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["Discrepancies in double-check",null,null,"Phase","Therapeutic area","Type of study","Sample size",null,null,"Randomisation",null,"Baseline characterization",null,"Blinded assessment",null,null,"Exclusion of data from analysis",null,"Controls",null,"Model choice",null,null,null,null,null,"Outcome choice",null,"Dose reponse \n(RATE ON IB LEVEL)",null,"Age matched to patients \n(RATE ON IB LEVEL)",null,"Mechanistic evidence \n(RATE ON IB LEVEL)","Replication of experiment \n(RATE ON IB LEVEL)",null,"Replication in different model \n(RATE ON IB LEVEL)",null,"Replication in different species (RATE ON IB LEVEL)",null,"Citation of references",null,"Reporting on direction of results",null,null,null,null,"Additional information?",null,"Numbers of Ibs checked","%","Numbers of PCES checked","%",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,6.8181818181818177E-2,6.8181818181818177E-2,5.3030303030303032E-2,5.3030303030303032E-2,5.3030303030303032E-2,0.10606060606060606,0.10606060606060606,5.3030303030303032E-2,5.3030303030303032E-2,5.3030303030303032E-2,6.0606060606060608E-2,6.0606060606060608E-2,0.16666666666666666,0.16666666666666666,5.3030303030303032E-2,5.3030303030303032E-2,5.3030303030303032E-2,5.3030303030303032E-2,7.575757575757576E-2,7.575757575757576E-2,6.8181818181818177E-2,0.12121212121212122,0.1875,6.25E-2,0,0,0.125,6.25E-2,0,0.125,0,6.25E-2,0,6.0606060606060608E-2,6.0606060606060608E-2,6.0606060606060608E-2,9.0909090909090912E-2,5.3030303030303032E-2,0]
[null,null,null,null,null,"Determine whether experiment listed in an efficacy study, Yes, no or unclear","Is sample size reported, Yes or no?","If yes, how many?","If yes, is sample size calculation reported, Yes or no?","Is randomisation reported, \nYes or no?","If yes, describe the method used to generate the randomization sequence.?","Is baseline characterization reported, \nYes or no?","If yes, what type?","Is blinded assessment  for treatment allocation reported, \nYes or no?","Is blinded assessment  for outcome assessment reported, \nYes or no?","If yes, when?","Is exclusion of data reported, Yes or no?","If yes, justification?","Is control group reported, Yes or no?","If yes, what type of control?","Is the species of animal reported?","If yes, what species?","Is the type of model reported?","If yes, what model?","Is the specifications of model reported?","If yes, details?","Is the outcome choice reported, \nYes or no?","If yes, is the metric or time-course or both reported?","Is dose response reported? Yes or no?","If yes, is positive reponse reported, Yes or no? ","Is the age of animals reported, \nYes or no?","If yes, is it matched to patients?","Yes or no?","Is there replication of experiment, Yes or no?","If no, is there other similar study?","Is there replication in different model, \nYes or no?","If yes, model type?","Is there replication in different species, \nYes or no?","If yes, species type?","Is there references reported, \nYes or no?","If yes, what type of references?","Is effect size reported? Yes or no? \n(Step 1)","Is  significant value reported? Yes or no? \n(Step 2)","Was the investigation positive, inconclusive or negative?","Extracted text example for negative findings","Reporting on effect other than with statistics/effect size/values: text examples (Step 3)","comments",null,16,{"$error":"#REF!"},132,0.1864406779661017,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,132,132,132,132,132,132,132,132,132,132,132,132,132,132,132,132,132,132,132,132,132,132,16,16,16,16,16,16,16,16,16,16,16,132,132,132,132,132,132]
["PCES","IB",null,null,null,"■ In cases where drug are tested for efficacy in their respective therapeutic indications,  complete experiment level and IB level extraction. DO NOT PERFORM AN EXTRACTION for non-efficacy studies","■ Does the experiment report sample sizes for all extractable groups?\n■ Is information provided on the number of animal per treatment group or total number of animal for the whole experiment?","n = ?","■ Has a power calculation been performed a priori to determine sample size?\n■ Select no if there are no explicit statements about sample size determination.","■ Were animals randomly assigned to treatment?\n■ Select unclear if there are no explicit statements about allocation.","Group designation, Cage randomization,\nPermanent designation, Randomization to treatment","■ Was the emergence of confounding physiological variables monitored and addressed (e.g. blood pressure, body temperature)?\n■ Were the groups similar at baseline or were they adjusted for confounders in the analysis?\n■ Was the distribution of relevant baseline characteristics balanced for the intervention and control groups?\n■ If relevant, did the investigators adequately adjust for unequal distribution of some relevant baseline characteristics in the analysis?\n■ Was the timing of disease induction adequate? \n\n","Sex, age, immune status, weight, microbial status of the animal ","■ Was treatment allocation concealed from the investigators during the experiment?\n■ Select no if there are no explicit statements about blinding to treatment allocation.","■ Were investigators blinded to treatment allocation during outcome assessment? \n■ Select no if there are no explicit statements about blinding to outcome assessment."," ","■ Do studies explain the flow of animals from inclusion through to analysis?\n■ Has every animal been accounted for, from entry into experiment through treatment, outcome assessment, sacri ce and analysis? ","Animal death","■ Were appropriate controls used in all in vivo experiments (e.g. positive, negative)?","Positive control, negative control, sham, comparator arm","Mouse, rat, dog, monkey, etc.",null,"Induced or Experimental, spontaneous (xenograft, orthotopic), transgenic, type of disease",null,"Tumor size, etc.",null,"Endpoints, type of measurement (survival, tumor shrinkage, etc), time-course of measurement, mean survival ",null,"■ Was there a demonstration of dose-response relationship of  the adverse effect?\n■ Was there a time course (e.g., onset and duration of response) of the adverse effect?\n■ Was the doses eliciting the adverse effect compared to the doses eliciting the primary pharmacodynamic effect in the test species or the proposed therapeutic effect in humans?\n■ Minimum of 3 different doses",null,"■ Is age of animals mentioned?","■ Check inclusion criteria of patients",null,"■ Is it the same model?\n■ Is it the same drug? \n■ Is it measuring the same outcome?",null,"■ Whether efficacy studies were replicated in more than one model. \n■ Is it the same species?","■ Different disease type, different route administration, different dosage form ","■ Whether efficacy studies were replicated in more than one species.",null,"■ If there is internal study number, citation, … then it is a yes.","Peer-reviewed, in house data",null,"■ Is there a p-value reported in the figure description or in the experiment results?","■ If p value significant (typically ≤ 0.05), then it is positiv.e",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,9,9,7,7,7,14,14,7,7,7,8,8,22,22,7,7,7,7,10,10,9,16,3,1,0,0,2,1,0,2,0,1,0,8,8,8,12,7,0]
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[null,"IB3",null,2,"Anti-neoplastic & immune-modulating agents","efficacy","yes","8-12 per tumor type","no","no",null,"no",null,"no","no",null,"no",null,"yes","negative","yes","Mouse","yes",null,"yes",null,"yes","both","yes","yes","no",null,"yes","no",null,"yes",null,"no",null,"yes","in-house","yes","no","positive",null,null,null,null,null,null,null,36,36,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,null,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,"IB4",null,1,"Anti-neoplastic & immune-modulating agents","efficacy","yes","10 per group","no","no",null,"no",null,"no","no",null,"no",null,"yes","negative","yes","Mouse","yes",null,"yes",null,"yes","metric","no",null,"no",null,"yes","yes",null,"no",null,"no",null,"no",null,"yes","yes","positive",null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,36,36,0,0,0,0,0,0,36,0,0,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0]
[null,"IB4",null,null,"Anti-neoplastic & immune-modulating agents","efficacy","yes","11 per group","no","no",null,"no",null,"no","no",null,"no",null,"yes","negative","yes","Mouse","yes",null,"yes",null,"yes","metric",null,null,null,null,null,null,null,null,null,null,null,"no",null,"yes","yes","positive",null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,36,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,"IB5",null,"2a","Cardiovascular","efficacy","yes","3 per group",null,"no",null,"no",null,"no","no",null,"no",null,"no",null,"yes","dogs","yes",null,"no",null,"yes","both","yes","yes","no",null,"yes","no",null,"yes",null,"yes",null,"yes","in-house","no","no","positive",null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,36,36,36,0,0,0,0,0,0,0,36,0,0,0,36,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0]
[null,"IB5",null,null,"Cardiovascular","efficacy","yes","9-15 per group","no","no",null,"no",null,"no","no",null,"no",null,"yes","negative","yes","hamster","yes",null,"yes",null,"yes","metric",null,null,null,null,null,null,null,null,null,null,null,"yes","in-house","no","yes","positive",null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,36,36,0,0,0,0,36,36,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,36,0,null,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0]
[null,"IB5",null,null,"Cardiovascular","efficacy","yes","13-15 per group","no","no",null,"no",null,"no","no",null,"no",null,"yes","positive, negative","yes","hamster","yes",null,"no",null,"yes","metric",null,null,null,null,null,null,null,null,null,null,null,"yes","in-house","no","yes","positive",null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,36,36,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,"IB5",null,null,"Cardiovascular","efficacy","yes","10-14 per group","no","no",null,"no",null,"no","no",null,"no",null,"yes","negative","yes","hamster","yes",null,"no",null,"yes","metric",null,null,null,null,null,null,null,null,null,null,null,"yes","in-house","no","yes","positive",null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,36,36,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,"IB5",null,null,"Cardiovascular","efficacy","yes","4 per group","no","no",null,"no",null,"no","no",null,"no",null,"yes","negative","yes","dogs","yes",null,"yes",null,"yes","both",null,null,null,null,null,null,null,null,null,null,null,"yes","in-house","no","yes","positive",null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,36,36,0,36,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
[null,"IB6",null,"2a","Anti-neoplastic & immune-modulating agents","efficacy","yes","8 per group","no","no",null,"no",null,"no","no",null,"no",null,"yes","positive, negative","yes","Mouse","yes",null,"no",null,"yes","metric","yes","yes","no",null,"yes","no",null,"no",null,"no",null,"yes","in-house","yes","yes","positive",null,null,null,null,null,null,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,36,36,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]

{"sheet":"results of doublecheck","index":1,"n_rows":17,"n_cols":81,"rows_kept":17,"cut":false,"hidden":false,"merged":[[0,13,0,14],[0,1,0,3],[0,4,0,5],[0,6,0,7],[0,8,0,10],[0,11,0,12],[0,32,0,33],[0,34,0,35],[0,36,0,38],[0,15,0,20],[0,21,0,22],[0,23,0,24],[0,25,0,26],[0,28,0,29],[0,30,0,31]]}
[null,"Sample size",null,null,"Randomisation",null,"Baseline characterization",null,"Blinded assessment",null,null,"Exclusion of data from analysis",null,"Controls",null,"Model choice",null,null,null,null,null,"Outcome choice",null,"Dose reponse \n(RATE ON IB LEVEL)",null,"Age matched to patients \n(RATE ON IB LEVEL)",null,"Mechanistic evidence \n(RATE ON IB LEVEL)","Replication of experiment \n(RATE ON IB LEVEL)",null,"Replication in different model \n(RATE ON IB LEVEL)",null,"Replication in different species (RATE ON IB LEVEL)",null,"Citation of references",null,"Reporting on direction of results",null,null,null,null,null,null,null,"Sample size",null,null,"Randomisation",null,"Baseline characterization",null,"Blinded assessment",null,null,"Exclusion of data from analysis",null,"Controls",null,"Model choice",null,null,null,null,null,"Outcome choice",null,"Dose reponse ",null,"Age matched to patients ",null,"Mechanistic evidence ","Replication of experiment ",null,"Replication in different model ",null,"Replication in different species",null,"Citation of references",null,"Reporting on direction of results","Mean reliability"]
[null,"Is sample size reported, Yes or no?","If yes, how many?","If yes, is sample size calculation reported, Yes or no?","Is randomisation reported, \nYes or no?","If yes, describe the method used to generate the randomization sequence.?","Is baseline characterization reported, \nYes or no?","If yes, what type?","Is blinded assessment  for treatment allocation reported, \nYes or no?","Is blinded assessment  for outcome assessment reported, \nYes or no?","If yes, when?","Is exclusion of data reported, Yes or no?","If yes, justification?","Is control group reported, Yes or no?","If yes, what type of control?","Is the species of animal reported?","If yes, what species?","Is the type of model reported?","If yes, what model?","Is the specifications of model reported?","If yes, details?","Is the outcome choice reported, \nYes or no?","If yes, is the metric or time-course or both reported?","Is dose response reported? Yes or no?","If yes, is positive reponse reported, Yes or no? ","Is the age of animals reported, \nYes or no?","If yes, is it matched to patients?","Yes or no?","Is there replication of experiment, Yes or no?","If no, is there other similar study?","Is there replication in different model, \nYes or no?","If yes, model type?","Is there replication in different species, \nYes or no?","If yes, species type?","Is there references reported, \nYes or no?","If yes, what type of references?","Is effect size reported? Yes or no? \n(Step 1)","Is  significant value reported? Yes or no? \n(Step 2)","Was the investigation positive, inconclusive or negative?"]
