35,\"*\")","v":0},{"$f":"COUNTIFS(F35,\"No\")","v":0},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB031","Phase 2","IB031","Phase 2",5,"IB6",1,"Blood product & biotech","efficacy",{"$f":"COUNTIF(AT:AT,\"IB31\")","v":5}]
["IB34","Phase 2 a",1,"a",0.3235294117647059,"No",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB032","Phase 2",null,null,0,"IB6",1,"Blood product & biotech","efficacy",{"$f":"COUNTIF(AT:AT,\"IB32\")","v":1}]
["IB35","Phase 2 a",8,"b",0.36029411764705882,"No",0,1,1,"IB79",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB033","Phase 2",null,null,0,"IB6",1,"Blood product & biotech","efficacy",{"$f":"COUNTIF(AT:AT,\"IB33\")","v":1}]
["IB36","Phase 2 a",8,"b",0.54411764705882348,"No",0,1,1,"IB84",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB034","Phase 2 a","IB034","Phase 2 a",1,"IB6",1,"Blood product & biotech","efficacy",{"$f":"COUNTIF(AT:AT,\"IB34\")","v":1}]
["IB37","Phase 3",0,null,null,null,0,0,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB035","Phase 2 a","IB035","Phase 2 a",8,"IB6",1,"Blood product & biotech","efficacy",{"$f":"COUNTIF(AT:AT,\"IB35\")","v":8}]
["IB38","Phase 3",0,null,null,null,0,0,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB036","Phase 2 a","IB036","Phase 2 a",8,"IB6",1,"Blood product & biotech","efficacy",{"$f":"COUNTIF(AT:AT,\"IB36\")","v":8}]
["IB039","Phase 2",0,null,null,null,0,0,0,"IB87",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB037","Phase 3",null,null,0,"IB6",1,"Blood product & biotech","efficacy",{"$f":"COUNTIF(AT:AT,\"IB37\")","v":1}]
["IB040","Phase 2",6,"b",0.46078431372549022,"No",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB038","Phase 3",null,null,0,"IB6",1,"Blood product & biotech","efficacy",{"$f":"COUNTIF(AT:AT,\"IB38\")","v":1}]
["IB041","Phase 2 b",0,null,null,null,0,0,0,"IB91",null,null,null,null,"von 91",null,"von 109",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB039","Phase 2",null,null,null,"IB6",1,"Blood product & biotech","efficacy",{"$f":"COUNTIF(AT:AT,\"IB39\")","v":1}]
[null,null,null,null,null,null,0,0,0,null,null,null,"Sum",null,{"$f":"SUM(C3:C107)","v":668},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB040","Phase 2","IB040","Phase 2",6,"IB6",1,"Blood product & biotech","efficacy",{"$f":"COUNTIF(AT:AT,\"IB40\")","v":6}]
["IB043","Phase 1",5,"a",0.6705882352941176,"Yes",1,1,0,null,null,null,"median",null,{"$f":"MEDIAN(C4:C17,C19:C33,C36:C38,C42,C44:C46,C48,C50:C51,C52:C56,C57:C59,C61,C64:C67,C68,C71:C72,C74:C75,C77:C79,C81:C82,C84,C86:C94,C96,C99:C100,C101,C104:C119)","v":6},null,{"$f":"MEDIAN(C3:C119)","v":5},{"$f":"_xlfn.STDEV.P(C3:C119)","v":6.6661513871416194},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB041","Phase 2 b",null,null,null,"IB7",1,"Blood product & biotech","efficacy",{"$f":"COUNTIF(AT:AT,\"IB41\")","v":1}]
["IB044","Phase 1 / 2",3,"a",0.49019607843137258,"No",0,1,1,null,null,null,"Average",null,{"$f":"AVERAGE(C4:C17,C19:C33,C36:C38,C42,C44:C46,C48,C50:C59,C61,C64:C68,C71:C72,C74:C75,C77:C79,C81:C82,C84,C86:C94,C96,C99:C101,C104,C105:C119)","v":7.7802197802197801},null,{"$f":"AVERAGE(C3:C119)","v":6.1034482758620694},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB042","Phase 3","IB042","Phase 3",2,"IB7",1,"Blood product & biotech","efficacy",{"$f":"COUNTIF(AT:AT,\"IB42\")","v":2}]
["IB045","Phase 2 b",0,null,null,null,0,0,0,null,null,"a","1-5",null,45,{"$f":"O47/O$52","v":0.49450549450549453},{"$f":"O47/109","v":0.41284403669724773},null,{"$f":"SUM(O48:O49)/O52","v":0.39560439560439559},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB043","Phase 1","IB043","Phase 1",5,"IB7",1,"Blood product & biotech","efficacy",{"$f":"COUNTIF(AT:AT,\"IB43\")","v":5}]
["IB046","unclear",7,"b",0.42016806722689071,"Yes",1,1,0,null,null,"b","6-10",null,21,{"$f":"O48/O$52","v":0.23076923076923078},{"$f":"O48/109","v":0.19266055045871561},null,{"$f":"SUM(O50:O51)/O52","v":0.10989010989010989},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB044","Phase 1 / 2","IB044","Phase 1 / 2",3,"IB7",1,"Blood product & biotech","efficacy",{"$f":"COUNTIF(AT:AT,\"IB44\")","v":3}]
["IB047","Phase 2",0,null,null,null,0,0,0,null,null,"c","11-15",null,{"$f":"COUNTIF(D$3:D$107,\"c\")","v":15},0.16483516483516483,0.13761467889908258,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB045","Phase 2 b",null,null,null,"IB7",1,"Blood product & biotech","efficacy",{"$f":"COUNTIF(AT:AT,\"IB45\")","v":1}]
["IB048","Phase 2",10,"b",0.5,"No",0,1,1,null,null,"d","16-30",null,{"$f":"COUNTIF(D$3:D$107,\"d\")","v":8},8.7912087912087919E-2,7.3394495412844041E-2,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB046","unclear","IB046","unclear",7,"IB7",1,"Blood product & biotech","efficacy",{"$f":"COUNTIF(AT:AT,\"IB46\")","v":7}]
["IB049","Phase 2",31,"e",0.29981024667931683,"No",0,1,1,null,null,"e",">30",null,{"$f":"COUNTIF(D$3:D$107,\"e\")","v":2},2.197802197802198E-2,1.834862385321101E-2,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB047","Phase 2",null,null,null,"IB7",1,"Blood product & biotech","efficacy",{"$f":"COUNTIF(AT:AT,\"IB47\")","v":1}]
["IB050","Phase 1 / 2",3,"a",0.29411764705882354,"Yes",1,1,0,null,null,null,null,null,{"$f":"SUM(O47:O51)","v":91},1,{"$f":"SUM(Q47:Q51)","v":0.83486238532110091},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"With PCES",{"$f":"COUNTIF('Coding matrix'!AG13:AG703,\"efficacy\")+COUNTIF('Coding matrix'!AG13:AG703,\"unclear\")","v":0},null,"Numbers","Percent",null,null,"IB048","Phase 2","IB048","Phase 2",10,"IB7",1,"Blood product & biotech","efficacy",{"$f":"COUNTIF(AT:AT,\"IB48\")","v":10}]
["IB051","Phase 2",2,"a",0.47058823529411764,"No",0,1,1,null,null,null,"Total",null,"Evaluated",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No PCES",{"$f":"COUNTIF('Coding matrix'!AG13:AG703,\"no efficacy\")","v":0},"Phase 1",11,0.13750000000000001,null,null,"IB049","Phase 2","IB049","Phase 2",31,"IB7",1,"Blood product & biotech","efficacy",{"$f":"COUNTIF(AT:AT,\"IB49\")","v":31}]
["IB052","Phase 1 b",5,"a",0.45882352941176474,"No",0,1,1,null,null,null,null,null,"Phase",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Phase 1/2",8,0.1,null,null,"IB050","Phase 1 / 2","IB050","Phase 1 / 2",3,"IB7",1,"Blood product & biotech","efficacy",{"$f":"COUNTIF(AT:AT,\"IB50\")","v":3}]
["IB053","Phase 2",7,"b",0.58823529411764708,"No",0,1,1,null,null,null,"Phase 1",6,"Phase 1",6,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Single IBss",{"$f":"AK58","v":80},"Phase 2",59,0.73750000000000004,null,null,"IB051","Phase 2","IB051","Phase 2",2,"IB7",1,"Blood product & biotech","efficacy",{"$f":"COUNTIF(AT:AT,\"IB51\")","v":2}]
["IB054","Phase 2",4,"a",0.41176470588235292,"No",0,1,1,null,null,null,"Phase 1 a",0,"Phase 1 a",0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Phase 3",1,1.2500000000000001E-2,null,null,"IB052","Phase 1 b","IB052","Phase 1 b",5,"IB7",1,"Blood product & biotech","efficacy",{"$f":"COUNTIF(AT:AT,\"IB52\")","v":5}]
["IB055","Phase 2 a / b",5,"a",0.35294117647058826,"No",0,1,1,null,null,null,"Phase 1 b",5,"Phase 1 b",5,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"unclear",1,1.2500000000000001E-2,null,null,"IB053","Phase 2","IB053","Phase 2",7,"IB7",1,"Blood product & biotech","efficacy",{"$f":"COUNTIF(AT:AT,\"IB53\")","v":7}]
["IB056","Phase 2",2,"a",0.41176470588235292,"No",0,1,1,null,null,null,"Phase 1 / 2",5,"Phase 1 / 2",5,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Total",80,1,null,null,"IB054","Phase 2","IB054","Phase 2",4,"IB7",1,"Blood product & biotech","efficacy",{"$f":"COUNTIF(AT:AT,\"IB54\")","v":4}]
["IB057","Phase 2 ",2,"a",0.23529411764705882,"No",0,1,1,null,null,null,"Phase 1 / 2 a",1,"Phase 1 / 2 a",1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB055","Phase 2 a / b","IB055","Phase 2 a / b",5,"IB7",1,"Blood product & biotech","efficacy",{"$f":"COUNTIF(AT:AT,\"IB55\")","v":5}]
["IB058","Phase 2 b",0,null,null,null,0,0,0,null,null,null,"Phase 1 b / 2",1,"Phase 1 b / 2",1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB056","Phase 2","IB056","Phase 2",2,"IB8",1,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB56\")","v":2}]
["IB059","Phase 2 ",6,"b",0.46078431372549017,"No",0,1,1,null,null,null,"Phase 1 b / 2 b",1,"Phase 1 b / 2 b",1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Total",null,"Evaluated",null,null,null,null,"IB057","Phase 2 ","IB057","Phase 2",2,"IB8",1,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB57\")","v":2}]
["IB060","Phase 2 a",0,null,null,null,0,0,0,null,null,null,"Phase 2",56,"Phase 2",52,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Phase",null,null,null,null,"IB058","Phase 2 b",null,null,null,"IB9","1/2a","Rheumatology","efficacy",{"$f":"COUNTIF(AT:AT,\"IB58\")","v":1}]
["IB061","Phase 2 b",0,null,null,null,0,0,0,null,null,null,"Phase 2 a",5,"Phase 2 a",4,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Phase 1",{"$f":"COUNTIFS(AP$4:AP$686,\"Phase 1\")","v":6},"Phase 1",{"$f":"COUNTIFS(AR$4:AR$686,\"Phase 1\")","v":6},null,null,null,"IB059","Phase 2 ","IB059","Phase 2",6,"IB9","1/2a","Rheumatology","efficacy",{"$f":"COUNTIF(AT:AT,\"IB59\")","v":6}]
["IB062","Phase 2",11,"c",0.35294117647058798,"No",0,1,1,null,null,null,"Phase 2 b",8,"Phase 2 b",2,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Phase 1 a",{"$f":"COUNTIFS(AP$4:AP$686,\"Phase 1 a\")","v":0},"Phase 1 a",{"$f":"COUNTIFS(AR$4:AR$686,\"Phase 1 a\")","v":0},null,null,null,"IB060","Phase 2 a",null,null,null,"IB9","1/2a","Rheumatology","efficacy",{"$f":"COUNTIF(AT:AT,\"IB60\")","v":1}]
["IB063","Phase 2 b",8,"b",0.43382352941176472,"No",0,1,1,null,null,null,"Phase 2 a / b",1,"Phase 2 a / b",1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Phase 1 b",{"$f":"COUNTIFS(AP$4:AP$686,\"Phase 1 b\")","v":5},"Phase 1 b",{"$f":"COUNTIFS(AR$4:AR$686,\"Phase 1 b\")","v":5},null,null,null,"IB061","Phase 2 b",null,null,null,"IB9","1/2a","Rheumatology","efficacy",{"$f":"COUNTIF(AT:AT,\"IB61\")","v":1}]
["IB064","Phase 2",6,"b",0.26470588235294118,"No",0,1,1,null,null,null,"Phase 3",3,"Phase 3",1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Phase 1 / 2",{"$f":"COUNTIFS(AP$4:AP$686,\"Phase 1 / 2\")","v":5},"Phase 1 / 2",{"$f":"COUNTIFS(AR$4:AR$686,\"Phase 1 / 2\")","v":5},null,null,null,"IB062","Phase 2","IB062","Phase 2",8,"IB13",2,"Anti-neoplastic & immune-modulating agents","efficacy",{"$f":"COUNTIF(AT:AT,\"IB62\")","v":8}]
["IB065","Phase 2",3,"a",0.4509803921568627,"No",{"$f":"COUNTIFS(F67,\"Yes\")","v":0},{"$f":"COUNTIFS(F67,\"*\")","v":1},{"$f":"COUNTIFS(F67,\"No\")","v":1},null,null,null,"unclear",1,"unclear",1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Phase 1 / 2 a",{"$f":"COUNTIFS(AP$4:AP$686,\"Phase 1 / 2 a\")","v":1},"Phase 1 / 2 a",{"$f":"COUNTIFS(AR$4:AR$686,\"Phase 1 / 2 a\")","v":1},null,null,null,"IB063","Phase 2 b","IB063","Phase 2 b",8,"IB13",2,"Anti-neoplastic & immune-modulating agents","efficacy",{"$f":"COUNTIF(AT:AT,\"IB63\")","v":8}]
["IB066","Phase 2",6,"b",0.24509803921568629,"No",0,1,1,null,null,null,null,93,null,80,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Phase 1 b / 2",{"$f":"COUNTIFS(AP$4:AP$686,\"Phase 1 b / 2\")","v":1},"Phase 1 b / 2",{"$f":"COUNTIFS(AR$4:AR$686,\"Phase 1 b / 2\")","v":1},null,null,null,"IB064","Phase 2","IB064","Phase 2",6,"IB13",2,"Anti-neoplastic & immune-modulating agents","efficacy",{"$f":"COUNTIF(AT:AT,\"IB64\")","v":6}]
["IB067","Not IB",0,null,null,null,0,0,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Phase 1 b / 2 b",{"$f":"COUNTIFS(AP$4:AP$686,\"Phase 1 b / 2 b\")","v":1},"Phase 1 b / 2 b",{"$f":"COUNTIFS(AR$4:AR$686,\"Phase 1 b / 2 b\")","v":1},null,null,null,"IB065","Phase 2","IB065","Phase 2",3,"IB13",2,"Anti-neoplastic & immune-modulating agents","efficacy",{"$f":"COUNTIF(AT:AT,\"IB65\")","v":3}]
["IB068","Phase 2 b",0,null,null,null,0,0,0,null,null,null,105,102,80,80,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Phase 2",{"$f":"COUNTIFS(AP$4:AP$686,\"Phase 2\")","v":56},"Phase 2",{"$f":"COUNTIFS(AR$4:AR$686,\"Phase 2\")","v":52},null,null,null,"IB066","Phase 2","IB066","Phase 2",6,"IB10","1b","Anti-neoplastic & immune-modulating agents","efficacy",{"$f":"COUNTIF(AT:AT,\"IB66\")","v":6}]
["IB069","Phase 2",5,"a",0.45882352941176474,"No",0,1,1,null,null,null,null,null,null,"N","%",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Phase 2 a",{"$f":"COUNTIFS(AP$4:AP$686,\"Phase 2 a\")","v":5},"Phase 2 a",{"$f":"COUNTIFS(AR$4:AR$686,\"Phase 2 a\")","v":4},null,null,null,"IB067","Not IB",null,null,null,"IB10","1b","Anti-neoplastic & immune-modulating agents","efficacy",{"$f":"COUNTIF(AT:AT,\"IB67\")","v":1}]
["IB070","Phase 2",12,"c",0.2990196078431373,"No",0,1,1,null,null,null,null,null,"Phase 1",15,{"$f":"P72/P$76","v":0.16483516483516483},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Phase 2 b",{"$f":"COUNTIFS(AP$4:AP$686,\"Phase 2 b\")","v":8},"Phase 2 b",{"$f":"COUNTIFS(AR$4:AR$686,\"Phase 2 b\")","v":2},null,null,null,"IB068","Phase 2 b",null,null,null,"IB10","1b","Anti-neoplastic & immune-modulating agents","efficacy",{"$f":"COUNTIF(AT:AT,\"IB68\")","v":1}]
["IB071","Phase 2",0,null,null,null,0,0,0,null,null,null,null,null,"Phase 1/2",10,{"$f":"P73/P$76","v":0.10989010989010989},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Phase 2 a / b",{"$f":"COUNTIFS(AP$4:AP$686,\"Phase 2 a / b\")","v":1},"Phase 2 a / b",{"$f":"COUNTIFS(AR$4:AR$686,\"Phase 2 a / b\")","v":1},null,null,null,"IB069","Phase 2","IB069","Phase 2",5,"IB10","1b","Anti-neoplastic & immune-modulating agents","efficacy",{"$f":"COUNTIF(AT:AT,\"IB69\")","v":5}]
["IB072","Phase 1 b",5,"a",0.32941176470588235,"No",0,1,1,null,null,null,null,null,"Phase 2",65,0.7142857142857143,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Phase 3",{"$f":"COUNTIFS(AP$4:AP$686,\"Phase 3\")","v":3},"Phase 3",{"$f":"COUNTIFS(AR$4:AR$686,\"Phase 3\")","v":1},null,null,null,"IB070","Phase 2","IB070","Phase 2",12,"IB10","1b","Anti-neoplastic & immune-modulating agents","efficacy",{"$f":"COUNTIF(AT:AT,\"IB70\")","v":12}]
["IB073","Phase 2",5,"a",0.3411764705882353,"No",0,1,1,null,null,null,null,null,"unclear",1,1.098901098901099E-2,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"unclear",{"$f":"COUNTIFS(AP$4:AP$686,\"unclear\")","v":1},"unclear",{"$f":"COUNTIFS(AR$4:AR$686,\"unclear\")","v":1},null,null,null,"IB071","Phase 2",null,null,null,"IB10","1b","Anti-neoplastic & immune-modulating agents","efficacy",{"$f":"COUNTIF(AT:AT,\"IB71\")","v":1}]
["IB074",null,0,null,null,null,0,0,0,null,null,null,null,null,"Total",{"$f":"SUM(P72:P75)","v":91},1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"SUM(AI63:AI75)","v":93},null,{"$f":"SUM(AK63:AK75)","v":80},null,null,null,"IB072","Phase 1 b","IB072","Phase 1 b",5,"IB11","1b/2","Anti-neoplastic & immune-modulating agents","efficacy",{"$f":"COUNTIF(AT:AT,\"IB72\")","v":5}]
["IB075","Phase 1 / 2",5,"a",0.58823529411764708,"No",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB073","Phase 2","IB073","Phase 2",5,"IB11","1b/2","Anti-neoplastic & immune-modulating agents","efficacy",{"$f":"COUNTIF(AT:AT,\"IB73\")","v":5}]
["IB076","Phase 2",6,"b",0.24509803921568624,"No",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"COUNTIFS(AO12:AO121,\"*\")","v":98},{"$f":"COUNTIFS(AP12:AP121,\"*\")","v":95},{"$f":"COUNTIFS(AQ12:AQ121,\"*\")","v":74},{"$f":"COUNTIFS(AR12:AR121,\"*\")","v":74},null,null,null,"IB074",null,null,null,null,"IB11","1b/2","Anti-neoplastic & immune-modulating agents","efficacy",{"$f":"COUNTIF(AT:AT,\"IB74\")","v":1}]
["IB077","Phase 2",32,"e",0.52022058823529405,"No",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Numbers","Percent",null,null,"IB075","Phase 1 / 2","IB075","Phase 1 / 2",5,"IB11","1b/2","Anti-neoplastic & immune-modulating agents","efficacy",{"$f":"COUNTIF(AT:AT,\"IB75\")","v":5}]
["IB078",null,0,null,null,null,0,0,0,null,null,null,null,null,null,null,null,null,"PCES",null,"IBs",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Phase 1",{"$f":"SUM(AK63:AK65)","v":11},{"$f":"AK80/$AK$85","v":0.13750000000000001},null,null,"IB076","Phase 2","IB076","Phase 2",6,"IB11","1b/2","Anti-neoplastic & immune-modulating agents","efficacy",{"$f":"COUNTIF(AT:AT,\"IB76\")","v":6}]
["IB079","Phase 2",3,"a",0.50980392156862753,"No",0,1,1,null,null,null,null,null,null,null,null,null,"n","%","n","%",null,null,null,null,null,null,null,null,null,null,null,null,null,"Phase 1/2",{"$f":"SUM(AK66:AK69)","v":8},{"$f":"AK81/$AK$85","v":0.1},null,null,"IB077","Phase 2","IB077","Phase 2",23,"IB11","1b/2","Anti-neoplastic & immune-modulating agents","efficacy",{"$f":"COUNTIF(AT:AT,\"IB77\")","v":23}]
["IB080","Phase 2 ",12,"c",0.2745098039215686,"No",0,1,1,null,null,null,null,null,null,null,null,"Blood product & biotech",{"$f":"COUNTIFS('Coding matrix'!E:E,\"blood product*\")","v":74},{"$f":"S82/S$93","v":0.10451977401129943},{"$f":"'Therapeutic areas'!G3","v":6},{"$f":"'Therapeutic areas'!H3","v":5.5045871559633031E-2},{"$f":"COUNTIFS('Therapeutic areas'!D3:D722,\"blood product*\")","v":6},{"$f":"W82/W$93","v":5.5045871559633031E-2},null,null,null,null,null,null,null,null,null,null,null,"Phase 2",{"$f":"SUM(AK70:AK73)","v":59},0.73750000000000004,null,null,"IB078",null,null,null,null,"IB11","1b/2","Anti-neoplastic & immune-modulating agents","efficacy",{"$f":"COUNTIF(AT:AT,\"IB78\")","v":1}]
["IB081","Phase 2",0,null,null,null,0,0,0,null,null,null,null,null,null,null,null,"Anti-neoplastic & immune-modulating agents",{"$f":"COUNTIFS('Coding matrix'!E:E,\"anti-neo*\")","v":437},0.61723163841807904,{"$f":"'Therapeutic areas'!G4","v":55},{"$f":"'Therapeutic areas'!H4","v":0.50458715596330272},{"$f":"COUNTIFS('Therapeutic areas'!D3:D722,\"anti-neo*\")","v":55},{"$f":"W83/W$93","v":0.50458715596330272},null,null,null,null,null,null,null,null,null,null,null,"Phase 3",{"$f":"SUM(AK74)","v":1},1.2500000000000001E-2,null,null,"IB079","Phase 2","IB079","Phase 2",3,"IB11","1b/2","Anti-neoplastic & immune-modulating agents","efficacy",{"$f":"COUNTIF(AT:AT,\"IB79\")","v":3}]
["IB082","Phase 2",1,"a",0.47058823529411764,"No",0,1,1,null,null,null,null,null,null,null,null,"Respiratory system",{"$f":"COUNTIFS('Coding matrix'!E:E,\"resp*\")","v":59},8.3333333333333329E-2,{"$f":"'Therapeutic areas'!G5","v":6},{"$f":"'Therapeutic areas'!H5","v":5.5045871559633031E-2},{"$f":"COUNTIFS('Therapeutic areas'!D3:D722,\"resp*\")","v":6},5.5045871559633031E-2,null,null,null,null,null,null,null,null,null,null,null,"unclear",{"$f":"SUM(AK75)","v":1},1.2500000000000001E-2,null,null,"IB080","Phase 2 ","IB080","Phase 2",12,"IB12",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB80\")","v":12}]
["IB083","Phase 2",0,null,null,null,0,0,0,null,null,null,null,null,null,null,null,"Rheumatology",{"$f":"COUNTIFS('Coding matrix'!E:E,\"rheum*\")","v":10},1.4124293785310734E-2,{"$f":"'Therapeutic areas'!G6","v":4},{"$f":"'Therapeutic areas'!H6","v":3.669724770642202E-2},{"$f":"COUNTIFS('Therapeutic areas'!D3:D722,\"rheum*\")","v":4},3.669724770642202E-2,null,null,null,null,null,null,null,null,null,null,null,"Total",{"$f":"SUM(AK80:AK84)","v":80},1,null,null,"IB081","Phase 2",null,null,null,"IB12",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB81\")","v":1}]
["IB084","Phase 2",13,"c",0.34389140271493207,"No",0,1,1,null,null,null,null,null,null,null,null,"Dermatologicals",{"$f":"COUNTIFS('Coding matrix'!E:E,\"derm*\")","v":10},1.4124293785310734E-2,{"$f":"'Therapeutic areas'!G7","v":2},{"$f":"'Therapeutic areas'!H7","v":1.834862385321101E-2},{"$f":"COUNTIFS('Therapeutic areas'!D3:D722,\"derm*\")","v":2},1.834862385321101E-2,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB082","Phase 2","IB082","Phase 2",1,"IB12",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB82\")","v":1}]
["IB085","Phase 2",12,"c",0.38725490196078427,"No",0,1,1,null,null,null,null,null,null,null,null,"Alimentary tract & metabolism",{"$f":"COUNTIFS('Coding matrix'!E:E,\"aliment*\")","v":33},4.6610169491525424E-2,{"$f":"'Therapeutic areas'!G8","v":7},{"$f":"'Therapeutic areas'!H8","v":6.4220183486238536E-2},{"$f":"COUNTIFS('Therapeutic areas'!D3:D722,\"aliment*\")","v":7},6.4220183486238536E-2,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB083","Phase 2",null,null,null,"IB12",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB83\")","v":1}]
["IB086","Phase 2",5,"a",0.36470588235294116,"No",0,1,1,null,null,null,null,null,null,null,null,"Anti-infectives",{"$f":"COUNTIFS('Coding matrix'!E:E,\"anti-inf*\")","v":48},6.7796610169491525E-2,{"$f":"'Therapeutic areas'!G9","v":20},{"$f":"'Therapeutic areas'!H9","v":0.1834862385321101},{"$f":"COUNTIFS('Therapeutic areas'!D3:D722,\"anti-inf*\")","v":20},0.1834862385321101,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB084","Phase 2","IB084","Phase 2",13,"IB12",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB84\")","v":13}]
["IB087","Phase 2",19,"d",0.30030959752321973,"No",0,1,1,null,null,null,null,null,null,null,null,"Allergy & Immunology",{"$f":"COUNTIFS('Coding matrix'!E:E,\"allerg*\")","v":9},1.2711864406779662E-2,{"$f":"'Therapeutic areas'!G10","v":3},{"$f":"'Therapeutic areas'!H10","v":2.7522935779816515E-2},{"$f":"COUNTIFS('Therapeutic areas'!D3:D722,\"allerg*\")","v":3},2.7522935779816515E-2,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB085","Phase 2","IB085","Phase 2",12,"IB12",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB85\")","v":12}]
["IB088","Phase 2",10,"b",0.55882352941176472,"No",0,1,1,null,null,null,null,null,null,null,null,"Nervous system",{"$f":"COUNTIFS('Coding matrix'!E:E,\"nerv*\")","v":17},2.4011299435028249E-2,{"$f":"'Therapeutic areas'!G11","v":3},{"$f":"'Therapeutic areas'!H11","v":2.7522935779816515E-2},{"$f":"COUNTIFS('Therapeutic areas'!D3:D722,\"nerv*\")","v":3},2.7522935779816515E-2,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB086","Phase 2","IB086","Phase 2",5,"IB12",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB86\")","v":5}]
["IB089","Phase 2",13,"c",0.29864253393665158,"No",0,1,1,null,null,null,null,null,null,null,null,"Blood & blood forming organs",{"$f":"COUNTIFS('Coding matrix'!E:E,\"blood &*\")","v":6},8.4745762711864406E-3,{"$f":"'Therapeutic areas'!G12","v":2},{"$f":"'Therapeutic areas'!H12","v":1.834862385321101E-2},{"$f":"COUNTIFS('Therapeutic areas'!D3:D722,\"blood &*\")","v":2},1.834862385321101E-2,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB087","Phase 2","IB087","Phase 2",19,"IB12",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB87\")","v":19}]
["IB090","Phase 2",3,"a",0.43137254901960786,"No",0,1,1,null,null,null,null,null,null,null,null,"Cardiovascular",{"$f":"COUNTIFS('Coding matrix'!E:E,\"cardio*\")","v":5},7.0621468926553672E-3,{"$f":"'Therapeutic areas'!G13","v":1},{"$f":"'Therapeutic areas'!H13","v":9.1743119266055051E-3},{"$f":"COUNTIFS('Therapeutic areas'!D3:D722,\"cardio*\")","v":1},9.1743119266055051E-3,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB088","Phase 2","IB088","Phase 2",10,"IB12",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB88\")","v":10}]
["IB091","Phase 2",6,"b",0.27450980392156865,"No",0,1,1,null,null,null,null,null,null,null,null,"Total ",{"$f":"SUM(S82:S92)","v":708},1,{"$f":"'Therapeutic areas'!G14","v":109},{"$f":"'Therapeutic areas'!H14","v":1},{"$f":"SUM(W82:W92)","v":109},1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB089","Phase 2","IB089","Phase 2",13,"IB12",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB89\")","v":13}]
["IB092","Phase 1",11,"c",0.56149732620320858,"No",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB090","Phase 2","IB090","Phase 2",3,"IB12",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB90\")","v":3}]
["IB093",null,0,null,null,null,0,0,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB091","Phase 2","IB091","Phase 2",6,"IB12",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB91\")","v":6}]
["IB094","Phase 2 ",7,"b",0.41176470588235292,"No",0,1,1,null,null,null,null,null,null,null,null,"With PCES",{"$f":"COUNTIF('Coding matrix'!F5:F735,\"efficacy\")+COUNTIF('Coding matrix'!F5:F735,\"unclear\")","v":708},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB092","Phase 1","IB092","Phase 1",11,"IB12",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB92\")","v":11}]
["IB095","Phase 2 ",0,null,null,null,0,0,0,null,null,null,null,null,null,null,null,"No PCES",{"$f":"COUNTIF('Coding matrix'!F5:F735,\"no efficacy\")","v":21},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB093",null,null,null,null,"IB12",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB93\")","v":1}]
["IB096","Phase 2 b",0,null,null,null,0,0,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB094","Phase 2 ","IB094","Phase 2",7,"IB12",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB94\")","v":7}]
["IB097","Phase 1 b",2,"a",0.47058823529411764,"No",{"$f":"COUNTIFS(F99,\"Yes\")","v":0},{"$f":"COUNTIFS(F99,\"*\")","v":1},{"$f":"COUNTIFS(F99,\"No\")","v":1},null,null,null,null,null,null,null,null,"Single IBss",{"$f":"Results!F50","v":0},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB095","Phase 2 ",null,null,null,"IB12",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB95\")","v":1}]
["IB098","Phase 2 b",7,"b",0.43697478991596639,"No",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB096","Phase 2 b",null,null,null,"IB12",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB96\")","v":1}]
["IB099","Phase 2 ",11,"c",0.43850267379679142,"No",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB097","Phase 1 b","IB097","Phase 1 b",2,"IB12",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB97\")","v":2}]
["IB100","Phase 2 ",0,null,null,null,0,0,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB098","Phase 2 b","IB098","Phase 2 b",7,"IB12",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB98\")","v":7}]
["IB101","Phase 2 ",0,null,null,null,0,0,0,"No",{"$f":"SUM(I3:I119)","v":84},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB099","Phase 2 ","IB099","Phase 2",11,"IB12",2,"Respiratory system","efficacy",{"$f":"COUNTIF(AT:AT,\"IB99\")","v":11}]
["IB102","Phase 1 / 2",13,"c",0.34389140271493207,"No",0,1,1,"Unclear",{"$f":"K106-K103-K105","v":0},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB100","Phase 2 ",null,null,null,"IB14",2,"Anti-neoplastic & immune-modulating agents","efficacy",{"$f":"COUNTIF(AT:AT,\"IB100\")","v":1}]
["IB103","Phase 1 b / 2 b",5,"a",0.11764705882352941,"No",0,1,1,"First-in-man",{"$f":"SUM(G3:G119)","v":7},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB101","Phase 2 ",null,null,null,"IB14",2,"Anti-neoplastic & immune-modulating agents","efficacy",{"$f":"COUNTIF(AT:AT,\"IB101\")","v":1}]
["IB104","Phase 2 a",5,"a",0.44705882352941173,"No",0,1,1,"All Ibs",{"$f":"SUM(H3:H119)","v":91},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB102","Phase 1 / 2","IB102","Phase 1 / 2",13,"IB15",2,"Anti-neoplastic & immune-modulating agents","efficacy",{"$f":"COUNTIF(AT:AT,\"IB102\")","v":13}]
["IB105","Phase 1 / 2",6,"b",0.49019607843137258,"No",0,1,1,"Percentage",{"$f":"K105/K106","v":7.6923076923076927E-2},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB103","Phase 1 b / 2 b","IB103","Phase 1 b / 2 b",5,"IB15",2,"Anti-neoplastic & immune-modulating agents","efficacy",{"$f":"COUNTIF(AT:AT,\"IB103\")","v":5}]
["IB1a","Phase 1 b",3,"a",0.49019607843137247,"no",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB104","Phase 2 a","IB104","Phase 2 a",5,"IB15",2,"Anti-neoplastic & immune-modulating agents","efficacy",{"$f":"COUNTIF(AT:AT,\"IB104\")","v":5}]
["IB2a","Phase 2 a",3,"a",0.52941176470588236,"no",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB105","Phase 1 / 2","IB105","Phase 1 / 2",6,"IB15",2,"Anti-neoplastic & immune-modulating agents","efficacy",{"$f":"COUNTIF(AT:AT,\"IB105\")","v":6}]
["IB3a",2,1,"a",0.52941176470588236,"no",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"SUM(AS5:AS109)","v":658},"IB15",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
["IB4a",1,2,"a",0.47058823529411764,"yes",1,1,0,{"$f":"SUM(C115,C117,C111,C52,C48,C45,C5)","v":30},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB15",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
["IB5a","Phase 2 a",5,"a",0.41176470588235292,"no",0,1,1,{"$f":"708-J111","v":678},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB15",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
["IB6a","Phase 2 a",1,"a",0.54117647058823526,"no",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB15",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
["IB1b","Phase 2 a",1,"a",0.41176470588235292,"no",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB15",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
["IB2b","Phase 1",3,"a",0.58823529411764708,"yes",1,1,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB15",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
["IB3b","Phase 1 / 2",5,"a",0.54117647058823526,"no",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB15",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
["IB4b","Phase 1",8,"b",0.65441176470588236,"yes",1,1,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB15",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
["IB5b","Phase 2 a",4,"a",0.30882352941176472,"no",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB15",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
["IB6b","Phase 1 / 2",4,"a",0.52941176470588236,"no",0,1,1,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB15",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB15",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,708,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB15",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB17",2,"Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB17",2,"Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB17",2,"Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB17",2,"Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB17",2,"Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB17",2,"Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB17",2,"Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB18",2,"Alimentary tract & metabolism","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB18",2,"Alimentary tract & metabolism","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB18",2,"Alimentary tract & metabolism","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB18",2,"Alimentary tract & metabolism","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB18",2,"Alimentary tract & metabolism","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB18",2,"Alimentary tract & metabolism","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB18",2,"Alimentary tract & metabolism","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB18",2,"Alimentary tract & metabolism","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB18",2,"Alimentary tract & metabolism","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB18",2,"Alimentary tract & metabolism","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB18",2,"Alimentary tract & metabolism","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB19",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB20",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB20",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB20",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB20",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB20",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB20",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB20",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB20",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB20",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB20",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB20",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB20",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB20",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB20",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB20",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB20",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB21",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB21",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB21",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB21",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB21",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB21",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB21",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB21",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB21",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
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[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB23",2,"Blood product & biotech","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB24",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
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[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB25",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB25",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB25",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB25",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB25",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB25",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB25",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB25",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB25",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB26",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB26",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB26",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB26",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB27",2,"Allergy & Immunology","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB27",2,"Allergy & Immunology","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB27",2,"Allergy & Immunology","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB28",2,"Respiratory system","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB28",2,"Respiratory system","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB28",2,"Respiratory system","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB28",2,"Respiratory system","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB28",2,"Respiratory system","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB28",2,"Respiratory system","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB28",2,"Respiratory system","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB29",2,"Blood product & biotech","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB29",2,"Blood product & biotech","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB29",2,"Blood product & biotech","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB29",2,"Blood product & biotech","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB29",2,"Blood product & biotech","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB29",2,"Blood product & biotech","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB29",2,"Blood product & biotech","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB29",2,"Blood product & biotech","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB29",2,"Blood product & biotech","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB29",2,"Blood product & biotech","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB29",2,"Blood product & biotech","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB29",2,"Blood product & biotech","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB29",2,"Blood product & biotech","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB29",2,"Blood product & biotech","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB30",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB30",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB30",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB30",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB30",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB30",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB30",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB30",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB30",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB30",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB30",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB31",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB31",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB31",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB31",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB31",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB34","2a","Allergy & Immunology","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB35","2a","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB35","2a","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB35","2a","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB35","2a","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB35","2a","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB35","2a","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB35","2a","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB35","2a","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB36","2a","Dermatologicals","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB36","2a","Dermatologicals","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB36","2a","Dermatologicals","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB36","2a","Dermatologicals","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB36","2a","Dermatologicals","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB36","2a","Dermatologicals","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB36","2a","Dermatologicals","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB36","2a","Dermatologicals","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB40",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB40",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB40",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB40",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB40",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB40",2,"Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB42","3","Rheumatology","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB42","3","Rheumatology","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB43","1","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB43","1","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB43","1","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB43","1","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB43","1","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB44","1/2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB44","1/2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB44","1/2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB46","-","Respiratory system","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB46","-","Respiratory system","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB46","-","Respiratory system","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB46","-","Respiratory system","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB46","-","Respiratory system","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB46","-","Respiratory system","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB46","-","Respiratory system","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB48","2","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB48","2","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB48","2","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB48","2","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB48","2","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB48","2","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB48","2","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB48","2","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB48","2","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB48","2","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB49","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB49","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB49","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB49","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB49","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB49","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB49","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB49","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB49","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB49","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB49","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB49","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB49","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB49","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB49","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB49","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB49","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB49","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB49","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB49","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB49","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB49","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB49","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB49","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB49","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB49","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB49","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB49","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB49","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB49","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB49","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB50","1/2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB50","1/2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB50","1/2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB51","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB51","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB52","1b","Alimentary tract & metabolism","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB52","1b","Alimentary tract & metabolism","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB52","1b","Alimentary tract & metabolism","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB52","1b","Alimentary tract & metabolism","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB52","1b","Alimentary tract & metabolism","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB53","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB53","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB53","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB53","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB53","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB53","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB53","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB54","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB54","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB54","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB54","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB55","2a/b","Allergy & Immunology","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB55","2a/b","Allergy & Immunology","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB55","2a/b","Allergy & Immunology","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB55","2a/b","Allergy & Immunology","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB55","2a/b","Allergy & Immunology","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB56","2","Rheumatology","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB56","2","Rheumatology","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB57","2","Nervous system","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB57","2","Nervous system","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB59","2","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB59","2","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB59","2","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB59","2","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB59","2","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB59","2","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB62","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB62","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB62","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB62","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB62","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB62","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB62","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB62","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB63","2b","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB63","2b","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB63","2b","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB63","2b","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB63","2b","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB63","2b","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB63","2b","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB63","2b","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB64","2","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB64","2","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB64","2","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB64","2","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB64","2","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB64","2","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB65","2","Alimentary tract & metabolism","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB65","2","Alimentary tract & metabolism","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB65","2","Alimentary tract & metabolism","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB66","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB66","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB66","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB66","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB66","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB66","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB69","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB69","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB69","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB69","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB69","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB70","2","Nervous system","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB70","2","Nervous system","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB70","2","Nervous system","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB70","2","Nervous system","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB70","2","Nervous system","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB70","2","Nervous system","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB70","2","Nervous system","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB70","2","Nervous system","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB70","2","Nervous system","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB70","2","Nervous system","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB70","2","Nervous system","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB70","2","Nervous system","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB72","1b","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB72","1b","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB72","1b","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB72","1b","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB73","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB73","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB73","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB73","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB73","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB75","1/2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB75","1/2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB75","1/2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB75","1/2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB75","1/2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB76","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB76","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB76","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB76","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB76","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB76","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB77","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB77","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB77","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB77","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB77","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB77","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB77","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB77","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB77","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB77","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB77","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB77","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB77","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB77","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB77","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB77","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB77","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB77","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB77","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB77","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB77","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB77","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB77","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB79","2","Blood & blood forming organs","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB79","2","Blood & blood forming organs","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB79","2","Blood & blood forming organs","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB80","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB80","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB80","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB80","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB80","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB80","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB80","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB80","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB80","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB80","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB80","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB80","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB82","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB84","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB84","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB84","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB84","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB84","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB84","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB84","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB84","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB84","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB84","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB84","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB84","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB84","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB85","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB85","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB85","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB85","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB85","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB85","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB85","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB85","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB85","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB85","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB85","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB85","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB86","2","Alimentary tract & metabolism","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB86","2","Alimentary tract & metabolism","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB86","2","Alimentary tract & metabolism","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB86","2","Alimentary tract & metabolism","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB86","2","Alimentary tract & metabolism","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB87","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB87","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB87","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB87","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB87","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB87","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB87","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB87","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB87","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB87","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB87","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB87","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB87","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB87","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB87","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB87","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB87","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB87","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB87","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB88","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB88","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB88","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB88","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB88","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB88","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB88","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB88","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB88","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB88","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB89","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB89","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB89","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB89","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB89","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB89","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB89","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB89","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB89","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB89","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB89","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB89","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB89","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB90","2","Blood & blood forming organs","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB90","2","Blood & blood forming organs","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB90","2","Blood & blood forming organs","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB91","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB91","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB91","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB91","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB91","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB91","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB92","1","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB92","1","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB92","1","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB92","1","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB92","1","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB92","1","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB92","1","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB92","1","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB92","1","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB92","1","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB92","1","Anti-infectives","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB94","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB94","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB94","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB94","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB94","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB94","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB94","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB97","1b","Dermatologicals","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB97","1b","Dermatologicals","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB98","2b","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB98","2b","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB98","2b","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB98","2b","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB98","2b","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB98","2b","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB98","2b","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB99","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB99","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB99","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB99","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB99","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB99","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB99","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB99","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB99","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB99","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB99","2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB102","1/2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB102","1/2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB102","1/2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB102","1/2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB102","1/2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB102","1/2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB102","1/2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB102","1/2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB102","1/2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB102","1/2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB102","1/2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB102","1/2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB102","1/2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB103","1b/2b","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB103","1b/2b","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB103","1b/2b","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB103","1b/2b","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB103","1b/2b","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB104","2a","Alimentary tract & metabolism","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB104","2a","Alimentary tract & metabolism","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB104","2a","Alimentary tract & metabolism","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB104","2a","Alimentary tract & metabolism","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB104","2a","Alimentary tract & metabolism","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB105","1/2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB105","1/2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB105","1/2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB105","1/2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB105","1/2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB105","1/2","Anti-neoplastic & immune-modulating agents","efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB1",2,null,"no efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB16",2,null,"no efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB32",2,null,"no efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB33",2,null,"no efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB37",3,null,"no efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB38",3,null,"no efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB39",2,null,"no efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB41","2b",null,"no efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB45","2b",null,"no efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB47","2",null,"no efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB58","2b",null,"no efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB60","2a",null,"no efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB61","2b",null,"no efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB68","2b",null,"no efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB71","2",null,"no efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB74","-",null,"no efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB78","2b",null,"no efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB81","2",null,"no efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB83","2",null,"no efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB93","2b",null,"no efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB95","2",null,"no efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB96","2b",null,"no efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB101","2",null,"no efficacy"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB67","-",null,"NOT IB document"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB72","1b","Anti-neoplastic & immune-modulating agents","unclear"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB100","2"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB1a","1b","Anti-neoplastic & immune-modulating agents"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB1a",null,"Anti-neoplastic & immune-modulating agents"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB1a",null,"Anti-neoplastic & immune-modulating agents"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB2a","2a","Rheumatology"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB2a",null,"Rheumatology"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB2a",null,"Rheumatology"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB3a",2,"Anti-neoplastic & immune-modulating agents"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB4a",1,"Anti-neoplastic & immune-modulating agents"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB4a",null,"Anti-neoplastic & immune-modulating agents"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB6a","2a","Anti-neoplastic & immune-modulating agents"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB5a","2a","Cardiovascular"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB5a",null,"Cardiovascular"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB5a",null,"Cardiovascular"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB5a",null,"Cardiovascular"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB5a",null,"Cardiovascular"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB1b","2a","Rheumatology"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB2b",1,"Nervous system"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB2b",null,"Nervous system"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB2b",null,"Nervous system"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB3b","1/2","Anti-neoplastic & immune-modulating agents"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB3b",null,"Anti-neoplastic & immune-modulating agents"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB3b",null,"Anti-neoplastic & immune-modulating agents"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB3b",null,"Anti-neoplastic & immune-modulating agents"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB3b",null,"Anti-neoplastic & immune-modulating agents"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB4b",1,"Anti-neoplastic & immune-modulating agents"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB4b",null,"Anti-neoplastic & immune-modulating agents"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB4b",null,"Anti-neoplastic & immune-modulating agents"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB4b",null,"Anti-neoplastic & immune-modulating agents"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB4b",null,"Anti-neoplastic & immune-modulating agents"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB4b",null,"Anti-neoplastic & immune-modulating agents"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB4b",null,"Anti-neoplastic & immune-modulating agents"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB4b",null,"Anti-neoplastic & immune-modulating agents"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB5b","2a","Blood product & biotech"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB5b",null,"Blood product & biotech"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB5b",null,"Blood product & biotech"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB5b",null,"Blood product & biotech"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB6b","1/2","Alimentary tract & metabolism"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB6b",null,"Alimentary tract & metabolism"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB6b",null,"Alimentary tract & metabolism"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB6b",null,"Alimentary tract & metabolism"]

