10 Years From Now In Oncology
QUICK READ
Welcome to ‘10 Years From Now in Oncology’, MEDSIR’s exclusive newsletter
At MEDSIR, we specialize in designing and managing cutting-edge clinical trials to advance oncology research worldwide. Our mission is to transform patient outcomes by collaborating with experts, leveraging innovation, and unlocking the full potential of data-driven research.
Through this newsletter, we invite you to explore groundbreaking studies, key milestones, and insights from the forefront of cancer research.
Special Guest
Dr. Nancy Lin, MD, on the Challenge of Brain Metastases in HER2-Positive Breast Cancer
T-DXd for brain metastases? Yes and the results are promising.
Dr. Nancy Lin shares findings from a pooled analysis of three studies, pointing to the potential of T-DXd to deliver clinically relevant intracranial outcomes in patients with HER2-positive breast cancer and active brain metastases.
This pooled analysis includes data from TUXEDO-1 study(NCT04752059), sponsored by the Medical University of Vienna ; the DEBBRAH study (NCT04420598), sponsored by MEDSIR; and a multicenter retrospective study involving patients who met the pooling criteria, sponsored by Dana-Farber Cancer Institute , Duke University , and MD Anderson Cancer Center .
👉 Watch the video to learn more about this clinical breakthrough.
A Continuum of Innovation for Impact
Heading to AACR Annual Meeting 2025 in Chicago? If you're advancing clinical research and looking for a disruptive approach to clinical trials, MEDSIR is here to partner with you.
From novel molecules to cutting-edge trial designs, we’re dedicated to helping you bring transformative therapies to patients faster.
Let’s connect at AACR 2025 and explore how we can drive your research forward.
DEEP DIVE- AI and Clinical Research: struggling with data
Why Patient Data Matters
Every interaction with a healthcare professional generates valuable insights. From height and weight to disease progression and treatments, this wealth of information—known as patient data—holds the potential to answer critical medical questions. At MEDSIR, we believe that by analyzing and refining this data, we can pave the way for better patient care, improved safety, and groundbreaking treatments.
How MEDSIR is Innovating: The RosHER Study.
We’re proud to highlight the ROSHER study, a groundbreaking project utilizing AI to extract meaningful insights from patient data.
HER2 expression, crucial for determining treatment plans in breast cancer, isn’t static—it can evolve over time. Yet, this dynamic has been underexplored. RosHER was a large, multi-center research project that addressed this gap by collecting data from patients diagnosed with early, advanced, or metastatic breast cancer between 2005 and 2021. We used natural language processing (NLP), an AI-powered tool, to extract HER2 information from patients’ health records. This technology helped track changes in HER2 status from initial diagnosis to recurrence or disease progression, as well as analyze patients' baseline health data and treatment patterns.
HER2 expression is not static and can change during the course of treatment or in the unfortunate case of recurrence. While it is known that this can occur, currently, HER2 dynamics have not been well characterized. Therefore, the RosHER study used an artificial intelligence-based tool to extract information from real-world data (thousands of electronic health records) to evaluate HER2 status between the initial diagnosis and progression or relapse. By harnessing AI and real-world data, we’re advancing personalized medicine and empowering oncologists with the tools to make informed decisions.
Challenges in Patient Data Utilization
While AI offers transformative opportunities, limitations exist:
At MEDSIR, we’re committed to overcoming these hurdles to unlock the full potential of patient data.
Tips for Improving Patient Data Collection
Every interaction counts. Here are some best practices to ensure data is useful for future research:
Want to Learn More?
Dive deeper into our findings by reading our recently published paper on the RosHER study.
Job Vacancies at MEDSIR
We’re growing, and we want you to be part of our journey. Check out our latest job openings and join us in shaping the future of clinical research.
Subscribe to Stay Updated
Follow our journey as we explore innovations in oncology research and share milestones that bring us closer to better care for cancer patients.