[null,"■ Does the experiment report sample sizes for all extractable groups?\n■ Is information provided on the number of animal per treatment group or total number of animal for the whole experiment?","n = ?","■ Has a power calculation been performed a priori to determine sample size?\n■ Select no if there are no explicit statements about sample size determination.","■ Were animals randomly assigned to treatment?\n■ Select unclear if there are no explicit statements about allocation.","Group designation, Cage randomization,\nPermanent designation, Randomization to treatment","■ Was the emergence of confounding physiological variables monitored and addressed (e.g. blood pressure, body temperature)?\n■ Were the groups similar at baseline or were they adjusted for confounders in the analysis?\n■ Was the distribution of relevant baseline characteristics balanced for the intervention and control groups?\n■ If relevant, did the investigators adequately adjust for unequal distribution of some relevant baseline characteristics in the analysis?\n■ Was the timing of disease induction adequate? \n\n","Sex, age, immune status, weight, microbial status of the animal ","■ Was treatment allocation concealed from the investigators during the experiment?\n■ Select no if there are no explicit statements about blinding to treatment allocation.","■ Were investigators blinded to treatment allocation during outcome assessment? \n■ Select no if there are no explicit statements about blinding to outcome assessment."," ","■ Do studies explain the flow of animals from inclusion through to analysis?\n■ Has every animal been accounted for, from entry into experiment through treatment, outcome assessment, sacri ce and analysis? ","Animal death","■ Were appropriate controls used in all in vivo experiments (e.g. positive, negative)?","Positive control, negative control, sham, comparator arm","Mouse, rat, dog, monkey, etc.",null,"Induced or Experimental, spontaneous (xenograft, orthotopic), transgenic, type of disease",null,"Tumor size, etc.",null,"Endpoints, type of measurement (survival, tumor shrinkage, etc), time-course of measurement, mean survival ",null,"■ Was there a demonstration of dose-response relationship of  the adverse effect?\n■ Was there a time course (e.g., onset and duration of response) of the adverse effect?\n■ Was the doses eliciting the adverse effect compared to the doses eliciting the primary pharmacodynamic effect in the test species or the proposed therapeutic effect in humans?\n■ Minimum of 3 different doses",null,"■ Is age of animals mentioned?","■ Check inclusion criteria of patients",null,"■ Is it the same model?\n■ Is it the same drug? \n■ Is it measuring the same outcome?",null,"■ Whether efficacy studies were replicated in more than one model. \n■ Is it the same species?","■ Different disease type, different route administration, different dosage form ","■ Whether efficacy studies were replicated in more than one species.",null,"■ If there is internal study number, citation, … then it is a yes.","Peer-reviewed, in house data",null,"■ Is there a p-value reported in the figure description or in the experiment results?","■ If p value significant (typically ≤ 0.05), then it is positiv.e"]
[null,6.8181818181818177E-2,6.8181818181818177E-2,5.3030303030303032E-2,5.3030303030303032E-2,5.3030303030303032E-2,0.10606060606060606,0.10606060606060606,5.3030303030303032E-2,5.3030303030303032E-2,5.3030303030303032E-2,6.0606060606060608E-2,6.0606060606060608E-2,0.16666666666666666,0.16666666666666666,5.3030303030303032E-2,5.3030303030303032E-2,5.3030303030303032E-2,5.3030303030303032E-2,7.575757575757576E-2,7.575757575757576E-2,6.8181818181818177E-2,0.12121212121212122,0.1875,6.25E-2,0,0,0.125,6.25E-2,0,0.125,0,6.25E-2,0,6.0606060606060608E-2,6.0606060606060608E-2,6.0606060606060608E-2,9.0909090909090912E-2,5.3030303030303032E-2]
["Total number",132,132,132,132,132,132,132,132,132,132,132,132,132,132,132,132,132,132,132,132,132,132,16,16,16,16,16,16,16,16,16,16,16,132,132,132,132,132]
["Number of changes",9,9,7,7,7,14,14,7,7,7,8,8,22,22,7,7,7,7,10,10,9,16,3,1,0,0,2,1,0,2,0,1,0,8,8,8,12,7]
[null,6.3131313131313135E-2,null,null,5.3030303030303032E-2,null,0.10606060606060606,null,5.3030303030303032E-2,null,null,6.0606060606060608E-2,null,0.16666666666666666,null,6.0606060606060608E-2,null,null,null,null,null,9.4696969696969696E-2,null,0.125,null,0,null,0.125,3.125E-2,null,6.25E-2,null,3.125E-2,null,6.0606060606060608E-2,null,6.8181818181818191E-2,null,null,7.2601010101010097E-2]
[null,0.93686868686868696,null,null,0.94696969696969702,null,0.89393939393939392,null,0.94696969696969702,null,null,0.93939393939393945,null,0.83333333333333337,null,0.93939393939393945,null,null,null,null,null,0.90530303030303028,null,0.875,null,1,null,0.875,0.96875,null,0.9375,null,0.96875,null,0.93939393939393945,null,0.93181818181818177,null,null,0.92739898989898994]
["Sum total",3740]
["Sum changed",274,7.3262032085561493E-2]
[]
[]
[]
[]
[null,"Rated by CF","Rated by SW","Rated by WC"]
["PCES",77,75,132]
["IB",10,8,16]

{"sheet":"Compilation","index":2,"n_rows":51,"n_cols":43,"rows_kept":51,"cut":false,"hidden":true,"merged":[[3,0,3,2],[0,0,2,2],[1,30,1,31],[1,32,1,33],[1,34,1,35],[0,36,0,42],[1,3,1,5],[1,6,1,7],[1,8,1,9],[1,10,1,11],[1,12,1,13],[1,14,1,15],[1,16,1,17],[1,18,1,22],[1,25,1,27],[0,3,0,15],[0,16,0,29],[0,30,0,35],[1,28,1,29],[1,36,1,37],[1,38,1,42]]}
["Efficacy studies",null,null,"Evaluate in light of threats to internal validity",null,null,null,null,null,null,null,null,null,null,null,null,"Evaluate in light of threats to construct validity",null,null,null,null,null,null,null,null,null,null,null,null,null,"Evaluate in light of threats to external validity",null,null,null,null,null,"Others"]
[null,null,null,"Sample size",null,null,"Randomisation",null,"Blinded assessment",null,"Exclusion of data from analysis",null,"Controls",null,"Dose reponse \n(RATED ON IB LEVEL)",null,"Baseline characterization",null,"Model choice",null,null,null,null,null,"Mechanistic evidence (RATED ON IB LEVEL)","Outcome choice",null,null,"Age matched to patients (RATED ON IB LEVEL)",null,"Replication of experiment",null,"Replication in different model",null,"Replication in different species",null,"References",null,"Inferential statistics"]
[null,null,null,"yes or no?","If yes, how many?","Justification?","yes or no?","If yes, type of randomization","yes or no?","If yes, when?","yes or no?","If yes, justification?","yes or no?","If yes, what type of control?","yes or no?","If yes, positive reponse reported? ","yes or no?","If yes, what type?","Reporting of species?","If yes, what species?","Reporting of model?","If yes, what model?","Reporting of specifications?","If yes, details","yes or no?","yes or no?",null,"If yes, justification?","yes or no?","Is it matched to patients?","yes or no?","If no, is there other similar study?","yes or no?","If yes, model type?","yes or no?","If yes, species type?","yes or no?","If yes, what type of references","yes or no?","Is effect size reported?","Effect size value?","Is it significant or not?","Significant value?"]
["Coding criteria",null,null,null,null,null,null,"Group Designation, Cage Randomization,\nPermanent Designation, Randomization to Treatment","Coding of animals, aims and groups of treatments investigated ",null,"Statement of animal flow, number of deaths.",null,null,"Positive control, negative control, sham, comparator arm","Minimum of 3 different doses, statement of dose reponse",null,"Sex, age, immune status, weight, microbial status of the animal","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","Mouse, rat, dog, monkey, etc.",null,"Induced (or Experimental), spontaneous (xenograft, orthotopic), transgenic, type of disease",null,"Tumor size, etc.",null,"(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","METRICS Endpoints, type of measurement (survival, tumor shrinkage, etc),  mean survival ","TIMING \n(timing of measurement)","An outcome is considered to be fully reported if the metrics and timing is provided","Is age of animals mentioned?","Check inclusion criteria of patients","Is it the same model?Is it the same drug? Is it measuring the same outcome?",null,"Is it the same species?","Different disease type, different route administration, different dosage form ",null,null,null,"Peer-reviewed, in house data"]
["IB1",null,"no efficacy"]
["IB2","MC38.OVA Colorectal model in C57BL6 mice","efficacy","no","-","-","no","-","no","-","no","-","yes","Positive control","no","-","no","-","yes","Mouse","yes","xenograft","yes","tumor size at day 0","yes","yes","yes","yes","no","-","no","no","yes","Different disease type","no","-","yes","In house","no","yes","118%, 116%, 119% tumor growth inhibition","no"]
["IB2","MC38 Colorectal model in C57BL6 mice","efficacy","no","-","-","no","-","no","-","no","-","yes","Positive control","no","-","no","-","yes","Mouse","yes","xenograft","yes","tumor size at day 0","yes","yes","yes","yes","no","-","no","no","yes","Different disease type","no","-","yes","In house","no","yes","76%, 98%,103% tumor growth inhibition","no"]
["IB2","CT26 colorecteal model in BALB/c mice","efficacy","no","-","-","no","-","no","-","no","-","yes","Positive control","no","-","no","-","yes","Mouse","yes","xenograft","yes","tumor size at day 0","yes","yes","yes","yes","no","-","no","no","yes","Different disease type","no","-","yes","In house","no","yes","92% tumor growth inhibition","no"]
["IB2","Cloudman S91 melanoma model in DBA/2 mice","efficacy","no","-","-","no","-","no","-","no","-","yes","Positive control","no","-","no","-","yes","Mouse","yes","xenograft","yes","tumor size at day 0","yes","yes",null,"yes","no","-","no","no","yes","Different disease type","no","-","yes","In house","no","yes","78% tumor growth inhibition","no"]
["IB3","Tail tip bleeding","efficacy","no","-","-","no","-","no","-","no","-","yes","Positive control, negative control","no","-","yes","Bodyweight","yes","Mouse","yes","Tail tip bleeding","yes",null,"?","yes","yes","yes","no","-","no","no","no","no","no","no","no","-","yes","yes","22 mg/g BW"]
["IB3","Carotid Occlusion Model ","efficacy",null,12,"no","no","-","no","-","no","-","yes","Positive control, negative control","no","-","yes","Sex","yes","Mouse","yes","Carotid Occlusion Model ","yes",null,"?","yes","yes","yes","no","-","no","no","no","no","no","no","no","-","yes","yes","6.0 min"]
["IB4","DOD15077-05-D","efficacy","no",null,"no","no","-","no","-","no","-","no","-","no","-","no","-","no","-","yes","xenograft","no","-",null,"yes","no","no",null,null,"no",null,"yes",null,"no",null,"yes","in house","yes","no",null,"yes","p 0,004"]
["IB4","OD14848m-05-A","efficacy","no",null,"no","no","-","no","-","no","-","no","-","no","-","no","-","no","-","yes","xenograft","no","-",null,"yes","no","no",null,null,"no",null,"yes",null,"no",null,"yes","in house","yes","no",null,"yes","p 0,041"]
["IB4","1041806-05-B","efficacy","no",null,"no","no","-","no","-","no","-","no","-","no","-","no","-","no","-","yes","xenograft","no","-",null,"yes","no","no",null,null,"no",null,"yes",null,"no",null,"yes","in house","yes","no",null,"yes","p 0,004"]
["IB4","1050304-05A","efficacy","no",null,"no","no","-","no","-","no","-","no","-","no","-","no","-","no","-","yes","xenograft","no","-",null,"yes","no","no",null,null,"no",null,"yes",null,"no",null,"yes","in house","yes","no",null,"yes","p 0,007"]
["IB4","D5124-06-02","efficacy","no",null,"no","no","-","no","-","no","-","no","-","no","-","no","-","no","-","yes","xenograft","no","-",null,"yes","no","no",null,null,"no",null,"yes",null,"no",null,"yes","in house","yes","no",null,"yes","p 0,022"]
["IB4","1051178-05-A","efficacy","no",null,"no","no","-","no","-","no","-","no","-","no","-","no","-","no","-","yes","xenograft","no","-",null,"yes","no","no",null,null,"no",null,"yes",null,"no",null,"yes","in house","yes","no",null,"yes","p <0,001"]
["IB4","Dose escalation of Vismodegib vs subcu murine medulloblastoma 09-2968","efficacy","yes","5-7 size per group, 9 groups","no","no","-","no","-","no","-","yes","negative","yes","yes","no","-","yes","murine","yes","xenograft","Tumors were allowed to \ngrow to a range of 100−500 mm\n3",null,null,"yes","yes","yes","no","-","no",null,"no",null,"no",null,"yes","in hiouse","no","no",null,"no","-"]
["IB5","Therapeutic method for inhibition & dissolution of fibrosis-dog","efficacy","no",null,null,"no","-","no","-","no","-","no","-","no","-","no","-","yes","Dog","yes","Fibrosis model","no","no","no","no","no","yes","yes",null,"no",null,"no",null,"no",null,"yes","In house","no","no",null,"no","-"]
["IB5","In vivo study in post-treatment effect of S-7701 in bleomycin-i","efficacy","no",null,null,"no","-","no","-","no","-","no","-","no","-","no","-","yes","Mouse","yes","bleomycin-induced\npulmonary fibrosis","no","no","no","no","no","no","no",null,"no",null,"no",null,"no",null,"yes","In house","no","no",null,"no","-"]
