α-synuclein pathology in aging and Alzheimer's: A CSF study

Epigenetics & cardiology 🧬🫀 Interesting new research suggests that only a fraction of patients exposed to group-A strep develop rhematic heart valve disease, possibly due to genetic and epigenetic factors. Multi-omics approaches may help us discover why. As clinicians and data scientists, we should harness these insights to improve early diagnosis and personalise treatment. #Cardiology #Epigenetics #DataScience

Porphyromonas gingivalis, a bacterium linked to gum disease, may play a significant role in Alzheimer's disease by entering the bloodstream, reaching the brain, and triggering inflammatory and neurodegenerative processes. This bacterium produces toxic proteases called gingipains, which can damage brain cells and contribute to neuroinflammation, amyloid plaque formation, and tau pathology. Studies have found P. gingivalis in the brains of Alzheimer's patients, and its presence is associated with increased risk of cognitive decline. Research suggests that gingipain inhibitors may be a potential therapeutic target to prevent or slow disease progression. The connection between P. gingivalis and Alzheimer's highlights the importance of oral health in overall brain health, and further research is needed to understand the mechanisms and potential treatments. We are about to release our upcoming issue and we are open for new submissions and you can submit yours here: clinicalpractice@genesispub.org #AlzheimersDisease #PorphyromonasGingivalis #GumDisease #Neurodegeneration #Neuroinflammation #BrainHealth #NeurologicalDisorders #MedicalResearch #HealthcareInnovation

TBI research is moving into a new chapter. We’ve known for a long time that brain injury can set the stage for neurodegeneration, but actually tracking those molecular changes in patients has been a challenge. Part of the difficulty comes from the wide range of injury parameters (severity, frequency, mechanism) and the even wider range of sequelae that follow. No two TBIs look alike and that complexity has slowed progress in predicting outcomes and tailoring treatments. A recent review in Frontiers in Neurology (Giarratana AO, 2025) stood out to me because it shows how PET biomarkers can help bring order to that complexity: ✅ Amyloid and tau imaging tie TBI pathology to Alzheimer’s-like processes 🧠 Neuroinflammation tracers pick up on persistent microglial activation long after the injury 🔬 Metabolic and neurotransmitter PET shine a light on disrupted circuitry What I really like is the use of the term neurotheranostic — tools that don’t just describe pathology, but guide interventions. My research in TBI and neuroinflammation keeps pointing to the same truth: we need tools that bridge mechanism to medicine. Neurotheranostics feels like a step in that direction. The aim should be to benefit every patient from "mild" injuries to the most severe cases. 👉 Here’s the link if you want to take a look: https://lnkd.in/d4ygvvfM #Neuroscience #TraumaticBrainInjury #Neurotheranostics #Neurodegeneration #PETImaging #PrecisionMedicine #TranslationalResearch

Your gut has a lot to say, but it often takes a microscope to understand the message. As a histotechnician, I see the behind the scenes work that turns symptoms into answers. Every biopsy, every stain, every sample is part of a patient’s story. This roadmap is a simple way to show how gut symptoms connect to the right screenings, and why the lab matters in every diagnosis. Gut health is powerful, and so is the work happening quietly in pathology. #Histology #GIHealth #Pathology #Healthcare #sciencebrainstorytellerheart

Duchenne Muscular Dystrophy (DMD) – Explained for Medical Learners DMD is an X-linked recessive inherited muscle disorder caused by dystrophin deficiency. This video covers: ✔ Genetics of DMD – mutation in dystrophin gene ✔ Early childhood symptoms – calf hypertrophy, scoliosis, Gowers sign ✔ Disease progression – loss of ambulation, respiratory & cardiac weakness ✔ Life expectancy and prognosis 🎥 Watch here: https://lnkd.in/d8Spc3kK #DMD #MedicalEducation #Genetics #Neurology #Healthcare #VBAnatomy

A human MRI study reveals shared cortical abnormalities in both migraine and post-traumatic headache patients. Compared to healthy controls, both groups exhibit expansion of the cingular and parietal cortices. Notably, this cortical alteration is present in migraine subgroups regardless of aura and in episodic migraine cases. These findings suggest that therapeutic interventions targeting cortical circuits may offer efficacy across headache disorders with differing origins. https://lnkd.in/gK73_ukz

🩻🧠 Advanced Tools for MS Diagnosis The Central Vein Sign (CVS) is emerging as a key biomarker in Multiple Sclerosis. QMENTA’s platform provides automated CVS detection to support clinicians with more consistent imaging analysis and greater diagnostic confidence. 🔗 Learn more: https://hubs.la/Q03Dldz10 #MultipleSclerosis #MedicalImaging #Neuroimaging #AIinHealthcare #ClinicalResearch

💊🧠 For all our sciences friends out there… did you know? As a marketing agency specialised in pharma and life sciences, we’re always scanning the horizon for the innovations shaping tomorrow’s clinical research. Sharing these stories is how we help keep our network ahead of the curve. One company making waves here is QMENTA,  with an AI-powered neuroimaging platform that: ✔️ Automates CVS detection ✔️ Brings consistency to imaging analysis in trials ✔️ Strengthens evidence generation for new therapies 👉 Definitely one to keep an eye on. 🔗 Check it out: https://hubs.la/Q03Dldz10 #Pharma #MultipleSclerosis #Neuroimaging #AIinHealthcare #ClinicalResearch #MedicalImaging

A new Italian study reported that relapsing-remitting multiple sclerosis (MS) potentially can involve the morpho-functional of all macular areas and sectors, and this can occur even in patients who have no history of optic neuropathy, reported first author Lucilla Barbano, MD, from the Istituto di Ricovero e Cura a Carattere Scientifico—Fondazione Bietti, Rome. A great deal of research has been conducted, particularly on the macular unmyelinated axons of the retinal ganglion cells (RGCs), to determine the retinal involvement in patients with MS. “These neuronal elements, in fact, can be considered as the cellular target of the retinal neurodegenerative process due to MS, as a consequence of the frequent inflammatory process of the optic nerve, known as optic neuritis (ON),” the authors commented Read More: https://hubs.li/Q03Jwtfj0

Product Citation: Lewy pathology in the enteric nervous system has been observed to precede motor symptom onset in Parkinson's disease. Our ATTO-594 Alpha Synuclein PFFs (SPR-322-A594) were used in this study evaluating their uptake and effect in the ENS. https://lnkd.in/gzkb547Z