What makes pioneering possible? The people. We are a team of brave, bold thinkers who push the boundaries of knowledge to imagine and build a better future for people and the planet. 🌟 Our Why I Pioneer campaign celebrates not just the breakthroughs we’ve achieved, but the people who make them happen. Read personal stories about the passion and purpose that drive our team at Flagship, shaping our culture of fearless exploration and discovery: https://bit.ly/41QfkEi #WeAreFlagship #BiggerLeaps
Flagship Pioneering
Biotechnology Research
Cambridge, MA 134,226 followers
We are a biotechnology company that invents and builds platform companies that change the world.
About us
Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple transformative human health and sustainability products. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures. The current Flagship ecosystem comprises over 40 companies, including Denali Therapeutics, Foghorn Therapeutics, Generate:Biomedicines, Inari, Indigo Agriculture, and Tessera Therapeutics.
- Website
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http://www.flagshippioneering.com
External link for Flagship Pioneering
- Industry
- Biotechnology Research
- Company size
- 501-1,000 employees
- Headquarters
- Cambridge, MA
- Type
- Privately Held
- Founded
- 2000
- Specialties
- life sciences, biotech, therapeutics, diagnostics, sustainability, climate change, artificial intelligence, machine learning, agtech, medicines, therapeutics, biology, entrepreneurship, biotechnology, science, innovation, and ventures
Locations
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Primary
Get directions
55 Cambridge Parkway
Suite 800E
Cambridge, MA 02142, US
Employees at Flagship Pioneering
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Karim Lakhani
Professor Harvard Business School | Chair D^3 Institute at Harvard | Board member Cloudflare & Videahealth
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Renuka Babu
Experienced Leader | Entrepreneur | Advisor
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Venu Nagali
Strategy, Business Development & Finance Executive ✦ Increase Enterprise Value through Innovative Strategies and Building Results-Producing Teams
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David Khougazian
Executive Partner at Flagship Pioneering
Updates
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Hear from Raj Panjabi, M.D., Flagship Senior Partner, as he shares how his background as a physician, health official, and entrepreneur prepared him to lead Flagship’s Preemptive Health and Medicine (PH&M) Initiative. In this Three Questions, Raj unpacks: 🔹 What inspired him to lead PH&M 🔹 The advances enabling us to predict and preempt disease sooner 🔹 What's keeping him busy outside of work
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Exciting news from Sana Biotechnology, Inc. A study, published today in NEJM Group's New England Journal of Medicine, demonstrates that Sana’s novel HIP-modified pancreatic islet cells restore insulin production without the need for immunosuppression. The findings of this study represent a significant breakthrough to address type 1 diabetes. Read more here: http://bit.ly/4fhQnrG
We are thrilled to share that initial type 1 diabetes data highlighting the curative potential of our hypoimmune (HIP)-based therapies have been published in the NEJM Group's New England Journal of Medicine (NEJM). We believe the results from this first-in-human investigator-sponsored trial, conducted in partnership with Uppsala University Hospital, represent both a scientific and medical breakthrough. We look forward to advancing SC451, our HIP-modified, cell-derived therapy with scalable manufacturing as a potential one-time treatment for patients with type 1 diabetes. Learn more here: https://bit.ly/3ITxCPr
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🧪 Meet Rajib Mukherjee — a pioneering Metabolic Maverick leading in vitro biology and pharmacology research to uncover new approaches to obesity management and metabolic disease treatments: http://bit.ly/44Zu9Y2 🌟 Our Why I Pioneer campaign celebrates not just the breakthroughs we’ve achieved, but the people who make them happen. Read more about the passion and purpose that drive Rajib and other pioneers at Flagship, shaping our culture of fearless exploration and discovery: https://bit.ly/41QfkEi #WeAreFlagship #BiggerLeaps
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Chronic illnesses like Alzheimer’s, heart disease, and cancers don’t begin with symptoms — they begin in silence. At Flagship, we believe health breakthroughs will come from preventing disease from ever taking hold. That’s why we created our Preemptive Health & Medicine initiative — to predict and preempt disease before it starts. Explore how Flagship-founded Etiome is pioneering this approach, targeting the silent stages of disease progression, before symptoms ever appear, ushering in a future where more of us stay healthier, longer. Read the essay: http://bit.ly/3U3NhOn
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Wonder is at the heart of science - and at the heart of Flagship. This summer’s interns are asking big, bold questions, and helping us imagine what discovery looks like in the age of AI. #WeAreFlagship #BiggerLeaps
“As AI begins to allow us to program science, should we fear that it will turn scientists into engineers and take away the magic of discovery?” I was struck by this question, asked by one of Flagship Pioneering's summer interns in my Q&A session with all of them today. My answer? Science is inextricably about wonder. It’s fundamentally human to ask — why is this the way it is? How can I make it better? How can I grow better crops, or prevent disease, or know when it’s going to snow? AI doesn’t interfere with wonder — it gives us new tools to wonder. And these new tools are infinitely more powerful than our individual brains, or even our collective brains. We can wonder bigger, better, and further than we’ve ever been able to before. It’s no different than how humans used to walk wherever they wanted to go. Then they invented the wheel. Then they found that they could automate wheels into an automobile. And then they flew around in supersonic jets. It feels different to fly across the ocean than it does to paddle on a river, but not many of us paddle across the ocean when flying is an option. The opportunity to wonder at a supersonic scale is upon us, and I say we embrace it. To take full advantage of the possibilities these new tools offer we will need both science and engineering mindsets. Blurring the line between them will be for the better, not the worse. But the core competency of the best scientists — the ability to look around you and simply wonder — isn’t going to change. Science will remain, if you’ll forgive me, “wonder-ful.”