["IB6","Single-agent activity taxane-resistant colon cancer [U05-1888]), ","efficacy","no","-","-","no","-","no","-","no","-","no","-","yes","yes","yes","Nude","yes","Mouse","yes","Xenograft","no","yes","yes","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","yes","-","-","-"]
["IB6","Single-agent activity MLL-rearranged AML cell line [U11-1121-01] ","efficacy","no","-","-","no","-","no","-","no","-","no","-","yes","yes","yes","Nude","yes","Mouse","yes","Xenograft","no","yes","yes","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","-","-","-","-"]
["IB6","Single-agent activity disseminated lymphoma model [U05-2387]. ","efficacy","no","-","-","no","-","no","-","no","-","no","-","yes","yes","yes","Nude","yes","Mouse","yes","Xenograft","no","yes","no","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","-","-","-","-"]
["IB6","Combination therapy NCI-H460 xenograft study ","efficacy","no","-","-","no","-","no","-","no","-","yes","Postive control","no","-","yes","Nude","yes","Mouse","yes","Xenograft","no","?","no","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","-","-","-","-"]
["IB6","Combination therapy TOV-21G ovarian cancer ","efficacy","no","-","-","no","-","no","-","no","-","yes","Postive control","no","-","yes","Nude","yes","Mouse","yes","Xenograft","no","?","no","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","-","-","-","-"]
["IB6","Combination therapy AML xenograft model with cytarabine","efficacy","no","-","-","no","-","no","-","no","-","yes","Postive control","no","-","yes","Nude","yes","Mouse","yes","Xenograft","no","?","no","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","-","-","-","-"]
["IB6","Combination therapy AML xenograft model with decitabine ","efficacy","no","-","-","no","-","no","-","no","-","yes","Postive control","no","-","yes","Nude","yes","Mouse","yes","Xenograft","no","?","no","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","-","-","-","-"]
["IB6","Combination therapy AML xenograft model with azacitidine  ","efficacy","no","-","-","no","-","no","-","no","-","yes","Postive control","no","-","yes","Nude","yes","Mouse","yes","Xenograft","no","?","no","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","-","-","-","-"]
["IB7","Breast cancer","efficacy","no","-","-","no","-","no","-","no","-","no","-","no","-","yes","nude","yes","mice","yes","xenograft","no","yes","no","no","no","no",null,null,"no",null,"yes",null,"no",null,"yes","In house",null,null,null,null,"-"]
["IB7","Ovary","efficacy","no","-","-","no","-","no","-","no","-","no","-","no","-","yes","nude","yes","mice","yes","xenograft","no",null,"no","no","no","no",null,null,"no",null,"yes",null,"no",null,"yes","In house",null,null,null,null,"-"]
["IB7","disseminated model of AML [n00232929-01] ","efficacy","no","-","-","no","-","no","-","no","-","no","-","no","-","yes","nude","yes","mice","yes","xenograft","no",null,"no","no","no","no",null,null,"no",null,"yes",null,"no",null,"yes","In house",null,null,null,null,"-"]
["IB7","disseminated model of AML[P15-\n00294] Rudolph D, et al. Efficacy and mechanism of action of volasertib, a potent\nand selective inhibitor of Polo-like kinases, in preclinical models of acute\nmyeloid leukemia. J Pharmacol Exp Ther. 2015","efficacy","no","-","-","no","-","no","-","no","-","no","-","no","-","yes","nude","yes","mice","yes","xenograft","no",null,"no","no","no","no",null,null,"no",null,"yes",null,"no",null,"yes","Peer reviewed",null,null,null,null,"-"]
["IB7","Single-agent activity for cancers of the colon [U05-1895","efficacy","no","-","-","no","-","no","-","no","-","no","-","yes","yes","yes","Nude","yes","Mouse","yes","Xenograft","no","yes","yes","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","yes","-","-","-"]
["IB7","Single-agent activity pancreas [U05-1897] ","efficacy","no","-","-","no","-","no","-","no","-","no","-","yes","yes","yes","Nude","yes","Mouse","yes","Xenograft","no","yes","yes","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","yes","-","-","-"]
["IB7","Single-agent activity lung (NSCLC) [U05-1887]","efficacy","no","-","-","no","-","no","-","no","-","no","-","yes","yes","yes","Nude","yes","Mouse","yes","Xenograft","no","yes","yes","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","yes","-","-","-"]
["IB7","Single-agent activity taxane-resistant colon cancer [U05-1888]), ","efficacy","no","-","-","no","-","no","-","no","-","no","-","yes","yes","yes","Nude","yes","Mouse","yes","Xenograft","no","yes","yes","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","yes","-","-","-"]
["IB7","Single-agent activity MLL-rearranged AML cell line [U11-1121-01] ","efficacy","no","-","-","no","-","no","-","no","-","no","-","yes","yes","yes","Nude","yes","Mouse","yes","Xenograft","no","yes","yes","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","-","-","-","-"]
["IB7","Single-agent activity disseminated lymphoma model [U05-2387]. ","efficacy","no","-","-","no","-","no","-","no","-","no","-","yes","yes","yes","Nude","yes","Mouse","yes","Xenograft","no","yes","no","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","-","-","-","-"]
["IB7","Combination therapy NCI-H460 xenograft study ","efficacy","no","-","-","no","-","no","-","no","-","yes","Postive control","no","-","yes","Nude","yes","Mouse","yes","Xenograft","no","?","no","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","-","-","-","-"]
["IB7","Combination therapy TOV-21G ovarian cancer ","efficacy","no","-","-","no","-","no","-","no","-","yes","Postive control","no","-","yes","Nude","yes","Mouse","yes","Xenograft","no","?","no","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","-","-","-","-"]
["IB7","Combination therapy AML xenograft model with cytarabine","efficacy","no","-","-","no","-","no","-","no","-","yes","Postive control","no","-","yes","Nude","yes","Mouse","yes","Xenograft","no","?","no","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","-","-","-","-"]
["IB7","Combination therapy AML xenograft model with decitabine ","efficacy","no","-","-","no","-","no","-","no","-","yes","Postive control","no","-","yes","Nude","yes","Mouse","yes","Xenograft","no","?","no","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","-","-","-","-"]
["IB7","Combination therapy AML xenograft model with azacitidine  ","efficacy","no","-","-","no","-","no","-","no","-","yes","Postive control","no","-","yes","Nude","yes","Mouse","yes","Xenograft","no","?","no","no","no","no","-",null,"no","yes","yes","Xenograft","no","-","yes","In house","no","-","-","-","-"]
["IB8","n00240090-01 Nickolaus P. In-vivo inhibition by BI 113823 TA of LPS-induced\nneutrophil influx into the bronchoalveolar lavage of rats. BI 113823-\nNickolaus- n00240090-01, 09 Febr 2015","efficacy","no",null,null,"no","-","no",null,"no",null,"yes","negative, positive","yes","yes","yes","Wistar","yes","rat","yes","rat lung LPS model.",null,"normalized number of neutrophils in BALF of rats","yes","yes","yes","yes","no",null,"no",null,"no",null,"no",null,"yes","In house","no","yes","75%\ninhibition (vs the untreated LPS positive control group) of neutrophil influx was observed","no","-"]
["IB8","n00240091-01 Nickolaus P. Inhibition by BI 113823 TA of smoke-induced neutrophil\ninflux into the broncho-alveolar lavage fluid (BALF) and smoke-induced\ngoblet cell metaplasia in the airway epithelium of rats. BI 113823-\nNickolaus-n00240091-01, 23 Jan 2015.","efficacy","no",null,null,"no","-","no",null,"no",null,"yes","Negative","yes","yes","yes","Wistar","yes","rat","yes","smoke-induced neutrophil influx","yes","normalized number of neutrophils in BAL\nnormalized number of goblet cells per square mm in the airway epithelium","yes","yes","yes","yes","no",null,"no",null,"no",null,"no",null,"yes","In house","no","yes","Three times daily treatment of the animals with\nBI 113823 TA via gavage in Natrosol/Tween suspension at doses of 3, 10, and 30 mg/kg in\nthis disease related model produced a clear inhibition of the neutrophil influx into the BALF\n(-29, -45 and -37% respectively) and the development of goblet cell metaplasia (-31, -61 and\n-33% respectively).","no"]
["IB9","RCC Study N°\n856131","efficacy","yes",48,null,"no",null,"no",null,"no",null,"yes","Positive","no",null,"no",null,"yes","Rat","no",null,"no",null,null,"no","no","no","no",null,"yes",null,"no",null,"no",null,"yes","In house","no","no",null,null,"-"]
["IB9","(RCC Study N°\n858572)","efficacy","yes",70,null,"no","-","no",null,"no",null,"yes","Positive, Negative","yes","yes","no",null,"yes","Rat","no",null,"no",null,null,"no","no","no","no",null,"yes",null,"no",null,"no",null,"yes","In house","no","no",null,null,"-"]
["IB9","RCC Study N°\nA22263","efficacy","yes",50,null,"no","-","no",null,"no",null,"yes","Negative","yes","yes","yes","Sex, young adult","yes","Rat","yes","Intra-articular Injection of Monosodium Urate: An\nAnimal Model for Knee-Joint Arthritis","yes","yes","yes","yes","yes","yes","?",null,"no","yes","no",null,"no",null,"yes","In house","no","no",null,"no","-"]
["IB9","RCC\nStudy N° A81573","efficacy","yes",48,null,"no","-","no",null,"yes","2 rats died","yes","Negative","yes","yes","no",null,"yes","Rat","yes","Intra-articular Injection of Monosodium Urate: An\nAnimal Model for Knee-Joint Arthritis","yes","yes","yes","yes","yes","no","-",null,null,null,null,null,null,null,"yes","In house","no","no",null,null,"-"]
["IB13","4.2.1 Activity of Cabozantinib in the Transgenic RIP-Tag2 Model System *Figure 4.1a","efficacy","no","-","no","no","-","no",null,"yes","1 death in the treatment group from gavage injury","yes","Negative, positive","no",null,"no",null,"yes","Mice","yes","RIP-Tag2 mouse model of neuroendocrine pancreatic\ncancer that spontaneously develops aggressive tumors","no","no","yes","no","no","no","?",null,"no",null,"no",null,"no",null,"yes","Peer-reviewed","yes","yes","The number of liver metastases was 5-fold\ngreater in anti-VEGF antibody-treated animals compared with vehicle-treated animals,\nand no liver metastases were detected in cabozantinib-treated animals","yes"," P < 0.05"]
["IB13","4.2.1 Activity of Cabozantinib in the Transgenic RIP-Tag2 Model System *Figure 4.1b","efficacy","yes",6,"no","no","-","no",null,"yes","1 death in the treatment group from gavage injury","yes","Negative, positive","no",null,"no",null,"yes","Mice","yes","RIP-Tag2 mouse model of neuroendocrine pancreatic\ncancer that spontaneously develops aggressive tumors","no","no","yes","yes","yes","from age 14 to 17 weeks","?",null,"no",null,"no",null,"no",null,"yes","Peer-reviewed","yes","yes","Median survival was 14.7 weeks for vehicle-treated animals (n = 12) and\n16.4 weeks for anti-VEGF antibody-treated animals (n = 7; P < 0.05 vs vehicle), and all\ncabozantinib-treated animals survived for the full 20 weeks of observation (n = 6;\nP < 0.05 vs vehicle and anti-VEGF antibody;","yes"," P < 0.05"]

{"sheet":"IB1","index":3,"n_rows":5,"n_cols":43,"rows_kept":5,"cut":false,"hidden":true,"merged":[[0,18,0,27],[0,28,2,29],[0,30,0,35],[1,26,1,27],[1,30,1,31],[1,32,1,33],[1,34,1,35],[4,0,19,0],[4,16,19,16],[4,28,19,28],[0,36,0,42],[1,2,1,4],[1,5,1,6],[1,7,1,8],[1,9,1,10],[1,11,1,12],[1,13,1,15],[1,18,1,19],[1,20,1,22],[1,24,1,25],[0,0,2,1],[0,2,0,15],[0,16,2,17],[1,36,1,37],[1,38,1,42],[3,0,3,1],[3,16,3,17],[3,28,3,29]]}
["Efficacy studies",null,"Evaluate in light of threats to internal validity",null,null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to construct validity",null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to external validity",null,null,null,null,null,"Others"]
[null,null,"Sample size",null,null,"Randomisation",null,"Blinded assessment",null,"Exclusion of data from analysis",null,"Controls",null,"Dose reponse \n(RATED ON IB LEVEL)",null,null,null,null,"Baseline characterization",null,"Model choice",null,null,"Mechanistic evidence (RATED ON IB LEVEL)","Outcome choice",null,"Age matched to patients (RATED ON IB LEVEL)",null,null,null,"Replication of experiment",null,"Replication in different model",null,"Replication in different species",null,"References",null,"Inferential statistics"]
[null,null,"Yes or no?","If yes, how many?","Justification?","Yes or no?","If yes, type of randomization","Yes or no?","If yes, when?","Yes or no?","If yes, justification?","Yes or no?","If yes, what type of control?","Yes or no?","If yes, positive reponse reported? ","If no, justification?",null,null,"Yes or no?","If yes, what type?","Reporting of species?","Reporting of model?","Reporting of specifications?","Yes or no?","Yes or no?","If yes, justification?","Yes or no?","Is it matched to patients?",null,null,"Yes or no?","If no, is there other similar study?","Yes or no?","If yes, model type?","Yes or no?","If yes, species type?","Yes or no?","If yes, what type of references","Yes or no?","Is effect size reported?","Effect size value?","Is it significant or not?","Significant value?"]
