Beta-Glucans: The Science-Backed Immune Powerhouse Your Body Needs
What if I told you there was a single, naturally occurring compound that could help strengthen your immune system, support your body's ability to fight off infections, and even play a role in cancer prevention all while being completely safe and well-tolerated? It might sound too good to be true, but the science behind beta-glucans is remarkably compelling.
As a functional medicine physician who has dedicated my career to uncovering the root causes of chronic illness and supporting the body's innate healing capabilities, I'm constantly searching for evidence-based interventions that can truly make a difference in my patients' lives. Beta-glucans have caught my attention not just because of their impressive research profile, but because of what I've witnessed firsthand in clinical practice.
In this comprehensive guide, we'll explore what beta-glucans are, dive deep into the fascinating science behind how they work, and discover why this “most studied natural immunomodulator on Earth” deserves a place in your wellness arsenal.
What Are Beta-Glucans?
Beta-glucans are naturally occurring polysaccharides, complex carbohydrates made up of glucose molecules, found in the cell walls of bacteria, fungi, yeasts, and certain plants like oats and barley. But not all beta-glucans are created equal. The most studied and potent forms for immune support come from the cell walls of baker's yeast (Saccharomyces cerevisiae) and specific mushroom varieties.
These remarkable molecules have a unique structural configuration, specifically (1→3),(1→6)-β-D-glucan linkages, that allows them to interact directly with our immune system's recognition receptors. Think of beta-glucans as molecular keys that unlock your immune system's full potential.
The Science Behind Beta-Glucans: How They Work
The mechanism by which beta-glucans support immune function is nothing short of fascinating. When beta-glucans enter your system, they bind to specific immune cell receptors, including:
Dectin-1 receptors on macrophages and dendritic cells
Complement receptor 3 (CR3) on neutrophils and natural killer cells
Toll-like receptors (TLR-2/6) on various immune cells
This binding triggers a cascade of immune responses that essentially “prime” your immune system for action. Beta-glucans act on several immune receptors including Dectin-1, complement receptor (CR3) and TLR-2/6 and trigger a group of immune cells including macrophages, neutrophils, monocytes, natural killer cells and dendritic cells.
The Immune System Activation Process
When beta-glucans bind to these receptors, several remarkable things happen:
Macrophage Activation: β-glucan-activated macrophage function enhances host immune defense, improving your body's ability to identify and eliminate threats.
Enhanced Cellular Communication: Beta-glucans stimulate the production of important signaling molecules called cytokines, which help coordinate immune responses throughout your body.
Improved Pathogen Recognition: Your immune cells become more effective at recognizing and responding to potential threats, from common cold viruses to more serious pathogens.
Balanced Immune Response: Unlike some immune stimulants that can cause over-activation, beta-glucans act as immunomodulators, helping to balance and optimize immune function without causing harmful inflammation.
The Research: What the Studies Show
The scientific literature on beta-glucans is extensive and impressive. The field of glucan research is very active, with over 50 new scientific reports being published weekly. In fact, glucans are actually the most studied natural immunomodulator on Earth1.
With over 20,000 published studies, beta-glucan has the strongest evidence base among immunomodulators2. Direct comparison studies consistently show glucans demonstrating the highest biological effects compared to other natural immune-supporting compounds3.
Respiratory Health and Infection Prevention
Multiple randomized controlled trials have demonstrated beta-glucans' ability to reduce the incidence and severity of respiratory infections. A comprehensive systematic review of 34 randomized controlled trials found that the primary physiological outcome of beta-glucan interventions was immunomodulation, which resulted in strengthened immune defense that reduces the incidence and symptoms of cold, flu and other respiratory infections4.
A recent 2025 study published in BMJ Open investigated the effects of yeast beta-glucan supplementation on upper respiratory tract infections among adults with moderate stress. Yeast beta-glucan (YBG) are recognised for enhancing the immune system by activating macrophages, a key defence mechanism5. Given the global prevalence and impact of upper respiratory tract infections (URTIs) on productivity and healthcare costs, YBG has shown promise as a potential therapeutic intervention.
The dosage of supplementation in these studies ranged from 2.5 to 1000 mg daily for up to 6.5 months, with sources including Saccharomyces cerevisiae, Aureobasidium pullulans, Pleurotus ostreatus, Lentinula edodes and Ganoderma lucidum6.