{"sheet":"peer-reviewed publications pub","index":4,"n_rows":86,"n_cols":87,"rows_kept":86,"cut":false,"hidden":false,"merged":[[1,47,1,48],[1,18,1,19],[1,20,1,23],[1,24,1,25],[1,26,1,27],[1,28,1,29],[1,31,1,32],[1,34,1,35],[1,36,1,37],[1,38,1,40],[1,44,1,46],[1,16,1,17],[1,0,2,0],[1,6,1,8],[1,9,1,10],[1,11,1,12],[1,13,1,15]]}
["Please note: Some rows in this table might have been deleted due to confidentiality reasons!"]
["Additional info in publication: yes=green, no= red, discrepant=yellow",null,"Item","Phase","Therapeutic area","Type of study","Sample size",null,null,"Randomisation",null,"Baseline characterization",null,"Blinded assessment",null,null,"Exclusion of data from analysis",null,"Controls",null,"Model choice",null,null,null,"Outcome choice",null,"Dose reponse \n(RATE ON IB LEVEL)",null,"Age matched to patients \n(RATE ON IB LEVEL)",null,"Mechanistic evidence \n(RATE ON IB LEVEL)","Replication of experiment \n(RATE ON IB LEVEL)",null,"Replication in different model \n(RATE ON IB LEVEL)","Replication in different species (RATE ON IB LEVEL)",null,"Citation of references",null,"Reporting on direction of results",null,null,null,null,"Additional information?",null,null,null,null,null,0.91249999999999998,0,0,0.27500000000000002,0,0.76249999999999996,0,0,0.05,0,0.13750000000000001,0.1,0.97499999999999998,0,1,0,1,{"$error":"#REF!"},0.92500000000000004,{"$error":"#REF!"},1,0,0.65,0.65,0.7,0.05,0.75,0.4,0.15,0.95,{"$error":"#REF!"},0.4,0,1,0,0.61250000000000004,0.76249999999999996,0.96250000000000002]
[null,null,"Research questions",null,null,"Determine whether experiment listed in an efficacy study, Yes, no or unclear","Is sample size reported, Yes or no?","If yes, how many?","If yes, is sample size calculation reported, Yes or no?","Is randomisation reported, \nYes or no?","If yes, describe the method used to generate the randomization sequence.?","Is baseline characterization reported, \nYes or no?","If yes, what type?","Is blinded assessment  for treatment allocation reported, \nYes or no?","Is blinded assessment  for outcome assessment reported, \nYes or no?","If yes, when?","Is exclusion of data reported, Yes or no?","If yes, justification?","Is control group reported, Yes or no?","If yes, what type of control?","Is the species of animal reported?","If yes, what species?","Is the type of model reported?","Is the specifications of model reported?","Is the outcome choice reported, \nYes or no?","If yes, is the metric or time-course or both reported?","Is dose response reported? Yes or no?","If yes, is positive reponse reported, Yes or no? ","Is the age of animals reported, \nYes or no?","If yes, is it matched to patients?","Yes or no?","Is there replication of experiment, Yes or no?","If no, is there other similar study?","Is there replication in different model, \nYes or no?","Is there replication in different species, \nYes or no?","If yes, species type?","Is there references reported, \nYes or no?","If yes, what type of references?","Is effect size reported? Yes or no? \n(Step 1)","Is  significant value reported? Yes or no? \n(Step 2)","Was the investigation positive, inconclusive or negative?","Extracted text example for negative findings","Reporting on effect other than with statistics/effect size/values: text examples (Step 3)","comments",null,"Numbers of Ibs checked","%","Numbers of PCES checked","%",80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,20,20,20,20,20,20,20,20,1,20,20,80,80,80,80,80]
["PCES","IB","Coding criteria",null,null,"■ In cases where drug are tested for efficacy in their respective therapeutic indications,  complete experiment level and IB level extraction. DO NOT PERFORM AN EXTRACTION for non-efficacy studies","■ Does the experiment report sample sizes for all extractable groups?\n■ Is information provided on the number of animal per treatment group or total number of animal for the whole experiment?","n = ?","■ Has a power calculation been performed a priori to determine sample size?\n■ Select no if there are no explicit statements about sample size determination.","■ Were animals randomly assigned to treatment?\n■ Select unclear if there are no explicit statements about allocation.","Group designation, Cage randomization,\nPermanent designation, Randomization to treatment","■ Was the emergence of confounding physiological variables monitored and addressed (e.g. blood pressure, body temperature)?\n■ Were the groups similar at baseline or were they adjusted for confounders in the analysis?\n■ Was the distribution of relevant baseline characteristics balanced for the intervention and control groups?\n■ If relevant, did the investigators adequately adjust for unequal distribution of some relevant baseline characteristics in the analysis?\n■ Was the timing of disease induction adequate? \n\n","Sex, age, immune status, weight, microbial status of the animal ","■ Was treatment allocation concealed from the investigators during the experiment?\n■ Select no if there are no explicit statements about blinding to treatment allocation.","■ Were investigators blinded to treatment allocation during outcome assessment? \n■ Select no if there are no explicit statements about blinding to outcome assessment."," ","■ Do studies explain the flow of animals from inclusion through to analysis?\n■ Has every animal been accounted for, from entry into experiment through treatment, outcome assessment, sacri ce and analysis? ","Animal death","■ Were appropriate controls used in all in vivo experiments (e.g. positive, negative)?","Positive control, negative control, sham, comparator arm","Mouse, rat, dog, monkey, etc.",null,"Induced or Experimental, spontaneous (xenograft, orthotopic), transgenic, type of disease","Tumor size, etc.","Endpoints, type of measurement (survival, tumor shrinkage, etc), time-course of measurement, mean survival ",null,"■ Was there a demonstration of dose-response relationship of  the adverse effect?\n■ Was there a time course (e.g., onset and duration of response) of the adverse effect?\n■ Was the doses eliciting the adverse effect compared to the doses eliciting the primary pharmacodynamic effect in the test species or the proposed therapeutic effect in humans?\n■ Minimum of 3 different doses",null,"■ Is age of animals mentioned?","■ Check inclusion criteria of patients",null,"■ Is it the same model?\n■ Is it the same drug? \n■ Is it measuring the same outcome?",null,"■ Whether efficacy studies were replicated in more than one model. \n■ Is it the same species?","■ Whether efficacy studies were replicated in more than one species.",null,"■ If there is internal study number, citation, … then it is a yes.","Peer-reviewed, in house data",null,"■ Is there a p-value reported in the figure description or in the experiment results?","■ If p value significant (typically ≤ 0.05), then it is positiv.e",null,null,null,null,{"$f":"COUNTIF(AT5,\"*\")","v":0},{"$f":"AT4/'Coding matrix'!AJ702","v":{"$error":"#VALUE!"}},{"$f":"COUNTIF(B5:B48,\"*\")","v":44},{"$f":"AV4/'Coding matrix'!AO702","v":{"$error":"#VALUE!"}},73,0,0,22,0,61,0,0,4,0,11,8,78,0,80,0,80,{"$error":"#REF!"},74,{"$error":"#REF!"},80,0,13,13,14,1,15,8,3,19,{"$error":"#REF!"},8,0,80,0,49,61,77]
[45,"IB7",null,null,"Blood product & biotech","efficacy","no","-","na","no","-","yes","nude, female","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both","yes","yes","no","-","yes","no","yes","yes","no","-","yes","peer revieweded","yes","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,1,1,0,0,1,0,1,1,{"$error":"#REF!"},0,0,1,0,1,0,1]
[63,"IB13",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","4-7 mice per group","no","no","-","no","-","no","no","-","yes","yes","yes","Negative, positive","yes","mouse","yes","yes","yes","metric","no","-","yes","yes","yes","no","no","yes","no","-","yes","Peer-reviewed","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,0,0,0,0,0,1,1,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,1,1,1,0,0,1,{"$error":"#REF!"},0,0,1,0,1,1,1]
[64,"IB13",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",6,"no","no","-","no","-","no","no","-","yes","yes","yes","Negative, positive","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","Peer-reviewed","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,0,0,0,0,0,1,1,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,1,1]
[65,"IB13",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","8-10 per group","no","yes",null,"no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","Peer-reviewed","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,1,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,1,1]
[66,"IB13",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","7 per group","no","yes","Mice bearing successfully engrafted tumors were randomly distributed into two groups and treated with either cabozantinib (n = 7; \nXL184; Exelixis, South San Francisco, CA) or vehicle","yes","sex, age, housing, diet","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","Peer-reviewed","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,1,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,1,1]
[101,"IB14",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","5-8 per group","no","yes","random order of treatment","yes","sex, weight","no","no","-","no","-","yes","negative","yes","rat","yes","yes","yes","both","no","-","no","-","yes","no","no","yes","no","-","yes","peer revieweded","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,1,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,1,0,0,1,{"$error":"#REF!"},0,0,1,0,1,1,1]
[102,"IB14",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","4-8 per group","no","yes","randomisation to treatment","yes","weight, sex","no","no","-","no","-","yes","negative","yes","rat","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,1,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,1,1]
[104,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","6-7 per group","no","no","-","no","-","no","no","-","yes","yes (tumor-free death, thymoma)","yes","negative","yes","mouse","yes","yes","yes","both","yes","yes","yes","no","yes","yes","yes","yes","yes","rat, mice","yes","peer revieweded","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,0,0,0,0,0,1,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,1,1,1,0,1,1,1,1,{"$error":"#REF!"},1,0,1,0,1,1,1]
[105,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","6 per group","-","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,1,1]
[107,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",30,"-","yes","treatment assignment","yes","sex, age","no","no","-","no","-","yes","Negative, positive","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,1,0,0,1,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[108,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",30,"-","yes","treatment assignment","yes","sex, age","no","no","-","no","-","yes","Negative, positive","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,1,0,0,1,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[109,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","yes","Positive, negative control","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[110,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","6+2 per time point","no","no","-","yes","sex, age, weight","no","no","-","no","-","yes","Postive control, negative control","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[111,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",21,"no","no","-","yes","sex, age","no","no","-","no","-","yes","Positive, negative control","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,1,1]
[112,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",21,"no","no","-","yes","sex, age","no","no","-","no","-","yes","Positive, negative control","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[113,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","5 per group","no","no","-","yes","sex, age","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,1,1]
[114,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","5 per group","no","no","-","yes","sex, bodyweight","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,1,1]
[115,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","4-5 per group","no","no","-","yes","sex, female","no","yes","blinded assessment of histology","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,1,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,1,1]
[116,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","5 per group","no","no","-","no","-","no","no","-","yes","Animal death","yes","Negative, positive","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,0,0,0,0,0,1,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,1,1]
[117,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","4-12 per group","no","no","-","yes","sex, age","no","no","-","no","-","yes","negative","yes","rat","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,1,1]
[118,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","5-15 per group","-","no","-","yes","sex, age","no","no","-","no","-","yes","Postive, neagtive control","yes","rat","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,1,1]
[206,"IB23",null,null,"Blood product & biotech","efficacy","yes","8 per group","no","no","-","yes","sex, age","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both","yes","yes","yes","no","no","yes","-","yes","yes","mice, dogs","yes","peer revieweded","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,1,1,1,0,0,1,0,1,{"$error":"#REF!"},1,0,1,0,1,1,1]
[209,"IB23",null,null,"Blood product & biotech","efficacy","yes",20,"no","no","-","yes","age","no","no","-","no","-","yes","negative and positive","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,1,1]
[227,"IB23",null,null,"Blood product & biotech","efficacy","yes",17,"no","no","-","yes","age, sex, weight, tumor type","no","no","-","no","-","no","-","yes","dogs","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,1,1]
[257,"IB28",null,null,"Respiratory system","efficacy","yes","7-9 per group","no","yes","-","yes","sex, weight","no","no","-","no","-","yes","negative","yes","rat","yes","yes","yes","metric","yes","yes","no","-","yes","yes","-","yes","yes","mice, rats, dogs","yes","peer revieweded ","no","yes","positive",null,null,null,null,null,null,null,null,1,0,0,1,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,1,1,0,0,1,1,0,1,{"$error":"#REF!"},1,0,1,0,0,1,1]
[310,"IB40",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","6 per group; 4 groups","no","no","-","yes","sex, age","no","no","-","yes","yes","yes","negative","yes","mouse","yes","yes","yes","both","no","-","yes","no","yes","yes","-","yes","no","-","yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,1,1,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,1,0,1,1,0,1,{"$error":"#REF!"},0,0,1,0,0,1,1]
[315,"IB40",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","4-9 per group","-","yes","no","yes","sex, age","no","no","-","no","-","yes","Positive, Negative","yes","mice","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,null,1,0,0,1,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,1,1]
[336,"IB48",null,null,"Anti-infectives","efficacy","yes",4,"no","no","-","yes","age","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","metric","yes","yes","yes","no","yes","yes","-","yes","no","-","yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,1,1,1,0,1,1,0,1,{"$error":"#REF!"},0,0,1,0,0,0,1]
[344,"IB48",null,null,"Anti-infectives","efficacy","yes","2-6 per group","no","no","-","yes","age","no","no","-","no","-","yes","positive","yes","mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,1,1]
[401,"IB55",null,null,"Allergy & Immunology","efficacy","yes","10-14 per group","no","yes","group randomization, crossover design","yes","sex","no","no","-","no","-","yes","negative","yes","guinea pigs","yes","yes","yes","both","yes","yes","no","-","no","no","allergic and inflamation models","yes","yes","mice, rat, guinea pigs","yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,1,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,1,1,0,0,0,0,0,1,{"$error":"#REF!"},1,0,1,0,1,1,1]
[408,"IB59",null,null,"Anti-infectives","efficacy","yes",12,"no","no","-","yes","weight","no","no",null,"no","-","yes","negative","yes","hamster","yes","yes","yes","metric","no","-","no","-","no","no","-","yes","no","-","yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,1,{"$error":"#REF!"},0,0,1,0,1,1,1]
[410,"IB59",null,null,"Anti-infectives","efficacy","yes","5 per group","no","no","-","yes","weight","no","no",null,"yes","yes","yes","negative","yes","hamster","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,1,1,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,1,1]
[412,"IB59",null,null,"Anti-infectives","efficacy","yes","83 (2-5 per group","no","no","-","yes","weight","no","no",null,"no","-","yes","negative","yes","hamster","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","no","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,0,1]
[424,"IB63",null,null,"Anti-infectives","efficacy","yes","3 per group","no","no","-","no","-","no","no","-","no","-","yes","positive","yes","mouse","yes","yes","yes","both","yes","yes","yes","no","yes","no","-","yes","no","-","yes","peer reviewed","yes","no","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,1,1,1,0,1,0,0,1,{"$error":"#REF!"},0,0,1,0,1,0,1]
[425,"IB63",null,null,"Anti-infectives","efficacy","yes","3 per group","no","no","-","no","-","no","no","-","no","-","yes","positive","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","no","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,0,1]
[428,"IB63",null,null,"Anti-infectives","efficacy","yes","5-9 per group","no","no","-","yes","sex, age","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,1,1]
[429,"IB63",null,null,"Anti-infectives","efficacy","yes","3-7 per group","no","no","-","yes","sex, age","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,1,1]
[443,"IB66",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","8-10 animals per group",null,"no","-","yes","sex","no","no","-","no","-","yes","untreated?","yes","mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,1,1]
[445,"IB66",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","192 (6-10 per group)","no","no","-","yes","weight","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","time-course","yes","yes","yes","no","yes","no","-","no","yes","-","yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,1,1,1,0,1,0,0,0,{"$error":"#REF!"},1,0,1,0,0,0,1]
[446,"IB66",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","8-10 per group","no","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[468,"IB72",null,null,"Anti-neoplastic & immune-modulating agents","unclear","yes","8-11 per group","no","no","-","yes","age","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both","no","-","yes","no","yes","no","-","yes","no","-","yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,1,0,1,0,0,1,{"$error":"#REF!"},0,0,1,0,1,1,1]
[499,"IB77",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","6 per group","no","yes","no","yes","age, weight","no","no","-","no","-","yes","negative","yes","hamster","yes","yes","yes","both","yes","yes","yes","no","yes","yes","-","yes","yes","rat, hamster, mouse","yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,null,1,0,0,1,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,1,1,1,0,1,1,0,1,{"$error":"#REF!"},1,0,1,0,0,1,1]
[501,"IB77",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","yes","age","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,1,1]
[504,"IB77",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","6-10 per group","no","no","-","yes","sex, age","no","no","-","no","-","yes","positive, negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,1,1]
[506,"IB77",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","6 per group","no","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,1,1]
[508,"IB77",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",31,"no","no","-","no","-","no","no","-","no","-","yes","negative","yes","rat","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,1,1]
[509,"IB77",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",28,"no","yes","no","yes","sex, age","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,1,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,1,1]
[516,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","10 per group","no","no","-","yes","age, sex","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","metric","yes","yes","yes","no","yes","no","-","yes","no","-","yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,1,1,1,0,1,0,0,1,{"$error":"#REF!"},0,0,1,0,1,1,1]
[517,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","10 per group","no","no","-","yes","age, sex","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,1,1]
[518,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","10 per group","no","no","-","yes","age, sex","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,1,1]
[519,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","5 for control and 7 for intervention","no","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[520,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","6 per group, 4 groups","no","yes","no","yes","age, sex","no","no","-","no","-","yes","negative, the 2 combination drugs alone","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,1,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,1,1]
[521,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,"no","-","yes","sex, weight","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,1,1]
[522,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","9 for intervention, 6 for control","no","no","-","yes","sex, weight","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,1,1]
[523,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","11 for intervention, 5+5 for control","no","no","-","yes","sex, weight","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[524,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,"no","-","yes","sex, weight","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,1,1]
[525,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","4 intervention groups (n=4-6) and 4 control groups (n= 4-7)","no","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","inconclusive",null,null,null,null,null,null,null,null,1,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,1,0]
[526,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","3 per group","no","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","inconclusive",null,null,null,null,null,null,null,null,1,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,1,0]
[527,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","3 per group","no","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","inconclusive",null,null,null,null,null,null,null,null,1,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,1,0]
[546,"IB85",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","control n=3 and intervention n=3","no","no","-","yes","sex","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","both","no","-","no","-","yes","yes","-","yes","no","-","yes","peer reviewed","yes","no","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,1,1,0,1,{"$error":"#REF!"},0,0,1,0,1,0,1]
[547,"IB85",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","5 per group","no","no","-","yes","sex, age","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,1,1]
[548,"IB85",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","5-7 per group","no","yes","no","yes","sex, weight","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,1,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,1,1]
[549,"IB85",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","at least 7 per group","no","no","-","yes","sex, age","no","no","-","yes","no","no","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,1,0,0,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,1,1]
[550,"IB85",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","6 per group","no","yes","no","yes","sex, age","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,1,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,1,1]
[590,"IB89",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","7-15 per group","no","yes","-","yes","sex","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both","yes","yes","yes","no","yes","no","-","yes","no","-","yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,1,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,1,1,1,0,1,0,0,1,{"$error":"#REF!"},0,0,1,0,1,1,1]
[591,"IB89",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","7-15 per group","no","yes","-","yes","sex","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,1,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,1,1]
[592,"IB89",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","6-12 per group","no","yes","-","yes","sex, age, body weight","no","yes","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,null,1,0,0,1,0,1,0,0,1,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,1,1]
[593,"IB89",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","yes","-","yes","sex, age","no","no","-","yes","yes","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,null,0,0,0,1,0,1,0,0,0,0,1,1,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,1,1]
[594,"IB89",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","5-10 per group","no","yes","no","yes","sex, age","no","no","-","no","-","yes","negative","yes","mice","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","no","positive",null,null,null,null,null,null,null,null,1,0,0,1,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,0,1]
[597,"IB89",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","10 per group","-","no","-","yes","age, sex","no","no","-","yes","yes","yes","negative","yes","mice","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,1,1,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[598,"IB89",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","7 per group","-","yes","\"restricted randomization\"","yes","age, sex","no","no","-","no","-","yes","negative","yes","mice","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,1,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,1,1]
[620,"IB92",null,null,"Anti-infectives","efficacy","yes","2-6 per group","-","no","-","yes","age","no","no","-","no","-","yes","positive","yes","mouse","yes","yes","yes","both","yes","yes","yes","no","yes","yes","-","yes","yes","-","yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,1,1,1,0,1,1,0,1,{"$error":"#REF!"},1,0,1,0,0,1,1]
[635,"IB98",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","5-15 per group","no","no","-","yes","sex, age","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both","no","-","yes","no","no","no","-","yes","yes","-","yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,1,0,0,0,0,1,{"$error":"#REF!"},1,0,1,0,0,1,1]
[637,"IB98",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","6 per group","-","yes","no","yes","sex, age","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,1,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,1,1]
[639,"IB98",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",12,"no","no","-","no",null,"no","no","-","no","-","yes","negative","yes","rat","yes","yes","yes","time-course",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,1,1]
[640,"IB98",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","10 per group","no","no","-","yes","sex, age","no","yes","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,1,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,1,1]
[641,"IB98",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",48,"no","yes","no","yes","sex","no","yes","-","yes","yes","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,null,1,0,0,1,0,1,0,0,1,0,1,1,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,1,1]
[655,"IB102",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no",null,"no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","metric","yes","yes","yes","no","no","no","yes","yes","no","-","yes","peer reviewed","yes","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,1,1,1,0,0,0,1,1,{"$error":"#REF!"},0,0,1,0,1,0,1]
[656,"IB102",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","5 per group","no","no","-","yes","age, sex","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,1,1]
[667,"IB102",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",30,"no","no","-","no","-","no","no","-","yes","yes","yes","negative","yes","mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","no","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,0,0,0,0,0,1,1,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,0,1]
[]
[null,"21 Ibs","113 PCES"]

