Min proteins provide max efficiency during cell division

By forming oscillating patterns between the ends of a cell (poles), the Min protein system provides protection against abnormal cell division in bacteria. Despite decades of theoretical work, predicting the protein concentrations at which oscillations start and whether cells can maintain them under different conditions has been a challenge. Understanding these thresholds is important because they reveal how efficient this self-organizing system is in guiding division to the right place.

UC San Diego researchers have engineered Escherichia coli cells to independently control Min protein expression levels. In their work, the team was able to show that oscillations were stable across a wide range of concentrations, with E. coli producing only the minimal necessary amounts while maintaining a constant oscillation wavelength.

The research is published in the journal Nature Physics.

The results provide a powerful example of the potential of integrating quantitative cell physiology and biophysical modeling to understand the fundamental mechanisms controlling cell division machinery. This integrated approach reframes long-standing research questions and opens new avenues for inquiry. Such cross-disciplinary strategies can unlock further insights into cellular organization and function.

UC San Diego authors are Suckjoon Jun, Michael Sandler, Ziyuan Ren, Haochen Fu, Dongyang Li, Cindy Sou, and Daniel Villarreal (Physics), and Judy Kim and Chanin B. Tangtartharaku (Chemistry/Biochemistry).