["Coding criteria",null,null,null,null,null,"Group Designation, Cage Randomization,\nPermanent Designation, Randomization to Treatment","Coding of animals, aims and groups of treatments investigated ",null,"Statement of animal flow, number of deaths.",null,null,"Positive control, negative control, sham, comparator arm","Minimum of 3 different doses, statement of dose reponse",null,null,"Coding criteria",null,"Sex, age, immune status, weight, microbial status of the animal","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","Mouse, rat, dog, monkey, etc.","Induced (or Experimental), spontaneous (xenograft, orthotopic), transgenic, type of disease","Tumor size, etc.","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","(DIFFERENTIATE BETWEEN METRICS AND TIMING?) Endpoints, type of measurement (survival, tumor shrinkage, etc), timing of measurement, mean survival ","(NEEDED?)","Is age of animals mentioned?","Check inclusion criteria of patients","Coding criteria",null,"Is it the same model?Is it the same drug? Is it measuring the same outcome?",null,"Is it the same species?","Different disease type, different route administration, different dosage form ",null,null,null,"Peer-reviewed, in house data"]
["IB1","No efficacy study",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IB1",null,null,null,null,null,null,null,null,null,null,null,"IB1"]

{"sheet":"IB2","index":4,"n_rows":15,"n_cols":49,"rows_kept":15,"cut":false,"hidden":true,"merged":[[1,41,1,42],[1,43,1,48],[3,0,3,1],[3,17,3,18],[3,33,3,34],[0,0,2,1],[0,35,0,40],[1,31,1,32],[1,35,1,36],[1,37,1,38],[1,39,1,40],[4,17,19,17],[4,33,19,33],[0,41,0,48],[1,3,1,5],[1,6,1,7],[1,8,1,9],[1,10,1,11],[1,12,1,13],[1,14,1,16],[1,19,1,20],[1,21,1,25],[1,28,1,30],[0,3,0,16],[0,17,2,18],[0,19,0,32],[0,33,2,34]]}
["Efficacy studies",null,null,"Evaluate in light of threats to internal validity",null,null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to construct validity",null,null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to external validity",null,null,null,null,null,"Others"]
[null,null,null,"Sample size",null,null,"Randomisation",null,"Blinded assessment",null,"Exclusion of data from analysis",null,"Controls",null,"Dose reponse \n(RATED ON IB LEVEL)",null,null,null,null,"Baseline characterization",null,"Model choice",null,null,null,null,null,"Mechanistic evidence (RATED ON IB LEVEL)","Outcome choice",null,null,"Age matched to patients (RATED ON IB LEVEL)",null,null,null,"Replication of experiment",null,"Replication in different model",null,"Replication in different species",null,"References",null,"Inferential statistics"]
[null,null,null,"Yes or no?","If yes, how many?","Justification?","Yes or no?","If yes, type of randomization","Yes or no?","If yes, when?","Yes or no?","If yes, justification?","Yes or no?","If yes, what type of control?","Yes or no?","If yes, positive reponse reported? ","If no, justification?",null,null,"Yes or no?","If yes, what type?","Reporting of species?",null,"Reporting of model?",null,"Reporting of specifications?",null,"Yes or no?","Metric\nYes or no?","Timing\nYes or no?","Full reporting of outcome choice, Y or N","Yes or no?","Is it matched to patients?",null,null,"Yes or no?","If no, is there other similar study?","Yes or no?","If yes, model type?","Yes or no?","If yes, species type?","Yes or no? If there is internal study number, citation, … then it is a yes","If yes, what type of references","Yes or no?","Is effect size reported?","Effect size value?","Is  significant value reported?","Was the investigation positive, inconclusive or negative?","Significant value?"]
["Coding criteria",null,"Efficacy , Yes, no or unclear",null,null,null,null,"Group Designation, Cage Randomization,\nPermanent Designation, Randomization to Treatment","Coding of animals, aims and groups of treatments investigated ",null,"Statement of animal flow, number of deaths.",null,null,"Positive control, negative control, sham, comparator arm","Minimum of 3 different doses, statement of dose reponse",null,null,"Coding criteria",null,"Sex, age, immune status, weight, microbial status of the animal","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","Mouse, rat, dog, monkey, etc.",null,"Induced (or Experimental), spontaneous (xenograft, orthotopic), transgenic, type of disease",null,"Tumor size, etc.",null,"(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","(DIFFERENTIATE BETWEEN METRICS AND TIMING?) Endpoints, type of measurement (survival, tumor shrinkage, etc), timing of measurement, mean survival ",null,"(NEEDED?)","Is age of animals mentioned?","Check inclusion criteria of patients","Coding criteria",null,"Is it the same model?Is it the same drug? Is it measuring the same outcome?",null,"Is it the same species?","Different disease type, different route administration, different dosage form ",null,null,null,"Peer-reviewed, in house data",null,null,null,null,"if p value significant, then it is positive"]
["IB2","MC38.OVA Colorectal model in C57BL6 mice",null,"No","-","-","No","-","No","-","No","-","Yes","Positive control","No","-","No","IB2","MC38.OVA Colorectal model in C57BL6 mice","No","-","Yes",null,"Yes",null,"Yes",null,"Yes","Yes","Yes","Yes","No","-","IB2","MC38.OVA Colorectal model in C57BL6 mice","No","No","Yes","Different disease type","No","-","Yes","In house","No","Yes","118%, 116%, 119% tumor growth inhibition","No",null,"-"]
[null,"MC38 Colorectal model in C57BL6 mice",null,"No","-","-","No","-","No","-","No","-","Yes","Positive control","No","-","No",null,"MC38 Colorectal model in C57BL6 mice","No","-","Yes",null,"Yes",null,"Yes",null,"Yes","Yes","Yes","Yes","No","-",null,"MC38 Colorectal model in C57BL6 mice","No","No","Yes","Different disease type","No","-","Yes","In house","No","Yes","76%, 98%,103% tumor growth inhibition","No",null,"-"]
[null,"CT26 colorecteal model in BALB/c mice",null,"No","-","-","No","-","No","-","No","-","Yes","Positive control","No","-","No",null,"CT26 colorecteal model in BALB/c mice","No","-","Yes",null,"Yes",null,"Yes",null,"Yes","Yes","Yes","Yes","No","-",null,"CT26 colorecteal model in BALB/c mice","No","No","Yes","Different disease type","No","-","Yes","In house","No","Yes","92% tumor growth inhibition","No",null,"-"]
[null,"Cloudman S91 melanoma model in DBA/2 mice",null,"No","-","-","No","-","No","-","No","-","Yes","Positive control","No","-","No",null,"Cloudman S91 melanoma model in DBA/2 mice","No","-","Yes",null,"Yes",null,"Yes",null,"Yes","Yes",null,"Yes","No","-",null,"Cloudman S91 melanoma model in DBA/2 mice","No","No","Yes","Different disease type","No","-","Yes","In house","No","Yes","78% tumor growth inhibition","No",null,"-"]
[null,"Evaluation of the Immune Response to Lymphocytic",null,"No","-","-","No","-","No","-","No","-","No","-","No","-","No",null,"Evaluation of the Immune Response to Lymphocytic","No","-","Yes",null,"Yes",null,"No",null,"Yes","Yes","Yes","Yes","No","-",null,"Evaluation of the Immune Response to Lymphocytic","No","No","Yes","Diffent clone strain","No","-","Yes","In house"]
[null,"Testing Different Anti−PD-L1 Antibodies and Times of",null,"No","-","-","No","-","No","-","No","-","No","-","No","-","No",null,"Testing Different Anti−PD-L1 Antibodies and Times of","No","-","Yes",null,"Yes",null,"No",null,"Yes","Yes","Yes","Yes","No","-",null,"Testing Different Anti−PD-L1 Antibodies and Times of","No","No","Yes","Diffent clone strain","No","-","Yes","In house"]
[null,"Evaluation of Anti−PD-L1 Antibody Dose Response in",null,"No","-","-","No","-","No","-","No","-","No","-","Yes","Yes","-",null,"Evaluation of Anti−PD-L1 Antibody Dose Response in","No","-","Yes",null,"Yes",null,"No",null,"Yes","Yes","Yes","Yes","No","-",null,"Evaluation of Anti−PD-L1 Antibody Dose Response in","No","No","Yes","Diffent clone strain","No","-","Yes","In house"]
[null,"Evaluation of the Host Response to Armstrong and CL-13",null,"No","-","-","No","-","No","-","No","-","No","-","No","-","No",null,"Evaluation of the Host Response to Armstrong and CL-13","No","-","Yes",null,"Yes",null,"No",null,"Yes","No","Yes","Yes","No","-",null,"Evaluation of the Host Response to Armstrong and CL-13","No","No","Yes","Diffent clone strain","No","-","Yes","In house"]
[null,"Single Dose of Anti−PD-L1 Antibody at Different Times during In",null,"No","-","-","No","-","No","-","No","-","No","-","No","-","No",null,"Single Dose of Anti−PD-L1 Antibody at Different Times during In","No","-","Yes",null,"Yes",null,"No",null,"No","Yes","Yes","Yes","No","No",null,"Single Dose of Anti−PD-L1 Antibody at Different Times during In","No","No","Yes","Diffent clone strain","No",null,"Yes","In house"]
[null,"Studies to Address Mechanism of Anti−PD-L1 Enhanced",null,"No","-","-","No","-","No","-","No","-","No","-","No","-","No",null,"Studies to Address Mechanism of Anti−PD-L1 Enhanced","No","-","Yes",null,"Yes",null,"No",null,"Yes","Yes","Yes","Yes","No","No",null,"Studies to Address Mechanism of Anti−PD-L1 Enhanced","No","No","Yes","Diffent clone strain","No",null,"Yes","In house"]
[null,"Evaluation of the Combined Effects of Adenovirus",null,"No","-","-","No","-","No","-","No","-","No","-","No","-","No",null,"Evaluation of the Combined Effects of Adenovirus","No","-","Yes",null,"Yes",null,"No",null,"Yes","Yes","Yes","Yes","No","No",null,"Evaluation of the Combined Effects of Adenovirus","No","No","Yes","Diffent clone strain","No",null,"Yes","In house"]

{"sheet":"IB3","index":5,"n_rows":6,"n_cols":47,"rows_kept":6,"cut":false,"hidden":true,"merged":[[1,36,1,37],[1,38,1,39],[0,40,0,46],[1,34,1,35],[0,0,2,1],[1,40,1,41],[0,2,0,15],[1,42,1,46],[0,18,0,31],[0,34,0,39],[1,2,1,4],[1,9,1,10],[1,13,1,15],[1,18,1,19],[0,32,2,33],[0,16,2,17],[3,16,3,17],[1,20,1,24],[3,0,3,1],[3,32,3,33],[1,5,1,6],[1,7,1,8],[1,11,1,12],[1,27,1,29],[1,30,1,31]]}
["Efficacy studies",null,"Evaluate in light of threats to internal validity",null,null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to construct validity",null,null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to external validity",null,null,null,null,null,"Others"]
[null,null,"Sample size",null,null,"Randomisation",null,"Blinded assessment",null,"Exclusion of data from analysis",null,"Controls",null,"Dose reponse \n(RATED ON IB LEVEL)",null,null,null,null,"Baseline characterization",null,"Model choice",null,null,null,null,null,"Mechanistic evidence (RATED ON IB LEVEL)","Outcome choice",null,null,"Age matched to patients (RATED ON IB LEVEL)",null,null,null,"Replication of experiment",null,"Replication in different model",null,"Replication in different species",null,"References",null,"Inferential statistics"]
[null,null,"Yes or no?","If yes, how many?","Justification?","Yes or no?","If yes, type of randomization","Yes or no?","If yes, when?","Yes or no?","If yes, justification?","Yes or no?","If yes, what type of control?","Yes or no?","If yes, positive reponse reported? ","If no, justification?",null,null,"Yes or no?","If yes, what type?","Reporting of species?","If yes, what type?","Reporting of model?","If yes, what type","Reporting of specifications?",null,"Yes or no?","Yes or no?",null,"If yes, justification?","Yes or no?","Is it matched to patients?",null,null,"Yes or no?","If no, is there other similar study?","Yes or no?","If yes, model type?","Yes or no?","If yes, species type?","Yes or no?","If yes, what type of references","Yes or no?","Is effect size reported?","Effect size - postive or not?","Is it significant or not?","Significant value?"]