{"sheet":"peer-reviewed publications IB","index":5,"n_rows":86,"n_cols":126,"rows_kept":86,"cut":false,"hidden":false,"merged":[[1,47,1,48],[1,18,1,19],[1,20,1,23],[1,24,1,25],[1,26,1,27],[1,28,1,29],[1,31,1,32],[1,34,1,35],[1,36,1,37],[1,38,1,40],[1,44,1,46],[1,16,1,17],[1,0,2,0],[1,6,1,8],[1,9,1,10],[1,11,1,12],[1,13,1,15]]}
["Please note: Some rows in this table might have been deleted due to confidentiality reasons!"]
["Additional info in publication: yes=green, no= red, discrepant=yellow",null,"Item","Phase","Therapeutic area","Type of study","Sample size",null,null,"Randomisation",null,"Baseline characterization",null,"Blinded assessment",null,null,"Exclusion of data from analysis",null,"Controls",null,"Model choice",null,null,null,"Outcome choice",null,"Dose reponse \n(RATE ON IB LEVEL)",null,"Age matched to patients \n(RATE ON IB LEVEL)",null,"Mechanistic evidence \n(RATE ON IB LEVEL)","Replication of experiment \n(RATE ON IB LEVEL)",null,"Replication in different model \n(RATE ON IB LEVEL)","Replication in different species (RATE ON IB LEVEL)",null,"Citation of references",null,"Reporting on direction of results",null,null,null,null,"Additional information?",null,null,null,null,null,8.7499999999999994E-2,0,0,1.2500000000000001E-2,0,0.05,0,0,0,0,0.05,0.05,0.36249999999999999,1.2500000000000001E-2,0.85,1.2500000000000001E-2,0.9,{"$error":"#REF!"},0.13750000000000001,{"$error":"#REF!"},0.82499999999999996,0,0.6,0.6,0.1,0.05,0.7,0.4,0.15,0.9,{"$error":"#REF!"},0.4,0,0.98750000000000004,0,0.16250000000000001,0.13750000000000001,0.97499999999999998,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$error":"#DIV/0!"},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,null,"Research questions",null,null,"Determine whether experiment listed in an efficacy study, Yes, no or unclear","Is sample size reported, Yes or no?","If yes, how many?","If yes, is sample size calculation reported, Yes or no?","Is randomisation reported, \nYes or no?","If yes, describe the method used to generate the randomization sequence.?","Is baseline characterization reported, \nYes or no?","If yes, what type?","Is blinded assessment  for treatment allocation reported, \nYes or no?","Is blinded assessment  for outcome assessment reported, \nYes or no?","If yes, when?","Is exclusion of data reported, Yes or no?","If yes, justification?","Is control group reported, Yes or no?","If yes, what type of control?","Is the species of animal reported?","If yes, what species?","Is the type of model reported?","Is the specifications of model reported?","Is the outcome choice reported, \nYes or no?","If yes, is the metric or time-course or both reported?","Is dose response reported? Yes or no?","If yes, is positive reponse reported, Yes or no? ","Is the age of animals reported, \nYes or no?","If yes, is it matched to patients?","Yes or no?","Is there replication of experiment, Yes or no?","If no, is there other similar study?","Is there replication in different model, \nYes or no?","Is there replication in different species, \nYes or no?","If yes, species type?","Is there references reported, \nYes or no?","If yes, what type of references?","Is effect size reported? Yes or no? \n(Step 1)","Is  significant value reported? Yes or no? \n(Step 2)","Was the investigation positive, inconclusive or negative?","Extracted text example for negative findings","Reporting on effect other than with statistics/effect size/values: text examples (Step 3)","comments",null,"Numbers of Ibs checked","%","Numbers of PCES checked","%",80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,20,20,20,20,20,20,20,20,1,20,20,80,80,80,80,80,24,24,24,24,24,24,24,24,24,24,24,24,24,24,null,24,24,24,24,24,24,24,24,24,24,24,24,24,24,24,24,24,24,24,24,24,24,24,24]
["PCES","IB","Coding criteria",null,null,"■ In cases where drug are tested for efficacy in their respective therapeutic indications,  complete experiment level and IB level extraction. DO NOT PERFORM AN EXTRACTION for non-efficacy studies","■ Does the experiment report sample sizes for all extractable groups?\n■ Is information provided on the number of animal per treatment group or total number of animal for the whole experiment?","n = ?","■ Has a power calculation been performed a priori to determine sample size?\n■ Select no if there are no explicit statements about sample size determination.","■ Were animals randomly assigned to treatment?\n■ Select unclear if there are no explicit statements about allocation.","Group designation, Cage randomization,\nPermanent designation, Randomization to treatment","■ Was the emergence of confounding physiological variables monitored and addressed (e.g. blood pressure, body temperature)?\n■ Were the groups similar at baseline or were they adjusted for confounders in the analysis?\n■ Was the distribution of relevant baseline characteristics balanced for the intervention and control groups?\n■ If relevant, did the investigators adequately adjust for unequal distribution of some relevant baseline characteristics in the analysis?\n■ Was the timing of disease induction adequate? \n\n","Sex, age, immune status, weight, microbial status of the animal ","■ Was treatment allocation concealed from the investigators during the experiment?\n■ Select no if there are no explicit statements about blinding to treatment allocation.","■ Were investigators blinded to treatment allocation during outcome assessment? \n■ Select no if there are no explicit statements about blinding to outcome assessment."," ","■ Do studies explain the flow of animals from inclusion through to analysis?\n■ Has every animal been accounted for, from entry into experiment through treatment, outcome assessment, sacri ce and analysis? ","Animal death","■ Were appropriate controls used in all in vivo experiments (e.g. positive, negative)?","Positive control, negative control, sham, comparator arm","Mouse, rat, dog, monkey, etc.",null,"Induced or Experimental, spontaneous (xenograft, orthotopic), transgenic, type of disease","Tumor size, etc.","Endpoints, type of measurement (survival, tumor shrinkage, etc), time-course of measurement, mean survival ",null,"■ Was there a demonstration of dose-response relationship of  the adverse effect?\n■ Was there a time course (e.g., onset and duration of response) of the adverse effect?\n■ Was the doses eliciting the adverse effect compared to the doses eliciting the primary pharmacodynamic effect in the test species or the proposed therapeutic effect in humans?\n■ Minimum of 3 different doses",null,"■ Is age of animals mentioned?","■ Check inclusion criteria of patients",null,"■ Is it the same model?\n■ Is it the same drug? \n■ Is it measuring the same outcome?",null,"■ Whether efficacy studies were replicated in more than one model. \n■ Is it the same species?","■ Whether efficacy studies were replicated in more than one species.",null,"■ If there is internal study number, citation, … then it is a yes.","Peer-reviewed, in house data",null,"■ Is there a p-value reported in the figure description or in the experiment results?","■ If p value significant (typically ≤ 0.05), then it is positiv.e",null,null,null,null,{"$f":"COUNTIF(AT5,\"*\")","v":0},{"$f":"AT4/'Coding matrix'!AJ702","v":{"$error":"#VALUE!"}},{"$f":"COUNTIF(B5:B48,\"*\")","v":44},{"$f":"AV4/'Coding matrix'!AO702","v":{"$error":"#VALUE!"}},7,0,0,1,0,4,0,0,0,0,4,4,29,1,68,1,72,{"$error":"#REF!"},11,{"$error":"#REF!"},66,0,12,12,2,1,14,8,3,18,{"$error":"#REF!"},8,0,79,0,13,11,78,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[45,"IB7",null,null,"Blood product & biotech","efficacy","no","-","na","no","-","yes","nude, female","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-","yes","yes","no","-","yes","no","yes","yes","no","-","yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,1,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},0,0,1,1,0,0,1,0,1,1,{"$error":"#REF!"},0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[63,"IB13",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","no","no","-","no","-","no","no","-","yes","yes","yes","Negative, positive","yes","mouse","yes","no","yes","metric","no","-","yes","yes","yes","no","no","no","no","-","yes","Peer-reviewed","no","yes","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,1,1,1,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,1,1,1,0,0,0,{"$error":"#REF!"},0,0,1,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[64,"IB13",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","no","no","-","no","-","no","no","-","yes","yes","yes","Negative, positive","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","Peer-reviewed","no","yes","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,1,1,1,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[65,"IB13",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","no","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","Peer-reviewed","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[66,"IB13",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","no","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","Peer-reviewed","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[101,"IB14",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","no","no","-","no","-","no","no","-","no","-","no","-","yes","rat","yes","no","yes","both","no","-","no","-","yes","no","no","yes","no","-","yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,1,0,0,1,{"$error":"#REF!"},0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[102,"IB14",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","no","no","-","no","-","no","no","-","no","-","no","-","yes","rat","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[104,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","no","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both","yes","yes","no","-","yes","no","yes","yes","yes","rat, mice","yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,1,1,0,0,1,0,1,1,{"$error":"#REF!"},1,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[105,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[107,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","yes","Negative, positive","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[108,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","yes","Negative, positive","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[109,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","yes","Positive, negative control","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[110,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","no","no","-","no","-","no","no","-","no","-","yes","Postive control, negative control","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[111,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","no","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","no","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,{"$error":"#REF!"},0,{"$error":"#REF!"},0,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[112,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","no","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","no","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,{"$error":"#REF!"},0,{"$error":"#REF!"},0,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[113,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","no","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},0,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[114,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","no","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[115,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","no","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},0,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[116,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","no","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},0,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[117,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","no","no","-","no","-","no","no","-","no","-","no","-","yes","rat","no","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,{"$error":"#REF!"},0,{"$error":"#REF!"},0,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[118,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","yes","Postive, neagtive control","yes","rat","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[206,"IB23",null,null,"Blood product & biotech","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric","yes","yes","no","-","no","yes","-","yes","yes","mice, dogs","yes","peer revieweded","yes","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,1,1,0,0,0,1,0,1,{"$error":"#REF!"},1,0,1,0,1,0,1]
[209,"IB23",null,null,"Blood product & biotech","efficacy","no","-","no","no","-","no","-","no","no","-","no","-","yes","negative and positive","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[227,"IB23",null,null,"Blood product & biotech","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,0,1]
[257,"IB28",null,null,"Respiratory system","efficacy","no","-","no","no","-","no","-","no","no","-","no","-","yes","negative","yes","rat","yes","no","yes","metric","yes","yes","no","-","yes","yes","-","yes","yes","mice, rats, dogs","yes","peer revieweded ","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,1,1,0,0,1,1,0,1,{"$error":"#REF!"},1,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[310,"IB40",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","6 per group; 4 groups","no","no","-","yes","-","no","no","-","yes","yes","yes","negative","yes","mouse","yes","no","yes","both","no","-","no","-","yes","yes","-","yes","no","-","yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,1,0,0,0,0,1,1,1,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,1,1,0,1,{"$error":"#REF!"},0,0,1,0,0,1,1]
[315,"IB40",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","yes","Positive, Negative","no","-","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[336,"IB48",null,null,"Anti-infectives","efficacy","yes",4,"no","no","-","no","-","no","no","-","no","-","yes",null,"yes","mouse","yes","no","yes","metric","yes","yes","no","-","yes","yes","-","yes","no","-","yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,1,1,0,0,1,1,0,1,{"$error":"#REF!"},0,0,1,0,0,0,1]
[344,"IB48",null,null,"Anti-infectives","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","yes","positive","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,1,1]
[401,"IB55",null,null,"Allergy & Immunology","efficacy","no","-",null,"no","-","no",null,"no","no","-","no","-","no","-","yes","guinea pigs","yes","no","yes","metric","yes","yes","no","-","no","no","allergic and inflamation models","yes","yes","mice, rat, guinea pigs","yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,1,1,0,0,0,0,0,1,{"$error":"#REF!"},1,0,1,0,0,0,1]
[408,"IB59",null,null,"Anti-infectives","efficacy","yes",12,"no","no","-","no",null,"no","no",null,"no","-","yes","negative","yes","hamster","yes","yes","yes","metric","no","-","no","-","no","yes","-","yes","no","-","yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,0,1,0,0,0,1]
[410,"IB59",null,null,"Anti-infectives","efficacy","no","-",null,"no","-","no",null,"no","no",null,"no","-","no","-","yes","hamster","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[412,"IB59",null,null,"Anti-infectives","efficacy","no",null,null,"no","-","no",null,"no","no",null,"no","-","yes","negative","yes","hamster","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[424,"IB63",null,null,"Anti-infectives","efficacy","no","-",null,"no","-","no","-","no","no","-","no","-","yes","positive","yes","mouse","yes","yes","yes","time-course","yes","yes","yes","no","yes","no","-","yes","no","-","yes","peer reviewed","yes","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,1,1,1,0,1,0,0,1,{"$error":"#REF!"},0,0,1,0,1,0,1]
[425,"IB63",null,null,"Anti-infectives","efficacy","no","-",null,"no","-","no","-","no","no","-","no","-","yes","positive","yes","mouse","yes","yes","yes","time-course",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,0,1]
[{"$f":"A39+1","v":426},"IB63",null,null,"Anti-infectives","efficacy","no","-",null,"no","-","yes","age","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,1,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,1,1]
[427,"IB63",null,null,"Anti-infectives","efficacy","no","-",null,"no","-","no","-","no","no","-","no","-","yes","wildtype, vehicle","yes","mouse","yes","no","no",null,null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},0,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[428,"IB66",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","8-10 animals per group",null,"no","-","yes","sex","no","no","-","no","-","yes","untreated?","yes","mouse","yes","yes","yes","metric","yes","yes","yes","no","yes","no","-","no","yes","-","yes","peer reviewed","yes","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,{"$error":"#REF!"},0,{"$error":"#REF!"},0,0,1,1,0,0,0,0,0,0,{"$error":"#REF!"},1,0,1,0,1,0,1]
[445,"IB66",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,"no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no",null,null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},0,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[446,"IB66",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,"no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no",null,null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},0,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[468,"IB72",null,null,"Anti-neoplastic & immune-modulating agents","unclear","no","-","-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","no","no","-","no","-","yes","no","-","yes","no","-","yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,1,0,0,1,{"$error":"#REF!"},0,0,1,0,0,0,1]
[499,"IB77",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no",null,"yes","hamster","yes","no","yes","metric","yes","yes","no","-","yes","yes","-","yes","yes","rat, hamster, mouse","yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,1,1,0,0,1,1,0,1,{"$error":"#REF!"},1,0,1,0,0,0,1]
[501,"IB77",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no",null,"yes","mouse","yes","no","no",null,null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","inconclusive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},0,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,0]
[504,"IB77",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no",null,"yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","inconclusive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,0]
[506,"IB77",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no",null,"yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[508,"IB77",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",31,"no","no","-","no","-","no","no","-","no","-","yes","negative","yes","rat","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[509,"IB77",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no",null,"yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[516,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,"no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric","no","-","no","-","yes","no","-","yes","no","-","yes","peer reviewed","yes","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,1,0,0,1,{"$error":"#REF!"},0,0,1,0,1,0,1]
[517,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,"no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,0,1]
[518,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,"no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,0,1]
[519,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,"no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[520,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,"no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[521,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,"no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[522,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,"no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[523,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,"no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[524,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,"no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[525,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,"no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[526,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,"no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[527,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,"no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[546,"IB85",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,"no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric","no","-","no","-","yes","yes","-","yes","no","-","yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,1,1,0,1,{"$error":"#REF!"},0,0,1,0,0,0,1]
[547,"IB85",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,"no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[548,"IB85",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,"no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,1,1]
[549,"IB85",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,"no","-","no","-","no","no","-","no","-","no","-","no",null,"yes","no","no",null,null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},0,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,1,1]
[550,"IB85",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,"no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,0,1]
[590,"IB89",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","no","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","both","yes","yes","no","-","yes","no","-","yes","no","-","yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,1,1,0,0,1,0,0,1,{"$error":"#REF!"},0,0,1,0,0,0,1]
[591,"IB89",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","no","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[592,"IB89",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","no","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,1,1]
[593,"IB89",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no","-","no","-","no","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[594,"IB89",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no","-","no","-","no","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[597,"IB89",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[598,"IB89",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[620,"IB92",null,null,"Anti-infectives","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","yes","yes","both","yes","yes","no","-","yes","yes","-","yes","yes","-","yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,1,1,0,0,1,1,0,1,{"$error":"#REF!"},1,0,1,0,0,1,1]
[635,"IB98",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","no","no","-","no",null,"no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","metric","no","-","no","-","no","no","-","yes","yes","-","yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,1,{"$error":"#REF!"},1,0,1,0,0,1,1]
[637,"IB98",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no",null,"no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,1,0,1]
[639,"IB98",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",12,"no","no","-","no",null,"no","no","-","no","-","yes","negative","yes","rat","yes","yes","yes","time-course",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,1,1]
[640,"IB98",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","no","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[641,"IB98",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",48,"no","yes","no","yes","sex","no","no","-","yes","yes","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,1,0,0,1,0,1,0,0,0,0,1,1,1,0,1,0,1,{"$error":"#REF!"},1,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[655,"IB102",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no",null,"no","no","-","no","-","no","-","yes","mouse","no","no","yes","metric","yes","yes","no","-","no","no","yes","yes","no","-","yes","peer reviewed","yes","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,1,1,0,0,0,0,1,1,{"$error":"#REF!"},0,0,1,0,1,0,1]
[656,"IB102",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","no","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","no","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,{"$error":"#REF!"},0,{"$error":"#REF!"},0,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[667,"IB102",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",30,"no","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,null,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,{"$error":"#REF!"},0,{"$error":"#REF!"},1,0,0,0,0,0,0,0,0,0,{"$error":"#REF!"},0,0,1,0,0,0,1]
[]
[null,"21 Ibs","113 PCES"]

