Researchers at Baylor College of Medicine have developed a powerful new data analysis method named COOKIE-Pro (Covalent Occupancy Kinetic Enrichment via Proteomics) that provides a comprehensive, unbiased view of how a class ...
Biochemistry
Sep 30, 2025
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7
Membrane proteins are crucial for numerous biological processes and serve as important drug targets. For decades, scientists have relied on detergents to extract membrane proteins from cell membranes for structural studies.
Cell & Microbiology
Sep 23, 2025
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50
Small but powerful: Ubiquitin controls the lifespan and distribution of proteins in the cell, but it can also determine their shape, function, or interactions with other cellular components. Ubiquitin ligases are key to this ...
Biotechnology
Sep 17, 2025
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63
Since its release in 2024, the open-source platform BindCraft, developed at EPFL, has already disrupted the world of protein design. Physical interactions between proteins influence anything from cell signaling and growth ...
Biotechnology
Aug 29, 2025
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6
Scientists have discovered how a small protein in plants that acts like a molecular form of Velcro helps stick to other target proteins, creating new connections that enable plants to respond better to environmental stresses ...
Molecular & Computational biology
Aug 28, 2025
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41
Soybeans (Glycine max) are a vital global source of plant protein and oil, used in food, feed, and industry. Increasing soybean yields is critical for ensuring food security and promoting sustainable agriculture. However, ...
Molecular & Computational biology
Aug 26, 2025
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0
One class of drugs that has shown promise in treating diseases ranging from lung cancer to COVID-19 are targeted covalent inhibitors (TCIs). These small molecule drugs form covalent bonds with their target proteins, allowing ...
Analytical Chemistry
Aug 23, 2025
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0
Traditional drug development methods involve identifying a target protein (e.g., a cancer cell receptor) that causes disease, and then searching through countless molecular candidates (potential drugs) that could bind to ...
Biochemistry
Aug 11, 2025
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54
An easy method for efficiently identifying proteins that interact with bioactive molecules has been developed by chemical biologists at RIKEN. This innovation, published in ChemBioChem, could help to speed up the development ...
Molecular & Computational biology
Jul 15, 2025
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0
The ability of protein kinases to transfer a phosphate group to target proteins plays an important role in many cellular processes. Scientists at the Max Planck Institute for Medical Research in Heidelberg have now developed ...
Biotechnology
Jul 10, 2025
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