["Coding criteria",null,null,null,null,null,"Group Designation, Cage Randomization,\nPermanent Designation, Randomization to Treatment","Coding of animals, aims and groups of treatments investigated ",null,"Statement of animal flow, number of deaths.",null,null,"Positive control, negative control, sham, comparator arm","Minimum of 3 different doses, statement of dose reponse",null,null,"Coding criteria",null,"Sex, age, immune status, weight, microbial status of the animal","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","Mouse, rat, dog, monkey, etc.",null,"Induced (or Experimental), spontaneous (xenograft, orthotopic), transgenic, type of disease",null,"Tumor size, etc.",null,"(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","(DIFFERENTIATE BETWEEN METRICS AND TIMING?) Endpoints, type of measurement (survival, tumor shrinkage, etc), timing of measurement, mean survival ",null,"(NEEDED?)","Is age of animals mentioned?","Check inclusion criteria of patients","Coding criteria",null,"Is it the same model?Is it the same drug? Is it measuring the same outcome?",null,"Is it the same species?","Different disease type, different route administration, different dosage form ",null,null,null,"Peer-reviewed, in house data",null,null,"Only if significant effect reported "]
["IB3","Tail tip bleeding","No","-","-","No","-","No","-","No","-","Yes","Positive control, negative control","No","-","-","IB3","Tail tip bleeding","Yes","Bodyweight","Yes","Mouse","Yes","Tail tip bleeding","Yes",null,"yes","Yes","Yes","Yes","No","-","IB3","Tail tip bleeding","No","No","No","No","No","No","No","-","Yes","Yes","22 mg/g BW","Yes","p = 0.0018"]
[null,"Carotid Occlusion Model ","Yes",12,"No","No","-","No","-","No","-","Yes","Positive control, negative control","No","-","-",null,"Carotid Occlusion Model ","Yes","Sex","Yes","Mouse","Yes","Carotid Occlusion Model ","Yes",null,"Yes","Yes","Yes","Yes","No","-",null,"Carotid Occlusion Model ","No","No","No","No","No","No","No","-","Yes","Yes","6.0 min","Yes","p < 0.0001"]

{"sheet":"IB4","index":6,"n_rows":20,"n_cols":47,"rows_kept":20,"cut":false,"hidden":true,"merged":[[15,0,29,0],[15,15,29,15],[15,31,29,31],[1,39,1,40],[1,41,1,45],[2,26,2,27],[3,0,3,1],[3,15,3,16],[3,31,3,32],[0,0,2,1],[1,33,1,34],[1,35,1,36],[1,37,1,38],[0,39,0,45],[1,2,1,3],[1,4,1,5],[0,2,0,14],[0,15,2,16],[0,17,0,30],[1,6,1,7],[1,8,1,9],[1,10,1,11],[1,12,1,14],[1,17,1,18],[0,31,2,32],[0,33,0,38],[1,29,1,30],[1,19,1,23],[1,26,1,28]]}
["Efficacy studies",null,"Evaluate in light of threats to internal validity",null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to construct validity",null,null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to external validity",null,null,null,null,null,"Others"]
[null,null,"Sample size",null,"Randomisation",null,"Blinded assessment",null,"Exclusion of data from analysis",null,"Controls",null,"Dose reponse \n(RATED ON IB LEVEL)",null,null,null,null,"Baseline characterization",null,"Model choice",null,null,null,null,null,"Mechanistic evidence (RATED ON IB LEVEL)","Outcome choice",null,null,"Age matched to patients (RATED ON IB LEVEL)",null,null,null,"Replication of experiment",null,"Replication in different model",null,"Replication in different species",null,"References",null,"Inferential statistics"]
[null,null,"Yes or no?","If yes, how many?","Yes or no?","If yes, type of randomization","Yes or no?","If yes, when?","Yes or no?","If yes, justification?","Yes or no?","If yes, what type of control?","Yes or no?","If yes, positive reponse reported? ","If no, justification?",null,null,"Yes or no?","If yes, what type?","Reporting of species?",null,"Reporting of model?",null,"Reporting of specifications?",null,"Yes or no?","Reporting of temporal metric (measurement of endpoint and timing)",null,"Full reporting of outcome choice, yes or no?","Yes or no?","Is it matched to patients?",null,null,"Yes or no?","If no, is there other similar study?","Yes or no?","If yes, model type?","Yes or no?","If yes, species type?","Yes or no?","If yes, what type of references","Yes or no?","Is effect size reported? Y or N","Effect size value?","Is it significant value reported or not","Significant value?","Variance? SD, SE, CI"]
["Coding criteria",null,null,null,null,"Group Designation, Cage Randomization,\nPermanent Designation, Randomization to Treatment","Coding of animals, aims and groups of treatments investigated ",null,"Statement of animal flow, number of deaths, if it is reported that no exclusion was performed, then it is a yes.",null,null,"Positive control, negative control, sham, comparator arm","Minimum of 3 different doses, statement of dose reponse",null,null,"Coding criteria",null,"Sex, age, immune status, weight, microbial status of the animal","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","Mouse, rat, dog, monkey, etc.",null,"Induced (or Experimental), spontaneous (xenograft, orthotopic), transgenic, type of disease",null,"Tumor size, etc.",null,"(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","METRICS Endpoints, type of measurement (survival, tumor shrinkage, etc),  mean survival ","TIMING \n(timing of measurement)","An outcome is considered to be fully reported if the metrics and timing is provided","Is age of animals mentioned?","Check inclusion criteria of patients","Coding criteria",null,"Is it the same model?Is it the same drug? Is it measuring the same outcome?",null,"Is it the same species?","Different disease type, different route administration, different dosage form ",null,null,null,"Peer-reviewed, in house data"]
[null,"Murine medulloblastoma allografts 09-2968","No",null,"No",null,"No",null,"No",null,"No",null,"Yes",null,null,null,null,"No",null,"Yes","Mouse","Yes","Xenograft","Tumors were allowed to \ngrow to a range of 100−500 mm\n3",null,"Yes","Yes","Yes","Yes",null,null,null,null,"No",null,"Yes",null,"No",null,null,null,null,null,null,null,"-"]
["done","Murine basal cell carcinoma allografts","yes","4-6 mice, 9 groups","no",null,"no",null,"no",null,"yes","negative","yes","yes",null,null,null,"no",null,"yes","mice","yes","allograft","yes, ",null,null,"yes","yes","yes",null,null,null,null,"no",null,"no",null,"no",null,"yes","in house","no",null,null,null,"-"]
["done","D5123-05-04","no",null,"no",null,"no",null,"no",null,"yes","negative","yes","yes",null,null,null,"no",null,"yes","mice","yes","xenograft","yes",null,"yes","yes","yes","yes","no",null,null,null,"no",null,"yes",null,"no",null,"yes","in house","yes",null,null,"yes","p 0,041"]
["done","DOD15077-05-D","no",null,"no",null,"no",null,"no",null,"no",null,"no",null,null,null,null,"no",null,"no",null,"yes","xenograft","no",null,null,"yes","no","no",null,null,null,null,"no",null,"yes",null,"no",null,"yes","in house","yes","no",null,"yes","p 0,004"]
["done","OD14848m-05-A","no",null,"no",null,"no",null,"no",null,"no",null,"no",null,null,null,null,"no",null,"no",null,"yes","xenograft","no",null,null,"yes","no","no",null,null,null,null,"no",null,"yes",null,"no",null,"yes","in house","yes","no",null,"yes","p 0,041"]
[null,"1041806-05-B","no",null,"no",null,"no",null,"no",null,"no",null,"no",null,null,null,null,"no",null,"no",null,"yes","xenograft","no",null,null,"yes","no","no",null,null,null,null,"no",null,"yes",null,"no",null,"yes","in house","yes","no",null,"yes","p 0,004"]
[null,"1050304-05A","no",null,"no",null,"no",null,"no",null,"no",null,"no",null,null,null,null,"no",null,"no",null,"yes","xenograft","no",null,null,"yes","no","no",null,null,null,null,"no",null,"yes",null,"no",null,"yes","in house","yes","no",null,"yes","p 0,007"]
[null,"D5124-06-02","no",null,"no",null,"no",null,"no",null,"no",null,"no",null,null,null,null,"no",null,"no",null,"yes","xenograft","no",null,null,"yes","no","no",null,null,null,null,"no",null,"yes",null,"no",null,"yes","in house","yes","no",null,"yes","p 0,022"]
[null,"1051178-05-A","no",null,"no",null,"no",null,"no",null,"no",null,"no",null,null,null,null,"no",null,"no",null,"yes","xenograft","no",null,null,"yes","no","no",null,null,null,null,"no",null,"yes",null,"no",null,"yes","in house","yes","no",null,"yes","p <0,001"]
[null,"Dose escalation of Vismodegib vs subcu murine medulloblastoma 09-2968","yes","5-7 size per group, 9 groups","no",null,"no",null,"no",null,"yes","negative","yes","yes",null,null,null,"no",null,"yes","murine","yes","xenograft","Tumors were allowed to \ngrow to a range of 100−500 mm\n3",null,null,"yes","yes","yes","no","-",null,null,"no",null,"no",null,"no",null,"yes","in hiouse","no","no",null,"no","-"]
[null,"PK/PD of vismodegib in a subcu murine medulloblastoma allograft",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,"please see carol rating. Wc didn’t acess the appendix",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]

{"sheet":"IB5","index":7,"n_rows":6,"n_cols":47,"rows_kept":6,"cut":false,"hidden":true,"merged":[[1,39,1,40],[1,41,1,45],[2,26,2,27],[3,0,3,1],[3,16,3,17],[3,31,3,32],[0,0,2,1],[1,33,1,34],[1,35,1,36],[1,37,1,38],[0,39,0,45],[1,2,1,4],[1,5,1,6],[0,2,0,15],[0,16,2,17],[0,18,0,30],[1,7,1,8],[1,9,1,10],[1,11,1,12],[1,13,1,15],[1,18,1,19],[0,31,2,32],[0,33,0,38],[1,29,1,30],[1,20,1,24],[1,26,1,28]]}
["Efficacy studies",null,"Evaluate in light of threats to internal validity",null,null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to construct validity",null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to external validity",null,null,null,null,null,"Others"]
[null,null,"Sample size",null,null,"Randomisation",null,"Blinded assessment",null,"Exclusion of data from analysis",null,"Controls",null,"Dose reponse \n(RATED ON IB LEVEL)",null,null,null,null,"Baseline characterization",null,"Model choice",null,null,null,null,"Mechanistic evidence (RATED ON IB LEVEL)","Outcome choice",null,null,"Age matched to patients (RATED ON IB LEVEL)",null,null,null,"Replication of experiment",null,"Replication in different model",null,"Replication in different species",null,"References",null,"Inferential statistics"]
[null,null,"Yes or no?","If yes, how many?","Justification?","Yes or no?","If yes, type of randomization","Yes or no?","If yes, when?","Yes or no?","If yes, justification?","Yes or no?","If yes, what type of control?","Yes or no?","If yes, positive reponse reported? ","If no, justification?",null,null,"Yes or no?","If yes, what type?","Reporting of species?",null,"Reporting of model?",null,"Reporting of specifications?","Yes or no?","Reporting of temporal metric (measurement of endpoint and timing)",null,"Full reporting of outcome choice, yes or no?","Yes or no?","Is it matched to patients?",null,null,"Yes or no?","If no, is there other similar study?","Yes or no?","If yes, model type?","Yes or no?","If yes, species type?","Yes or no?","If yes, what type of references","Yes or no?","Is effect size reported? Y or N","Effect size value?","Is it significant value reported or not","Significant value?","Variance? SD, SE, CI"]
["Coding criteria",null,null,null,null,null,"Group Designation, Cage Randomization,\nPermanent Designation, Randomization to Treatment","Coding of animals, aims and groups of treatments investigated ",null,"Statement of animal flow, number of deaths, if it is reported that no exclusion was performed, then it is a yes.",null,null,"Positive control, negative control, sham, comparator arm","Minimum of 3 different doses, statement of dose reponse",null,null,"Coding criteria",null,"Sex, age, immune status, weight, microbial status of the animal","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","Mouse, rat, dog, monkey, etc.",null,"Induced (or Experimental), spontaneous (xenograft, orthotopic), transgenic, type of disease",null,"Tumor size, etc.","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","METRICS Endpoints, type of measurement (survival, tumor shrinkage, etc),  mean survival ","TIMING \n(timing of measurement)","An outcome is considered to be fully reported if the metrics and timing is provided","Is age of animals mentioned?","Check inclusion criteria of patients","Coding criteria",null,"Is it the same model?Is it the same drug? Is it measuring the same outcome?",null,"Is it the same species?","Different disease type, different route administration, different dosage form ",null,null,null,"Peer-reviewed, in house data"]