{"sheet":"peer-reviewed publications","index":6,"n_rows":161,"n_cols":126,"rows_kept":161,"cut":false,"hidden":false,"merged":[[1,6,1,8],[1,9,1,10],[1,11,1,12],[1,13,1,15],[1,16,1,17],[1,73,1,74],[1,34,1,35],[1,36,1,37],[1,38,1,40],[1,18,1,19],[1,20,1,23],[1,24,1,25],[1,26,1,27],[1,28,1,29],[1,31,1,32],[0,0,0,8],[1,75,1,76],[1,77,1,78],[1,79,1,81],[1,0,2,0],[1,44,1,46],[1,47,1,48],[1,49,1,50],[1,51,1,53],[1,54,1,55],[1,56,1,57],[1,58,1,63],[1,64,1,65],[1,66,1,67],[1,68,1,69],[1,71,1,72]]}
["Please note: Some rows in this table might have been deleted due to confidentiality reasons!"]
["Additional info in publication: yes=green, no= red, discrepant=yellow",null,"Item","Phase","Therapeutic area","Type of study","Sample size",null,null,"Randomisation",null,"Baseline characterization",null,"Blinded assessment",null,null,"Exclusion of data from analysis",null,"Controls",null,"Model choice",null,null,null,"Outcome choice",null,"Dose reponse \n(RATE ON IB LEVEL)",null,"Age matched to patients \n(RATE ON IB LEVEL)",null,"Mechanistic evidence \n(RATE ON IB LEVEL)","Replication of experiment \n(RATE ON IB LEVEL)",null,"Replication in different model \n(RATE ON IB LEVEL)","Replication in different species (RATE ON IB LEVEL)",null,"Citation of references",null,"Reporting on direction of results",null,null,null,null,"Additional information?",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,0,0,0.78749999999999998,0.78749999999999998,1.2500000000000001E-2,0.25,8.7499999999999994E-2,0.72499999999999998,0.72499999999999998,1.2500000000000001E-2,6.25E-2,2.5000000000000001E-2,0.1,8.7499999999999994E-2,0.61250000000000004,0.65,0.17499999999999999,0.17499999999999999,0.16250000000000001,0.8,0.26250000000000001,2.75,0.5,0.5,1.05,0,0.05,0,0,4,0,0,0,0,0.42499999999999999,0.625,3.7499999999999999E-2,0]
[null,null,"Research questions",null,null,"Determine whether experiment listed in an efficacy study, Yes, no or unclear","Is sample size reported, Yes or no?","If yes, how many?","If yes, is sample size calculation reported, Yes or no?","Is randomisation reported, \nYes or no?","If yes, describe the method used to generate the randomization sequence.?","Is baseline characterization reported, \nYes or no?","If yes, what type?","Is blinded assessment  for treatment allocation reported, \nYes or no?","Is blinded assessment  for outcome assessment reported, \nYes or no?","If yes, when?","Is exclusion of data reported, Yes or no?","If yes, justification?","Is control group reported, Yes or no?","If yes, what type of control?","Is the species of animal reported?","If yes, what species?","Is the type of model reported?","Is the specifications of model reported?","Is the outcome choice reported, \nYes or no?","If yes, is the metric or time-course or both reported?","Is dose response reported? Yes or no?","If yes, is positive reponse reported, Yes or no? ","Is the age of animals reported, \nYes or no?","If yes, is it matched to patients?","Yes or no?","Is there replication of experiment, Yes or no?","If no, is there other similar study?","Is there replication in different model, \nYes or no?","Is there replication in different species, \nYes or no?","If yes, species type?","Is there references reported, \nYes or no?","If yes, what type of references?","Is effect size reported? Yes or no? \n(Step 1)","Is  significant value reported? Yes or no? \n(Step 2)","Was the investigation positive, inconclusive or negative?","Extracted text example for negative findings","Reporting on effect other than with statistics/effect size/values: text examples (Step 3)","comments",null,"Numbers of Ibs checked","%","Numbers of PCES checked","%",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,20,20,20,20,20,20,20,20,1,20,20,80,80,80,80,80,80]
["PCES","IB","Coding criteria",null,null,"■ In cases where drug are tested for efficacy in their respective therapeutic indications,  complete experiment level and IB level extraction. DO NOT PERFORM AN EXTRACTION for non-efficacy studies","■ Does the experiment report sample sizes for all extractable groups?\n■ Is information provided on the number of animal per treatment group or total number of animal for the whole experiment?","n = ?","■ Has a power calculation been performed a priori to determine sample size?\n■ Select no if there are no explicit statements about sample size determination.","■ Were animals randomly assigned to treatment?\n■ Select unclear if there are no explicit statements about allocation.","Group designation, Cage randomization,\nPermanent designation, Randomization to treatment","■ Was the emergence of confounding physiological variables monitored and addressed (e.g. blood pressure, body temperature)?\n■ Were the groups similar at baseline or were they adjusted for confounders in the analysis?\n■ Was the distribution of relevant baseline characteristics balanced for the intervention and control groups?\n■ If relevant, did the investigators adequately adjust for unequal distribution of some relevant baseline characteristics in the analysis?\n■ Was the timing of disease induction adequate? \n\n","Sex, age, immune status, weight, microbial status of the animal ","■ Was treatment allocation concealed from the investigators during the experiment?\n■ Select no if there are no explicit statements about blinding to treatment allocation.","■ Were investigators blinded to treatment allocation during outcome assessment? \n■ Select no if there are no explicit statements about blinding to outcome assessment."," ","■ Do studies explain the flow of animals from inclusion through to analysis?\n■ Has every animal been accounted for, from entry into experiment through treatment, outcome assessment, sacri ce and analysis? ","Animal death","■ Were appropriate controls used in all in vivo experiments (e.g. positive, negative)?","Positive control, negative control, sham, comparator arm","Mouse, rat, dog, monkey, etc.",null,"Induced or Experimental, spontaneous (xenograft, orthotopic), transgenic, type of disease","Tumor size, etc.","Endpoints, type of measurement (survival, tumor shrinkage, etc), time-course of measurement, mean survival ",null,"■ Was there a demonstration of dose-response relationship of  the adverse effect?\n■ Was there a time course (e.g., onset and duration of response) of the adverse effect?\n■ Was the doses eliciting the adverse effect compared to the doses eliciting the primary pharmacodynamic effect in the test species or the proposed therapeutic effect in humans?\n■ Minimum of 3 different doses",null,"■ Is age of animals mentioned?","■ Check inclusion criteria of patients",null,"■ Is it the same model?\n■ Is it the same drug? \n■ Is it measuring the same outcome?",null,"■ Whether efficacy studies were replicated in more than one model. \n■ Is it the same species?","■ Whether efficacy studies were replicated in more than one species.",null,"■ If there is internal study number, citation, … then it is a yes.","Peer-reviewed, in house data",null,"■ Is there a p-value reported in the figure description or in the experiment results?","■ If p value significant (typically ≤ 0.05), then it is positiv.e",null,null,null,null,{"$f":"COUNTIF(AT5,\"*\")","v":0},{"$f":"AT4/'Coding matrix'!AJ702","v":{"$error":"#VALUE!"}},110,{"$error":"#VALUE!"},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0,0,0,63,63,1,20,7,58,58,1,5,2,8,7,49,52,14,14,13,64,21,55,10,10,21,0,1,0,0,4,0,0,0,0,34,50,3,0]
[45,"IB7",null,null,"Blood product & biotech","efficacy","no","-","no","no","-","yes","nude, female","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both","yes","yes","no","-","yes","no","yes","yes","no","-","yes","peer revieweded","yes","no","positive",null,null,null,null,null,null,null,0,0,0,38,38,38,38,38,38,38,38,38,38,38,38,35,35,38,38,38,35,35,35,38,38,38,38,38,38,38,38,38,38,0,0,35,38,38,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0]
[63,"IB13",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","4-7 mice per group","no","no","-","no","-","no","no","-","yes","yes","yes","Negative, positive","yes","mouse","yes","yes","yes","metric","no","-","yes","yes","yes","no","no","yes","no","-","yes","Peer-reviewed","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,35,38,38,0,0,38,38,0,0,0,35,0,0,0,0,38,38,38,null,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0]
[64,"IB13",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",6,"no","no","-","no","-","no","no","-","yes","yes","yes","Negative, positive","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","Peer-reviewed","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,35,38,38,0,0,38,38,0,0,0,35,0,0,0,0,38,38,38,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0]
[65,"IB13",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","8-10 per group","no","yes","ARCaPM cells were injected into the tibiae of nude mice on Day 1, and on Day 31 \nanimals with established bone lesions were randomized to receive cabozantinib or vehicle \nqd for 7 weeks of treatment","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","Peer-reviewed","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,36,36,38,38,38,38,38,38,38,38,38,38,38,38,38,38,35,0,0,38,38,0,0,0,35,0,0,0,0,35,35,38,null,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,1,1,0,0]
[66,"IB13",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","7 per group","no","yes","Mice bearing successfully engrafted tumors were randomly distributed into two groups and treated with either cabozantinib (n = 7; \nXL184; Exelixis, South San Francisco, CA) or vehicle","yes","sex, age, housing, diet","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","Peer-reviewed","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,35,35,35,35,38,38,38,38,38,35,35,38,38,38,35,38,38,0,0,38,38,0,0,0,35,0,0,0,0,38,35,38,null,0,0,0,1,1,0,1,1,1,1,0,0,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0]
[72,"IB10",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",2,"no","no","-","yes","sex","no","no","-","no","-","yes","unclear","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","Peer-reviewed","yes","no","positive"]
[101,"IB14",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","5-8 per group","no","yes","random order of treatment","yes","sex, weight","no","no","-","no","-","yes","negative","yes","rat","yes","yes","yes","both","no","-","no","-","yes","no","no","yes","no","-","yes","peer revieweded","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,35,35,35,35,38,38,38,38,38,35,35,38,38,38,35,38,35,38,38,38,38,38,38,38,38,38,38,0,0,35,35,38,null,0,0,0,1,1,0,1,1,1,1,0,0,0,0,0,1,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0]
[102,"IB14",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","4-8 per group","no","yes","randomisation to treatment","yes","weight, sex","no","no","-","no","-","yes","negative","yes","rat","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,35,35,35,35,38,38,38,38,38,35,35,38,38,38,35,38,35,0,0,0,0,0,0,0,0,0,0,0,0,35,35,38,null,0,0,0,1,1,0,1,1,1,1,0,0,0,0,0,1,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0]
[103,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no","-","yes","rat","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive"]
[104,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","6-7 per group","no","no","-","no","-","no","no","-","yes","yes (tumor-free death, thymoma)","yes","negative","yes","mouse","yes","yes","yes","both","yes","yes","yes","no","yes","yes (same publication)","yes","yes","yes","rat, mice","yes","peer revieweded","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,38,38,38,38,38,35,35,38,38,38,38,38,38,38,38,38,38,35,38,38,38,38,38,38,38,0,0,35,35,38,null,0,0,0,1,1,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,1,0,0]
[105,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","6 per group","-","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,0,0,0,0,0,0,0,0,0,0,0,0,35,35,38,null,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0]
[106,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","negative"]
[107,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",30,"-","yes","treatment assignment","yes","sex, age","no","no","-","no","-","yes","Negative, positive","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,0,0,0,38,38,38,35,35,35,35,38,38,38,38,38,38,38,38,38,38,35,38,35,0,0,0,0,0,0,0,0,0,0,0,0,38,38,38,null,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[108,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",30,"-","yes","treatment assignment","yes","sex, age","no","no","-","no","-","yes","Negative, positive","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,0,0,0,38,38,38,35,35,35,35,38,38,38,38,38,38,38,38,38,38,35,38,35,0,0,0,0,0,0,0,0,0,0,0,0,38,38,38,null,0,0,0,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[109,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","yes","Positive, negative control","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,0,0,0,38,38,38,38,38,38,38,38,38,38,38,38,38,35,38,38,38,38,38,38,0,0,0,0,0,0,0,0,0,0,0,0,38,38,38,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[110,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","6+2 per time point","no","no","-","yes","sex, age, weight","no","no","-","no","-","yes","Postive control, negative control","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,35,35,38,38,38,38,38,38,35,38,38,38,35,38,38,0,0,0,0,0,0,0,0,0,0,0,0,38,38,38,null,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[111,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",21,"no","no","-","yes","sex, age","no","no","-","no","-","yes","Positive, negative control","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,35,35,38,38,38,38,38,35,35,38,38,35,35,35,35,0,0,0,0,0,0,0,0,0,0,0,0,38,35,38,null,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,1,1,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0]
[112,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",21,"no","no","-","yes","sex, age","no","no","-","no","-","yes","Positive, negative control","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,35,35,38,38,38,38,38,35,35,38,38,35,35,35,35,0,0,0,0,0,0,0,0,0,0,0,0,38,38,38,null,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,1,1,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[113,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","5 per group","no","no","-","yes","sex, age","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,35,35,38,38,38,38,38,35,35,38,38,38,35,35,35,0,0,0,0,0,0,0,0,0,0,0,0,38,35,38,null,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,1,1,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0]
[114,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","5 per group","no","no","-","yes","sex, bodyweight","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,35,35,38,38,38,38,38,35,35,38,38,38,35,38,35,0,0,0,0,0,0,0,0,0,0,0,0,38,35,38,null,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,1,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0]
[115,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","4-5 per group","no","no","-","yes","sex, female","no","yes","blinded assessment of histology","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,38,38,38,35,35,38,38,35,35,38,38,38,35,35,35,0,0,0,0,0,0,0,0,0,0,0,0,38,35,38,null,0,0,0,1,1,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0]
[116,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","5 per group","no","no","-","no","-","no","no","-","yes","Animal death","yes","Negative, positive","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,38,38,38,38,38,35,35,35,35,38,38,38,35,35,35,0,0,0,0,0,0,0,0,0,0,0,0,38,35,38,null,0,0,0,1,1,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0]
[117,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","4-12 per group","no","no","-","yes","sex, age","no","no","-","no","-","yes","negative","yes","rat","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,35,35,38,38,38,38,38,35,35,38,38,35,35,35,35,0,0,0,0,0,0,0,0,0,0,0,0,35,35,38,null,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,1,1,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0]
[118,"IB15",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","5-15 per group","-","no","-","yes","sex, age","no","no","-","no","-","yes","Postive, neagtive control","yes","rat","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,35,35,38,38,38,38,38,38,38,38,38,38,35,38,38,0,0,0,0,0,0,0,0,0,0,0,0,38,35,38,null,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0]
[120,"IB17",null,null,"Anti-infectives","efficacy","yes",31,"no","no","-","yes","bodyweight at day 0","no","no","-","yes","no","yes","negative","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","yes","positive"]
[121,"IB17",null,null,"Anti-infectives","efficacy","yes",16,"no","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","yes","positive"]
[139,"IB20",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","no","no",null,"no","no","-","no","-","no","-","yes","rat","yes","yes","no","-",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive"]
[140,"IB20",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","no","yes","sex","no","no","-","no","-","yes","negative","yes","rat","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive"]
[141,"IB20",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","no","yes","sex","no","no","-","no","-","yes","negative","yes","rat","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive"]
[142,"IB20",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","no","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive"]
[143,"IB20",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","no","no","-","no","no","-","no","-","yes","Negative, positive","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive"]
[144,"IB20",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","no","no","-","no","no","-","no","-","yes","Negative, positive","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive"]
[145,"IB20",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","no","no","-","no","no","-","no","-","yes","positive","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive"]
[146,"IB20",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","no","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive"]
[147,"IB20",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","no","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive"]
[148,"IB20",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","no","yes","sex","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive"]
[149,"IB20",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","no","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive"]
[150,"IB20",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","no","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive"]
[151,"IB20",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","no","no","-","no","no","-","no","-","no","-","yes","rat","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive"]
[152,"IB20",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","no","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive"]
[153,"IB20",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","no","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive"]
[154,"IB20",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","no","no","-","no","no","-","no","-","yes","positive","yes","rat","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","no","no","positive"]
[206,"IB23",null,null,"Blood product & biotech","efficacy","yes","8 per group","no","no","-","yes","sex, age","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both","yes","yes","yes","no","no","yes","-","yes","yes","mice, dogs","yes","peer revieweded","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,35,35,38,38,38,38,38,35,35,38,38,38,35,38,35,38,38,35,38,38,38,38,38,38,38,0,0,38,35,38,null,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,1,1,0,0,0,1,0,1,0,0,1,0,0,0,0,0,0,0,0,0,0,1,0,0]
[207,"IB23",null,null,"Blood product & biotech","efficacy","yes",31,"no","no","-","yes","sex","no","no","-","yes","yes","yes","negative","yes","mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","yes","positive"]
[209,"IB23",null,null,"Blood product & biotech","efficacy","yes",20,"no","no","-","yes","age","no","no","-","no","-","yes","negative and positive","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,35,35,38,38,38,38,38,38,35,38,38,38,35,38,35,0,0,0,0,0,0,0,0,0,0,0,0,38,35,38,null,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0]
[210,"IB23",null,null,"Blood product & biotech","efficacy","yes",20,"no","no","-","yes","sex","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive"]
[211,"IB23",null,null,"Blood product & biotech","efficacy","yes",30,"no","no","-","yes","sex","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive"]
[213,"IB23",null,null,"Blood product & biotech","efficacy","no","-",null,"no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive"]
[214,"IB23",null,null,"Blood product & biotech","efficacy","yes",40,"no","no","-","no","-","no","no","-","no","-","yes","negative, positive","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","yes","positive"]
[215,"IB23",null,null,"Blood product & biotech","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive"]
[216,"IB23",null,null,"Blood product & biotech","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive"]
[224,"IB23",null,null,"Blood product & biotech","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive"]
[225,"IB23",null,null,"Blood product & biotech","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive"]
[226,"IB23",null,null,"Blood product & biotech","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive"]
[227,"IB23",null,null,"Blood product & biotech","efficacy","yes",17,"no","no","-","yes","age, sex, weight, tumor type","no","no","-","no","-","no","-","yes","dogs","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,35,35,38,38,38,38,38,38,38,38,38,38,35,38,35,0,0,0,0,0,0,0,0,0,0,0,0,38,35,38,null,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0]
[228,"IB23",null,null,"Blood product & biotech","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded","yes","no","positive"]
[247,"IB26",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",5,"no","no","-","yes","sex","no","no","-","no","-","yes","positive","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer revieweded ","yes","yes","positive"]
[257,"IB28",null,null,"Respiratory system","efficacy","yes","7-9 per group","no","yes","-","yes","sex, weight","no","no","-","no","-","yes","negative","yes","rat","yes","yes","yes","metric","yes","yes","no","-","yes","yes","-","yes","yes","mice, rats, dogs","yes","peer revieweded ","no","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,35,38,35,35,38,38,38,38,38,38,38,38,38,38,35,38,38,38,38,38,38,38,38,38,38,38,38,0,0,38,35,38,null,0,0,0,1,1,0,1,0,1,1,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0]
[302,"IB36",null,null,"Dermatologicals","efficacy","yes","5 per group","no","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewedd","no","no","positive"]
[310,"IB40",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","6 per group; 4 groups","no","no","-","yes","sex, age","no","no","-","yes","yes","yes","negative","yes","mouse","yes","yes","yes","both","no","-","yes","no","yes","yes","-","yes","no","-","yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,0,0,0,38,38,38,38,38,35,35,38,38,38,38,38,38,38,38,38,38,35,38,38,38,38,35,38,38,38,38,38,38,38,0,0,38,38,38,null,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0]
[313,"IB40",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[314,"IB40",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[315,"IB40",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","4-9 per group","-","yes","no","yes","sex, age","no","no","-","no","-","yes","Positive, Negative","yes","mice","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,35,38,35,35,38,38,38,38,38,38,38,35,35,38,35,38,38,0,0,0,0,0,0,0,0,0,0,0,0,38,35,38,null,0,0,0,1,1,0,1,0,1,1,0,0,0,0,0,0,0,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0]
[317,"IB42",null,null,"Rheumatology","efficacy","no","-","-","no","-","no",null,"no","no","-","no","-","no",null,"yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[318,"IB42",null,null,"Rheumatology","efficacy","yes",5,"no","no","-","no",null,"no","no","-","no","-","yes","negative","yes","minipig","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[319,"IB43",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","yes","amount of tumor cell, tumor size","no","no","-","no","-","yes","positive, negative","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive"]
[336,"IB48",null,null,"Anti-infectives","efficacy","yes",4,"no","no","-","yes","age","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","metric","yes","yes","yes","no","yes","yes","-","yes","no","-","yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,0,0,0,38,38,38,38,38,35,35,38,38,38,38,38,38,38,38,38,38,35,38,38,38,38,35,38,38,38,38,38,38,38,0,0,38,38,38,null,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0]
[337,"IB48",null,null,"Anti-infectives","efficacy","yes",8,"no","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[338,"IB48",null,null,"Anti-infectives","efficacy","yes","8 mice per group","no","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[339,"IB48",null,null,"Anti-infectives","efficacy","yes",14,"no","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","yes","positive"]
[340,"IB48",null,null,"Anti-infectives","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[341,"IB48",null,null,"Anti-infectives","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","yes","positive"]
[344,"IB48",null,null,"Anti-infectives","efficacy","yes","2-6 per group","no","no","-","yes","age","no","no","-","no","-","yes","positive","yes","mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,35,35,38,38,38,38,38,38,38,38,38,38,35,38,38,0,0,0,0,0,0,0,0,0,0,0,0,38,38,38,null,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[345,"IB48",null,null,"Anti-infectives","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","yes","positive","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","yes","positive"]
[376,"IB49",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[398,"IB55",null,null,"Allergy & Immunology","efficacy","no","-",null,"no","-","no",null,"no","no","-","no","-","no","-","yes","rat","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[399,"IB55",null,null,"Allergy & Immunology","efficacy","no","-",null,"no","-","no",null,"no","no","-","no","-","no","-","yes","rat","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[400,"IB55",null,null,"Allergy & Immunology","efficacy","no","-",null,"no","-","no",null,"no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[401,"IB55",null,null,"Allergy & Immunology","efficacy","yes","10-14 per group","no","yes","group randomization, crossover design","yes","sex","no","no","-","no","-","yes","negative","yes","guinea pigs","yes","yes","yes","both","yes","yes","no","-","no","no","allergic and inflamation models","yes","yes","mice, rat, guinea pigs","yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,35,35,35,35,38,38,38,38,38,35,35,38,38,38,35,38,35,38,38,38,38,38,38,38,38,38,38,0,0,35,35,38,null,0,0,0,1,1,0,1,1,1,1,0,0,0,0,0,1,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0]
[402,"IB55",null,null,"Allergy & Immunology","efficacy","no","-",null,"no","-","no",null,"no","no","-","no","-","no","-","yes","rat","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[408,"IB59",null,null,"Anti-infectives","efficacy","yes",12,"no","no","-","yes","weight","no","no",null,"no","-","yes","negative","yes","hamster","yes","yes","yes","metric","no","-","no","-","no","no","-","yes","no","-","yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,38,38,38,38,38,35,35,35,35,35,35,35,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,0,0,35,35,38,null,0,0,0,0,0,0,0,0,1,1,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0]
[409,"IB59",null,null,"Anti-infectives","efficacy","no","-",null,"no","-","no",null,"no","no",null,"no","-","yes","negative","yes","hamster","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[410,"IB59",null,null,"Anti-infectives","efficacy","yes","5 per group","no","no","-","yes","weight","no","no",null,"yes","yes","yes","negative","yes","hamster","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,35,35,38,38,38,35,35,35,35,38,38,38,38,38,38,0,0,0,0,0,0,0,0,0,0,0,0,35,35,38,null,0,0,0,1,1,0,0,0,1,1,0,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0]
[411,"IB59",null,null,"Anti-infectives","efficacy","yes",40,"no","no","-","no",null,"no","no",null,"no","-","yes","negative","yes","hamster","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[412,"IB59",null,null,"Anti-infectives","efficacy","yes","83 (2-5 per group","no","no","-","yes","weight","no","no",null,"no","-","yes","negative","yes","hamster","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","no","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,35,35,38,38,38,38,38,38,38,38,38,38,38,38,38,0,0,0,0,0,0,0,0,0,0,0,0,35,38,38,null,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0]
[413,"IB59",null,null,"Anti-infectives","efficacy","yes",16,"no","no","-","no",null,"no","no",null,"no","-","yes","negative","yes","hamster","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[424,"IB63",null,null,"Anti-infectives","efficacy","yes","3 per group","no","no","-","no","-","no","no","-","no","-","yes","positive","yes","mouse","yes","yes","yes","both","yes","yes","yes","no","yes","no","-","yes","no","-","yes","peer reviewed","yes","no","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,35,38,38,38,38,38,38,38,38,38,38,0,0,38,38,38,null,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[425,"IB63",null,null,"Anti-infectives","efficacy","yes","3 per group","no","no","-","no","-","no","no","-","no","-","yes","positive","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","no","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,35,0,0,0,0,0,0,0,0,0,0,0,0,38,38,38,null,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[426,"IB63",null,null,"Anti-infectives","efficacy","yes",8,"no","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[427,"IB63",null,null,"Anti-infectives","efficacy","yes",19,"no","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[428,"IB63",null,null,"Anti-infectives","efficacy","yes","5-9 per group","no","no","-","yes","sex, age","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,35,35,38,38,38,38,38,38,38,38,38,38,38,38,38,0,0,0,0,0,0,0,0,0,0,0,0,38,38,38,null,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[429,"IB63",null,null,"Anti-infectives","efficacy","yes","3-7 per group","no","no","-","yes","sex, age","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,35,35,38,38,38,38,38,35,35,38,38,38,38,35,35,0,0,0,0,0,0,0,0,0,0,0,0,38,35,38,null,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,1,1,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0]
[441,"IB66",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,"no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no",null,null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[442,"IB66",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,"no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no",null,null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[443,"IB66",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","8-10 animals per group",null,"no","-","yes","sex","no","no","-","no","-","yes","untreated?","yes","mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,35,35,38,38,38,38,38,35,35,38,38,38,35,38,38,0,0,0,0,0,0,0,0,0,0,0,0,38,35,38,null,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0]
[444,"IB66",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,"no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","no",null,null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[445,"IB66",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","192 (6-10 per group)","no","no","-","yes","weight","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","time-course","yes","yes","yes","no","yes","no","-","no","yes","-","yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,0,0,0,35,35,35,38,38,35,35,38,38,38,38,38,38,38,38,38,38,35,35,35,38,38,35,38,35,38,38,38,38,38,0,0,38,38,38,null,0,0,0,1,1,1,0,0,1,1,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0]
[446,"IB66",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","8-10 per group","no","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,38,38,38,38,38,38,38,35,35,38,38,38,35,35,35,0,0,0,0,0,0,0,0,0,0,0,0,38,38,38,null,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[468,"IB72",null,null,"Anti-neoplastic & immune-modulating agents","unclear","yes","8-11 per group","no","no","-","yes","age","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both","no","-","yes","no","yes","no","-","yes","no","-","yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,35,35,38,38,38,38,38,35,35,38,38,38,35,38,35,38,38,35,38,38,38,38,38,38,38,0,0,35,35,38,null,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,1,1,0,0,0,1,0,1,0,0,1,0,0,0,0,0,0,0,0,0,1,1,0,0]
[490,"IB77",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no",null,"yes","chicken","yes","no","no",null,null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[491,"IB77",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no",null,"yes","chicken","yes","no","no",null,null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[493,"IB77",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no",null,"yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[496,"IB77",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no",null,"yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[498,"IB77",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no",null,"yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[499,"IB77",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","6 per group","no","yes","no","yes","age, weight","no","no","-","no","-","yes","negative","yes","hamster","yes","yes","yes","both","yes","yes","yes","no","yes","yes","-","yes","yes","rat, hamster, mouse","yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,35,38,35,35,38,38,38,38,38,35,35,38,38,38,35,38,35,38,38,35,38,38,38,38,38,38,38,0,0,38,35,38,null,0,0,0,1,1,0,1,0,1,1,0,0,0,0,0,1,1,0,0,0,1,0,1,0,0,1,0,0,0,0,0,0,0,0,0,0,1,0,0]
[500,"IB77",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no",null,"yes","mouse","yes","no","no",null,null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[501,"IB77",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","yes","age","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,38,38,38,38,38,35,35,38,38,38,38,38,35,35,38,38,38,35,35,35,0,0,0,0,0,0,0,0,0,0,0,0,35,35,35,null,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,1,1,0,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0]
[502,"IB77",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no",null,"yes","rat","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[503,"IB77",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no",null,"yes","rabbit","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[504,"IB77",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","6-10 per group","no","no","-","yes","sex, age","no","no","-","no","-","yes","positive, negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,35,35,38,38,38,38,38,35,35,38,38,38,35,38,35,0,0,0,0,0,0,0,0,0,0,0,0,38,35,35,null,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,1,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0]
[505,"IB77",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no",null,"yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[506,"IB77",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","6 per group","no","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,38,38,38,38,38,38,38,35,35,38,38,38,38,38,35,0,0,0,0,0,0,0,0,0,0,0,0,38,35,38,null,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0]
[507,"IB77",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no",null,"yes","rat","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[508,"IB77",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",31,"no","no","-","no","-","no","no","-","no","-","yes","negative","yes","rat","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,0,0,0,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,35,38,38,0,0,0,0,0,0,0,0,0,0,0,0,38,35,38,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0]
[509,"IB77",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",28,"no","yes","no","yes","sex, age","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,35,38,35,35,38,38,38,38,38,35,35,38,38,38,35,38,38,0,0,0,0,0,0,0,0,0,0,0,0,35,35,38,null,0,0,0,1,1,0,1,0,1,1,0,0,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0]
[516,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","10 per group","no","no","-","yes","age, sex","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","metric","yes","yes","yes","no","yes","no","-","yes","no","-","yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,35,35,38,38,38,38,38,35,35,35,35,35,35,35,35,35,35,35,38,38,38,38,38,38,38,0,0,38,35,38,null,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,1,1,1,1,1,1,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,1,0,0]
[517,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","10 per group","no","no","-","yes","age, sex","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,35,35,38,38,38,38,38,35,35,35,35,35,35,35,35,35,35,35,0,38,0,0,38,0,0,0,0,38,35,38,null,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,1,1,1,1,1,1,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,1,0,0]
[518,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","10 per group","no","no","-","yes","age, sex","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,35,35,38,38,38,38,38,35,35,35,35,35,35,35,35,35,35,35,0,38,0,0,38,0,0,0,0,38,35,38,null,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,1,1,1,1,1,1,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,1,0,0]
[519,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","5 for control and 7 for intervention","no","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,38,38,38,38,38,38,38,35,35,35,35,35,35,35,35,35,35,35,0,38,0,0,38,0,0,0,0,0,0,0,null,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,1,1,1,1,1,1,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0]
[520,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","6 per group, 4 groups","no","yes","no","yes","age, sex","no","no","-","no","-","yes","negative, the 2 combination drugs alone","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,35,38,35,35,38,38,38,38,38,35,35,35,35,38,35,35,35,35,35,35,0,38,0,0,38,0,0,0,0,35,35,38,null,0,0,0,1,1,0,1,0,1,1,0,0,0,0,0,1,1,1,1,0,1,1,1,1,1,1,0,0,0,0,0,0,0,0,0,1,1,0,0]
[521,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,"no","-","yes","sex, weight","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,38,38,38,38,38,35,35,38,38,38,38,38,35,35,35,35,38,35,38,35,2,2,2,2,2,2,2,2,2,2,2,2,35,35,38,null,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,1,1,1,1,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0]
[522,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","9 for intervention, 6 for control","no","no","-","yes","sex, weight","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,35,35,38,38,38,38,38,35,35,38,38,38,35,35,35,35,35,35,0,38,0,0,38,0,0,0,0,35,35,35,null,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,1,1,0,0,0,1,1,1,1,1,1,0,0,0,0,0,0,0,0,0,1,1,1,0]
[523,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","11 for intervention, 5+5 for control","no","no","-","yes","sex, weight","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,35,35,38,38,38,38,38,35,35,35,35,38,35,38,35,35,35,35,0,38,0,0,38,0,0,0,0,35,35,38,null,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,1,1,1,1,0,1,0,1,1,1,1,0,0,0,0,0,0,0,0,0,1,1,0,0]
[524,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-",null,"no","-","yes","sex, weight","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,38,38,38,38,38,35,35,38,38,38,38,38,35,35,35,35,38,35,38,35,2,2,2,2,2,2,2,2,2,2,2,2,35,35,38,null,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,1,1,1,1,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0]
[525,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","4 intervention groups (n=4-6) and 4 control groups (n= 4-7)","no","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","inconclusive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,38,38,38,38,38,38,38,35,35,38,38,38,35,35,35,35,35,35,0,38,0,0,38,0,0,0,0,35,35,36,null,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,1,1,1,1,1,1,0,0,0,0,0,0,0,0,0,1,1,0,0]
[526,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","3 per group","no","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","inconclusive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,38,38,38,38,38,38,38,35,35,38,38,38,35,38,38,35,35,35,0,38,0,0,38,0,0,0,0,35,35,36,null,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,1,0,0,1,1,1,0,0,0,0,0,0,0,0,0,1,1,0,0]
[527,"IB80",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","3 per group","no","no","-","no","-","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","inconclusive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,38,38,38,38,38,38,38,35,35,38,38,38,35,35,35,35,35,35,0,38,0,0,38,0,0,0,0,35,35,36,null,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,1,1,1,1,1,1,0,0,0,0,0,0,0,0,0,1,1,0,0]
[546,"IB85",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","control n=3 and intervention n=3","no","no","-","yes","sex","no","no","-","no","-","yes","negative","yes","mouse","yes","no","yes","both","no","-","no","-","yes","yes","-","yes","no","-","yes","peer reviewed","yes","no","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,35,35,38,38,38,38,38,35,35,38,38,38,38,38,35,38,38,38,38,38,38,38,38,38,38,0,0,35,38,38,null,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,1,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0]
[547,"IB85",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","5 per group","no","no","-","yes","sex, age","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,35,35,38,38,38,38,38,35,35,38,38,35,35,38,35,2,2,2,2,2,2,2,2,2,2,2,2,35,35,38,null,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,1,1,0,0,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0]
[548,"IB85",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","5-7 per group","no","yes","no","yes","sex, weight","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,35,38,35,35,38,38,38,38,38,35,35,38,38,38,35,38,35,0,0,0,0,0,0,0,0,0,0,0,0,35,38,38,null,0,0,0,1,1,0,1,0,1,1,0,0,0,0,0,1,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0]
[549,"IB85",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","at least 7 per group","no","no","-","yes","sex, age","no","no","-","yes","no","no","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,35,35,38,38,38,35,38,35,35,35,35,35,35,35,35,0,0,0,0,0,0,0,0,0,0,0,0,35,38,38,null,0,0,0,1,1,0,0,0,1,1,0,0,0,1,0,1,1,1,1,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0]
[550,"IB85",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","6 per group","no","yes","no","yes","sex, age","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,35,38,35,35,38,38,38,38,38,38,38,38,38,38,38,38,35,0,0,0,0,0,0,0,0,0,0,0,0,38,35,38,null,0,0,0,1,1,0,1,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0]
[590,"IB89",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","7-15 per group","no","yes","-","yes","sex","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both","yes","yes","yes","no","yes","no","-","yes","no","-","yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,35,38,35,35,38,38,38,38,38,35,35,38,38,38,35,38,35,38,38,35,38,38,38,38,38,38,38,0,0,35,35,38,null,0,0,0,1,1,0,1,0,1,1,0,0,0,0,0,1,1,0,0,0,1,0,1,0,0,1,0,0,0,0,0,0,0,0,0,1,1,0,0]
[591,"IB89",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","7-15 per group","no","yes","-","yes","sex","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,35,38,35,35,38,38,38,38,38,35,35,38,38,38,35,38,35,0,0,0,0,0,0,0,0,0,0,0,0,35,35,38,null,0,0,0,1,1,0,1,0,1,1,0,0,0,0,0,1,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0]
[592,"IB89",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","6-12 per group","no","yes","-","yes","sex, age, body weight","no","yes","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,35,38,35,35,38,35,38,38,38,35,35,38,38,38,35,38,35,0,0,0,0,0,0,0,0,0,0,0,0,38,38,38,null,0,0,0,1,1,0,1,0,1,1,0,1,0,0,0,1,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[593,"IB89",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","yes","-","yes","sex, age","no","no","-","yes","yes","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,38,38,38,35,38,35,35,38,38,38,35,35,35,35,35,35,35,35,38,35,0,0,0,0,0,0,0,0,0,0,0,0,35,35,38,null,0,0,0,0,0,0,1,0,1,1,0,0,0,1,1,1,1,1,1,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0]
[594,"IB89",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","5-10 per group","no","yes","no","yes","sex, age","no","no","-","no","-","yes","negative","yes","mice","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","no","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,35,38,35,35,38,38,38,38,38,38,38,35,35,35,35,38,35,0,0,0,0,0,0,0,0,0,0,0,0,35,38,38,null,0,0,0,1,1,0,1,0,1,1,0,0,0,0,0,0,0,1,1,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0]
[595,"IB89",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no","-","no","-","no","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[596,"IB89",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no","-","no","-","yes","no","no","-",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[597,"IB89",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","10 per group","-","no","-","yes","age, sex","no","no","-","yes","yes","yes","negative","yes","mice","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,35,35,38,38,38,35,35,35,35,35,35,38,35,38,35,0,0,0,0,0,0,0,0,0,0,0,0,38,38,38,null,0,0,0,1,1,0,0,0,1,1,0,0,0,1,1,1,1,1,1,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[598,"IB89",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","7 per group","-","yes","\"restricted randomization\"","yes","age, sex","no","no","-","no","-","yes","negative","yes","mice","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,35,35,35,35,38,38,38,38,38,35,35,35,35,38,35,38,35,0,0,0,0,0,0,0,0,0,0,0,0,35,35,38,null,0,0,0,1,1,0,1,1,1,1,0,0,0,0,0,1,1,1,1,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0]
[599,"IB89",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","no","positive"]
[600,"IB89",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[601,"IB89",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no","-","yes","mouse","yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[602,"IB89",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no","-","no","no","-","no","-","no","-","no",null,"yes","no","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","no","positive"]
[620,"IB92",null,null,"Anti-infectives","efficacy","yes","2-6 per group","-","no","-","yes","age","no","no","-","no","-","yes","positive","yes","mouse","yes","yes","yes","both","yes","yes","yes","no","yes","yes","-","yes","yes","-","yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,35,35,38,38,38,38,38,35,35,38,38,38,35,38,35,38,38,35,38,38,38,38,38,38,38,0,0,38,38,38,null,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,1,1,0,0,0,1,0,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0]
[635,"IB98",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","5-15 per group","no","no","-","yes","sex, age","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both","no","-","yes","no","no","no","-","yes","yes","-","yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,35,35,38,38,38,38,38,38,38,38,38,38,35,38,35,38,38,35,38,38,38,38,38,38,38,0,0,38,38,38,null,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0]
[637,"IB98",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","6 per group","-","yes","no","yes","sex, age","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,35,38,35,35,38,38,38,38,38,38,38,38,38,38,35,38,38,0,0,0,0,0,0,0,0,0,0,0,0,38,35,38,null,0,0,0,1,1,0,1,0,1,1,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0]
[638,"IB98",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",13,"no","no","-","yes","body weight","no","no","-","no","-","yes","negative","yes","rabbit","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive"]
[639,"IB98",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",12,"no","no","-","no",null,"no","no","-","no","-","yes","negative","yes","rat","yes","yes","yes","time-course",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,0,0,0,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,38,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[640,"IB98",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","10 per group","no","no","-","yes","sex, age","no","yes","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,35,35,38,35,38,38,38,38,38,38,38,38,35,38,35,0,0,0,0,0,0,0,0,0,0,0,0,35,38,38,null,0,0,0,1,1,0,0,0,1,1,0,1,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0]
[641,"IB98",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",48,"no","yes","no","yes","sex","no","yes","-","yes","yes","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","no","yes","positive",null,null,null,null,null,null,null,0,0,0,38,38,38,38,38,38,38,38,35,38,38,38,38,38,38,38,38,38,38,35,0,0,0,0,0,0,0,0,0,0,0,0,38,35,38,null,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0]
[655,"IB102",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","no","-","-","no","-","no",null,"no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","metric","yes","yes","yes","no","no","no","yes","yes","no","-","yes","peer reviewed","yes","no","positive",null,null,null,null,null,null,null,0,0,0,38,38,38,38,38,38,38,38,38,38,38,38,35,35,38,38,35,35,38,38,38,38,35,38,38,38,38,38,38,38,0,0,38,38,38,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0]
[656,"IB102",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","5 per group","no","no","-","yes","age, sex","no","no","-","no","-","yes","negative","yes","mouse","yes","yes","yes","both",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,35,35,38,38,38,35,35,38,38,38,38,38,35,35,38,38,35,35,35,35,0,0,0,0,0,0,0,0,0,0,0,0,35,35,38,null,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,1,1,0,0,1,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0]
[667,"IB102",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes",30,"no","no","-","no","-","no","no","-","yes","yes","yes","negative","yes","mouse","yes","yes","yes","metric",null,null,null,null,null,null,null,null,null,null,"yes","peer reviewed","yes","no","positive",null,null,null,null,null,null,null,0,0,0,38,38,38,38,38,38,38,38,38,38,35,35,35,35,38,38,38,35,38,38,0,0,0,0,0,0,0,0,0,0,0,0,35,38,38,null,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0]
[]
[null,"21 Ibs","113 PCES"]

