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Couldn’t make it to HubSpot’s INBOUND25 in San Francisco? Or maybe you went, but you’d rather skip the noise and get the highlights in plain…
Couldn’t make it to HubSpot’s INBOUND25 in San Francisco? Or maybe you went, but you’d rather skip the noise and get the highlights in plain…
Liked by Klemen Hrovat
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HubSpot is evolving. Fast. INBOUND 2025 brought 200+ updates, from innovative AI integrations and a fresh rebranding to upgrades across CRM, Data…
HubSpot is evolving. Fast. INBOUND 2025 brought 200+ updates, from innovative AI integrations and a fresh rebranding to upgrades across CRM, Data…
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With all the product updates, new interface rolling out, and varying degrees of participation in betas, has anyone else experienced an uptick in…
With all the product updates, new interface rolling out, and varying degrees of participation in betas, has anyone else experienced an uptick in…
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Methods of amorphization and investigation of the amorphous state.
Acta Pharmaceutica
The amorphous form of pharmaceutical materials represents the most energetic solid state of a material. It provides advantages in terms of dissolution rate and bioavailability. This review presents the methods of solid- -state amorphization described in literature (supercooling of liquids, milling, lyophilization, spray drying, dehydration of crystalline hydrates), with the emphasis on milling. Furthermore, we describe how amorphous state of pharmaceuticals differ depending on the method of…
The amorphous form of pharmaceutical materials represents the most energetic solid state of a material. It provides advantages in terms of dissolution rate and bioavailability. This review presents the methods of solid- -state amorphization described in literature (supercooling of liquids, milling, lyophilization, spray drying, dehydration of crystalline hydrates), with the emphasis on milling. Furthermore, we describe how amorphous state of pharmaceuticals differ depending on the method of preparation and how these differences can be screened by a variety of spectroscopic (X-ray powder diffraction, solid state nuclear magnetic resonance, atomic pairwise distribution, infrared spectroscopy, terahertz spectroscopy) and calorimetry methods.
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