Visualizing small proteins – a crucial part of understanding disease drivers – has long been one of the toughest challenges in cryo-electron microscopy. Our scientists have overcome this obstacle by developing “Rigid Fabs,” a groundbreaking innovation which can transform antibody fragments into rigid scaffolds, making it possible to capture high-resolution images of small proteins. The video shows we are able to resolve small proteins to high resolution by cryoEM using our newly developed technology. Read more about this advancement in Nature Communications to learn how this technology is paving the way for accelerated drug discovery. http://spr.ly/6040A9no6

Mehrnaz Lotfali

Pharm.D. | Medical Advisor · Medical Affairs & Regulatory Strategist | Clinical Research & Pharmacovigilance | Portfolio Development | Pharma · Dermo-Cosmetics · Supplements | ICH/EMA-GVP · AI Analytics

14h

Rigid Fabs represent a structural biology breakthrough—enabling high-resolution cryo-EM of small proteins that previously evaded characterization. 🎯🔬 #StructuralBiology #DrugDiscovery

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Way to go Jen!

Rita Chappelle

Chief, External & Congressional Affairs, Outreach and Media, US Department of Veterans Affairs, Philadelphia VA Healthcare System

1d

Pioneering research that will improve health outcomes for all

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William Nicolas

Senior Scientist II @ Exelixis | CryoEM Facility Lead

2d

😍

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