{"sheet":"results of publications","index":7,"n_rows":18,"n_cols":39,"rows_kept":18,"cut":false,"hidden":false,"merged":[[1,13,1,14],[1,1,1,3],[1,4,1,5],[1,6,1,7],[1,8,1,10],[1,11,1,12],[1,32,1,33],[1,34,1,35],[1,36,1,38],[1,15,1,20],[1,21,1,22],[1,23,1,24],[1,25,1,26],[1,28,1,29],[1,30,1,31]]}
["Please note: Some rows in this table might have been deleted due to confidentiality reasons!"]
[null,"Sample size",null,null,"Randomisation",null,"Baseline characterization",null,"Blinded assessment",null,null,"Exclusion of data from analysis",null,"Controls",null,"Model choice",null,null,null,null,null,"Outcome choice",null,"Dose reponse \n(RATE ON IB LEVEL)",null,"Age matched to patients \n(RATE ON IB LEVEL)",null,"Mechanistic evidence \n(RATE ON IB LEVEL)","Replication of experiment \n(RATE ON IB LEVEL)",null,"Replication in different model \n(RATE ON IB LEVEL)",null,"Replication in different species (RATE ON IB LEVEL)",null,"Citation of references",null,"Reporting on direction of results"]
[null,"Sample size",null,null,"Randomisation",null,"Baseline characterization",null,"Blinding for treatment allocation","Blinding for outcome assessment",null,"Exclusion of data from analysis",null,"Controls",null,"Species of animals",null,"Model type",null,"Specifications of the model",null,"Outcome choice",null,"Dose reponse ",null,"Age of animals",null,"Mechanistic evidence","Replication of experiment",null,"Replication in different model",null,"Replication in different species",null,null,null,"Effect size","Significance value","Direction of results"]
[null,"Is sample size reported, Yes or no?","If yes, how many?","If yes, is sample size calculation reported, Yes or no?","Is randomisation reported, \nYes or no?","If yes, describe the method used to generate the randomization sequence.?","Is baseline characterization reported, \nYes or no?","If yes, what type?","Is blinded assessment  for treatment allocation reported, \nYes or no?","Is blinded assessment  for outcome assessment reported, \nYes or no?","If yes, when?","Is exclusion of data reported, Yes or no?","If yes, justification?","Is control group reported, Yes or no?","If yes, what type of control?","Is the species of animal reported?","If yes, what species?","Is the type of model reported?","If yes, what model?","Is the specifications of model reported?","If yes, details?","Is the outcome choice reported, \nYes or no?","If yes, is the metric or time-course or both reported?","Is dose response reported? Yes or no?","If yes, is positive reponse reported, Yes or no? ","Is the age of animals reported, \nYes or no?","If yes, is it matched to patients?","Yes or no?","Is there replication of experiment, Yes or no?","If no, is there other similar study?","Is there replication in different model, \nYes or no?","If yes, model type?","Is there replication in different species, \nYes or no?","If yes, species type?","Is there references reported, \nYes or no?","If yes, what type of references?","Is effect size reported? Yes or no? \n(Step 1)","Is  significant value reported? Yes or no? \n(Step 2)","Was the investigation positive, inconclusive or negative?"]
[null,"■ Does the experiment report sample sizes for all extractable groups?\n■ Is information provided on the number of animal per treatment group or total number of animal for the whole experiment?","n = ?","■ Has a power calculation been performed a priori to determine sample size?\n■ Select no if there are no explicit statements about sample size determination.","■ Were animals randomly assigned to treatment?\n■ Select unclear if there are no explicit statements about allocation.","Group designation, Cage randomization,\nPermanent designation, Randomization to treatment","■ Was the emergence of confounding physiological variables monitored and addressed (e.g. blood pressure, body temperature)?\n■ Were the groups similar at baseline or were they adjusted for confounders in the analysis?\n■ Was the distribution of relevant baseline characteristics balanced for the intervention and control groups?\n■ If relevant, did the investigators adequately adjust for unequal distribution of some relevant baseline characteristics in the analysis?\n■ Was the timing of disease induction adequate? \n\n","Sex, age, immune status, weight, microbial status of the animal ","■ Was treatment allocation concealed from the investigators during the experiment?\n■ Select no if there are no explicit statements about blinding to treatment allocation.","■ Were investigators blinded to treatment allocation during outcome assessment? \n■ Select no if there are no explicit statements about blinding to outcome assessment."," ","■ Do studies explain the flow of animals from inclusion through to analysis?\n■ Has every animal been accounted for, from entry into experiment through treatment, outcome assessment, sacri ce and analysis? ","Animal death","■ Were appropriate controls used in all in vivo experiments (e.g. positive, negative)?","Positive control, negative control, sham, comparator arm","Mouse, rat, dog, monkey, etc.",null,"Induced or Experimental, spontaneous (xenograft, orthotopic), transgenic, type of disease",null,"Tumor size, etc.",null,"Endpoints, type of measurement (survival, tumor shrinkage, etc), time-course of measurement, mean survival ",null,"■ Was there a demonstration of dose-response relationship of  the adverse effect?\n■ Was there a time course (e.g., onset and duration of response) of the adverse effect?\n■ Was the doses eliciting the adverse effect compared to the doses eliciting the primary pharmacodynamic effect in the test species or the proposed therapeutic effect in humans?\n■ Minimum of 3 different doses",null,"■ Is age of animals mentioned?","■ Check inclusion criteria of patients",null,"■ Is it the same model?\n■ Is it the same drug? \n■ Is it measuring the same outcome?",null,"■ Whether efficacy studies were replicated in more than one model. \n■ Is it the same species?","■ Different disease type, different route administration, different dosage form ","■ Whether efficacy studies were replicated in more than one species.",null,"■ If there is internal study number, citation, … then it is a yes.","Peer-reviewed, in house data",null,"■ Is there a p-value reported in the figure description or in the experiment results?","■ If p value significant (typically ≤ 0.05), then it is positiv.e"]
["Percentage of publications with additional information",0.78749999999999998,0.78749999999999998,0,0.25,8.7499999999999994E-2,0.72499999999999998,0.72499999999999998,0,6.25E-2,2.5000000000000001E-2,0.1,8.7499999999999994E-2,0.61250000000000004,0.65,0.17499999999999999,0.17499999999999999,0.16250000000000001,0.17499999999999999,0.8,0.8,0.26250000000000001,0.6875,0.05,0.05,0.6,0,0.05,0,0,0.2,0.2,0,0,0,0,0.42499999999999999,0.625,3.7499999999999999E-2]
["Total number",80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,20,20,20,20,20,20,20,20,20,20,20,80,80,80,80,80]
["Additional info in publication",63,63,0,20,7,58,58,0,5,2,8,7,49,52,14,14,13,14,64,64,21,55,1,1,12,0,1,0,0,4,4,0,0,0,0,34,50,3]
[]
[]
["Percentage of publications with  information",0.91249999999999998,0,0,0.27500000000000002,0,0.76249999999999996,0,0,0.05,0,0.13750000000000001,0.1,0.97499999999999998,0,1,0,1,0,0.92500000000000004,0,1,0,0.65,0.65,0.7,0.05,0.75,0.4,0.15,0.95,0,0.4,0,1,0,0.61250000000000004,0.76249999999999996,0.96250000000000002]
["Total number",80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,20,20,20,20,20,20,20,20,20,20,20,80,80,80,80,80]
["Info in publication",73,0,0,22,0,61,0,0,4,0,11,8,78,0,80,0,80,0,74,0,80,0,13,13,14,1,15,8,3,19,0,8,0,80,0,49,61,77]
[]
[]
["Percentage of PCES with  information",8.7499999999999994E-2,0,0,1.2500000000000001E-2,0,0.05,0,0,0,0,0.05,0.05,0.36249999999999999,1.2500000000000001E-2,0.85,1.2500000000000001E-2,0.9,0,0.13750000000000001,1.2500000000000001E-2,0.82499999999999996,0,0.6,0.6,0.1,0.05,0.7,0.4,0.15,0.9,0,0.4,0,0.98750000000000004,0,0.16250000000000001,0.13750000000000001,0.97499999999999998]
["Total number",80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,80,20,20,20,20,20,20,20,20,20,20,20,80,80,80,80,80]
["Info in IB",7,0,0,1,0,4,0,0,0,0,4,4,29,1,68,1,72,0,11,1,66,0,12,12,2,1,14,8,3,18,0,8,0,79,0,13,11,78]

{"sheet":"Compilation","index":8,"n_rows":51,"n_cols":43,"rows_kept":51,"cut":false,"hidden":true,"merged":[[3,0,3,2],[0,0,2,2],[1,30,1,31],[1,32,1,33],[1,34,1,35],[0,36,0,42],[1,3,1,5],[1,6,1,7],[1,8,1,9],[1,10,1,11],[1,12,1,13],[1,14,1,15],[1,16,1,17],[1,18,1,22],[1,25,1,27],[0,3,0,15],[0,16,0,29],[0,30,0,35],[1,28,1,29],[1,36,1,37],[1,38,1,42]]}
["Efficacy studies",null,null,"Evaluate in light of threats to internal validity",null,null,null,null,null,null,null,null,null,null,null,null,"Evaluate in light of threats to construct validity",null,null,null,null,null,null,null,null,null,null,null,null,null,"Evaluate in light of threats to external validity",null,null,null,null,null,"Others"]
[null,null,null,"Sample size",null,null,"Randomisation",null,"Blinded assessment",null,"Exclusion of data from analysis",null,"Controls",null,"Dose reponse \n(RATED ON IB LEVEL)",null,"Baseline characterization",null,"Model choice",null,null,null,null,null,"Mechanistic evidence (RATED ON IB LEVEL)","Outcome choice",null,null,"Age matched to patients (RATED ON IB LEVEL)",null,"Replication of experiment",null,"Replication in different model",null,"Replication in different species",null,"References",null,"Inferential statistics"]
[null,null,null,"yes or no?","If yes, how many?","Justification?","yes or no?","If yes, type of randomization","yes or no?","If yes, when?","yes or no?","If yes, justification?","yes or no?","If yes, what type of control?","yes or no?","If yes, positive reponse reported? ","yes or no?","If yes, what type?","Reporting of species?","If yes, what species?","Reporting of model?","If yes, what model?","Reporting of specifications?","If yes, details","yes or no?","yes or no?",null,"If yes, justification?","yes or no?","Is it matched to patients?","yes or no?","If no, is there other similar study?","yes or no?","If yes, model type?","yes or no?","If yes, species type?","yes or no?","If yes, what type of references","yes or no?","Is effect size reported?","Effect size value?","Is it significant or not?","Significant value?"]
["Coding criteria",null,null,null,null,null,null,"Group Designation, Cage Randomization,\nPermanent Designation, Randomization to Treatment","Coding of animals, aims and groups of treatments investigated ",null,"Statement of animal flow, number of deaths.",null,null,"Positive control, negative control, sham, comparator arm","Minimum of 3 different doses, statement of dose reponse",null,"Sex, age, immune status, weight, microbial status of the animal","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","Mouse, rat, dog, monkey, etc.",null,"Induced (or Experimental), spontaneous (xenograft, orthotopic), transgenic, type of disease",null,"Tumor size, etc.",null,"(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","METRICS Endpoints, type of measurement (survival, tumor shrinkage, etc),  mean survival ","TIMING \n(timing of measurement)","An outcome is considered to be fully reported if the metrics and timing is provided","Is age of animals mentioned?","Check inclusion criteria of patients","Is it the same model?Is it the same drug? Is it measuring the same outcome?",null,"Is it the same species?","Different disease type, different route administration, different dosage form ",null,null,null,"Peer-reviewed, in house data"]
["IB1",null,"no efficacy"]
["IB2","MC38.OVA Colorectal model in C57BL6 mice","efficacy","no","-","-","no","-","no","-","no","-","yes","Positive control","no","-","no","-","yes","Mouse","yes","xenograft","yes","tumor size at day 0","yes","yes","yes","yes","no","-","no","no","yes","Different disease type","no","-","yes","In house","no","yes","118%, 116%, 119% tumor growth inhibition","no"]
["IB2","MC38 Colorectal model in C57BL6 mice","efficacy","no","-","-","no","-","no","-","no","-","yes","Positive control","no","-","no","-","yes","Mouse","yes","xenograft","yes","tumor size at day 0","yes","yes","yes","yes","no","-","no","no","yes","Different disease type","no","-","yes","In house","no","yes","76%, 98%,103% tumor growth inhibition","no"]
["IB2","CT26 colorecteal model in BALB/c mice","efficacy","no","-","-","no","-","no","-","no","-","yes","Positive control","no","-","no","-","yes","Mouse","yes","xenograft","yes","tumor size at day 0","yes","yes","yes","yes","no","-","no","no","yes","Different disease type","no","-","yes","In house","no","yes","92% tumor growth inhibition","no"]
["IB2","Cloudman S91 melanoma model in DBA/2 mice","efficacy","no","-","-","no","-","no","-","no","-","yes","Positive control","no","-","no","-","yes","Mouse","yes","xenograft","yes","tumor size at day 0","yes","yes",null,"yes","no","-","no","no","yes","Different disease type","no","-","yes","In house","no","yes","78% tumor growth inhibition","no"]
["IB3","Tail tip bleeding","efficacy","no","-","-","no","-","no","-","no","-","yes","Positive control, negative control","no","-","yes","Bodyweight","yes","Mouse","yes","Tail tip bleeding","yes",null,"?","yes","yes","yes","no","-","no","no","no","no","no","no","no","-","yes","yes","22 mg/g BW"]
["IB3","Carotid Occlusion Model ","efficacy",null,12,"no","no","-","no","-","no","-","yes","Positive control, negative control","no","-","yes","Sex","yes","Mouse","yes","Carotid Occlusion Model ","yes",null,"?","yes","yes","yes","no","-","no","no","no","no","no","no","no","-","yes","yes","6.0 min"]
["IB4","DOD15077-05-D","efficacy","no",null,"no","no","-","no","-","no","-","no","-","no","-","no","-","no","-","yes","xenograft","no","-",null,"yes","no","no",null,null,"no",null,"yes",null,"no",null,"yes","in house","yes","no",null,"yes","p 0,004"]
["IB4","OD14848m-05-A","efficacy","no",null,"no","no","-","no","-","no","-","no","-","no","-","no","-","no","-","yes","xenograft","no","-",null,"yes","no","no",null,null,"no",null,"yes",null,"no",null,"yes","in house","yes","no",null,"yes","p 0,041"]
["IB4","1041806-05-B","efficacy","no",null,"no","no","-","no","-","no","-","no","-","no","-","no","-","no","-","yes","xenograft","no","-",null,"yes","no","no",null,null,"no",null,"yes",null,"no",null,"yes","in house","yes","no",null,"yes","p 0,004"]
["IB4","1050304-05A","efficacy","no",null,"no","no","-","no","-","no","-","no","-","no","-","no","-","no","-","yes","xenograft","no","-",null,"yes","no","no",null,null,"no",null,"yes",null,"no",null,"yes","in house","yes","no",null,"yes","p 0,007"]
["IB4","D5124-06-02","efficacy","no",null,"no","no","-","no","-","no","-","no","-","no","-","no","-","no","-","yes","xenograft","no","-",null,"yes","no","no",null,null,"no",null,"yes",null,"no",null,"yes","in house","yes","no",null,"yes","p 0,022"]
["IB4","1051178-05-A","efficacy","no",null,"no","no","-","no","-","no","-","no","-","no","-","no","-","no","-","yes","xenograft","no","-",null,"yes","no","no",null,null,"no",null,"yes",null,"no",null,"yes","in house","yes","no",null,"yes","p <0,001"]
["IB4","Dose escalation of Vismodegib vs subcu murine medulloblastoma 09-2968","efficacy","yes","5-7 size per group, 9 groups","no","no","-","no","-","no","-","yes","negative","yes","yes","no","-","yes","murine","yes","xenograft","Tumors were allowed to \ngrow to a range of 100−500 mm\n3",null,null,"yes","yes","yes","no","-","no",null,"no",null,"no",null,"yes","in hiouse","no","no",null,"no","-"]
["IB5","Therapeutic method for inhibition & dissolution of fibrosis-dog","efficacy","no",null,null,"no","-","no","-","no","-","no","-","no","-","no","-","yes","Dog","yes","Fibrosis model","no","no","no","no","no","yes","yes",null,"no",null,"no",null,"no",null,"yes","In house","no","no",null,"no","-"]
["IB5","In vivo study in post-treatment effect of S-7701 in bleomycin-i","efficacy","no",null,null,"no","-","no","-","no","-","no","-","no","-","no","-","yes","Mouse","yes","bleomycin-induced\npulmonary fibrosis","no","no","no","no","no","no","no",null,"no",null,"no",null,"no",null,"yes","In house","no","no",null,"no","-"]
["IB6","Single-agent activity taxane-resistant colon cancer [U05-1888]), ","efficacy","no","-","-","no","-","no","-","no","-","no","-","yes","yes","yes","Nude","yes","Mouse","yes","Xenograft","no","yes","yes","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","yes","-","-","-"]
["IB6","Single-agent activity MLL-rearranged AML cell line [U11-1121-01] ","efficacy","no","-","-","no","-","no","-","no","-","no","-","yes","yes","yes","Nude","yes","Mouse","yes","Xenograft","no","yes","yes","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","-","-","-","-"]
["IB6","Single-agent activity disseminated lymphoma model [U05-2387]. ","efficacy","no","-","-","no","-","no","-","no","-","no","-","yes","yes","yes","Nude","yes","Mouse","yes","Xenograft","no","yes","no","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","-","-","-","-"]
["IB6","Combination therapy NCI-H460 xenograft study ","efficacy","no","-","-","no","-","no","-","no","-","yes","Postive control","no","-","yes","Nude","yes","Mouse","yes","Xenograft","no","?","no","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","-","-","-","-"]
["IB6","Combination therapy TOV-21G ovarian cancer ","efficacy","no","-","-","no","-","no","-","no","-","yes","Postive control","no","-","yes","Nude","yes","Mouse","yes","Xenograft","no","?","no","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","-","-","-","-"]
["IB6","Combination therapy AML xenograft model with cytarabine","efficacy","no","-","-","no","-","no","-","no","-","yes","Postive control","no","-","yes","Nude","yes","Mouse","yes","Xenograft","no","?","no","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","-","-","-","-"]
["IB6","Combination therapy AML xenograft model with decitabine ","efficacy","no","-","-","no","-","no","-","no","-","yes","Postive control","no","-","yes","Nude","yes","Mouse","yes","Xenograft","no","?","no","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","-","-","-","-"]
["IB6","Combination therapy AML xenograft model with azacitidine  ","efficacy","no","-","-","no","-","no","-","no","-","yes","Postive control","no","-","yes","Nude","yes","Mouse","yes","Xenograft","no","?","no","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","-","-","-","-"]
["IB7","Breast cancer","efficacy","no","-","-","no","-","no","-","no","-","no","-","no","-","yes","nude","yes","mice","yes","xenograft","no","yes","no","no","no","no",null,null,"no",null,"yes",null,"no",null,"yes","In house",null,null,null,null,"-"]
["IB7","Ovary","efficacy","no","-","-","no","-","no","-","no","-","no","-","no","-","yes","nude","yes","mice","yes","xenograft","no",null,"no","no","no","no",null,null,"no",null,"yes",null,"no",null,"yes","In house",null,null,null,null,"-"]
["IB7","disseminated model of AML [n00232929-01] ","efficacy","no","-","-","no","-","no","-","no","-","no","-","no","-","yes","nude","yes","mice","yes","xenograft","no",null,"no","no","no","no",null,null,"no",null,"yes",null,"no",null,"yes","In house",null,null,null,null,"-"]
["IB7","disseminated model of AML[P15-\n00294] Rudolph D, et al. Efficacy and mechanism of action of volasertib, a potent\nand selective inhibitor of Polo-like kinases, in preclinical models of acute\nmyeloid leukemia. J Pharmacol Exp Ther. 2015","efficacy","no","-","-","no","-","no","-","no","-","no","-","no","-","yes","nude","yes","mice","yes","xenograft","no",null,"no","no","no","no",null,null,"no",null,"yes",null,"no",null,"yes","Peer reviewed",null,null,null,null,"-"]
["IB7","Single-agent activity for cancers of the colon [U05-1895","efficacy","no","-","-","no","-","no","-","no","-","no","-","yes","yes","yes","Nude","yes","Mouse","yes","Xenograft","no","yes","yes","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","yes","-","-","-"]
["IB7","Single-agent activity pancreas [U05-1897] ","efficacy","no","-","-","no","-","no","-","no","-","no","-","yes","yes","yes","Nude","yes","Mouse","yes","Xenograft","no","yes","yes","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","yes","-","-","-"]
["IB7","Single-agent activity lung (NSCLC) [U05-1887]","efficacy","no","-","-","no","-","no","-","no","-","no","-","yes","yes","yes","Nude","yes","Mouse","yes","Xenograft","no","yes","yes","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","yes","-","-","-"]
["IB7","Single-agent activity taxane-resistant colon cancer [U05-1888]), ","efficacy","no","-","-","no","-","no","-","no","-","no","-","yes","yes","yes","Nude","yes","Mouse","yes","Xenograft","no","yes","yes","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","yes","-","-","-"]
["IB7","Single-agent activity MLL-rearranged AML cell line [U11-1121-01] ","efficacy","no","-","-","no","-","no","-","no","-","no","-","yes","yes","yes","Nude","yes","Mouse","yes","Xenograft","no","yes","yes","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","-","-","-","-"]
["IB7","Single-agent activity disseminated lymphoma model [U05-2387]. ","efficacy","no","-","-","no","-","no","-","no","-","no","-","yes","yes","yes","Nude","yes","Mouse","yes","Xenograft","no","yes","no","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","-","-","-","-"]
["IB7","Combination therapy NCI-H460 xenograft study ","efficacy","no","-","-","no","-","no","-","no","-","yes","Postive control","no","-","yes","Nude","yes","Mouse","yes","Xenograft","no","?","no","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","-","-","-","-"]
["IB7","Combination therapy TOV-21G ovarian cancer ","efficacy","no","-","-","no","-","no","-","no","-","yes","Postive control","no","-","yes","Nude","yes","Mouse","yes","Xenograft","no","?","no","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","-","-","-","-"]
["IB7","Combination therapy AML xenograft model with cytarabine","efficacy","no","-","-","no","-","no","-","no","-","yes","Postive control","no","-","yes","Nude","yes","Mouse","yes","Xenograft","no","?","no","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","-","-","-","-"]
["IB7","Combination therapy AML xenograft model with decitabine ","efficacy","no","-","-","no","-","no","-","no","-","yes","Postive control","no","-","yes","Nude","yes","Mouse","yes","Xenograft","no","?","no","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","-","-","-","-"]
["IB7","Combination therapy AML xenograft model with azacitidine  ","efficacy","no","-","-","no","-","no","-","no","-","yes","Postive control","no","-","yes","Nude","yes","Mouse","yes","Xenograft","no","?","no","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","-","-","-","-"]
["IB8","n00240090-01 Nickolaus P. In-vivo inhibition by BI 113823 TA of LPS-induced\nneutrophil influx into the bronchoalveolar lavage of rats. BI 113823-\nNickolaus- n00240090-01, 09 Febr 2015","efficacy","no",null,null,"no","-","no",null,"no",null,"yes","negative, positive","yes","yes","yes","Wistar","yes","rat","yes","rat lung LPS model.",null,"normalized number of neutrophils in BALF of rats","yes","yes","yes","yes","no",null,"no",null,"no",null,"no",null,"yes","In house","no","yes","75%\ninhibition (vs the untreated LPS positive control group) of neutrophil influx was observed","no","-"]
["IB8","n00240091-01 Nickolaus P. Inhibition by BI 113823 TA of smoke-induced neutrophil\ninflux into the broncho-alveolar lavage fluid (BALF) and smoke-induced\ngoblet cell metaplasia in the airway epithelium of rats. BI 113823-\nNickolaus-n00240091-01, 23 Jan 2015.","efficacy","no",null,null,"no","-","no",null,"no",null,"yes","Negative","yes","yes","yes","Wistar","yes","rat","yes","smoke-induced neutrophil influx","yes","normalized number of neutrophils in BAL\nnormalized number of goblet cells per square mm in the airway epithelium","yes","yes","yes","yes","no",null,"no",null,"no",null,"no",null,"yes","In house","no","yes","Three times daily treatment of the animals with\nBI 113823 TA via gavage in Natrosol/Tween suspension at doses of 3, 10, and 30 mg/kg in\nthis disease related model produced a clear inhibition of the neutrophil influx into the BALF\n(-29, -45 and -37% respectively) and the development of goblet cell metaplasia (-31, -61 and\n-33% respectively).","no"]
["IB9","RCC Study N°\n856131","efficacy","yes",48,null,"no",null,"no",null,"no",null,"yes","Positive","no",null,"no",null,"yes","Rat","no",null,"no",null,null,"no","no","no","no",null,"yes",null,"no",null,"no",null,"yes","In house","no","no",null,null,"-"]
["IB9","(RCC Study N°\n858572)","efficacy","yes",70,null,"no","-","no",null,"no",null,"yes","Positive, Negative","yes","yes","no",null,"yes","Rat","no",null,"no",null,null,"no","no","no","no",null,"yes",null,"no",null,"no",null,"yes","In house","no","no",null,null,"-"]
["IB9","RCC Study N°\nA22263","efficacy","yes",50,null,"no","-","no",null,"no",null,"yes","Negative","yes","yes","yes","Sex, young adult","yes","Rat","yes","Intra-articular Injection of Monosodium Urate: An\nAnimal Model for Knee-Joint Arthritis","yes","yes","yes","yes","yes","yes","?",null,"no","yes","no",null,"no",null,"yes","In house","no","no",null,"no","-"]
["IB9","RCC\nStudy N° A81573","efficacy","yes",48,null,"no","-","no",null,"yes","2 rats died","yes","Negative","yes","yes","no",null,"yes","Rat","yes","Intra-articular Injection of Monosodium Urate: An\nAnimal Model for Knee-Joint Arthritis","yes","yes","yes","yes","yes","no","-",null,null,null,null,null,null,null,"yes","In house","no","no",null,null,"-"]
["IB13","4.2.1 Activity of Cabozantinib in the Transgenic RIP-Tag2 Model System *Figure 4.1a","efficacy","no","-","no","no","-","no",null,"yes","1 death in the treatment group from gavage injury","yes","Negative, positive","no",null,"no",null,"yes","Mice","yes","RIP-Tag2 mouse model of neuroendocrine pancreatic\ncancer that spontaneously develops aggressive tumors","no","no","yes","no","no","no","?",null,"no",null,"no",null,"no",null,"yes","Peer-reviewed","yes","yes","The number of liver metastases was 5-fold\ngreater in anti-VEGF antibody-treated animals compared with vehicle-treated animals,\nand no liver metastases were detected in cabozantinib-treated animals","yes"," P < 0.05"]
["IB13","4.2.1 Activity of Cabozantinib in the Transgenic RIP-Tag2 Model System *Figure 4.1b","efficacy","yes",6,"no","no","-","no",null,"yes","1 death in the treatment group from gavage injury","yes","Negative, positive","no",null,"no",null,"yes","Mice","yes","RIP-Tag2 mouse model of neuroendocrine pancreatic\ncancer that spontaneously develops aggressive tumors","no","no","yes","yes","yes","from age 14 to 17 weeks","?",null,"no",null,"no",null,"no",null,"yes","Peer-reviewed","yes","yes","Median survival was 14.7 weeks for vehicle-treated animals (n = 12) and\n16.4 weeks for anti-VEGF antibody-treated animals (n = 7; P < 0.05 vs vehicle), and all\ncabozantinib-treated animals survived for the full 20 weeks of observation (n = 6;\nP < 0.05 vs vehicle and anti-VEGF antibody;","yes"," P < 0.05"]

{"sheet":"IB1","index":9,"n_rows":5,"n_cols":43,"rows_kept":5,"cut":false,"hidden":true,"merged":[[0,18,0,27],[0,28,2,29],[0,30,0,35],[1,26,1,27],[1,30,1,31],[1,32,1,33],[1,34,1,35],[4,0,19,0],[4,16,19,16],[4,28,19,28],[0,36,0,42],[1,2,1,4],[1,5,1,6],[1,7,1,8],[1,9,1,10],[1,11,1,12],[1,13,1,15],[1,18,1,19],[1,20,1,22],[1,24,1,25],[0,0,2,1],[0,2,0,15],[0,16,2,17],[1,36,1,37],[1,38,1,42],[3,0,3,1],[3,16,3,17],[3,28,3,29]]}
["Efficacy studies",null,"Evaluate in light of threats to internal validity",null,null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to construct validity",null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to external validity",null,null,null,null,null,"Others"]
[null,null,"Sample size",null,null,"Randomisation",null,"Blinded assessment",null,"Exclusion of data from analysis",null,"Controls",null,"Dose reponse \n(RATED ON IB LEVEL)",null,null,null,null,"Baseline characterization",null,"Model choice",null,null,"Mechanistic evidence (RATED ON IB LEVEL)","Outcome choice",null,"Age matched to patients (RATED ON IB LEVEL)",null,null,null,"Replication of experiment",null,"Replication in different model",null,"Replication in different species",null,"References",null,"Inferential statistics"]
[null,null,"Yes or no?","If yes, how many?","Justification?","Yes or no?","If yes, type of randomization","Yes or no?","If yes, when?","Yes or no?","If yes, justification?","Yes or no?","If yes, what type of control?","Yes or no?","If yes, positive reponse reported? ","If no, justification?",null,null,"Yes or no?","If yes, what type?","Reporting of species?","Reporting of model?","Reporting of specifications?","Yes or no?","Yes or no?","If yes, justification?","Yes or no?","Is it matched to patients?",null,null,"Yes or no?","If no, is there other similar study?","Yes or no?","If yes, model type?","Yes or no?","If yes, species type?","Yes or no?","If yes, what type of references","Yes or no?","Is effect size reported?","Effect size value?","Is it significant or not?","Significant value?"]
["Coding criteria",null,null,null,null,null,"Group Designation, Cage Randomization,\nPermanent Designation, Randomization to Treatment","Coding of animals, aims and groups of treatments investigated ",null,"Statement of animal flow, number of deaths.",null,null,"Positive control, negative control, sham, comparator arm","Minimum of 3 different doses, statement of dose reponse",null,null,"Coding criteria",null,"Sex, age, immune status, weight, microbial status of the animal","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","Mouse, rat, dog, monkey, etc.","Induced (or Experimental), spontaneous (xenograft, orthotopic), transgenic, type of disease","Tumor size, etc.","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","(DIFFERENTIATE BETWEEN METRICS AND TIMING?) Endpoints, type of measurement (survival, tumor shrinkage, etc), timing of measurement, mean survival ","(NEEDED?)","Is age of animals mentioned?","Check inclusion criteria of patients","Coding criteria",null,"Is it the same model?Is it the same drug? Is it measuring the same outcome?",null,"Is it the same species?","Different disease type, different route administration, different dosage form ",null,null,null,"Peer-reviewed, in house data"]
["IB1","No efficacy study",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB1",null,null,null,null,null,null,null,null,null,null,null,"IB1"]