[null,"Therapeutic method for inhibition & dissolution of fibrosis-dog","No",null,null,"No",null,"No",null,"No",null,"No",null,"No",null,null,null,null,"No",null,"Yes","Dog","Yes","Fibrosis model","No","No","No","No","No","Yes","Yes",null,null,"No",null,"No",null,"No",null,"Yes","In house","No","No",null,"No","-"]
[null,"In vivo study in post-treatment effect of S-7701 in bleomycin-i","No",null,null,"No",null,"No",null,"No",null,"No",null,"No",null,null,null,null,"No",null,"Yes","Mouse","Yes","bleomycin-induced\npulmonary fibrosis","No","No","No","No","No","No","No",null,null,"No",null,"No",null,"No",null,"Yes","In house","No","No",null,"No","-"]

{"sheet":"IB6","index":8,"n_rows":15,"n_cols":47,"rows_kept":15,"cut":false,"hidden":true,"merged":[[3,31,3,32],[1,5,1,6],[1,7,1,8],[1,11,1,12],[1,26,1,28],[1,29,1,30],[0,31,2,32],[10,0,24,0],[0,16,2,17],[3,16,3,17],[1,20,1,24],[3,0,3,1],[1,2,1,4],[1,9,1,10],[1,13,1,15],[1,18,1,19],[1,35,1,36],[1,37,1,38],[0,39,0,45],[1,33,1,34],[0,0,2,1],[1,39,1,40],[0,2,0,15],[1,41,1,45],[0,18,0,30],[0,33,0,38],[2,26,2,27]]}
["Efficacy studies",null,"Evaluate in light of threats to internal validity",null,null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to construct validity",null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to external validity",null,null,null,null,null,"Others"]
[null,null,"Sample size",null,null,"Randomisation",null,"Blinded assessment",null,"Exclusion of data from analysis",null,"Controls",null,"Dose reponse \n(RATED ON IB LEVEL)",null,null,null,null,"Baseline characterization",null,"Model choice",null,null,null,null,"Mechanistic evidence (RATED ON IB LEVEL)","Outcome choice",null,null,"Age matched to patients (RATED ON IB LEVEL)",null,null,null,"Replication of experiment",null,"Replication in different model",null,"Replication in different species",null,"References",null,"Inferential statistics"]
[null,null,"Yes or no?","If yes, how many?","Justification?","Yes or no?","If yes, type of randomization","Yes or no?","If yes, when?","Yes or no?","If yes, justification?","Yes or no?","If yes, what type of control?","Yes or no?","If yes, positive reponse reported? ","If no, justification?",null,null,"Yes or no?","If yes, what type?","Reporting of species?",null,"Reporting of model?",null,"Reporting of specifications?","Yes or no?","Reporting of temporal metric (measurement of endpoint and timing)",null,"Full reporting of outcome choice, yes or no?","Yes or no?","Is it matched to patients?",null,null,"Yes or no?","If no, is there other similar study?","Yes or no?","If yes, model type?","Yes or no?","If yes, species type?","Yes or no?","If yes, what type of references","Yes or no?","Is effect size reported? Y or N","Effect size value?","Is it significant value reported or not","Significant value?","Variance? SD, SE, CI"]
["Coding criteria",null,null,null,null,null,"Group Designation, Cage Randomization,\nPermanent Designation, Randomization to Treatment","Coding of animals, aims and groups of treatments investigated ",null,"Statement of animal flow, number of deaths, if it is reported that no exclusion was performed, then it is a yes.",null,null,"Positive control, negative control, sham, comparator arm","Minimum of 3 different doses, statement of dose reponse",null,null,"Coding criteria",null,"Sex, age, immune status, weight, microbial status of the animal","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","Mouse, rat, dog, monkey, etc.",null,"Induced (or Experimental), spontaneous (xenograft, orthotopic), transgenic, type of disease",null,"Tumor size, etc.","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","METRICS Endpoints, type of measurement (survival, tumor shrinkage, etc),  mean survival ","TIMING \n(timing of measurement)","An outcome is considered to be fully reported if the metrics and timing is provided","Is age of animals mentioned?","Check inclusion criteria of patients","Coding criteria",null,"Is it the same model?Is it the same drug? Is it measuring the same outcome?",null,"Is it the same species?","Different disease type, different route administration, different dosage form ",null,null,null,"Peer-reviewed, in house data"]
[null,"Single-agent activity for cancers of the colon [U05-1895","No","-","-","No","-","No","-","No","-","No","-","Yes","Yes","NA",null,null,"No","Nude","Yes","Mouse","Yes","Xenograft","No","Yes","Yes","No","No","No","-",null,null,"No","Yes","Yes","Xenograft","No","-","Yes","In house","No","Yes","-","-","-"]
[null,"Single-agent activity pancreas [U05-1897] ","No","-","-","No","-","No","-","No","-","No","-","Yes","Yes","NA",null,null,"No","Nude","Yes","Mouse","Yes","Xenograft","No","Yes","Yes","No","No","No","-",null,null,"No","Yes","Yes","Xenograft","No","-","Yes","In house","No","Yes","-","-","-"]
[null,"Single-agent activity lung (NSCLC) [U05-1887]","No","-","-","No","-","No","-","No","-","No","-","Yes","Yes","NA",null,null,"No","Nude","Yes","Mouse","Yes","Xenograft","No","Yes","Yes","No","No","No","-",null,null,"No","Yes","Yes","Xenograft","No","-","Yes","In house","No","Yes","-","-","-"]
[null,"Single-agent activity taxane-resistant colon cancer [U05-1888]), ","No","-","-","No","-","No","-","No","-","No","-","Yes","Yes","NA",null,null,"No","Nude","Yes","Mouse","Yes","Xenograft","No","Yes","Yes","No","No","No","-",null,null,"No","Yes","Yes","Xenograft","No","-","Yes","In house","No","Yes","-","-","-"]
[null,"Single-agent activity MLL-rearranged AML cell line [U11-1121-01] ","No","-","-","No","-","No","-","No","-","No","-","Yes","Yes","NA",null,null,"No","Nude","Yes","Mouse","Yes","Xenograft","No","Yes","Yes","No","No","No","-",null,null,"No","Yes","Yes","Xenograft","No","-","Yes","In house","No","-","-","-","-"]
[null,"Single-agent activity disseminated lymphoma model [U05-2387]. ","No","-","-","No","-","No","-","No","-","No","-","Yes","Yes","NA",null,null,"No","Nude","Yes","Mouse","Yes","Xenograft","No","Yes","Yes","No","No","No","-",null,null,"No","Yes","Yes","Xenograft","No","-","Yes","In house","No","-","-","-","-"]
[null,"Combination therapy NCI-H460 xenograft study ","No","-","-","No","-","No","-","No","-","Yes","Postive control","No","-","NA",null,"Combination therapy NCI-H460 xenograft study ","No","Nude","Yes","Mouse","Yes","Xenograft","No","?","Yes","No","No","No","-",null,"Combination therapy NCI-H460 xenograft study ","No","Yes","Yes","Xenograft","No","-","Yes","In house","No","-","-","-","-"]
[null,"Combination therapy TOV-21G ovarian cancer ","No","-","-","No","-","No","-","No","-","Yes","Postive control","No","-","NA",null,"Combination therapy TOV-21G ovarian cancer ","No","Nude","Yes","Mouse","Yes","Xenograft","No","?","Yes","No","No","No","-",null,"Combination therapy TOV-21G ovarian cancer ","No","Yes","Yes","Xenograft","No","-","Yes","In house","No","-","-","-","-"]
[null,"Combination therapy AML xenograft model with cytarabine","No","-","-","No","-","No","-","No","-","Yes","Postive control","No","-","NA",null,"Combination therapy AML xenograft model with cytarabine","No","Nude","Yes","Mouse","Yes","Xenograft","No","?","Yes","No","No","No","-",null,"Combination therapy AML xenograft model with cytarabine","No","Yes","Yes","Xenograft","No","-","Yes","In house","No","-","-","-","-"]
[null,"Combination therapy AML xenograft model with decitabine ","No","-","-","No","-","No","-","No","-","Yes","Postive control","No","-","NA",null,"Combination therapy AML xenograft model with decitabine ","No","Nude","Yes","Mouse","Yes","Xenograft","No","?","Yes","No","No","No","-",null,"Combination therapy AML xenograft model with decitabine ","No","Yes","Yes","Xenograft","No","-","Yes","In house","No","-","-","-","-"]
[null,"Combination therapy AML xenograft model with azacitidine  ","No","-","-","No","-","No","-","No","-","Yes","Postive control","No","-","NA",null,"Combination therapy AML xenograft model with azacitidine  ","No","Nude","Yes","Mouse","Yes","Xenograft","No","?","Yes","No","No","No","-",null,"Combination therapy AML xenograft model with azacitidine  ","No","Yes","Yes","Xenograft","No","-","Yes","In house","No","-","-","-","-"]

{"sheet":"IB7","index":9,"n_rows":15,"n_cols":47,"rows_kept":15,"cut":false,"hidden":true,"merged":[[10,0,24,0],[10,16,24,16],[10,31,24,31],[1,39,1,40],[1,41,1,45],[2,26,2,27],[3,0,3,1],[3,16,3,17],[3,31,3,32],[0,0,2,1],[1,33,1,34],[1,35,1,36],[1,37,1,38],[0,39,0,45],[1,2,1,4],[1,5,1,6],[0,2,0,15],[0,16,2,17],[0,18,0,30],[1,7,1,8],[1,9,1,10],[1,11,1,12],[1,13,1,15],[1,18,1,19],[0,31,2,32],[0,33,0,38],[1,29,1,30],[1,20,1,24],[1,26,1,28]]}
["Efficacy studies",null,"Evaluate in light of threats to internal validity",null,null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to construct validity",null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to external validity",null,null,null,null,null,"Others"]
[null,null,"Sample size",null,null,"Randomisation",null,"Blinded assessment",null,"Exclusion of data from analysis",null,"Controls",null,"Dose reponse \n(RATED ON IB LEVEL)",null,null,null,null,"Baseline characterization",null,"Model choice",null,null,null,null,"Mechanistic evidence (RATED ON IB LEVEL)","Outcome choice",null,null,"Age matched to patients (RATED ON IB LEVEL)",null,null,null,"Replication of experiment",null,"Replication in different model",null,"Replication in different species",null,"References",null,"Inferential statistics"]
[null,null,"Yes or no?","If yes, how many?","Justification?","Yes or no?","If yes, type of randomization","Yes or no?","If yes, when?","Yes or no?","If yes, justification?","Yes or no?","If yes, what type of control?","Yes or no?","If yes, positive reponse reported? ","If no, justification?",null,null,"Yes or no?","If yes, what type?","Is there reporting of species?","If yes, what species?","Is there reporting of model?","If yes, what model?","Reporting of specifications?","Yes or no?","Reporting of temporal metric (measurement of endpoint and timing)",null,"Full reporting of outcome choice, yes or no?","Yes or no?","Is it matched to patients?",null,null,"Yes or no?","If no, is there other similar study?","Yes or no?","If yes, model type?","Yes or no?","If yes, species type?","Yes or no?","If yes, what type of references","Yes or no?","Is effect size reported? Y or N","Effect size value?","Is it significant value reported or not","Significant value?","Variance? SD, SE, CI"]
