DNA aptamers are powerful molecular tools in biosensing, bioimaging and therapeutics. However, a limited understanding of their tertiary structures and binding mechanisms hinders their further optimizations and applications.
Biotechnology
Aug 26, 2025
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Drug-carrying DNA aptamers can deliver a one-two punch to leukemia by precisely targeting the elusive cancer stem cells that seed cancer relapses, researchers at the University of Illinois Urbana-Champaign report.
Bio & Medicine
Apr 3, 2025
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91
Researchers at the University of Toronto have invented a new method that uses DNA sequencing to measure metabolites. This enables rapid and precise analysis of biological compounds, such as sugars, vitamins, hormones and ...
Biotechnology
Feb 4, 2025
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In a study published in PNAS, a research team has resolved the first high-resolution structure of the sgc8c DNA aptamer that targets protein tyrosine kinase 7 (PTK7), engineered two optimal sgc8c variants for disease theranostics ...
Molecular & Computational biology
Jul 19, 2024
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32
New findings about chitinases, enzymes found naturally in plants, could allow farmers to address fungal infections sooner and more efficiently.
Plants & Animals
Jul 2, 2024
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G-quadruplexes (G4), which are special structures in DNA and RNA that play a crucial role in cells, have been associated with cancers and neurological diseases. A research team from City University of Hong Kong (CityU) recently ...
Biotechnology
Mar 21, 2024
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One double-helix strand of DNA could extend six feet, but it is so tightly coiled that it packs an entire sequence of nucleotides into the tiny nucleus of a cell. If that same DNA was instead split into two strands and divided ...
Biotechnology
Oct 17, 2023
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85
Discovering and developing drugs can be slow, costly and high-risk, but harnessing advances in artificial intelligence (AI) can help with these processes, say Brock University researchers.
Molecular & Computational biology
Aug 1, 2023
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Investigators led by Shana Kelley, Ph.D., the Neena B. Schwartz Professor of Chemistry, Biomedical Engineering, and of Biochemistry and Molecular Genetics, have developed a novel approach for identifying sequences of artificial ...
Biochemistry
Jul 27, 2023
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39
When is having trillions of choices not enough? Apparently when making aptamers.
Biochemistry
Jul 6, 2023
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