{"sheet":"IB2","index":10,"n_rows":15,"n_cols":49,"rows_kept":15,"cut":false,"hidden":true,"merged":[[1,41,1,42],[1,43,1,48],[3,0,3,1],[3,17,3,18],[3,33,3,34],[0,0,2,1],[0,35,0,40],[1,31,1,32],[1,35,1,36],[1,37,1,38],[1,39,1,40],[4,17,19,17],[4,33,19,33],[0,41,0,48],[1,3,1,5],[1,6,1,7],[1,8,1,9],[1,10,1,11],[1,12,1,13],[1,14,1,16],[1,19,1,20],[1,21,1,25],[1,28,1,30],[0,3,0,16],[0,17,2,18],[0,19,0,32],[0,33,2,34]]}
["Efficacy studies",null,null,"Evaluate in light of threats to internal validity",null,null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to construct validity",null,null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to external validity",null,null,null,null,null,"Others"]
[null,null,null,"Sample size",null,null,"Randomisation",null,"Blinded assessment",null,"Exclusion of data from analysis",null,"Controls",null,"Dose reponse \n(RATED ON IB LEVEL)",null,null,null,null,"Baseline characterization",null,"Model choice",null,null,null,null,null,"Mechanistic evidence (RATED ON IB LEVEL)","Outcome choice",null,null,"Age matched to patients (RATED ON IB LEVEL)",null,null,null,"Replication of experiment",null,"Replication in different model",null,"Replication in different species",null,"References",null,"Inferential statistics"]
[null,null,null,"Yes or no?","If yes, how many?","Justification?","Yes or no?","If yes, type of randomization","Yes or no?","If yes, when?","Yes or no?","If yes, justification?","Yes or no?","If yes, what type of control?","Yes or no?","If yes, positive reponse reported? ","If no, justification?",null,null,"Yes or no?","If yes, what type?","Reporting of species?",null,"Reporting of model?",null,"Reporting of specifications?",null,"Yes or no?","Metric\nYes or no?","Timing\nYes or no?","Full reporting of outcome choice, Y or N","Yes or no?","Is it matched to patients?",null,null,"Yes or no?","If no, is there other similar study?","Yes or no?","If yes, model type?","Yes or no?","If yes, species type?","Yes or no? If there is internal study number, citation, … then it is a yes","If yes, what type of references","Yes or no?","Is effect size reported?","Effect size value?","Is  significant value reported?","Was the investigation positive, inconclusive or negative?","Significant value?"]
["Coding criteria",null,"Efficacy , Yes, no or unclear",null,null,null,null,"Group Designation, Cage Randomization,\nPermanent Designation, Randomization to Treatment","Coding of animals, aims and groups of treatments investigated ",null,"Statement of animal flow, number of deaths.",null,null,"Positive control, negative control, sham, comparator arm","Minimum of 3 different doses, statement of dose reponse",null,null,"Coding criteria",null,"Sex, age, immune status, weight, microbial status of the animal","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","Mouse, rat, dog, monkey, etc.",null,"Induced (or Experimental), spontaneous (xenograft, orthotopic), transgenic, type of disease",null,"Tumor size, etc.",null,"(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","(DIFFERENTIATE BETWEEN METRICS AND TIMING?) Endpoints, type of measurement (survival, tumor shrinkage, etc), timing of measurement, mean survival ",null,"(NEEDED?)","Is age of animals mentioned?","Check inclusion criteria of patients","Coding criteria",null,"Is it the same model?Is it the same drug? Is it measuring the same outcome?",null,"Is it the same species?","Different disease type, different route administration, different dosage form ",null,null,null,"Peer-reviewed, in house data",null,null,null,null,"if p value significant, then it is positive"]
["IB2","MC38.OVA Colorectal model in C57BL6 mice",null,"No","-","-","No","-","No","-","No","-","Yes","Positive control","No","-","No","IB2","MC38.OVA Colorectal model in C57BL6 mice","No","-","Yes",null,"Yes",null,"Yes",null,"Yes","Yes","Yes","Yes","No","-","IB2","MC38.OVA Colorectal model in C57BL6 mice","No","No","Yes","Different disease type","No","-","Yes","In house","No","Yes","118%, 116%, 119% tumor growth inhibition","No",null,"-"]
[null,"MC38 Colorectal model in C57BL6 mice",null,"No","-","-","No","-","No","-","No","-","Yes","Positive control","No","-","No",null,"MC38 Colorectal model in C57BL6 mice","No","-","Yes",null,"Yes",null,"Yes",null,"Yes","Yes","Yes","Yes","No","-",null,"MC38 Colorectal model in C57BL6 mice","No","No","Yes","Different disease type","No","-","Yes","In house","No","Yes","76%, 98%,103% tumor growth inhibition","No",null,"-"]
[null,"CT26 colorecteal model in BALB/c mice",null,"No","-","-","No","-","No","-","No","-","Yes","Positive control","No","-","No",null,"CT26 colorecteal model in BALB/c mice","No","-","Yes",null,"Yes",null,"Yes",null,"Yes","Yes","Yes","Yes","No","-",null,"CT26 colorecteal model in BALB/c mice","No","No","Yes","Different disease type","No","-","Yes","In house","No","Yes","92% tumor growth inhibition","No",null,"-"]
[null,"Cloudman S91 melanoma model in DBA/2 mice",null,"No","-","-","No","-","No","-","No","-","Yes","Positive control","No","-","No",null,"Cloudman S91 melanoma model in DBA/2 mice","No","-","Yes",null,"Yes",null,"Yes",null,"Yes","Yes",null,"Yes","No","-",null,"Cloudman S91 melanoma model in DBA/2 mice","No","No","Yes","Different disease type","No","-","Yes","In house","No","Yes","78% tumor growth inhibition","No",null,"-"]
[null,"Evaluation of the Immune Response to Lymphocytic",null,"No","-","-","No","-","No","-","No","-","No","-","No","-","No",null,"Evaluation of the Immune Response to Lymphocytic","No","-","Yes",null,"Yes",null,"No",null,"Yes","Yes","Yes","Yes","No","-",null,"Evaluation of the Immune Response to Lymphocytic","No","No","Yes","Diffent clone strain","No","-","Yes","In house"]
[null,"Testing Different Anti−PD-L1 Antibodies and Times of",null,"No","-","-","No","-","No","-","No","-","No","-","No","-","No",null,"Testing Different Anti−PD-L1 Antibodies and Times of","No","-","Yes",null,"Yes",null,"No",null,"Yes","Yes","Yes","Yes","No","-",null,"Testing Different Anti−PD-L1 Antibodies and Times of","No","No","Yes","Diffent clone strain","No","-","Yes","In house"]
[null,"Evaluation of Anti−PD-L1 Antibody Dose Response in",null,"No","-","-","No","-","No","-","No","-","No","-","Yes","Yes","-",null,"Evaluation of Anti−PD-L1 Antibody Dose Response in","No","-","Yes",null,"Yes",null,"No",null,"Yes","Yes","Yes","Yes","No","-",null,"Evaluation of Anti−PD-L1 Antibody Dose Response in","No","No","Yes","Diffent clone strain","No","-","Yes","In house"]
[null,"Evaluation of the Host Response to Armstrong and CL-13",null,"No","-","-","No","-","No","-","No","-","No","-","No","-","No",null,"Evaluation of the Host Response to Armstrong and CL-13","No","-","Yes",null,"Yes",null,"No",null,"Yes","No","Yes","Yes","No","-",null,"Evaluation of the Host Response to Armstrong and CL-13","No","No","Yes","Diffent clone strain","No","-","Yes","In house"]
[null,"Single Dose of Anti−PD-L1 Antibody at Different Times during In",null,"No","-","-","No","-","No","-","No","-","No","-","No","-","No",null,"Single Dose of Anti−PD-L1 Antibody at Different Times during In","No","-","Yes",null,"Yes",null,"No",null,"No","Yes","Yes","Yes","No","No",null,"Single Dose of Anti−PD-L1 Antibody at Different Times during In","No","No","Yes","Diffent clone strain","No",null,"Yes","In house"]
[null,"Studies to Address Mechanism of Anti−PD-L1 Enhanced",null,"No","-","-","No","-","No","-","No","-","No","-","No","-","No",null,"Studies to Address Mechanism of Anti−PD-L1 Enhanced","No","-","Yes",null,"Yes",null,"No",null,"Yes","Yes","Yes","Yes","No","No",null,"Studies to Address Mechanism of Anti−PD-L1 Enhanced","No","No","Yes","Diffent clone strain","No",null,"Yes","In house"]
[null,"Evaluation of the Combined Effects of Adenovirus",null,"No","-","-","No","-","No","-","No","-","No","-","No","-","No",null,"Evaluation of the Combined Effects of Adenovirus","No","-","Yes",null,"Yes",null,"No",null,"Yes","Yes","Yes","Yes","No","No",null,"Evaluation of the Combined Effects of Adenovirus","No","No","Yes","Diffent clone strain","No",null,"Yes","In house"]

{"sheet":"IB3","index":11,"n_rows":6,"n_cols":47,"rows_kept":6,"cut":false,"hidden":true,"merged":[[1,36,1,37],[1,38,1,39],[0,40,0,46],[1,34,1,35],[0,0,2,1],[1,40,1,41],[0,2,0,15],[1,42,1,46],[0,18,0,31],[0,34,0,39],[1,2,1,4],[1,9,1,10],[1,13,1,15],[1,18,1,19],[0,32,2,33],[0,16,2,17],[3,16,3,17],[1,20,1,24],[3,0,3,1],[3,32,3,33],[1,5,1,6],[1,7,1,8],[1,11,1,12],[1,27,1,29],[1,30,1,31]]}
["Efficacy studies",null,"Evaluate in light of threats to internal validity",null,null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to construct validity",null,null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to external validity",null,null,null,null,null,"Others"]
[null,null,"Sample size",null,null,"Randomisation",null,"Blinded assessment",null,"Exclusion of data from analysis",null,"Controls",null,"Dose reponse \n(RATED ON IB LEVEL)",null,null,null,null,"Baseline characterization",null,"Model choice",null,null,null,null,null,"Mechanistic evidence (RATED ON IB LEVEL)","Outcome choice",null,null,"Age matched to patients (RATED ON IB LEVEL)",null,null,null,"Replication of experiment",null,"Replication in different model",null,"Replication in different species",null,"References",null,"Inferential statistics"]
[null,null,"Yes or no?","If yes, how many?","Justification?","Yes or no?","If yes, type of randomization","Yes or no?","If yes, when?","Yes or no?","If yes, justification?","Yes or no?","If yes, what type of control?","Yes or no?","If yes, positive reponse reported? ","If no, justification?",null,null,"Yes or no?","If yes, what type?","Reporting of species?","If yes, what type?","Reporting of model?","If yes, what type","Reporting of specifications?",null,"Yes or no?","Yes or no?",null,"If yes, justification?","Yes or no?","Is it matched to patients?",null,null,"Yes or no?","If no, is there other similar study?","Yes or no?","If yes, model type?","Yes or no?","If yes, species type?","Yes or no?","If yes, what type of references","Yes or no?","Is effect size reported?","Effect size - postive or not?","Is it significant or not?","Significant value?"]
["Coding criteria",null,null,null,null,null,"Group Designation, Cage Randomization,\nPermanent Designation, Randomization to Treatment","Coding of animals, aims and groups of treatments investigated ",null,"Statement of animal flow, number of deaths.",null,null,"Positive control, negative control, sham, comparator arm","Minimum of 3 different doses, statement of dose reponse",null,null,"Coding criteria",null,"Sex, age, immune status, weight, microbial status of the animal","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","Mouse, rat, dog, monkey, etc.",null,"Induced (or Experimental), spontaneous (xenograft, orthotopic), transgenic, type of disease",null,"Tumor size, etc.",null,"(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","(DIFFERENTIATE BETWEEN METRICS AND TIMING?) Endpoints, type of measurement (survival, tumor shrinkage, etc), timing of measurement, mean survival ",null,"(NEEDED?)","Is age of animals mentioned?","Check inclusion criteria of patients","Coding criteria",null,"Is it the same model?Is it the same drug? Is it measuring the same outcome?",null,"Is it the same species?","Different disease type, different route administration, different dosage form ",null,null,null,"Peer-reviewed, in house data",null,null,"Only if significant effect reported "]
["IB3","Tail tip bleeding","No","-","-","No","-","No","-","No","-","Yes","Positive control, negative control","No","-","-","IB3","Tail tip bleeding","Yes","Bodyweight","Yes","Mouse","Yes","Tail tip bleeding","Yes",null,"yes","Yes","Yes","Yes","No","-","IB3","Tail tip bleeding","No","No","No","No","No","No","No","-","Yes","Yes","22 mg/g BW","Yes","p = 0.0018"]
[null,"Carotid Occlusion Model ","Yes",12,"No","No","-","No","-","No","-","Yes","Positive control, negative control","No","-","-",null,"Carotid Occlusion Model ","Yes","Sex","Yes","Mouse","Yes","Carotid Occlusion Model ","Yes",null,"Yes","Yes","Yes","Yes","No","-",null,"Carotid Occlusion Model ","No","No","No","No","No","No","No","-","Yes","Yes","6.0 min","Yes","p < 0.0001"]

{"sheet":"IB4","index":12,"n_rows":20,"n_cols":47,"rows_kept":20,"cut":false,"hidden":true,"merged":[[15,0,29,0],[15,15,29,15],[15,31,29,31],[1,39,1,40],[1,41,1,45],[2,26,2,27],[3,0,3,1],[3,15,3,16],[3,31,3,32],[0,0,2,1],[1,33,1,34],[1,35,1,36],[1,37,1,38],[0,39,0,45],[1,2,1,3],[1,4,1,5],[0,2,0,14],[0,15,2,16],[0,17,0,30],[1,6,1,7],[1,8,1,9],[1,10,1,11],[1,12,1,14],[1,17,1,18],[0,31,2,32],[0,33,0,38],[1,29,1,30],[1,19,1,23],[1,26,1,28]]}
["Efficacy studies",null,"Evaluate in light of threats to internal validity",null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to construct validity",null,null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to external validity",null,null,null,null,null,"Others"]
[null,null,"Sample size",null,"Randomisation",null,"Blinded assessment",null,"Exclusion of data from analysis",null,"Controls",null,"Dose reponse \n(RATED ON IB LEVEL)",null,null,null,null,"Baseline characterization",null,"Model choice",null,null,null,null,null,"Mechanistic evidence (RATED ON IB LEVEL)","Outcome choice",null,null,"Age matched to patients (RATED ON IB LEVEL)",null,null,null,"Replication of experiment",null,"Replication in different model",null,"Replication in different species",null,"References",null,"Inferential statistics"]
[null,null,"Yes or no?","If yes, how many?","Yes or no?","If yes, type of randomization","Yes or no?","If yes, when?","Yes or no?","If yes, justification?","Yes or no?","If yes, what type of control?","Yes or no?","If yes, positive reponse reported? ","If no, justification?",null,null,"Yes or no?","If yes, what type?","Reporting of species?",null,"Reporting of model?",null,"Reporting of specifications?",null,"Yes or no?","Reporting of temporal metric (measurement of endpoint and timing)",null,"Full reporting of outcome choice, yes or no?","Yes or no?","Is it matched to patients?",null,null,"Yes or no?","If no, is there other similar study?","Yes or no?","If yes, model type?","Yes or no?","If yes, species type?","Yes or no?","If yes, what type of references","Yes or no?","Is effect size reported? Y or N","Effect size value?","Is it significant value reported or not","Significant value?","Variance? SD, SE, CI"]
["Coding criteria",null,null,null,null,"Group Designation, Cage Randomization,\nPermanent Designation, Randomization to Treatment","Coding of animals, aims and groups of treatments investigated ",null,"Statement of animal flow, number of deaths, if it is reported that no exclusion was performed, then it is a yes.",null,null,"Positive control, negative control, sham, comparator arm","Minimum of 3 different doses, statement of dose reponse",null,null,"Coding criteria",null,"Sex, age, immune status, weight, microbial status of the animal","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","Mouse, rat, dog, monkey, etc.",null,"Induced (or Experimental), spontaneous (xenograft, orthotopic), transgenic, type of disease",null,"Tumor size, etc.",null,"(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","METRICS Endpoints, type of measurement (survival, tumor shrinkage, etc),  mean survival ","TIMING \n(timing of measurement)","An outcome is considered to be fully reported if the metrics and timing is provided","Is age of animals mentioned?","Check inclusion criteria of patients","Coding criteria",null,"Is it the same model?Is it the same drug? Is it measuring the same outcome?",null,"Is it the same species?","Different disease type, different route administration, different dosage form ",null,null,null,"Peer-reviewed, in house data"]
[null,"Murine medulloblastoma allografts 09-2968","No",null,"No",null,"No",null,"No",null,"No",null,"Yes",null,null,null,null,"No",null,"Yes","Mouse","Yes","Xenograft","Tumors were allowed to \ngrow to a range of 100−500 mm\n3",null,"Yes","Yes","Yes","Yes",null,null,null,null,"No",null,"Yes",null,"No",null,null,null,null,null,null,null,"-"]
["done","Murine basal cell carcinoma allografts","yes","4-6 mice, 9 groups","no",null,"no",null,"no",null,"yes","negative","yes","yes",null,null,null,"no",null,"yes","mice","yes","allograft","yes, ",null,null,"yes","yes","yes",null,null,null,null,"no",null,"no",null,"no",null,"yes","in house","no",null,null,null,"-"]
["done","D5123-05-04","no",null,"no",null,"no",null,"no",null,"yes","negative","yes","yes",null,null,null,"no",null,"yes","mice","yes","xenograft","yes",null,"yes","yes","yes","yes","no",null,null,null,"no",null,"yes",null,"no",null,"yes","in house","yes",null,null,"yes","p 0,041"]
["done","DOD15077-05-D","no",null,"no",null,"no",null,"no",null,"no",null,"no",null,null,null,null,"no",null,"no",null,"yes","xenograft","no",null,null,"yes","no","no",null,null,null,null,"no",null,"yes",null,"no",null,"yes","in house","yes","no",null,"yes","p 0,004"]
["done","OD14848m-05-A","no",null,"no",null,"no",null,"no",null,"no",null,"no",null,null,null,null,"no",null,"no",null,"yes","xenograft","no",null,null,"yes","no","no",null,null,null,null,"no",null,"yes",null,"no",null,"yes","in house","yes","no",null,"yes","p 0,041"]
[null,"1041806-05-B","no",null,"no",null,"no",null,"no",null,"no",null,"no",null,null,null,null,"no",null,"no",null,"yes","xenograft","no",null,null,"yes","no","no",null,null,null,null,"no",null,"yes",null,"no",null,"yes","in house","yes","no",null,"yes","p 0,004"]
[null,"1050304-05A","no",null,"no",null,"no",null,"no",null,"no",null,"no",null,null,null,null,"no",null,"no",null,"yes","xenograft","no",null,null,"yes","no","no",null,null,null,null,"no",null,"yes",null,"no",null,"yes","in house","yes","no",null,"yes","p 0,007"]
[null,"D5124-06-02","no",null,"no",null,"no",null,"no",null,"no",null,"no",null,null,null,null,"no",null,"no",null,"yes","xenograft","no",null,null,"yes","no","no",null,null,null,null,"no",null,"yes",null,"no",null,"yes","in house","yes","no",null,"yes","p 0,022"]
[null,"1051178-05-A","no",null,"no",null,"no",null,"no",null,"no",null,"no",null,null,null,null,"no",null,"no",null,"yes","xenograft","no",null,null,"yes","no","no",null,null,null,null,"no",null,"yes",null,"no",null,"yes","in house","yes","no",null,"yes","p <0,001"]
[null,"Dose escalation of Vismodegib vs subcu murine medulloblastoma 09-2968","yes","5-7 size per group, 9 groups","no",null,"no",null,"no",null,"yes","negative","yes","yes",null,null,null,"no",null,"yes","murine","yes","xenograft","Tumors were allowed to \ngrow to a range of 100−500 mm\n3",null,null,"yes","yes","yes","no","-",null,null,"no",null,"no",null,"no",null,"yes","in hiouse","no","no",null,"no","-"]
[null,"PK/PD of vismodegib in a subcu murine medulloblastoma allograft",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,"please see carol rating. Wc didn’t acess the appendix",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]

{"sheet":"IB5","index":13,"n_rows":6,"n_cols":47,"rows_kept":6,"cut":false,"hidden":true,"merged":[[1,39,1,40],[1,41,1,45],[2,26,2,27],[3,0,3,1],[3,16,3,17],[3,31,3,32],[0,0,2,1],[1,33,1,34],[1,35,1,36],[1,37,1,38],[0,39,0,45],[1,2,1,4],[1,5,1,6],[0,2,0,15],[0,16,2,17],[0,18,0,30],[1,7,1,8],[1,9,1,10],[1,11,1,12],[1,13,1,15],[1,18,1,19],[0,31,2,32],[0,33,0,38],[1,29,1,30],[1,20,1,24],[1,26,1,28]]}
["Efficacy studies",null,"Evaluate in light of threats to internal validity",null,null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to construct validity",null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to external validity",null,null,null,null,null,"Others"]
[null,null,"Sample size",null,null,"Randomisation",null,"Blinded assessment",null,"Exclusion of data from analysis",null,"Controls",null,"Dose reponse \n(RATED ON IB LEVEL)",null,null,null,null,"Baseline characterization",null,"Model choice",null,null,null,null,"Mechanistic evidence (RATED ON IB LEVEL)","Outcome choice",null,null,"Age matched to patients (RATED ON IB LEVEL)",null,null,null,"Replication of experiment",null,"Replication in different model",null,"Replication in different species",null,"References",null,"Inferential statistics"]
[null,null,"Yes or no?","If yes, how many?","Justification?","Yes or no?","If yes, type of randomization","Yes or no?","If yes, when?","Yes or no?","If yes, justification?","Yes or no?","If yes, what type of control?","Yes or no?","If yes, positive reponse reported? ","If no, justification?",null,null,"Yes or no?","If yes, what type?","Reporting of species?",null,"Reporting of model?",null,"Reporting of specifications?","Yes or no?","Reporting of temporal metric (measurement of endpoint and timing)",null,"Full reporting of outcome choice, yes or no?","Yes or no?","Is it matched to patients?",null,null,"Yes or no?","If no, is there other similar study?","Yes or no?","If yes, model type?","Yes or no?","If yes, species type?","Yes or no?","If yes, what type of references","Yes or no?","Is effect size reported? Y or N","Effect size value?","Is it significant value reported or not","Significant value?","Variance? SD, SE, CI"]
["Coding criteria",null,null,null,null,null,"Group Designation, Cage Randomization,\nPermanent Designation, Randomization to Treatment","Coding of animals, aims and groups of treatments investigated ",null,"Statement of animal flow, number of deaths, if it is reported that no exclusion was performed, then it is a yes.",null,null,"Positive control, negative control, sham, comparator arm","Minimum of 3 different doses, statement of dose reponse",null,null,"Coding criteria",null,"Sex, age, immune status, weight, microbial status of the animal","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","Mouse, rat, dog, monkey, etc.",null,"Induced (or Experimental), spontaneous (xenograft, orthotopic), transgenic, type of disease",null,"Tumor size, etc.","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","METRICS Endpoints, type of measurement (survival, tumor shrinkage, etc),  mean survival ","TIMING \n(timing of measurement)","An outcome is considered to be fully reported if the metrics and timing is provided","Is age of animals mentioned?","Check inclusion criteria of patients","Coding criteria",null,"Is it the same model?Is it the same drug? Is it measuring the same outcome?",null,"Is it the same species?","Different disease type, different route administration, different dosage form ",null,null,null,"Peer-reviewed, in house data"]
[null,"Therapeutic method for inhibition & dissolution of fibrosis-dog","No",null,null,"No",null,"No",null,"No",null,"No",null,"No",null,null,null,null,"No",null,"Yes","Dog","Yes","Fibrosis model","No","No","No","No","No","Yes","Yes",null,null,"No",null,"No",null,"No",null,"Yes","In house","No","No",null,"No","-"]
[null,"In vivo study in post-treatment effect of S-7701 in bleomycin-i","No",null,null,"No",null,"No",null,"No",null,"No",null,"No",null,null,null,null,"No",null,"Yes","Mouse","Yes","bleomycin-induced\npulmonary fibrosis","No","No","No","No","No","No","No",null,null,"No",null,"No",null,"No",null,"Yes","In house","No","No",null,"No","-"]

{"sheet":"IB6","index":14,"n_rows":15,"n_cols":47,"rows_kept":15,"cut":false,"hidden":true,"merged":[[3,31,3,32],[1,5,1,6],[1,7,1,8],[1,11,1,12],[1,26,1,28],[1,29,1,30],[0,31,2,32],[10,0,24,0],[0,16,2,17],[3,16,3,17],[1,20,1,24],[3,0,3,1],[1,2,1,4],[1,9,1,10],[1,13,1,15],[1,18,1,19],[1,35,1,36],[1,37,1,38],[0,39,0,45],[1,33,1,34],[0,0,2,1],[1,39,1,40],[0,2,0,15],[1,41,1,45],[0,18,0,30],[0,33,0,38],[2,26,2,27]]}
["Efficacy studies",null,"Evaluate in light of threats to internal validity",null,null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to construct validity",null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to external validity",null,null,null,null,null,"Others"]
[null,null,"Sample size",null,null,"Randomisation",null,"Blinded assessment",null,"Exclusion of data from analysis",null,"Controls",null,"Dose reponse \n(RATED ON IB LEVEL)",null,null,null,null,"Baseline characterization",null,"Model choice",null,null,null,null,"Mechanistic evidence (RATED ON IB LEVEL)","Outcome choice",null,null,"Age matched to patients (RATED ON IB LEVEL)",null,null,null,"Replication of experiment",null,"Replication in different model",null,"Replication in different species",null,"References",null,"Inferential statistics"]
[null,null,"Yes or no?","If yes, how many?","Justification?","Yes or no?","If yes, type of randomization","Yes or no?","If yes, when?","Yes or no?","If yes, justification?","Yes or no?","If yes, what type of control?","Yes or no?","If yes, positive reponse reported? ","If no, justification?",null,null,"Yes or no?","If yes, what type?","Reporting of species?",null,"Reporting of model?",null,"Reporting of specifications?","Yes or no?","Reporting of temporal metric (measurement of endpoint and timing)",null,"Full reporting of outcome choice, yes or no?","Yes or no?","Is it matched to patients?",null,null,"Yes or no?","If no, is there other similar study?","Yes or no?","If yes, model type?","Yes or no?","If yes, species type?","Yes or no?","If yes, what type of references","Yes or no?","Is effect size reported? Y or N","Effect size value?","Is it significant value reported or not","Significant value?","Variance? SD, SE, CI"]
["Coding criteria",null,null,null,null,null,"Group Designation, Cage Randomization,\nPermanent Designation, Randomization to Treatment","Coding of animals, aims and groups of treatments investigated ",null,"Statement of animal flow, number of deaths, if it is reported that no exclusion was performed, then it is a yes.",null,null,"Positive control, negative control, sham, comparator arm","Minimum of 3 different doses, statement of dose reponse",null,null,"Coding criteria",null,"Sex, age, immune status, weight, microbial status of the animal","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","Mouse, rat, dog, monkey, etc.",null,"Induced (or Experimental), spontaneous (xenograft, orthotopic), transgenic, type of disease",null,"Tumor size, etc.","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","METRICS Endpoints, type of measurement (survival, tumor shrinkage, etc),  mean survival ","TIMING \n(timing of measurement)","An outcome is considered to be fully reported if the metrics and timing is provided","Is age of animals mentioned?","Check inclusion criteria of patients","Coding criteria",null,"Is it the same model?Is it the same drug? Is it measuring the same outcome?",null,"Is it the same species?","Different disease type, different route administration, different dosage form ",null,null,null,"Peer-reviewed, in house data"]
[null,"Single-agent activity for cancers of the colon [U05-1895","No","-","-","No","-","No","-","No","-","No","-","Yes","Yes","NA",null,null,"No","Nude","Yes","Mouse","Yes","Xenograft","No","Yes","Yes","No","No","No","-",null,null,"No","Yes","Yes","Xenograft","No","-","Yes","In house","No","Yes","-","-","-"]
[null,"Single-agent activity pancreas [U05-1897] ","No","-","-","No","-","No","-","No","-","No","-","Yes","Yes","NA",null,null,"No","Nude","Yes","Mouse","Yes","Xenograft","No","Yes","Yes","No","No","No","-",null,null,"No","Yes","Yes","Xenograft","No","-","Yes","In house","No","Yes","-","-","-"]
[null,"Single-agent activity lung (NSCLC) [U05-1887]","No","-","-","No","-","No","-","No","-","No","-","Yes","Yes","NA",null,null,"No","Nude","Yes","Mouse","Yes","Xenograft","No","Yes","Yes","No","No","No","-",null,null,"No","Yes","Yes","Xenograft","No","-","Yes","In house","No","Yes","-","-","-"]
[null,"Single-agent activity taxane-resistant colon cancer [U05-1888]), ","No","-","-","No","-","No","-","No","-","No","-","Yes","Yes","NA",null,null,"No","Nude","Yes","Mouse","Yes","Xenograft","No","Yes","Yes","No","No","No","-",null,null,"No","Yes","Yes","Xenograft","No","-","Yes","In house","No","Yes","-","-","-"]
[null,"Single-agent activity MLL-rearranged AML cell line [U11-1121-01] ","No","-","-","No","-","No","-","No","-","No","-","Yes","Yes","NA",null,null,"No","Nude","Yes","Mouse","Yes","Xenograft","No","Yes","Yes","No","No","No","-",null,null,"No","Yes","Yes","Xenograft","No","-","Yes","In house","No","-","-","-","-"]
[null,"Single-agent activity disseminated lymphoma model [U05-2387]. ","No","-","-","No","-","No","-","No","-","No","-","Yes","Yes","NA",null,null,"No","Nude","Yes","Mouse","Yes","Xenograft","No","Yes","Yes","No","No","No","-",null,null,"No","Yes","Yes","Xenograft","No","-","Yes","In house","No","-","-","-","-"]
[null,"Combination therapy NCI-H460 xenograft study ","No","-","-","No","-","No","-","No","-","Yes","Postive control","No","-","NA",null,"Combination therapy NCI-H460 xenograft study ","No","Nude","Yes","Mouse","Yes","Xenograft","No","?","Yes","No","No","No","-",null,"Combination therapy NCI-H460 xenograft study ","No","Yes","Yes","Xenograft","No","-","Yes","In house","No","-","-","-","-"]
[null,"Combination therapy TOV-21G ovarian cancer ","No","-","-","No","-","No","-","No","-","Yes","Postive control","No","-","NA",null,"Combination therapy TOV-21G ovarian cancer ","No","Nude","Yes","Mouse","Yes","Xenograft","No","?","Yes","No","No","No","-",null,"Combination therapy TOV-21G ovarian cancer ","No","Yes","Yes","Xenograft","No","-","Yes","In house","No","-","-","-","-"]
[null,"Combination therapy AML xenograft model with cytarabine","No","-","-","No","-","No","-","No","-","Yes","Postive control","No","-","NA",null,"Combination therapy AML xenograft model with cytarabine","No","Nude","Yes","Mouse","Yes","Xenograft","No","?","Yes","No","No","No","-",null,"Combination therapy AML xenograft model with cytarabine","No","Yes","Yes","Xenograft","No","-","Yes","In house","No","-","-","-","-"]
[null,"Combination therapy AML xenograft model with decitabine ","No","-","-","No","-","No","-","No","-","Yes","Postive control","No","-","NA",null,"Combination therapy AML xenograft model with decitabine ","No","Nude","Yes","Mouse","Yes","Xenograft","No","?","Yes","No","No","No","-",null,"Combination therapy AML xenograft model with decitabine ","No","Yes","Yes","Xenograft","No","-","Yes","In house","No","-","-","-","-"]
[null,"Combination therapy AML xenograft model with azacitidine  ","No","-","-","No","-","No","-","No","-","Yes","Postive control","No","-","NA",null,"Combination therapy AML xenograft model with azacitidine  ","No","Nude","Yes","Mouse","Yes","Xenograft","No","?","Yes","No","No","No","-",null,"Combination therapy AML xenograft model with azacitidine  ","No","Yes","Yes","Xenograft","No","-","Yes","In house","No","-","-","-","-"]

{"sheet":"IB7","index":15,"n_rows":15,"n_cols":47,"rows_kept":15,"cut":false,"hidden":true,"merged":[[10,0,24,0],[10,16,24,16],[10,31,24,31],[1,39,1,40],[1,41,1,45],[2,26,2,27],[3,0,3,1],[3,16,3,17],[3,31,3,32],[0,0,2,1],[1,33,1,34],[1,35,1,36],[1,37,1,38],[0,39,0,45],[1,2,1,4],[1,5,1,6],[0,2,0,15],[0,16,2,17],[0,18,0,30],[1,7,1,8],[1,9,1,10],[1,11,1,12],[1,13,1,15],[1,18,1,19],[0,31,2,32],[0,33,0,38],[1,29,1,30],[1,20,1,24],[1,26,1,28]]}
["Efficacy studies",null,"Evaluate in light of threats to internal validity",null,null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to construct validity",null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to external validity",null,null,null,null,null,"Others"]
[null,null,"Sample size",null,null,"Randomisation",null,"Blinded assessment",null,"Exclusion of data from analysis",null,"Controls",null,"Dose reponse \n(RATED ON IB LEVEL)",null,null,null,null,"Baseline characterization",null,"Model choice",null,null,null,null,"Mechanistic evidence (RATED ON IB LEVEL)","Outcome choice",null,null,"Age matched to patients (RATED ON IB LEVEL)",null,null,null,"Replication of experiment",null,"Replication in different model",null,"Replication in different species",null,"References",null,"Inferential statistics"]
[null,null,"Yes or no?","If yes, how many?","Justification?","Yes or no?","If yes, type of randomization","Yes or no?","If yes, when?","Yes or no?","If yes, justification?","Yes or no?","If yes, what type of control?","Yes or no?","If yes, positive reponse reported? ","If no, justification?",null,null,"Yes or no?","If yes, what type?","Is there reporting of species?","If yes, what species?","Is there reporting of model?","If yes, what model?","Reporting of specifications?","Yes or no?","Reporting of temporal metric (measurement of endpoint and timing)",null,"Full reporting of outcome choice, yes or no?","Yes or no?","Is it matched to patients?",null,null,"Yes or no?","If no, is there other similar study?","Yes or no?","If yes, model type?","Yes or no?","If yes, species type?","Yes or no?","If yes, what type of references","Yes or no?","Is effect size reported? Y or N","Effect size value?","Is it significant value reported or not","Significant value?","Variance? SD, SE, CI"]
["Coding criteria",null,null,null,null,null,"Group Designation, Cage Randomization,\nPermanent Designation, Randomization to Treatment","Coding of animals, aims and groups of treatments investigated ",null,"Statement of animal flow, number of deaths, if it is reported that no exclusion was performed, then it is a yes.",null,null,"Positive control, negative control, sham, comparator arm","Minimum of 3 different doses, statement of dose reponse",null,null,"Coding criteria",null,"Sex, age, immune status, weight, microbial status of the animal","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","Mouse, rat, dog, monkey, etc.",null,"Induced (or Experimental), spontaneous (xenograft, orthotopic), transgenic, type of disease",null,"Tumor size, etc.","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","METRICS Endpoints, type of measurement (survival, tumor shrinkage, etc),  mean survival ","TIMING \n(timing of measurement)","An outcome is considered to be fully reported if the metrics and timing is provided","Is age of animals mentioned?","Check inclusion criteria of patients","Coding criteria",null,"Is it the same model?Is it the same drug? Is it measuring the same outcome?",null,"Is it the same species?","Different disease type, different route administration, different dosage form ",null,null,null,"Peer-reviewed, in house data"]
[null,"Breast cancer","No",null,null,"No",null,"No",null,"No",null,"No",null,"No",null,null,null,null,"yes","nude","yes","mice","yes","xenograft","no","yes","no","no","no","no",null,null,null,"no",null,"yes",null,"no",null,"Yes","In house",null,null,null,null,"-"]
[null,"Ovary","No",null,null,"No",null,"No",null,"No",null,"No",null,"No",null,null,null,null,"yes","nude","yes","mice","yes","xenograft","no",null,"no","no","no","no",null,null,null,"no",null,"yes",null,"no",null,"Yes","In house",null,null,null,null,"-"]
[null,"disseminated model of AML [n00232929-01] ","No",null,null,"No",null,"No",null,"No",null,"No",null,"No",null,null,null,null,"yes","nude","yes","mice","yes","xenograft","no",null,"no","no","no","no",null,null,null,"no",null,"yes",null,"no",null,"Yes","In house",null,null,null,null,"-"]
[null,"disseminated model of AML[P15-\n00294] Rudolph D, et al. Efficacy and mechanism of action of volasertib, a potent\nand selective inhibitor of Polo-like kinases, in preclinical models of acute\nmyeloid leukemia. J Pharmacol Exp Ther. 2015","No",null,null,"No",null,"No",null,"No",null,"No",null,"No",null,null,null,null,"yes","nude","yes","mice","yes","xenograft","no",null,"no","no","no","no",null,null,null,"no",null,"yes",null,"no",null,"Yes","Peer reviewed",null,null,null,null,"-"]
[null,"skipped for later",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]