["Coding criteria",null,null,null,null,null,"Group Designation, Cage Randomization,\nPermanent Designation, Randomization to Treatment","Coding of animals, aims and groups of treatments investigated ",null,"Statement of animal flow, number of deaths, if it is reported that no exclusion was performed, then it is a yes.",null,null,"Positive control, negative control, sham, comparator arm","Minimum of 3 different doses, statement of dose reponse",null,null,"Coding criteria",null,"Sex, age, immune status, weight, microbial status of the animal","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","Mouse, rat, dog, monkey, etc.",null,"Induced (or Experimental), spontaneous (xenograft, orthotopic), transgenic, type of disease",null,"Tumor size, etc.","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","METRICS Endpoints, type of measurement (survival, tumor shrinkage, etc),  mean survival ","TIMING \n(timing of measurement)","An outcome is considered to be fully reported if the metrics and timing is provided","Is age of animals mentioned?","Check inclusion criteria of patients","Coding criteria",null,"Is it the same model?Is it the same drug? Is it measuring the same outcome?",null,"Is it the same species?","Different disease type, different route administration, different dosage form ",null,null,null,"Peer-reviewed, in house data"]
[null,"Breast cancer","No",null,null,"No",null,"No",null,"No",null,"No",null,"No",null,null,null,null,"yes","nude","yes","mice","yes","xenograft","no","yes","no","no","no","no",null,null,null,"no",null,"yes",null,"no",null,"Yes","In house",null,null,null,null,"-"]
[null,"Ovary","No",null,null,"No",null,"No",null,"No",null,"No",null,"No",null,null,null,null,"yes","nude","yes","mice","yes","xenograft","no",null,"no","no","no","no",null,null,null,"no",null,"yes",null,"no",null,"Yes","In house",null,null,null,null,"-"]
[null,"disseminated model of AML [n00232929-01] ","No",null,null,"No",null,"No",null,"No",null,"No",null,"No",null,null,null,null,"yes","nude","yes","mice","yes","xenograft","no",null,"no","no","no","no",null,null,null,"no",null,"yes",null,"no",null,"Yes","In house",null,null,null,null,"-"]
[null,"disseminated model of AML[P15-\n00294] Rudolph D, et al. Efficacy and mechanism of action of volasertib, a potent\nand selective inhibitor of Polo-like kinases, in preclinical models of acute\nmyeloid leukemia. J Pharmacol Exp Ther. 2015","No",null,null,"No",null,"No",null,"No",null,"No",null,"No",null,null,null,null,"yes","nude","yes","mice","yes","xenograft","no",null,"no","no","no","no",null,null,null,"no",null,"yes",null,"no",null,"Yes","Peer reviewed",null,null,null,null,"-"]
[null,"skipped for later",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]

{"sheet":"IB8","index":10,"n_rows":15,"n_cols":47,"rows_kept":15,"cut":false,"hidden":true,"merged":[[10,0,24,0],[10,16,24,16],[10,31,24,31],[1,39,1,40],[1,41,1,45],[2,26,2,27],[3,0,3,1],[3,16,3,17],[3,31,3,32],[0,0,2,1],[1,33,1,34],[1,35,1,36],[1,37,1,38],[0,39,0,45],[1,2,1,4],[1,5,1,6],[0,2,0,15],[0,16,2,17],[0,18,0,30],[1,7,1,8],[1,9,1,10],[1,11,1,12],[1,13,1,15],[1,18,1,19],[0,31,2,32],[0,33,0,38],[1,29,1,30],[1,20,1,24],[1,26,1,28]]}
["Efficacy studies",null,"Evaluate in light of threats to internal validity",null,null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to construct validity",null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to external validity",null,null,null,null,null,"Others"]
[null,null,"Sample size",null,null,"Randomisation",null,"Blinded assessment",null,"Exclusion of data from analysis",null,"Controls",null,"Dose reponse \n(RATED ON IB LEVEL)",null,null,null,null,"Baseline characterization",null,"Model choice",null,null,null,null,"Mechanistic evidence (RATED ON IB LEVEL)","Outcome choice",null,null,"Age matched to patients (RATED ON IB LEVEL)",null,null,null,"Replication of experiment",null,"Replication in different model",null,"Replication in different species",null,"References",null,"Inferential statistics"]
[null,null,"Yes or no?","If yes, how many?","Justification?","Yes or no?","If yes, type of randomization","Yes or no?","If yes, when?","Yes or no?","If yes, justification?","Yes or no?","If yes, what type of control?","Yes or no?","If yes, positive reponse reported? ","If no, justification?",null,null,"Yes or no?","If yes, what type?","Reporting of species?",null,"Reporting of model?",null,"Reporting of specifications?","Yes or no?","Reporting of temporal metric (measurement of endpoint and timing)",null,"Full reporting of outcome choice, yes or no?","Yes or no?","Is it matched to patients?",null,null,"Yes or no?","If no, is there other similar study?","Yes or no?","If yes, model type?","Yes or no?","If yes, species type?","Yes or no?","If yes, what type of references","Yes or no?","Is effect size reported? Y or N","Effect size value?","Is it significant value reported or not","Significant value?","Variance? SD, SE, CI"]
["Coding criteria",null,null,null,null,null,"Group Designation, Cage Randomization,\nPermanent Designation, Randomization to Treatment","Coding of animals, aims and groups of treatments investigated ",null,"Statement of animal flow, number of deaths, if it is reported that no exclusion was performed, then it is a yes.",null,null,"Positive control, negative control, sham, comparator arm","Minimum of 3 different doses, statement of dose reponse",null,null,"Coding criteria",null,"Sex, age, immune status, weight, microbial status of the animal","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","Mouse, rat, dog, monkey, etc.",null,"Induced (or Experimental), spontaneous (xenograft, orthotopic), transgenic, type of disease",null,"Tumor size, etc.","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","METRICS Endpoints, type of measurement (survival, tumor shrinkage, etc),  mean survival ","TIMING \n(timing of measurement)","An outcome is considered to be fully reported if the metrics and timing is provided","Is age of animals mentioned?","Check inclusion criteria of patients","Coding criteria",null,"Is it the same model?Is it the same drug? Is it measuring the same outcome?",null,"Is it the same species?","Different disease type, different route administration, different dosage form ",null,null,null,"Peer-reviewed, in house data"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]

{"sheet":"IB9","index":11,"n_rows":15,"n_cols":48,"rows_kept":15,"cut":false,"hidden":true,"merged":[[10,0,24,0],[10,16,24,16],[10,32,24,32],[1,40,1,41],[1,42,1,46],[2,27,2,28],[3,0,3,1],[3,16,3,17],[3,32,3,33],[0,0,2,1],[1,34,1,35],[1,36,1,37],[1,38,1,39],[0,40,0,46],[1,2,1,4],[1,5,1,6],[0,2,0,15],[0,16,2,17],[0,18,0,31],[1,7,1,8],[1,9,1,10],[1,11,1,12],[1,13,1,15],[1,18,1,19],[0,32,2,33],[0,34,0,39],[1,30,1,31],[1,20,1,24],[1,27,1,29]]}
["Efficacy studies",null,"Evaluate in light of threats to internal validity",null,null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to construct validity",null,null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to external validity",null,null,null,null,null,"Others"]
[null,null,"Sample size",null,null,"Randomisation",null,"Blinded assessment",null,"Exclusion of data from analysis",null,"Controls",null,"Dose reponse \n(RATED ON IB LEVEL)",null,null,null,null,"Baseline characterization",null,"Model choice",null,null,null,null,null,"Mechanistic evidence (RATED ON IB LEVEL)","Outcome choice",null,null,"Age matched to patients (RATED ON IB LEVEL)",null,null,null,"Replication of experiment",null,"Replication in different model",null,"Replication in different species",null,"References",null,"Inferential statistics"]
[null,null,"Yes or no?","If yes, how many?","Justification?","Yes or no?","If yes, type of randomization","Yes or no?","If yes, when?","Yes or no?","If yes, justification?","Yes or no?","If yes, what type of control?","Yes or no?","If yes, positive reponse reported? ","If no, justification?",null,null,"Yes or no?","If yes, what type?","Reporting of species?",null,"Reporting of model?",null,"Reporting of specifications?",null,"Yes or no?","Reporting of temporal metric (measurement of endpoint and timing)",null,"Full reporting of outcome choice, yes or no?","Yes or no?","Is it matched to patients?",null,null,"Yes or no?","If no, is there other similar study?","Yes or no?","If yes, model type?","Yes or no?","If yes, species type?","Yes or no?","If yes, what type of references","Yes or no?","Is effect size reported? Y or N","Effect size value?","Is it significant value reported or not","Significant value?","Variance? SD, SE, CI"]
["Coding criteria",null,null,null,null,null,"Group Designation, Cage Randomization,\nPermanent Designation, Randomization to Treatment","Coding of animals, aims and groups of treatments investigated ",null,"Statement of animal flow, number of deaths, if it is reported that no exclusion was performed, then it is a yes.",null,null,"Positive control, negative control, sham, comparator arm","Minimum of 3 different doses, statement of dose reponse",null,null,"Coding criteria",null,"Sex, age, immune status, weight, microbial status of the animal, breed","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","Mouse, rat, dog, monkey, etc.",null,"Induced (or Experimental), spontaneous (xenograft, orthotopic), transgenic, type of disease",null,"Tumor size, etc.",null,"(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","METRICS Endpoints, type of measurement (survival, tumor shrinkage, etc),  mean survival ","TIMING \n(timing of measurement)","An outcome is considered to be fully reported if the metrics and timing is provided","Is age of animals mentioned?","Check inclusion criteria of patients","Coding criteria",null,"Is it the same model?Is it the same drug? Is it measuring the same outcome?",null,"Is it the same species?","Different disease type, different route administration, different dosage form ",null,null,null,"Peer-reviewed, in house data"]
[null,"RCC Study N°\n856131","Yes",48,null,"No",null,"No",null,"No",null,"Yes","Positive","No",null,"No",null,null,"Yes","Sex, Wistar, young (age)","Yes","Rat","Yes","Intra-articular Injection of Monosodium Urate: An\nAnimal Model for Knee-Joint Arthritis","Yes",null,null,"Yes","Yes","Yes","yes","yes",null,null,"Yes",null,"No",null,"No",null,"Yes","In house",null,"Yes","number of rearings was reduced\non day 3 by 5.8% and 6.2%, and the total distance was reduced by 0.7% and 5.7% with\nRTX","No","-"]
[null,"(RCC Study N°\n858572)","Yes",70,null,"No",null,"No",null,"No",null,"Yes","Positive, Negative","Yes","Yes",null,null,null,"No",null,"Yes","Rat","No",null,"no",null,null,"no","no","no","No",null,null,null,"Yes",null,"No",null,"No",null,"Yes","In house","No","No",null,null,"-"]
[null,"RCC Study N°\nA22263","Yes",50,null,"No",null,"No",null,"No",null,"Yes","Negative","Yes","Yes","-",null,null,"Yes","Sex, young adult","Yes","Rat","Yes","Intra-articular Injection of Monosodium Urate: An\nAnimal Model for Knee-Joint Arthritis","Yes",null,"Yes","Yes","Yes","Yes","Yes","?",null,null,"No","Yes","No",null,"No",null,"Yes","In house","No","No",null,"No","-"]
[null,"RCC\nStudy N° A81573","Yes",48,null,"NO",null,"No",null,"Yes","2 rats died","Yes","Negative","Yes","Yes","-",null,null,"No",null,"Yes","Rat","Yes","Intra-articular Injection of Monosodium Urate: An\nAnimal Model for Knee-Joint Arthritis","Yes",null,"Yes","Yes","Yes","Yes","No","-",null,null,null,null,null,null,null,null,"yes","In house","No","no",null,null,"-"]
[null,"carole has 3 additional studie. They are published literature. CF said it should be included in the list. WC disagreed. Check with DS",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]

{"sheet":"IB13","index":12,"n_rows":16,"n_cols":47,"rows_kept":16,"cut":false,"hidden":true,"merged":[[11,0,25,0],[11,16,25,16],[11,31,25,31],[1,39,1,40],[1,41,1,45],[2,26,2,27],[3,0,3,1],[3,16,3,17],[3,31,3,32],[0,0,2,1],[1,33,1,34],[1,35,1,36],[1,37,1,38],[0,39,0,45],[1,2,1,4],[1,5,1,6],[0,2,0,15],[0,16,2,17],[0,18,0,30],[1,7,1,8],[1,9,1,10],[1,11,1,12],[1,13,1,15],[1,18,1,19],[0,31,2,32],[0,33,0,38],[1,29,1,30],[1,20,1,24],[1,26,1,28]]}
