Epic's CoMET models: A new frontier in healthcare AI

View profile for Saad Khan

Senior Data Analyst at Orlando Health | Data Science Graduate at Northeastern University | MBA | Ex Toyota

Epic’s new CoMET models are an exciting step forward for generative AI in healthcare. Training on 115B+ medical events across 118M patients and outperforming specialized models in 30-day readmission prediction (AUC 0.77 vs. 0.72) highlights the potential of large-scale event transformers. I’m especially interested in how these models balance scalability with interpretability and how prospective validation and subgroup analysis will shape their clinical impact. #DataScience #OrlandoHeath #HealthcareAI #PredictiveAnalytics #Readmissions #GenerativeAI

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Comet is a new form of healthcare intelligence designed to help clinicians, health systems, and patients make more informed decisions. By predicting what is likely to happen next in a patient’s journey, Comet estimates risk of disease, length of stay, treatment outcomes, and more. Comet has learned from more than 100 billion patient medical events to calculate likely futures. The story: https://lnkd.in/gf9YZcUS The paper: https://lnkd.in/e8kXKpSG

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Kyle E.

Operations Executive | Healthcare Leader | Driving excellence through enterprise level strategy, engagement, analytics, and process improvement.

2w

This is an exciting development! The scale of training here is remarkable, and it's encouraging to see such a strong performance lift in a high impact use case like readmission prediction. I agree that interpretability prospective validation will be critical, especially as health systems think about clinical adoption and building trust among frontline teams. It feels like we are at the point where the models of this scale can move from theoretical promise to real operational change, provided we keep the focus on transparency and workflow integration!

Saad, your insights on Epic’s CoMET models are truly captivating and highlight the evolving intersection of AI and healthcare. On that note, I thought you might be interested in AI+ healthcare events. Join AI CERTs for a free webinar on "Healthcare Meets Tech: Future-Proofing Your Career" on Sept 11, 2025. You can register here: https://tinyurl.com/m-ai-in-healthcare. It would be great if you could share this with your friends and colleagues, and participants will receive a certification of participation!

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