{"sheet":"IB8","index":16,"n_rows":15,"n_cols":47,"rows_kept":15,"cut":false,"hidden":true,"merged":[[10,0,24,0],[10,16,24,16],[10,31,24,31],[1,39,1,40],[1,41,1,45],[2,26,2,27],[3,0,3,1],[3,16,3,17],[3,31,3,32],[0,0,2,1],[1,33,1,34],[1,35,1,36],[1,37,1,38],[0,39,0,45],[1,2,1,4],[1,5,1,6],[0,2,0,15],[0,16,2,17],[0,18,0,30],[1,7,1,8],[1,9,1,10],[1,11,1,12],[1,13,1,15],[1,18,1,19],[0,31,2,32],[0,33,0,38],[1,29,1,30],[1,20,1,24],[1,26,1,28]]}
["Efficacy studies",null,"Evaluate in light of threats to internal validity",null,null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to construct validity",null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to external validity",null,null,null,null,null,"Others"]
[null,null,"Sample size",null,null,"Randomisation",null,"Blinded assessment",null,"Exclusion of data from analysis",null,"Controls",null,"Dose reponse \n(RATED ON IB LEVEL)",null,null,null,null,"Baseline characterization",null,"Model choice",null,null,null,null,"Mechanistic evidence (RATED ON IB LEVEL)","Outcome choice",null,null,"Age matched to patients (RATED ON IB LEVEL)",null,null,null,"Replication of experiment",null,"Replication in different model",null,"Replication in different species",null,"References",null,"Inferential statistics"]
[null,null,"Yes or no?","If yes, how many?","Justification?","Yes or no?","If yes, type of randomization","Yes or no?","If yes, when?","Yes or no?","If yes, justification?","Yes or no?","If yes, what type of control?","Yes or no?","If yes, positive reponse reported? ","If no, justification?",null,null,"Yes or no?","If yes, what type?","Reporting of species?",null,"Reporting of model?",null,"Reporting of specifications?","Yes or no?","Reporting of temporal metric (measurement of endpoint and timing)",null,"Full reporting of outcome choice, yes or no?","Yes or no?","Is it matched to patients?",null,null,"Yes or no?","If no, is there other similar study?","Yes or no?","If yes, model type?","Yes or no?","If yes, species type?","Yes or no?","If yes, what type of references","Yes or no?","Is effect size reported? Y or N","Effect size value?","Is it significant value reported or not","Significant value?","Variance? SD, SE, CI"]
["Coding criteria",null,null,null,null,null,"Group Designation, Cage Randomization,\nPermanent Designation, Randomization to Treatment","Coding of animals, aims and groups of treatments investigated ",null,"Statement of animal flow, number of deaths, if it is reported that no exclusion was performed, then it is a yes.",null,null,"Positive control, negative control, sham, comparator arm","Minimum of 3 different doses, statement of dose reponse",null,null,"Coding criteria",null,"Sex, age, immune status, weight, microbial status of the animal","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","Mouse, rat, dog, monkey, etc.",null,"Induced (or Experimental), spontaneous (xenograft, orthotopic), transgenic, type of disease",null,"Tumor size, etc.","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","METRICS Endpoints, type of measurement (survival, tumor shrinkage, etc),  mean survival ","TIMING \n(timing of measurement)","An outcome is considered to be fully reported if the metrics and timing is provided","Is age of animals mentioned?","Check inclusion criteria of patients","Coding criteria",null,"Is it the same model?Is it the same drug? Is it measuring the same outcome?",null,"Is it the same species?","Different disease type, different route administration, different dosage form ",null,null,null,"Peer-reviewed, in house data"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]

{"sheet":"IB9","index":17,"n_rows":15,"n_cols":48,"rows_kept":15,"cut":false,"hidden":true,"merged":[[10,0,24,0],[10,16,24,16],[10,32,24,32],[1,40,1,41],[1,42,1,46],[2,27,2,28],[3,0,3,1],[3,16,3,17],[3,32,3,33],[0,0,2,1],[1,34,1,35],[1,36,1,37],[1,38,1,39],[0,40,0,46],[1,2,1,4],[1,5,1,6],[0,2,0,15],[0,16,2,17],[0,18,0,31],[1,7,1,8],[1,9,1,10],[1,11,1,12],[1,13,1,15],[1,18,1,19],[0,32,2,33],[0,34,0,39],[1,30,1,31],[1,20,1,24],[1,27,1,29]]}
["Efficacy studies",null,"Evaluate in light of threats to internal validity",null,null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to construct validity",null,null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to external validity",null,null,null,null,null,"Others"]
[null,null,"Sample size",null,null,"Randomisation",null,"Blinded assessment",null,"Exclusion of data from analysis",null,"Controls",null,"Dose reponse \n(RATED ON IB LEVEL)",null,null,null,null,"Baseline characterization",null,"Model choice",null,null,null,null,null,"Mechanistic evidence (RATED ON IB LEVEL)","Outcome choice",null,null,"Age matched to patients (RATED ON IB LEVEL)",null,null,null,"Replication of experiment",null,"Replication in different model",null,"Replication in different species",null,"References",null,"Inferential statistics"]
[null,null,"Yes or no?","If yes, how many?","Justification?","Yes or no?","If yes, type of randomization","Yes or no?","If yes, when?","Yes or no?","If yes, justification?","Yes or no?","If yes, what type of control?","Yes or no?","If yes, positive reponse reported? ","If no, justification?",null,null,"Yes or no?","If yes, what type?","Reporting of species?",null,"Reporting of model?",null,"Reporting of specifications?",null,"Yes or no?","Reporting of temporal metric (measurement of endpoint and timing)",null,"Full reporting of outcome choice, yes or no?","Yes or no?","Is it matched to patients?",null,null,"Yes or no?","If no, is there other similar study?","Yes or no?","If yes, model type?","Yes or no?","If yes, species type?","Yes or no?","If yes, what type of references","Yes or no?","Is effect size reported? Y or N","Effect size value?","Is it significant value reported or not","Significant value?","Variance? SD, SE, CI"]
["Coding criteria",null,null,null,null,null,"Group Designation, Cage Randomization,\nPermanent Designation, Randomization to Treatment","Coding of animals, aims and groups of treatments investigated ",null,"Statement of animal flow, number of deaths, if it is reported that no exclusion was performed, then it is a yes.",null,null,"Positive control, negative control, sham, comparator arm","Minimum of 3 different doses, statement of dose reponse",null,null,"Coding criteria",null,"Sex, age, immune status, weight, microbial status of the animal, breed","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","Mouse, rat, dog, monkey, etc.",null,"Induced (or Experimental), spontaneous (xenograft, orthotopic), transgenic, type of disease",null,"Tumor size, etc.",null,"(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","METRICS Endpoints, type of measurement (survival, tumor shrinkage, etc),  mean survival ","TIMING \n(timing of measurement)","An outcome is considered to be fully reported if the metrics and timing is provided","Is age of animals mentioned?","Check inclusion criteria of patients","Coding criteria",null,"Is it the same model?Is it the same drug? Is it measuring the same outcome?",null,"Is it the same species?","Different disease type, different route administration, different dosage form ",null,null,null,"Peer-reviewed, in house data"]
[null,"RCC Study N°\n856131","Yes",48,null,"No",null,"No",null,"No",null,"Yes","Positive","No",null,"No",null,null,"Yes","Sex, Wistar, young (age)","Yes","Rat","Yes","Intra-articular Injection of Monosodium Urate: An\nAnimal Model for Knee-Joint Arthritis","Yes",null,null,"Yes","Yes","Yes","yes","yes",null,null,"Yes",null,"No",null,"No",null,"Yes","In house",null,"Yes","number of rearings was reduced\non day 3 by 5.8% and 6.2%, and the total distance was reduced by 0.7% and 5.7% with\nRTX","No","-"]
[null,"(RCC Study N°\n858572)","Yes",70,null,"No",null,"No",null,"No",null,"Yes","Positive, Negative","Yes","Yes",null,null,null,"No",null,"Yes","Rat","No",null,"no",null,null,"no","no","no","No",null,null,null,"Yes",null,"No",null,"No",null,"Yes","In house","No","No",null,null,"-"]
[null,"RCC Study N°\nA22263","Yes",50,null,"No",null,"No",null,"No",null,"Yes","Negative","Yes","Yes","-",null,null,"Yes","Sex, young adult","Yes","Rat","Yes","Intra-articular Injection of Monosodium Urate: An\nAnimal Model for Knee-Joint Arthritis","Yes",null,"Yes","Yes","Yes","Yes","Yes","?",null,null,"No","Yes","No",null,"No",null,"Yes","In house","No","No",null,"No","-"]
[null,"RCC\nStudy N° A81573","Yes",48,null,"NO",null,"No",null,"Yes","2 rats died","Yes","Negative","Yes","Yes","-",null,null,"No",null,"Yes","Rat","Yes","Intra-articular Injection of Monosodium Urate: An\nAnimal Model for Knee-Joint Arthritis","Yes",null,"Yes","Yes","Yes","Yes","No","-",null,null,null,null,null,null,null,null,"yes","In house","No","no",null,null,"-"]
[null,"carole has 3 additional studie. They are published literature. CF said it should be included in the list. WC disagreed. Check with DS",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]

{"sheet":"IB13","index":18,"n_rows":16,"n_cols":47,"rows_kept":16,"cut":false,"hidden":true,"merged":[[11,0,25,0],[11,16,25,16],[11,31,25,31],[1,39,1,40],[1,41,1,45],[2,26,2,27],[3,0,3,1],[3,16,3,17],[3,31,3,32],[0,0,2,1],[1,33,1,34],[1,35,1,36],[1,37,1,38],[0,39,0,45],[1,2,1,4],[1,5,1,6],[0,2,0,15],[0,16,2,17],[0,18,0,30],[1,7,1,8],[1,9,1,10],[1,11,1,12],[1,13,1,15],[1,18,1,19],[0,31,2,32],[0,33,0,38],[1,29,1,30],[1,20,1,24],[1,26,1,28]]}
["Efficacy studies",null,"Evaluate in light of threats to internal validity",null,null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to construct validity",null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to external validity",null,null,null,null,null,"Others"]
[null,null,"Sample size",null,null,"Randomisation",null,"Blinded assessment",null,"Exclusion of data from analysis",null,"Controls",null,"Dose reponse \n(RATED ON IB LEVEL)",null,null,null,null,"Baseline characterization",null,"Model choice",null,null,null,null,"Mechanistic evidence (RATED ON IB LEVEL)","Outcome choice",null,null,"Age matched to patients (RATED ON IB LEVEL)",null,null,null,"Replication of experiment",null,"Replication in different model",null,"Replication in different species",null,"References",null,"Inferential statistics"]
[null,null,"Yes or no?","If yes, how many?","Justification?","Yes or no?","If yes, type of randomization","Yes or no?","If yes, when?","Yes or no?","If yes, justification?","Yes or no?","If yes, what type of control?","Yes or no?","If yes, positive reponse reported? ","If no, justification?",null,null,"Yes or no?","If yes, what type?","Reporting of species?",null,"Reporting of model?",null,"Reporting of specifications?","Yes or no?","Reporting of temporal metric (measurement of endpoint and timing)",null,"Full reporting of outcome choice, yes or no?","Yes or no?","Is it matched to patients?",null,null,"Yes or no?","If no, is there other similar study?","Yes or no?","If yes, model type?","Yes or no?","If yes, species type?","Yes or no?","If yes, what type of references","Yes or no?","Is effect size reported? Y or N","Effect size value?","Is it significant value reported or not","Significant value?","Variance? SD, SE, CI"]
["Coding criteria",null,null,null,"sample size calculation",null,"Group Designation, Cage Randomization,\nPermanent Designation, Randomization to Treatment","Coding of animals, aims and groups of treatments investigated ",null,"Statement of animal flow, number of deaths, if it is reported that no exclusion was performed, then it is a yes.",null,null,"Positive control, negative control, sham, comparator arm","Minimum of 3 different doses, statement of dose reponse",null,null,"Coding criteria",null,"Sex, age, immune status, weight, microbial status of the animal","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","Mouse, rat, dog, monkey, etc.",null,"Induced (or Experimental), spontaneous (xenograft, orthotopic), transgenic, type of disease",null,"Tumor size, etc.","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","METRICS Endpoints, type of measurement (survival, tumor shrinkage, etc),  mean survival ","TIMING \n(timing of measurement)","An outcome is considered to be fully reported if the metrics and timing is provided","Is age of animals mentioned?","Check inclusion criteria of patients","Coding criteria",null,"Is it the same model?Is it the same drug? Is it measuring the same outcome?",null,"Is it the same species?","Different disease type, different route administration, different dosage form ",null,null,null,"Peer-reviewed, in house data"]
[null,"4.2.1 Activity of Cabozantinib in the Transgenic RIP-Tag2 Model System *Figure 4.1a","No","-","no","No",null,"No",null,"No","1 death in the treatment group from gavage injury","Yes","Negative, positive","No",null,null,null,null,"No",null,"Yes","Mice","Yes","RIP-Tag2 mouse model of neuroendocrine pancreatic\ncancer that spontaneously develops aggressive tumors","No","No","Yes","NO","No","no","?",null,null,"No",null,"No",null,"No",null,"Yes","Peer-reviewed","Yes","Yes","The number of liver metastases was 5-fold\ngreater in anti-VEGF antibody-treated animals compared with vehicle-treated animals,\nand no liver metastases were detected in cabozantinib-treated animals","Yes"," P < 0.05"]
[null,"4.2.1 Activity of Cabozantinib in the Transgenic RIP-Tag2 Model System *Figure 4.1b","Yes",6,"no","No",null,"No",null,"No","1 death in the treatment group from gavage injury","Yes","Negative, positive","No",null,null,null,null,"No",null,"Yes","Mice","Yes","RIP-Tag2 mouse model of neuroendocrine pancreatic\ncancer that spontaneously develops aggressive tumors","No","No","Yes","Yes","Yes","from age 14 to 17 weeks","?",null,null,"No",null,"No",null,"No",null,"Yes","Peer-reviewed","Yes","Yes","Median survival was 14.7 weeks for vehicle-treated animals (n = 12) and\n16.4 weeks for anti-VEGF antibody-treated animals (n = 7; P < 0.05 vs vehicle), and all\ncabozantinib-treated animals survived for the full 20 weeks of observation (n = 6;\nP < 0.05 vs vehicle and anti-VEGF antibody;","Yes"," P < 0.05"]
[null,"A lot of peer reviewed studies were references"]
[null,"human prostate cancer model ARCaPM, which expresses both MET and the VEGF\nco-receptor NP-1 (Zhang et al 2010),",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,"prostate cancer(Schimmoller et al. 2011; Dai et al. 2014",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,"castration-resistant C4-2B PCa xenograft in the tibiae of SCID mice",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,"MDA-MB-231 breast cancer\nxenograft introduced intracardially into athymic nude mice (Mohammad et al. 2012",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,"NOD/SCID mice were injected intratibially with luciferase-expressing\nVCaP human prostate carcinoma cells resulting in lesions which were predominantly\nosteosclerotic with some osteolytic activity (Graham et al. 2014",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]

{"sheet":"Guiding criteria","index":19,"n_rows":24,"n_cols":10,"rows_kept":24,"cut":false,"hidden":false,"merged":[[11,0,16,0],[11,2,11,9],[17,0,20,0],[17,2,17,9],[2,6,3,6],[2,7,3,7],[2,8,3,8],[2,9,3,9],[4,0,10,0],[4,2,4,9],[2,0,3,0],[2,1,3,1],[2,2,3,2],[2,3,3,3],[2,4,3,4],[2,5,3,5]]}
["List of criteria for assisting in deciding the scientific acceptability of a preclinical studies\nand design of the testing procedures"]
[]
["Item","Domain","Guiding questions to facilitate judgment\n(Kimmelman & Henderson, 2015)","Validity Checklist for in vivo Efficacy Studies (STREAM)","\"Checklist\" questions adopted from SYRCLE","Additional info","Reference for additional info","ARRIVE","Further relevant explanation note","Reference for further relevant explanation note"]
[null,null,null,null,"Reformulated questions"]
["Step 1: a","Evaluate in light of threats to internal validity","Evaluate potential biases and random errors in preclinical studies that could lead to spurious causal interference."]
[null,"Sample size","Was the sample size sufficient to exclude random variation as an explanation of effect sizes?","Has a power calculation been performed a priori to determine sample size?","■ Is there information on the calculation of sample size?\n■ Is there a justification of sample size?\n\n","The size of the groups should be sufficient to\nallow meaningful scientific interpretation of\nthe data generated. Thus, the number of animals or isolated preparations should be \nadequate to demonstrate or rule out the presence of a biologically significant effect of the test substance. This should take into consideration the size of the biological effect that is of concern for humans. \n\nThe number of animals used per dose has a direct be aring on the ability to detect toxicity. A small sample size may lead to failure to observe toxic events due to observed frequency alone regardless of severity. The limitations that are imposed by sample size, as often is the case for non-human primate studies, may be in part compensated by increasing the frequency and duration of monitoring. Both genders should generally be used or justification given for specific omissions.","http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Safety/S7A/Step4/S7A_Guideline.pdf\n\nhttp://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500002828.pdf","Item 10: a. Specify the total number of animals used in each experiment, and the number of animals in each experimental group. \nb. Explain how the number of animals was arrived at. Provide details of any sample size calculation used.\nc. Indicate the number of independent replications of each experiment, if  relevant.","Thus, for single dose, acute toxicity tests, the requirement for groups and number of animals in groups is related to the reliable determination of acute toxic effects in rodents, for which purpose ten animals per group may constitute a sufficient number. The same number per sex and group can also be considered sufficient for most cases of subchronic and chronic toxicity testing. Due to the specific endpoints that are to be monitored, and due to their incidence in untreated control animals, the number per sex and group has to be increased in tests for reproductive toxicity, where 20 to 24 pregnant animals are conventionally used. In tests for carcinogenicity, where additionally the long duration of the experiment makes the surviving fraction a statistical issue, generally 50 to 60 animals per sex and group are used. For non-rodents, e.g. dogs or non-human primates, a number of four is conventionally accepted as sufficient also in chronic toxicity studies. ","http://www.who.int/tdr/publications/documents/safety_handbook.pdf\n\n\nhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826013/"]
[null,"Randomisation","Were animals randomly assigned to treatment?","■ Were treatments allocated to animals using a randomized procedure?\n■ If \\Yes\", describe the method used to generate the randomization sequence:\n■ If non-randomized allocation was used, were groups balanced by another\ncharacteristic (e.g. sex, age, disease status)?","■ Did the authors randomly place the cages or animals within the animal room/facility?\n■ Were animals selected at random during outcome assessment ?\n\n","Additional info:\nExamples of investigators using a non-random approach when placing the cages:\n■ Experimental groups were studied on various locations (e.g., group A in lab A or on shelf A; Group B in Lab B or on shelf B).","http://www.biomedcentral.com/1471-2288/14/43","Item 11: a. Give full details of how animals were allocated to experimental groups, including randomisation or matching if done.\nb. Describe the order in which the animals in the different experimental groups were treated and assessed.","The method used to randomize should be clearly stated. Dices, envelopes containing pieces of papers with codes, and tables with random numbers are examples of some frequent methods used for randomization. Experiments with either completely randomized groups or randomized blocking designs are all correct. Blocking refers to direct manipulation to control one or more independent variables and thus, avoid variation. Ancillary variables such as sex and weight may be firstly manipulated to confer minimal variation between the groups. The investigator may divide the animals that are comparable in cages and then randomize them to the groups.","http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502005000100002"]
[null,"Blinded assessment","Were outcome assessors blinded?","Was treatment allocation concealed from the investigators during the experiment?\nWere investigators blinded to treatment allocation during outcome assessment?","■ Was blinding of the outcome assessor ensured, and was it unlikely that blinding could have been broken?\n\n","Examples:\n■ ID cards of individual animals, or cage/animal\nlabels are coded and identical in appearance.\n■ Sequentially numbered drug containers are\nidentical in appearance.\n■ The circumstances during the intervention\nare specified and similar in both groups (#).\n■ Housing conditions of the animals during\nthe experiment are randomized within\nthe room\n\nExamples of inappropriate blinding:\n■ Colored cage labels (red for group A, yellow group B)\n■ Expected differences in visible effects between\ncontrol and experimental groups\n■ Housing conditions of the animals are not\nrandomized within the room during the experiment\n■ The individual who prepares the experiment is the\nsame as the one who conducts and analyses\nthe experiment\n■ Circumstances during the intervention are not similar in both groups\nExamples where circumstances during the intervention were not similar:\n■ Timing of administration of the placebo and exp\ndrug was different.\n■ Instruments used to conduct experiment differ between experimental and control group (e.g., experiment about effects abdominal pressure; exp group receives operation and needle to increase pressure, while\ncontrol group only has the operation).","http://www.biomedcentral.com/1471-2288/14/43",null,"When two or more treatments are being compared, the investigator must diminish the occurrence of bias. Thus, the experiment should be done \"blind\" to diminish the possibility of a subjective effect in collecting data. Along the entire study, the main investigator may need collaborators. It is important to code animals, specimens, and samples, and also not to inform any coworker responsible for registering data about both the aims and groups of treatments investigated in the experiment","http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502005000100002"]
[null,"Exclusion of data from analysis","Do studies explain the flow of animals from inclusion through to analysis?","Has every animal been accounted for, from entry into experiment through treatment, outcome assessment, sacri ce and analysis?","■ Were all animals included in the analysis? \n■ Were the reasons for missing outcome data unlikely to be related to true outcome? (e.g., technical failure)\n■ Are missing outcome data balanced in numbers across intervention groups, with similar reasons for missing data across groups?\n■ Are missing outcome data imputed using appropriate methods?",null,"http://www.biomedcentral.com/1471-2288/14/43","Item 15: a. Report the number of animals in each group included in each analysis. Report absolute numbers (e.g. 10/20, not 50%\nb. If any animals or data were not included in the analysis, explain why."]
[null,"Controls","Were appropriate controls included?","Were appropriate controls used in all in vivo experiments (e.g. positive, negative)?","Additional info:\nAppropriate negative and positive control groups should be included in the experimental design. In well-characterized in vivo test systems, positive controls may not be necessary. The exclusion of controls  from studies should be justified.  ",null,"http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Safety/S7A/Step4/S7A_Guideline.pdf","Item 7: For each experiment and each experimental group, including controls, provide precise details of all procedures carried out. For example:\na. How (e.g. drug formulation and dose, site and route of administration, anaesthesia\nand analgesia used [including monitoring], surgical procedure, method of euthanasia). Provide details of any specialist equipment used, including supplier(s).\nb. When (e.g. time of day).\nc. Where (e.g. home cage, laboratory, water maze).\nd. Why (e.g. rationale for choice of specific anaesthetic, route of administration, drug dose used)."]
[null,"Dose response","Was a dose-response relationship demonstrated?","Has a dose-response treatment effect been demonstrated?","■ Was there a demonstration of dose-response relationship of  the adverse effect?\n■ Was there a time course (e.g., onset and duration of response) of the adverse effect?\n■ Was the doses eliciting the adverse effect compared to the doses eliciting the primary pharmacodynamic effect in the test species or the proposed therapeutic effect in humans?\n\n","Additional note: \nIn the absence of an adverse effect on the safety harmacology parameter(s) evaluated in the study, the highest tested dose should be a dose that produces moderate adverse effects in this or in other studies of similar route and duration. These adverse effects can include dose-limiting pharmacodynamic effects or other toxicity. In practice, some effects in the toxic range (e.g., tremors or fasciculation during ECG recording) may confound the interpretation of the results and may also limit dose levels. Testing of a single group at the limiting dose as described above may be sufficient in the absence of an adverse effect on safety pharmacology endpoints in the test species.\n\nWC - I would code \"yes\" if there are a minimum of 3 doses tested (low, medium and high)","http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Safety/S7A/Step4/S7A_Guideline.pdf",null,"For acute, single dose testing, international guidelines provide a limit dose of 2000 mg/kg. Doses for subchronic and chronic, repeated dose studies will have to be set according to different considerations; in general, these call for a high dose which produces some evidence of toxicity, a low dose which does not influence the well-being of the animal, and a mid dose that is at the borderline of toxicity. Deriving, from the results of shorter-term studies (in the first instance from single dose toxicity), the respective dose levels for the longer-term investigations so as to meet these requirements,  may be regarded as much an art as a science. For carcinogenicity studies, still other considerations apply. Here, the historical convention has been to use, as the high dose, the “maximum tolerated dose” (MTD), defined as the dose that produces a body weight loss of 10% in comparison with untreated controls. Since, for relatively non-toxic compounds, this limit may be hard to achieve unless exaggerated amounts of test item are administered, other definitions for the high dose in carcinogenicity tests have been put forward. These are specified in the ICH Guidelines Dose selection for carcinogenicity studies of pharmaceuticals (guideline S1C), and Addendum to S1C: Addition of a limit dose and related notes (guideline S1C[R]); they include, among other possibilities, the use of doses that will yield an exposure (measured as the area under the plasma concentration curve [AUC]) of at least 25 times the expected (or determined) human exposure under therapeutic conditions.","http://www.who.int/tdr/publications/documents/safety_handbook.pdf"]
["Step 1: b","Evaluate in light of threats to construct validity","Evaluate the potential to mischaracterize the relationship between a preclinical study and ensuing trial. "]
[null,"Baseline characterization","· Whether animals were characterized at baseline and included based on pre-specified eligibility criteria.","Was the emergence of confounding physiological variables monitored and addressed (e.g. blood pressure, body temperature)?","■ Were the groups similar at baseline or were they adjusted for confounders in the analysis?\n■ Was the distribution of relevant baseline characteristics balanced for the intervention and control groups?\n■ If relevant, did the investigators adequately adjust for unequal distribution of some relevant baseline characteristics in the analysis?\n■ Was the timing of disease induction adequate? \n\n","Additional info:\n■ The number and type of baseline characteristics are dependent on the review question. Before starting their risk of bias assessment, therefore, reviewers need to discuss which baseline characteristics need to be comparable between the groups. \n\nA description of baseline characteristics and/or confounders usually contains:\n■ The sex, age and weight of the animals\n■ Baseline values of the outcomes which are\nof interest in the study\n\nExamples of adequate timing of disease induction:\n■ The disease was induced before randomization of the intervention.\n■ The disease was induced after randomization of the intervention, but the timing of disease induction","http://www.biomedcentral.com/1471-2288/14/43","Item 14: For each experimental group, report relevant \ncharacteristics and health status of animals (e.g. weight, microbiological status, and drug or test naïve) prior to treatment or testing. (This information can often be tabulated).","In all cases the animals should be healthy, of known origin, reasonably consistent in\nterms of age and body weight, and suitably acclimatized to the experimental environment before the study commences. In general, the internationally available and accepted guidelines do not specify specific age or weight ranges for test animals, but instead there may be general recommendations, for example, on the use of young adult animals. Newly arrived animals should be acclimatized to the conditions of the test facility for a certain time, generally not less than seven days. During this time the necessary health checks may be performed, weight ranges determined, animals marked individually, and preparations made for randomization into the study.","http://www.who.int/tdr/publications/documents/safety_handbook.pdf"]
[null,"Model choice","Whether animal models used are widely believed to offer the most faithful and available representation of the human disease that will be test in trials.",null,"■ Were there rationale / justification on the choice of animal model?\n\n","Additional info:\nA relevant  species is one in which the test material is pharmacologically active due to the expression of the \nreceptor or an epitope (in the case of monoclonal antibodies). A variety of techniques (e.g., immunochemical or functional tests) can be used to identify a relevant species.\n\nSafety evaluation programs should normally include two relevant species. However, in certain justified cases one relevant species may suffice (e.g., when only one relevant species can be identified or where the biological activity of the biopharmaceutical is well understood). In addition even where two species may be necessary to characterise toxicity in short term studies, it may be possible to justify the use of only one species for subsequent long term toxicity studies (e.g., if the toxicity profile in the two species is comparable in the short term).  \n\nWhen no relevant species exists, the use of relevant transgenic animals expressing the human receptor or the use of homologous proteins should be considered. Where it is not possible to use transgenic animal models or homologous proteins, it may still be prudent to assess some aspects of potential toxicity in a limited toxicity evaluation in a single species, e.g., a repeated dose toxicity study of ≤ 14 days duration that includes an evaluation of important functional endpoints (e.g., cardiovascular and respiratory).","http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500002828.pdf","Item 8: a. Provide details of the animals used, including species, strain, sex, developmental stage (e.g. mean or median age plus age range) and \nweight (e.g. mean or median weight plus weight range).\nb. Provide further relevant information such as the source of animals, international strain nomenclature, genetic modification status (e.g. \nknock-out or transgenic), genotype, health/immune status, drug or test naïve, previous procedures, etc."]
[null,"Mechanistic evidence","Whether studies established a mechanism of action.",null,"■ Is the hypothesized mode of action sufficiently supported  in test animals?\n\n■ Is the hypothesized mode of action relevant to humans",null,null,"Item 18: a. Interpret the results, taking into account the study objectives and \nhypotheses, current theory and other relevant studies in the literature.\nb. Comment \non the study limitations including any potential sources of bias, \nany limitations of the animal model, and the imprecision associated with \nthe results\n2\n.\nc. Describe any implications of your experimental methods or findings for \nthe replacement, refinement o\nr reduction (the 3Rs) of the use of animals \nin research.\n\nItem 19: Comment on whether, and how, the findings of this study are likely to  translate to other species or systems, including any relevance to human\nbiology."]
[null,"Outcome choice","Whether outcomes used in studies are good representation of clinical outcomes used in trials.",null,"■ Were there justification on the choice of outcome used in animal studies?","Are there graphs, tables or narratives that inform on the selected outcomes, e.g. say that \"tumor size was reduced\" or \"survival increased\" or give the respective numbers etc. ",null,"Item 15: Clearly define the primary and secondary experimental outcomes assessed (e.g. cell death, molecular markers, behavioural changes).\n\nItem 16: Report the results for each analysis carried out, \nwith a measure of precision\n(e.g. standard error or confidence interval)."]
[null,"Age matched to patients","Whether animal age is matched to age of patients (often, it is possible to scale an animal's age to that of a human being based on developmental milestones, longevity, etc.",null,"Same question"]
["Step 1: c","Evaluate in light of threats to external validity","Evaluate the possibility of fail clinical generalization due to idiosyncrasy on test conditions."]
[null,"Independent replication","Whether efficacy studies were replicated in more than one laboratory.","Were measures taken to ensure that outcome assessment techniques were consistent and reproducible (e.g. training of research personnel, performing assessments in same\nlocation)?","Same question","WC - if there is evidence that the experiment is replicated even though if it is from the same laboratory, I will code it as a Yes."]
[null,"Replication in different model","Whether efficacy studies were replicated in more than one model.","Have treatment effects been demonstrated in more than one model?","Same question"]
[null,"Replication in different species","Whether efficacy studies were replicated in more than one species.",null,"Same question",null,null,null,"At least two different species, one rodent and one non-rodent, should be included\nin the conventional toxicity testing programmes – it is assumed that the use of two, instead of one, species will provide a broader basis for the extrapolation to humans of any toxic effects observed in the animal models.","http://www.who.int/tdr/publications/documents/safety_handbook.pdf"]
["Reporting on direction of results","Effect size",null,null,null,"Is effect reported? (E.g. 90% reduction in tumor size). Don't infer from graphs etc. Yes or No."]
[null,"Significance value",null,null,null,"Is significance value reported? (E.g. p<0.05) Yes or No"]
[null,"Direction of results",null,null,null,"Do the given results or the narrative show, whether the intended effect was achieved? Yes, no or inconclusive"]

