Researchers at Pitt have produced the most detailed image to date of a bacteriophage–phage for short–that has allowed them to see for the first time the structural makeup of the part of the phage that directly attaches ...
Cell & Microbiology
Apr 15, 2025
0
2
Human immunodeficiency virus type 1 (HIV-1) targets important cells of our immune system, making infected individuals more vulnerable to diseases and infections. Once inside human cells, HIV integrates the viral genome into ...
Cell & Microbiology
Jan 20, 2025
0
102
A computational model of the more than 26 million atoms in a DNA-packed viral capsid expands our understanding of virus structure and DNA dynamics, insights that could provide new research avenues and drug targets, University ...
Cell & Microbiology
Mar 6, 2024
0
51
Each year, about 1 million individuals worldwide become infected with HIV, the virus that causes AIDS. To replicate and spread the infection, the virus must smuggle its genetic material into the cell nucleus and integrate ...
Cell & Microbiology
Jan 25, 2024
1
9
A new study led by Yale scientists shows that the activity of a portion of a human papillomavirus (HPV) protein does not depend on its amino acid sequence or composition. This discovery challenges the widely held belief that ...
Molecular & Computational biology
Oct 12, 2023
0
6
Scientists have engineered adeno-associated viruses (AAVs) to package and deliver gene therapies to cells in the body. But the field has struggled to develop AAVs that can efficiently target different cell types and organs ...
Biotechnology
Jul 20, 2023
0
28
Most cells can defend themselves against viruses after they have been activated by the body's own messenger substances (interferons). This happens with the help of proteins that recognize invading virus components and interfere ...
Biochemistry
Jul 1, 2022
0
19
Much remains to be discovered on how the HIV-1 virus infects our cells. Scientists know that it slips past the defenses of our immune system, entering white blood cells to deliver its genetic payload and hijack the cell's ...
Biotechnology
Jun 16, 2022
0
59
Each simple RNA virus has a genome, its "native RNA." This genome dictates how the virus replicates in cells to eventually cause disease. The genome also has the code for making a capsid, the protein shell of a virus that ...
Molecular & Computational biology
Mar 9, 2022
0
189
With up to 2.4 million U.S. cases and over 250 million chronic cases globally, hepatitis B infection persists despite the availability of a vaccine. Vaccines work by immunizing the body against a virus to prevent infection; ...
Molecular & Computational biology
Sep 7, 2021
0
39
