Since the dawn of human spaceflight, scientists have carefully studied the effects of space and microgravity on astronauts. After decades of observations and examinations, one truth is certain: space is brutal on the human ...
Space Exploration
Sep 9, 2025
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7
For this new Picture of the Month feature, the NASA/ESA/CSA James Webb Space Telescope has provided a fantastic new view of IRAS 04302+2247, a planet-forming disk located about 525 light-years away in a dark cloud within ...
Astronomy
Aug 29, 2025
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138
An international team of astronomers using NASA's IXPE (Imaging X-ray Polarimetry Explorer), has challenged our understanding of what happens to matter in the direct vicinity of a black hole.
Astronomy
Aug 13, 2025
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69
Researchers from the University of Greifswald and the Max Planck Institute for Astronomy (MPIA) in Heidelberg (both in Germany) have developed a prototype experimental setup that simulates flow properties using a water tornado ...
Astronomy
Jul 21, 2025
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35
Small breed dogs—including dachshunds and French bulldogs—have a high risk of developing a herniated disk in their middle back, which can lead to partial or complete paralysis in the hindlegs. Until recently, the only ...
Veterinary medicine
Jul 9, 2025
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0
A fascinating glimpse into how a solar system like our own is born has been revealed with the detection of planet-forming "pebbles" around two young stars.
Astronomy
Jul 7, 2025
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48
This new NASA/ESA/CSA James Webb Space Telescope Picture of the Month presents HH 30 in unprecedented detail. This target is an edge-on protoplanetary disk that is surrounded by jets and a disk wind, and is located in the ...
Astronomy
Feb 4, 2025
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115
Planets are formed when dust and rock in a disk around a young star collide and combine to form ever larger bodies. This so-called accretion is not yet fully understood. Astrophysicists at the University of Duisburg-Essen ...
Astronomy
Jan 22, 2025
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32
By peering into the cosmic dance of stars, a team led by researchers from the Leibniz Institute for Astrophysics Potsdam (AIP) has unraveled the complex structure of our Milky Way galaxy. Assuming that each observed star ...
Astronomy
Dec 19, 2024
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47
A small team of physicists at the University of Amsterdam has demonstrated the ability of 3D-printed particles to propel themselves across the surface of a fluid, given the right fuel. The group has posted a paper describing ...
PSD-95 (postsynaptic density protein 95) also known as SAP-90 (synapse-associated protein 90) is a protein that in humans is encoded by the DLG4 (disks large homolog 4) gene.
PSD-95 is a member of the membrane-associated guanylate kinase (MAGUK) family. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins.
PSD-95 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin, NMDA receptors, AMPA receptors, and potassium channels.
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