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["Item","Type of study","Sample size",null,null,"Randomisation",null,"Baseline characterization",null,"Blinded assessment",null,null,"Exclusion of data from analysis",null,"Controls",null,"Model choice",null,null,"Outcome choice",null,"Dose reponse \n(RATE ON IB LEVEL)",null,null,"Age matched to patients \n(RATE ON IB LEVEL)",null,"Mechanistic evidence \n(RATE ON IB LEVEL)","Replication of experiment \n(RATE ON IB LEVEL)",null,"Replication in different model \n(RATE ON IB LEVEL)",null,"Replication in different species (RATE ON IB LEVEL)",null,"Citation of references",null,"Inferential statistics"]
["Research questions","Determine whether experiment listed in an efficacy study, Yes, no or unclear","Is sample size reported, Yes or no?","If yes, how many?","Is sample size calculation reported, Yes or no?","Is randomisation reported, \nYes or no?","If yes, describe the method used to generate the randomization sequence.?","Is baseline characterization reported, \nYes or no?","If yes, what type?","Is blinded assessment  for treatment allocation reported, \nYes or no?","Is blinded assessment  for outcome assessment reported, \nYes or no?","If yes, when?","Is exclusion of data reported, Yes or no?","If yes, justification?","Is control group reported, Yes or no?","If yes, what type of control?","Is the species of animal reported?","Is the type of model reported?","Is the specifications of model reported?","Is the outcome choice reported, \nYes or no?","If yes, is the metric or time-course or both reported?","Is dose response reported? Yes or no?","If yes, is positive reponse reported, Yes or no? ","If no, justification?","Is the age of animals reported, \nYes or no?","Is it matched to patients?","Yes or no?","Is there replication of experiment, Yes or no?","If no, is there other similar study?","Is there replication in different model, \nYes or no?","If yes, model type?","Is there replication in different species, \nYes or no?","If yes, species type?","Is there references reported, \nYes or no?","If yes, what type of references?","Is effect size reported? Yes or no?","Is  significant value reported? Yes or no?","Was the investigation positive, inconclusive or negative?"]
["Coding criteria","■ In cases where drug are tested for efficacy in their respective therapeutic indications,  complete experiment level and IB level extraction. DO NOT PERFORM AN EXTRACTION for non-efficacy studies","■ Does the experiment report sample sizes for all extractable groups?\n■ Is information provided on the number of animal per treatment group or total number of animal for the whole experiment?","n = ?","■ Has a power calculation been performed a priori to determine sample size?\n■ Select no if there are no explicit statements about sample size determination.","■ Were animals randomly assigned to treatment?\n■ Select unclear if there are no explicit statements about allocation.","Group designation, Cage randomization,\nPermanent designation, Randomization to treatment","■ Was the emergence of confounding physiological variables monitored and addressed (e.g. blood pressure, body temperature)?\n■ Were the groups similar at baseline or were they adjusted for confounders in the analysis?\n■ Was the distribution of relevant baseline characteristics balanced for the intervention and control groups?\n■ If relevant, did the investigators adequately adjust for unequal distribution of some relevant baseline characteristics in the analysis?\n■ Was the timing of disease induction adequate? \n\n","Sex, age, immune status, weight, microbial status of the animal ","■ Was treatment allocation concealed from the investigators during the experiment?\n■ Select no if there are no explicit statements about blinding to treatment allocation.","■ Were investigators blinded to treatment allocation during outcome assessment? \n■ Select no if there are no explicit statements about blinding to outcome assessment.","■ Blinding of animals, aims and groups of treatments before investigation or during analysis? ","■ Do studies explain the flow of animals from inclusion through to analysis?\n■ Has every animal been accounted for, from entry into experiment through treatment, outcome assessment, sacri ce and analysis? ","Animal death","■ Were appropriate controls used in all in vivo experiments (e.g. positive, negative)?","Positive control, negative control, sham, comparator arm","Mouse, rat, dog, monkey, etc.","Induced or Experimental, spontaneous (xenograft, orthotopic), transgenic, type of disease","Tumor size, etc.","Endpoints, type of measurement (survival, tumor shrinkage, etc), time-course of measurement, mean survival ",null,"■ Was there a demonstration of dose-response relationship of  the adverse effect?\n■ Was there a time course (e.g., onset and duration of response) of the adverse effect?\n■ Was the doses eliciting the adverse effect compared to the doses eliciting the primary pharmacodynamic effect in the test species or the proposed therapeutic effect in humans?\n■ Minimum of 3 different doses",null,null,"■ Is age of animals mentioned?","■ Check inclusion criteria of patients",null,"■ Is it the same model?\n■ Is it the same drug? \n■ Is it measuring the same outcome?",null,"■ Whether efficacy studies were replicated in more than one model. \n■ Is it the same species?","■ Different disease type, different route administration, different dosage form ","■ Whether efficacy studies were replicated in more than one species.",null,"■ If there is internal study number, citation, … then it is a yes.","Peer-reviewed, in house data",null,"■ Is there a p-value reported in the figure description or in the experiment results?","■ If p value significant (typically ≤ 0.05), then it is positiv.e"]
["Study ID 1"]
["Study ID 2"]
["Study ID 3"]

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["Please note: Some rows in this table might have been deleted due to confidentiality reasons!"]
["IB",null,"clinical phase","therapeutic area"]
["IB2",null,2,"Anti-neoplastic & immune-modulating agents",null,"Blood product & biotech",{"$f":"COUNTIF(D$3:D$722,\"Blood product*\")","v":6},{"$f":"G3/G$14","v":5.5045871559633031E-2}]
["IB2",null,2,null,null,"Anti-neoplastic & immune-modulating agents",{"$f":"COUNTIF(D$3:D$722,\"Anti-neo*\")","v":55},0.50458715596330272]
["IB2",null,2,null,null,"Respiratory system",{"$f":"COUNTIF(D$3:D$722,\"Respiratory*\")","v":6},5.5045871559633031E-2]
["IB2",null,2,null,null,"Rheumatology",{"$f":"COUNTIF(D$3:D$722,\"Rheum*\")","v":4},3.669724770642202E-2]
["IB3",null,1,"Blood product & biotech",null,"Dermatologicals",{"$f":"COUNTIF(D$3:D$722,\"Derma*\")","v":2},1.834862385321101E-2]
["IB3",null,1,null,null,"Alimentary tract & metabolism",{"$f":"COUNTIF(D$3:D$722,\"Aliment*\")","v":7},6.4220183486238536E-2]
["IB4",null,2,"Respiratory system",null,"Anti-infectives",{"$f":"COUNTIF(D$3:D$722,\"Anti-inf*\")","v":20},0.1834862385321101]
["IB4",null,2,null,null,"Allergy & Immunology",{"$f":"COUNTIF(D$3:D$722,\"Allergy*\")","v":3},2.7522935779816515E-2]
["IB4",null,2,null,null,"Nervous system",{"$f":"COUNTIF(D$3:D$722,\"Nervous*\")","v":3},2.7522935779816515E-2]
["IB4",null,2,null,null,"Blood & blood forming organs",{"$f":"COUNTIF(D$3:D$722,\"Blood & blood*\")","v":2},1.834862385321101E-2]
["IB4",null,2,null,null,"Cardiovascular",{"$f":"COUNTIF(D$3:D$722,\"cardio*\")","v":1},9.1743119266055051E-3]
["IB4",null,2,null,null,"Total PCES",{"$f":"SUM(G3:G13)","v":109},1]
["IB4",null,2]
["IB4",null,2]
["IB4",null,2]
["IB4",null,2]
["IB4",null,2]
["IB4",null,2]
["IB4",null,2]
["IB4",null,2]
["IB4",null,2]
["IB4",null,2]
["IB4",null,2]
["IB4",null,2]
["IB4",null,2]
["IB4",null,2]
["IB4",null,2]
["IB5",null,"1b","Respiratory system"]
["IB5",null,"1b"]
["IB6",null,1,"Blood product & biotech"]
["IB6",null,1]
["IB6",null,1]
["IB6",null,1]
["IB6",null,1]
["IB6",null,1]
["IB6",null,1]
["IB6",null,1]
["IB6",null,1]
["IB6",null,1]
["IB6",null,1]
["IB7",null,1,"Blood product & biotech"]
["IB7",null,1]
["IB7",null,1]
["IB7",null,1]
["IB7",null,1]
["IB7",null,1]
["IB7",null,1]
["IB7",null,1]
["IB7",null,1]
["IB7",null,1]
["IB7",null,1]
["IB7",null,1]
["IB7",null,1]
["IB7",null,1]
["IB7",null,1]
["IB8",null,1,"Respiratory system"]
["IB8",null,1]
["IB9",null,"1/2a","Rheumatology"]
["IB9",null,"1/2a"]
["IB9",null,"1/2a"]
["IB9",null,"1/2a"]
["IB13",null,2,"Anti-neoplastic & immune-modulating agents"]
["IB13",null,2]
["IB13",null,2]
["IB13",null,2]
["IB10",null,"1b","Anti-neoplastic & immune-modulating agents"]
["IB10",null,"1b"]
["IB10",null,"1b"]
["IB10",null,"1b"]
["IB10",null,"1b"]
["IB10",null,"1b"]
["IB11",null,"1b/2","Anti-neoplastic & immune-modulating agents"]
["IB11",null,"1b/2"]
["IB11",null,"1b/2"]
["IB11",null,"1b/2"]
["IB11",null,"1b/2"]
["IB11",null,"1b/2"]
["IB11",null,"1b/2"]
["IB11",null,"1b/2"]
["IB12",null,2,"Respiratory system"]
["IB12",null,2]
["IB12",null,2]
["IB12",null,2]
["IB12",null,2]
["IB12",null,2]
["IB12",null,2]
["IB12",null,2]
["IB12",null,2]
["IB12",null,2]
["IB12",null,2]
["IB12",null,2]
["IB12",null,2]
["IB12",null,2]
["IB12",null,2]
["IB12",null,2]
["IB12",null,2]
["IB12",null,2]
["IB12",null,2]
["IB12",null,2]
["IB14",null,2,"Anti-neoplastic & immune-modulating agents"]
["IB14",null,2]
["IB15",null,2,"Anti-neoplastic & immune-modulating agents"]
["IB15",null,2]
["IB15",null,2]
["IB15",null,2]
["IB15",null,2]
["IB15",null,2]
["IB15",null,2]
["IB15",null,2]
["IB15",null,2]
["IB15",null,2]
["IB15",null,2]
["IB15",null,2]
["IB15",null,2]
["IB15",null,2]
["IB15",null,2]
["IB15",null,2]
["IB17",null,2,"Anti-infectives"]
["IB17",null,2]
["IB17",null,2]
["IB17",null,2]
["IB17",null,2]
["IB17",null,2]
["IB17",null,2]
["IB18",null,2,"Alimentary tract & metabolism"]
["IB18",null,2]
["IB18",null,2]
["IB18",null,2]
["IB18",null,2]
["IB18",null,2]
["IB18",null,2]
["IB18",null,2]
["IB18",null,2]
["IB18",null,2]
["IB18",null,2]
["IB19",null,2,"Anti-neoplastic & immune-modulating agents"]
["IB20",null,2,"Anti-neoplastic & immune-modulating agents"]
["IB20",null,2]
["IB20",null,2]
["IB20",null,2]
["IB20",null,2]
["IB20",null,2]
["IB20",null,2]
["IB20",null,2]
["IB20",null,2]
["IB20",null,2]
["IB20",null,2]
["IB20",null,2]
["IB20",null,2]
["IB20",null,2]
["IB20",null,2]
["IB20",null,2]
["IB21",null,2,"Anti-neoplastic & immune-modulating agents"]
["IB21",null,2]
["IB21",null,2]
["IB21",null,2]
["IB21",null,2]
["IB21",null,2]
["IB21",null,2]
["IB21",null,2]
["IB21",null,2]
["IB21",null,2]
["IB21",null,2]
["IB21",null,2]
["IB21",null,2]
["IB21",null,2]
["IB21",null,2]
["IB21",null,2]
["IB21",null,2]
["IB21",null,2]
["IB22",null,2,"Anti-neoplastic & immune-modulating agents"]
["IB22",null,2]
["IB22",null,2]
["IB22",null,2]
["IB22",null,2]
["IB22",null,2]
["IB22",null,2]
["IB22",null,2]
["IB22",null,2]
["IB22",null,2]
["IB22",null,2]
["IB22",null,2]
["IB22",null,2]
["IB22",null,2]
["IB22",null,2]
["IB22",null,2]
["IB22",null,2]
["IB22",null,2]
["IB22",null,2]
["IB22",null,2]
["IB22",null,2]
["IB22",null,2]
["IB22",null,2]
["IB22",null,2]
["IB22",null,2]
["IB22",null,2]
["IB22",null,2]
["IB22",null,2]
["IB23",null,2,"Blood product & biotech"]
["IB23",null,2]
["IB23",null,2]
["IB23",null,2]
["IB23",null,2]
["IB23",null,2]
["IB23",null,2]
["IB23",null,2]
["IB23",null,2]
["IB23",null,2]
["IB23",null,2]
["IB23",null,2]
["IB23",null,2]
["IB23",null,2]
["IB23",null,2]
["IB23",null,2]
["IB23",null,2]
["IB23",null,2]
["IB23",null,2]
["IB23",null,2]
["IB23",null,2]
["IB23",null,2]
["IB23",null,2]
["IB23",null,2]
["IB23",null,2]
["IB23",null,2]
["IB23",null,2]
["IB23",null,2]
["IB24",null,2,"Anti-neoplastic & immune-modulating agents"]
["IB24",null,2]
["IB24",null,2]
["IB24",null,2]
["IB25",null,2,"Anti-neoplastic & immune-modulating agents"]
["IB25",null,2]
["IB25",null,2]
["IB25",null,2]
["IB25",null,2]
["IB25",null,2]
["IB25",null,2]
["IB25",null,2]
["IB25",null,2]
["IB25",null,2]
["IB25",null,2]
["IB26",null,2,"Anti-neoplastic & immune-modulating agents"]
["IB26",null,2]
["IB26",null,2]
["IB26",null,2]
["IB27",null,2,"Allergy & Immunology"]
["IB27",null,2]
["IB27",null,2]
["IB28",null,2,"Respiratory system"]
["IB28",null,2]
["IB28",null,2]
["IB28",null,2]
["IB28",null,2]
["IB28",null,2]
["IB28",null,2]
["IB29",null,2,"Blood product & biotech"]
["IB29",null,2]
["IB29",null,2]
["IB29",null,2]
["IB29",null,2]
["IB29",null,2]
["IB29",null,2]
["IB29",null,2]
["IB29",null,2]
["IB29",null,2]
["IB29",null,2]
["IB29",null,2]
["IB29",null,2]
["IB29",null,2]
["IB30",null,2,"Anti-neoplastic & immune-modulating agents"]
["IB30",null,2]
["IB30",null,2]
["IB30",null,2]
["IB30",null,2]
["IB30",null,2]
["IB30",null,2]
["IB30",null,2]
["IB30",null,2]
["IB30",null,2]
["IB30",null,2]
["IB31",null,2,"Anti-neoplastic & immune-modulating agents"]
["IB31",null,2]
["IB31",null,2]
["IB31",null,2]
["IB31",null,2]
["IB34",null,"2a","Allergy & Immunology"]
["IB35",null,"2a","Anti-neoplastic & immune-modulating agents"]
["IB35",null,"2a"]
["IB35",null,"2a"]
["IB35",null,"2a"]
["IB35",null,"2a"]
["IB35",null,"2a"]
["IB35",null,"2a"]
["IB35",null,"2a"]
["IB36",null,"2a","Dermatologicals"]
["IB36",null,"2a"]
["IB36",null,"2a"]
["IB36",null,"2a"]
["IB36",null,"2a"]
["IB36",null,"2a"]
["IB36",null,"2a"]
["IB36",null,"2a"]
["IB40",null,2,"Anti-neoplastic & immune-modulating agents"]
["IB40",null,2]
["IB40",null,2]
["IB40",null,2]
["IB40",null,2]
["IB40",null,2]
["IB43",null,"1","Anti-neoplastic & immune-modulating agents"]
["IB43",null,"1"]
["IB43",null,"1"]
["IB43",null,"1"]
["IB43",null,"1"]
["IB44",null,"1/2","Anti-neoplastic & immune-modulating agents"]
["IB44",null,"1/2"]
["IB44",null,"1/2"]
["IB46",null,"-","Respiratory system"]
["IB46",null,"-"]
["IB46",null,"-"]
["IB46",null,"-"]
["IB46",null,"-"]
["IB46",null,"-"]
["IB46",null,"-"]
["IB48",null,"2","Anti-infectives"]
["IB48",null,"2"]
["IB48",null,"2"]
["IB48",null,"2"]
["IB48",null,"2"]
["IB48",null,"2"]
["IB48",null,"2"]
["IB48",null,"2"]
["IB48",null,"2"]
["IB48",null,"2"]
["IB49",null,"2","Anti-neoplastic & immune-modulating agents"]
["IB49",null,"2"]
["IB49",null,"2"]
["IB49",null,"2"]
["IB49",null,"2"]
["IB49",null,"2"]
["IB49",null,"2"]
["IB49",null,"2"]
["IB49",null,"2"]
["IB49",null,"2"]
["IB49",null,"2"]
["IB49",null,"2"]
["IB49",null,"2"]
["IB49",null,"2"]
["IB49",null,"2"]
["IB49",null,"2"]
["IB49",null,"2"]
["IB49",null,"2"]
["IB49",null,"2"]
["IB49",null,"2"]
["IB49",null,"2"]
["IB49",null,"2"]
["IB49",null,"2"]
["IB49",null,"2"]
["IB49",null,"2"]
["IB49",null,"2"]
["IB49",null,"2"]
["IB49",null,"2"]
["IB49",null,"2"]
["IB49",null,"2"]
["IB49",null,"2"]
["IB50",null,"1/2","Anti-neoplastic & immune-modulating agents"]
["IB50",null,"1/2"]
["IB50",null,"1/2"]
["IB51",null,"2","Anti-neoplastic & immune-modulating agents"]
["IB51",null,"2"]
["IB52",null,"1b","Alimentary tract & metabolism"]
["IB52",null,"1b"]
["IB52",null,"1b"]
["IB52",null,"1b"]
["IB52",null,"1b"]
["IB53",null,"2","Anti-neoplastic & immune-modulating agents"]
["IB53",null,"2"]
["IB53",null,"2"]
["IB53",null,"2"]
["IB53",null,"2"]
["IB53",null,"2"]
["IB53",null,"2"]
["IB54",null,"2","Anti-neoplastic & immune-modulating agents"]
["IB54",null,"2"]
["IB54",null,"2"]
["IB54",null,"2"]
["IB55",null,"2a/b","Allergy & Immunology"]
["IB55",null,"2a/b"]
["IB55",null,"2a/b"]
["IB55",null,"2a/b"]
["IB55",null,"2a/b"]
["IB56",null,"2","Rheumatology"]
["IB56",null,"2"]
["IB57",null,"2","Nervous system"]
["IB57",null,"2"]
["IB59",null,"2","Anti-infectives"]
["IB59",null,"2"]
["IB59",null,"2"]
["IB59",null,"2"]
["IB59",null,"2"]
["IB59",null,"2"]
["IB62",null,"2","Anti-neoplastic & immune-modulating agents"]
["IB62",null,"2"]
["IB62",null,"2"]
["IB62",null,"2"]
["IB62",null,"2"]
["IB62",null,"2"]
["IB62",null,"2"]
["IB62",null,"2"]
["IB63",null,"2b","Anti-infectives"]
["IB63",null,"2b"]
["IB63",null,"2b"]
["IB63",null,"2b"]
["IB63",null,"2b"]
["IB63",null,"2b"]
["IB63",null,"2b"]
["IB63",null,"2b"]
["IB64",null,"2","Anti-infectives"]
["IB64",null,"2"]
["IB64",null,"2"]
["IB64",null,"2"]
["IB64",null,"2"]
["IB64",null,"2"]
["IB65",null,"2","Alimentary tract & metabolism"]
["IB65",null,"2"]
["IB65",null,"2"]
["IB66",null,"2","Anti-neoplastic & immune-modulating agents"]
["IB66",null,"2"]
["IB66",null,"2"]
["IB66",null,"2"]
["IB66",null,"2"]
["IB66",null,"2"]
["IB69",null,"2","Anti-neoplastic & immune-modulating agents"]
["IB69",null,"2"]
["IB69",null,"2"]
["IB69",null,"2"]
["IB69",null,"2"]
["IB70",null,"2","Nervous system"]
["IB70",null,"2"]
["IB70",null,"2"]
["IB70",null,"2"]
["IB70",null,"2"]
["IB70",null,"2"]
["IB70",null,"2"]
["IB70",null,"2"]
["IB70",null,"2"]
["IB70",null,"2"]
["IB70",null,"2"]
["IB70",null,"2"]
["IB72",null,"1b","Anti-neoplastic & immune-modulating agents"]
["IB72",null,"1b"]
["IB72",null,"1b"]
["IB72",null,"1b"]
["IB73",null,"2","Anti-neoplastic & immune-modulating agents"]
["IB73",null,"2"]
["IB73",null,"2"]
["IB73",null,"2"]
["IB73",null,"2"]
["IB75",null,"1/2","Anti-neoplastic & immune-modulating agents"]
["IB75",null,"1/2"]
["IB75",null,"1/2"]
["IB75",null,"1/2"]
["IB75",null,"1/2"]
["IB76",null,"2","Anti-neoplastic & immune-modulating agents"]
["IB76",null,"2"]
["IB76",null,"2"]
["IB76",null,"2"]
["IB76",null,"2"]
["IB76",null,"2"]
["IB77",null,"2","Anti-neoplastic & immune-modulating agents"]
["IB77",null,"2"]
["IB77",null,"2"]
["IB77",null,"2"]
["IB77",null,"2"]
["IB77",null,"2"]
["IB77",null,"2"]
["IB77",null,"2"]
["IB77",null,"2"]
["IB77",null,"2"]
["IB77",null,"2"]
["IB77",null,"2"]
["IB77",null,"2"]
["IB77",null,"2"]
["IB77",null,"2"]
["IB77",null,"2"]
["IB77",null,"2"]
["IB77",null,"2"]
["IB77",null,"2"]
["IB77",null,"2"]
["IB77",null,"2"]
["IB77",null,"2"]
["IB77",null,"2"]
["IB79",null,"2","Blood & blood forming organs"]
["IB79",null,"2"]
["IB79",null,"2"]
["IB80",null,"2","Anti-neoplastic & immune-modulating agents"]
["IB80",null,"2"]
["IB80",null,"2"]
["IB80",null,"2"]
["IB80",null,"2"]
["IB80",null,"2"]
["IB80",null,"2"]
["IB80",null,"2"]
["IB80",null,"2"]
["IB80",null,"2"]
["IB80",null,"2"]
["IB80",null,"2"]
["IB82",null,"2","Anti-neoplastic & immune-modulating agents"]
["IB84",null,"2","Anti-neoplastic & immune-modulating agents"]
["IB84",null,"2"]
["IB84",null,"2"]
["IB84",null,"2"]
["IB84",null,"2"]
["IB84",null,"2"]
["IB84",null,"2"]
["IB84",null,"2"]
["IB84",null,"2"]
["IB84",null,"2"]
["IB84",null,"2"]
["IB84",null,"2"]
["IB84",null,"2"]
["IB85",null,"2","Anti-neoplastic & immune-modulating agents"]
["IB85",null,"2"]
["IB85",null,"2"]
["IB85",null,"2"]
["IB85",null,"2"]
["IB85",null,"2"]
["IB85",null,"2"]
["IB85",null,"2"]
["IB85",null,"2"]
["IB85",null,"2"]
["IB85",null,"2"]
["IB85",null,"2"]
["IB86",null,"2","Alimentary tract & metabolism"]
["IB86",null,"2"]
["IB86",null,"2"]
["IB86",null,"2"]
["IB86",null,"2"]
["IB87",null,"2","Anti-neoplastic & immune-modulating agents"]
["IB87",null,"2"]
["IB87",null,"2"]
["IB87",null,"2"]
["IB87",null,"2"]
["IB87",null,"2"]
["IB87",null,"2"]
["IB87",null,"2"]
["IB87",null,"2"]
["IB87",null,"2"]
["IB87",null,"2"]
["IB87",null,"2"]
["IB87",null,"2"]
["IB87",null,"2"]
["IB87",null,"2"]
["IB87",null,"2"]
["IB87",null,"2"]
["IB87",null,"2"]
["IB87",null,"2"]
["IB88",null,"2","Anti-neoplastic & immune-modulating agents"]
["IB88",null,"2"]
["IB88",null,"2"]
["IB88",null,"2"]
["IB88",null,"2"]
["IB88",null,"2"]
["IB88",null,"2"]
["IB88",null,"2"]
["IB88",null,"2"]
["IB88",null,"2"]
["IB89",null,"2","Anti-neoplastic & immune-modulating agents"]
["IB89",null,"2"]
["IB89",null,"2"]
["IB89",null,"2"]
["IB89",null,"2"]
["IB89",null,"2"]
["IB89",null,"2"]
["IB89",null,"2"]
["IB89",null,"2"]
["IB89",null,"2"]
["IB89",null,"2"]
["IB89",null,"2"]
["IB89",null,"2"]
["IB90",null,"2","Blood & blood forming organs"]
["IB90",null,"2"]
["IB90",null,"2"]
["IB91",null,"2","Anti-neoplastic & immune-modulating agents"]
["IB91",null,"2"]
["IB91",null,"2"]
["IB91",null,"2"]
["IB91",null,"2"]
["IB91",null,"2"]
["IB92",null,"1","Anti-infectives"]
["IB92",null,"1"]
["IB92",null,"1"]
["IB92",null,"1"]
["IB92",null,"1"]
["IB92",null,"1"]
["IB92",null,"1"]
["IB92",null,"1"]
["IB92",null,"1"]
["IB92",null,"1"]
["IB92",null,"1"]
["IB94",null,"2","Anti-neoplastic & immune-modulating agents"]
["IB94",null,"2"]
["IB94",null,"2"]
["IB94",null,"2"]
["IB94",null,"2"]
["IB94",null,"2"]
["IB94",null,"2"]
["IB97",null,"1b","Dermatologicals"]
["IB97",null,"1b"]
["IB98",null,"2b","Anti-neoplastic & immune-modulating agents"]
["IB98",null,"2b"]
["IB98",null,"2b"]
["IB98",null,"2b"]
["IB98",null,"2b"]
["IB98",null,"2b"]
["IB98",null,"2b"]
["IB99",null,"2","Anti-neoplastic & immune-modulating agents"]
["IB99",null,"2"]
["IB99",null,"2"]
["IB99",null,"2"]
["IB99",null,"2"]
["IB99",null,"2"]
["IB99",null,"2"]
["IB99",null,"2"]
["IB99",null,"2"]
["IB99",null,"2"]
["IB99",null,"2"]
["IB102",null,"1/2","Anti-neoplastic & immune-modulating agents"]
["IB102",null,"1/2"]
["IB102",null,"1/2"]
["IB102",null,"1/2"]
["IB102",null,"1/2"]
["IB102",null,"1/2"]
["IB102",null,"1/2"]
["IB102",null,"1/2"]
["IB102",null,"1/2"]
["IB102",null,"1/2"]
["IB102",null,"1/2"]
["IB102",null,"1/2"]
["IB102",null,"1/2"]
["IB103",null,"1b/2b","Anti-neoplastic & immune-modulating agents"]
["IB103",null,"1b/2b"]
["IB103",null,"1b/2b"]
["IB103",null,"1b/2b"]
["IB103",null,"1b/2b"]
["IB104",null,"2a","Alimentary tract & metabolism"]
["IB104",null,"2a"]
["IB104",null,"2a"]
["IB104",null,"2a"]
["IB104",null,"2a"]
["IB105",null,"1/2","Anti-neoplastic & immune-modulating agents"]
["IB105",null,"1/2"]
["IB105",null,"1/2"]
["IB105",null,"1/2"]
["IB105",null,"1/2",null,null,null,"Statements in IB without any PCES"]
["IB105",null,"1/2"]
["IB1",null,2,"Anti-infectives",null,"HCV","Total",18,{"$f":"H658/H$658","v":1}]
["IB16",null,2,"Anti-infectives",null,"HCV","No validated models",3,{"$f":"H659/H$658","v":0.16666666666666666}]
["IB32",null,2,"Anti-infectives",null,"HCV","immune reactions",1,5.5555555555555552E-2]
["IB33",null,2,"Anti-infectives",null,"HCV","Clinical proof of concept",2,0.1111111111111111]
["IB37",null,3,null,null,"HCV","Not applicable",1,{"$f":"H662/H$658","v":5.5555555555555552E-2}]
["IB38",null,3,null,null,"HCV","No reference to PCES",11,0.61111111111111116]
["IB39",null,2,"Anti-neoplastic & immune-modulating agents",null,"azacitidine - myelodysplastic syndrome"]
["IB41",null,"2b","Anti-infectives",null,"HCV"]
["IB45",null,"2b","Anti-infectives",null,"HCV"]
["IB47",null,"2","Anti-infectives",null,"HCV"]
["IB58",null,"2b","Anti-infectives",null,"HCV"]
["IB60",null,"2a","Anti-infectives",null,"HCV"]
["IB61",null,"2b","Anti-infectives",null,"HCV"]
["IB68",null,"2b","Anti-infectives",null,"HCV"]
["IB71",null,"2","Alimentary tract & metabolism",null,"Vitamin D - hypoparathyroidism"]
["IB74",null,"-","Anti-neoplastic & immune-modulating agents",null,"hexaminolevulinate - Cervix-CA"]
["IB78",null,"2b",null,null,"HCV"]
["IB81",null,"2","Anti-infectives",null,"HCV"]
["IB83",null,"2","Anti-neoplastic & immune-modulating agents",null,"human IgM"]
["IB93",null,"2b",null,null,"HCV"]
["IB95",null,"2","Anti-infectives",null,"HCV"]
["IB96",null,"2b","Anti-infectives",null,"HCV"]
["IB101",null,"2",null,null,"HCV"]
["IB67",null,"-"]
["IB100",null,"2"]
["IB1a",null,"1b","Anti-neoplastic & immune-modulating agents"]
["IB1a"]
["IB1a"]
["IB2a",null,"2a","Rheumatology"]
["IB2a"]
["IB2a"]
["IB3a",null,2,"Anti-neoplastic & immune-modulating agents"]
["IB4a",null,1,"Anti-neoplastic & immune-modulating agents"]
["IB4a"]
["IB6a",null,"2a","Anti-neoplastic & immune-modulating agents"]
["IB5a",null,"2a","Cardiovascular"]
["IB5a"]
["IB5a"]
["IB5a"]
["IB5a"]
["IB1b",null,"2a","Rheumatology"]
["IB2b",null,1,"Nervous system"]
["IB2b"]
["IB2b"]
["IB3b",null,"1/2","Anti-neoplastic & immune-modulating agents"]
["IB3b"]
["IB3b"]
["IB3b"]
["IB3b"]
["IB4b",null,1,"Anti-neoplastic & immune-modulating agents"]
["IB4b"]
["IB4b"]
["IB4b"]
["IB4b"]
["IB4b"]
["IB4b"]
["IB4b"]
["IB5b",null,"2a","Blood product & biotech"]
["IB5b"]
["IB5b"]
["IB5b"]
["IB6b",null,"1/2","Alimentary tract & metabolism"]
["IB6b"]
["IB6b"]
["IB6b"]

{"sheet":"Tabelle1","index":22,"n_rows":0,"n_cols":0,"rows_kept":0,"cut":false,"hidden":false,"merged":[]}