["Efficacy studies",null,"Evaluate in light of threats to internal validity",null,null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to construct validity",null,null,null,null,null,null,null,null,null,null,null,null,"Efficacy studies",null,"Evaluate in light of threats to external validity",null,null,null,null,null,"Others"]
[null,null,"Sample size",null,null,"Randomisation",null,"Blinded assessment",null,"Exclusion of data from analysis",null,"Controls",null,"Dose reponse \n(RATED ON IB LEVEL)",null,null,null,null,"Baseline characterization",null,"Model choice",null,null,null,null,"Mechanistic evidence (RATED ON IB LEVEL)","Outcome choice",null,null,"Age matched to patients (RATED ON IB LEVEL)",null,null,null,"Replication of experiment",null,"Replication in different model",null,"Replication in different species",null,"References",null,"Inferential statistics"]
[null,null,"Yes or no?","If yes, how many?","Justification?","Yes or no?","If yes, type of randomization","Yes or no?","If yes, when?","Yes or no?","If yes, justification?","Yes or no?","If yes, what type of control?","Yes or no?","If yes, positive reponse reported? ","If no, justification?",null,null,"Yes or no?","If yes, what type?","Reporting of species?",null,"Reporting of model?",null,"Reporting of specifications?","Yes or no?","Reporting of temporal metric (measurement of endpoint and timing)",null,"Full reporting of outcome choice, yes or no?","Yes or no?","Is it matched to patients?",null,null,"Yes or no?","If no, is there other similar study?","Yes or no?","If yes, model type?","Yes or no?","If yes, species type?","Yes or no?","If yes, what type of references","Yes or no?","Is effect size reported? Y or N","Effect size value?","Is it significant value reported or not","Significant value?","Variance? SD, SE, CI"]
["Coding criteria",null,null,null,"sample size calculation",null,"Group Designation, Cage Randomization,\nPermanent Designation, Randomization to Treatment","Coding of animals, aims and groups of treatments investigated ",null,"Statement of animal flow, number of deaths, if it is reported that no exclusion was performed, then it is a yes.",null,null,"Positive control, negative control, sham, comparator arm","Minimum of 3 different doses, statement of dose reponse",null,null,"Coding criteria",null,"Sex, age, immune status, weight, microbial status of the animal","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","Mouse, rat, dog, monkey, etc.",null,"Induced (or Experimental), spontaneous (xenograft, orthotopic), transgenic, type of disease",null,"Tumor size, etc.","(OPEN QUESTION: Maybe too time consuming? Decide after pilot test with CF and JK)","METRICS Endpoints, type of measurement (survival, tumor shrinkage, etc),  mean survival ","TIMING \n(timing of measurement)","An outcome is considered to be fully reported if the metrics and timing is provided","Is age of animals mentioned?","Check inclusion criteria of patients","Coding criteria",null,"Is it the same model?Is it the same drug? Is it measuring the same outcome?",null,"Is it the same species?","Different disease type, different route administration, different dosage form ",null,null,null,"Peer-reviewed, in house data"]
[null,"4.2.1 Activity of Cabozantinib in the Transgenic RIP-Tag2 Model System *Figure 4.1a","No","-","no","No",null,"No",null,"No","1 death in the treatment group from gavage injury","Yes","Negative, positive","No",null,null,null,null,"No",null,"Yes","Mice","Yes","RIP-Tag2 mouse model of neuroendocrine pancreatic\ncancer that spontaneously develops aggressive tumors","No","No","Yes","NO","No","no","?",null,null,"No",null,"No",null,"No",null,"Yes","Peer-reviewed","Yes","Yes","The number of liver metastases was 5-fold\ngreater in anti-VEGF antibody-treated animals compared with vehicle-treated animals,\nand no liver metastases were detected in cabozantinib-treated animals","Yes"," P < 0.05"]
[null,"4.2.1 Activity of Cabozantinib in the Transgenic RIP-Tag2 Model System *Figure 4.1b","Yes",6,"no","No",null,"No",null,"No","1 death in the treatment group from gavage injury","Yes","Negative, positive","No",null,null,null,null,"No",null,"Yes","Mice","Yes","RIP-Tag2 mouse model of neuroendocrine pancreatic\ncancer that spontaneously develops aggressive tumors","No","No","Yes","Yes","Yes","from age 14 to 17 weeks","?",null,null,"No",null,"No",null,"No",null,"Yes","Peer-reviewed","Yes","Yes","Median survival was 14.7 weeks for vehicle-treated animals (n = 12) and\n16.4 weeks for anti-VEGF antibody-treated animals (n = 7; P < 0.05 vs vehicle), and all\ncabozantinib-treated animals survived for the full 20 weeks of observation (n = 6;\nP < 0.05 vs vehicle and anti-VEGF antibody;","Yes"," P < 0.05"]
[null,"A lot of peer reviewed studies were references"]
[null,"human prostate cancer model ARCaPM, which expresses both MET and the VEGF\nco-receptor NP-1 (Zhang et al 2010),",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,"prostate cancer(Schimmoller et al. 2011; Dai et al. 2014",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,"castration-resistant C4-2B PCa xenograft in the tibiae of SCID mice",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,"MDA-MB-231 breast cancer\nxenograft introduced intracardially into athymic nude mice (Mohammad et al. 2012",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,"NOD/SCID mice were injected intratibially with luciferase-expressing\nVCaP human prostate carcinoma cells resulting in lesions which were predominantly\nosteosclerotic with some osteolytic activity (Graham et al. 2014",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"-"]

{"sheet":"New coding matrix","index":13,"n_rows":6,"n_cols":38,"rows_kept":6,"cut":false,"hidden":true,"merged":[[0,35,0,37],[0,5,0,6],[0,9,0,11],[0,12,0,13],[0,14,0,15],[0,21,0,23],[0,7,0,8],[0,16,0,18],[0,19,0,20],[0,24,0,25],[0,2,0,4],[0,27,0,28],[0,29,0,30],[0,31,0,32],[0,33,0,34]]}
["Item","Type of study","Sample size",null,null,"Randomisation",null,"Baseline characterization",null,"Blinded assessment",null,null,"Exclusion of data from analysis",null,"Controls",null,"Model choice",null,null,"Outcome choice",null,"Dose reponse \n(RATE ON IB LEVEL)",null,null,"Age matched to patients \n(RATE ON IB LEVEL)",null,"Mechanistic evidence \n(RATE ON IB LEVEL)","Replication of experiment \n(RATE ON IB LEVEL)",null,"Replication in different model \n(RATE ON IB LEVEL)",null,"Replication in different species (RATE ON IB LEVEL)",null,"Citation of references",null,"Inferential statistics"]
["Research questions","Determine whether experiment listed in an efficacy study, Yes, no or unclear","Is sample size reported, Yes or no?","If yes, how many?","Is sample size calculation reported, Yes or no?","Is randomisation reported, \nYes or no?","If yes, describe the method used to generate the randomization sequence.?","Is baseline characterization reported, \nYes or no?","If yes, what type?","Is blinded assessment  for treatment allocation reported, \nYes or no?","Is blinded assessment  for outcome assessment reported, \nYes or no?","If yes, when?","Is exclusion of data reported, Yes or no?","If yes, justification?","Is control group reported, Yes or no?","If yes, what type of control?","Is the species of animal reported?","Is the type of model reported?","Is the specifications of model reported?","Is the outcome choice reported, \nYes or no?","If yes, is the metric or time-course or both reported?","Is dose response reported? Yes or no?","If yes, is positive reponse reported, Yes or no? ","If no, justification?","Is the age of animals reported, \nYes or no?","Is it matched to patients?","Yes or no?","Is there replication of experiment, Yes or no?","If no, is there other similar study?","Is there replication in different model, \nYes or no?","If yes, model type?","Is there replication in different species, \nYes or no?","If yes, species type?","Is there references reported, \nYes or no?","If yes, what type of references?","Is effect size reported? Yes or no?","Is  significant value reported? Yes or no?","Was the investigation positive, inconclusive or negative?"]
["Coding criteria","■ In cases where drug are tested for efficacy in their respective therapeutic indications,  complete experiment level and IB level extraction. DO NOT PERFORM AN EXTRACTION for non-efficacy studies","■ Does the experiment report sample sizes for all extractable groups?\n■ Is information provided on the number of animal per treatment group or total number of animal for the whole experiment?","n = ?","■ Has a power calculation been performed a priori to determine sample size?\n■ Select no if there are no explicit statements about sample size determination.","■ Were animals randomly assigned to treatment?\n■ Select unclear if there are no explicit statements about allocation.","Group designation, Cage randomization,\nPermanent designation, Randomization to treatment","■ Was the emergence of confounding physiological variables monitored and addressed (e.g. blood pressure, body temperature)?\n■ Were the groups similar at baseline or were they adjusted for confounders in the analysis?\n■ Was the distribution of relevant baseline characteristics balanced for the intervention and control groups?\n■ If relevant, did the investigators adequately adjust for unequal distribution of some relevant baseline characteristics in the analysis?\n■ Was the timing of disease induction adequate? \n\n","Sex, age, immune status, weight, microbial status of the animal ","■ Was treatment allocation concealed from the investigators during the experiment?\n■ Select no if there are no explicit statements about blinding to treatment allocation.","■ Were investigators blinded to treatment allocation during outcome assessment? \n■ Select no if there are no explicit statements about blinding to outcome assessment.","■ Blinding of animals, aims and groups of treatments before investigation or during analysis? ","■ Do studies explain the flow of animals from inclusion through to analysis?\n■ Has every animal been accounted for, from entry into experiment through treatment, outcome assessment, sacri ce and analysis? ","Animal death","■ Were appropriate controls used in all in vivo experiments (e.g. positive, negative)?","Positive control, negative control, sham, comparator arm","Mouse, rat, dog, monkey, etc.","Induced or Experimental, spontaneous (xenograft, orthotopic), transgenic, type of disease","Tumor size, etc.","Endpoints, type of measurement (survival, tumor shrinkage, etc), time-course of measurement, mean survival ",null,"■ Was there a demonstration of dose-response relationship of  the adverse effect?\n■ Was there a time course (e.g., onset and duration of response) of the adverse effect?\n■ Was the doses eliciting the adverse effect compared to the doses eliciting the primary pharmacodynamic effect in the test species or the proposed therapeutic effect in humans?\n■ Minimum of 3 different doses",null,null,"■ Is age of animals mentioned?","■ Check inclusion criteria of patients",null,"■ Is it the same model?\n■ Is it the same drug? \n■ Is it measuring the same outcome?",null,"■ Whether efficacy studies were replicated in more than one model. \n■ Is it the same species?","■ Different disease type, different route administration, different dosage form ","■ Whether efficacy studies were replicated in more than one species.",null,"■ If there is internal study number, citation, … then it is a yes.","Peer-reviewed, in house data",null,"■ Is there a p-value reported in the figure description or in the experiment results?","■ If p value significant (typically ≤ 0.05), then it is positiv.e"]
["Study ID 1"]
["Study ID 2"]
["Study ID 3"]