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YourBio Health is focused on making pain free blood collection accessible anywhere. Read a new study with Columbia University Irving Medical Center that evaluates the accuracy and patient experience of YourBio's TAP Micro Select Device in fertility hormone monitoring. #FlagshipFounded
New Study Between YourBio Health & Columbia University Irving Medical Center Validates Needle-Free Blood Collection for Fertility Hormone Monitoring A prospective study conducted at Columbia University Fertility Center, published in Fertility & Sterility (2025), evaluated the accuracy and patient experience of the TAP Micro Select Device — a self-administered, needle-free capillary blood collection method — compared to traditional venipuncture. 📚 Study Design: 46 women undergoing fertility treatment provided paired blood samples: one via venipuncture, and one via TAP. Hormone concentrations for E2, LH, FSH, P4, and hCG were analyzed using FDA-cleared immunoassays on the same Beckman Coulter platform to ensure analytical consistency. 📊 Results: - Hormone levels obtained by TAP demonstrated strong concordance with venipuncture: - Spearman correlations ranged from 0.77 (hCG) to 0.99 (LH), all p < 0.00001 Concordance correlation coefficients > 0.97 for LH, FSH, and hCG - Pain was significantly lower for TAP (mean score 0.28 vs. 2.68; p < 0.001) 74% of participants preferred the TAP method; only 3% preferred venipuncture 💡Conclusion: Capillary blood collection using the TAP Micro Select Device enables accurate measurement of key reproductive hormones with significantly improved patient tolerability. This approach represents a viable alternative to venipuncture for repeated hormone monitoring during fertility treatment, with potential applications in both clinical and at-home settings. 📄 Reference: Lattin MT, DiBianco LP, Holcomb Z, et al. Painless, needle-free capillary blood collection for fertility hormone monitoring. Fertil Steril. 2025. https://lnkd.in/eAv27kCF #ReproductiveHealth #IVF #HormoneMonitoring #CapillaryBlood #NeedleFree #ClinicalInnovation #FertilityCare #MedTech
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"We’re not just doing science because it’s ‘cool,’ but we’re doing science because it has the potential to have a big impact on individuals who need novel therapies.” Michelle Werner, Flagship CEO-Partner & CEO of #FlagshipFounded Alltrna, shares how Alltrna is unlocking tRNA biology to treat disease and the importance of engaging patient communities every step of the way in this Advancing RNA article: https://lnkd.in/g_m9KtQy
Raiders of the Lost Codon: Part 2. The treasure hunt for therapeutic #tRNA continues. In this new Advancing RNA article, Alltrna CEO Michelle Werner unpacks what it takes to evolve an ancient molecule into a modern medicine—and why engaging patient communities early is key to doing it right. Because science with a purpose is the greatest find of all. Read Part 2 here: https://lnkd.in/g_m9KtQy ICMYI, here’s Part 1: https://lnkd.in/gD-XprXY #StopCodonDisease #rarediseases #tRNAmedicines #tRNA #tRNAtherapeutics
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Flagship Pioneering reposted this
🌱 CIBO’s New Partnership with Virginia Tech We are proud to announce that we’ve been selected as the technology partner for a groundbreaking $80 million USDA grant led by Virginia Tech University. The Alliance to Advance Climate-Smart Agriculture program will financially reward farmers in Arkansas, Minnesota, North Dakota, and Virginia for adopting conservation practices. Using our advanced modeling capabilities, we’ll quantify the environmental impact of practices like cover cropping and conservation rotation. This partnership shows how public-private collaboration can deliver financial incentives for farmers while enhancing agricultural resilience. As our CEO, Daniel Ryan, said, “This program aligns government funding with quantification tools to create a win-win for farmers, communities, and the planet.” Join us in driving sustainable agriculture forward! 💚 #CIBOTechnologies #ClimateSmartAg #SustainableAgriculture #VirginiaTech #RegenAg #Climate-Smart
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🍒 Chill hours—the number of cold hours fruit and nut trees need during dormancy—are critical for crops like cherries, peaches, and almonds to flower and fruit successfully in the spring and summer. Terrana Biosciences, our most recently unveiled company, is pioneering RNA-based agricultural solutions to deliver protective and enhanced crop traits designed to help crops thrive despite variable climate conditions, like warmer winters. For more on Terrana: https://bit.ly/4lBt0vb
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