Accurately Counting Low Platelets: Mindray’s Smart Automation Approach

Counting platelets in thrombocytopenic samples can be clinically challenging. Interferences from small RBC fragments, PLT clumps, or instrument sensitivity often lead to inaccurate results, causing repeat tests, manual smears, and delayed decisions.

Mindray’s high-end hematology analyzers tackle this head-on using a multi-technology approach that includes smart optical detection, de-aggregation chemistry, and adaptive counting algorithms—all aimed at delivering accurate low PLT counts without manual intervention.

Why this matters for hematology labs

• Reduces the blood smear review rate in low PLT cases

• Ensures accuracy even when PLT counts fall below 50×10⁹/L

• Differentiates true thrombocytopenia from pseudothrombocytopenia

• Avoids interference from RBC/WBC fragments or clumping

• Delivers results faster, improving lab turnaround time and confidence

How Mindray’s technology improves low PLT detection

1. Fluorescent Staining with High Specificity

Mindray uses a custom-designed fluorescent dye that binds specifically to nucleic acids inside PLTs, avoiding overlap with small RBCs or cell fragments. This ensures reliable detection even at low concentrations.

2. High-Resolution Optical Detection

 With advanced SiPM sensors and reflective light suppression, the analyzer detects particles as small as 1 µm, providing a stable signal-to-noise ratio even in weak samples.

3. PLT De-Aggregation Mechanism

To overcome pseudothrombocytopenia caused by in vitro PLT clumping, Mindray’s proprietary diluent uses targeted antagonists to prevent platelet aggregation at the pre-analytical stage.

4. Auto 8x PLT-O Counting

When the impedance count (PLT-I) falls below a threshold (50×10⁹/L), the analyzer triggers extended optical counting—up to 8x longer—without requiring extra reagents, samples, or user action.

The result? Better accuracy, less manual review, and higher lab efficiency.

Final note

In hematology, the ability to detect and quantify low platelet counts quickly and precisely is vital. Mindray’s intelligent hematology solutions deliver just that, backed by automated re-check protocols, stable optics, and patient safety at the core.

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How Mindray Counts Low Platelets Correctly