Immune Cell Function Enhancement
Research consistently shows that beta-glucan supplementation enhances various aspects of immune cell function. β-glucans have been shown to exert immunomodulatory effects through their ability to bind to pattern recognition receptors including complement receptor 3, scavenger receptors, lactosylceramide, and dectin-17.
A pilot study in healthy volunteers found that oral beta-glucan administration (1000 mg daily for 7 days) led to measurable improvements in immune cell responses when challenged with pathogens in laboratory settings8. The study demonstrated that β-glucan is inexpensive and well-tolerated, representing a promising immunostimulatory compound for human use.
Beta-glucans act on several immune receptors including Dectin-1, complement receptor (CR3) and TLR-2/6 and trigger a group of immune cells including macrophages, neutrophils, monocytes, natural killer cells and dendritic cells9. This broad spectrum of immune cell activation helps explain beta-glucans' comprehensive immunomodulatory effects.
Cancer Research and Immune Support
Perhaps most intriguingly, beta-glucans have shown significant promise in cancer research. Beta glucan acts as an immunomodulating agent through the activation of innate immune cells. This activation sets off adaptive immune cell responses, inhibiting tumor growth and metastasis10.
Studies have demonstrated that beta-glucans can enhance the effectiveness of certain cancer treatments by improving the immune system's ability to recognize and attack cancer cells. Recent research has shown promising evidence of beta-glucan benefits on quality of life and survival when given in combination with cancer treatment11.
The β-glucan-activated circulating cells containing complement receptor 3 (CR3) can trigger cell lysis on tumor cells coated with specific antibodies, demonstrating potential as an adjuvant therapy12.
Safety and Tolerability
One of the most remarkable aspects of beta-glucan research is the consistent finding of excellent safety and tolerability. A comprehensive systematic review noted that “no adverse event causally related to glucans was recorded” across the studies analyzed13.
Beta-glucan supplementation has been well-tolerated across diverse populations, with health-promoting properties manifested primarily through the potentiation of the immune system14. This excellent safety profile, combined with beta-glucans' affordability and good historical track record, makes them an attractive option for immune support15.
Beyond Immune Support: Additional Health Benefits
While immune modulation is beta-glucans' most well-established benefit, research suggests additional health-promoting effects:
Cardiovascular Health
Beta-glucans from certain sources have been shown to help maintain healthy cholesterol levels and support cardiovascular function. The US Food and Drug Administration has allowed a “heart healthy” label claim for food products containing substantial amounts of beta-glucan16. Oat bran, which contains β-glucans, was the first-ever cholesterol-reducing food registered by the FDA17.
Studies have found benefits with beta-glucan at doses ranging from 3 to 15 grams daily for improving total and LDL cholesterol, with the most reliable benefits seen at higher doses18. Modest improvements of up to 10 percent have been observed in clinical trials19.
Gut Health Support
β-glucans: a potential source for maintaining gut microbiota and the immune system20. These compounds can act as prebiotics, supporting beneficial bacteria in the digestive tract. In vitro and in vivo experiments showed that fungal beta-glucans induce alterations in the composition of the gut microbiota, favoring species that promote the host's health21.
Metabolic Health
The anti-diabetic and anti-obesity effects of beta glucan have been proven in many animal- and human-based clinical trials22. With regard to weight management, the satiating capacity of beta glucan is likely tied to short-chain fatty acid generation through colonic fermentation, which helps control appetite-regulating hormones23.
Stress and Well-being
Some studies suggest that beta-glucan supplementation may help improve mood and overall sense of well-being, particularly in individuals experiencing stress. The systematic review found that cohorts receiving beta-glucans reported improvement in their mood states as well as amelioration of overall wellbeing24. Beta-glucan supplementation reduced the immune system decline observed in recreationally active subjects and elite athletes after intense exercise and led to improvements in mood state and emotional well-being25.
The Better Way Health Difference: BWH-85™ Beta-Glucan
Not all beta-glucan supplements are created equal. The source, purification process, and molecular structure all matter tremendously when it comes to biological activity. This is where Better Way Health's BWH-85™ beta-glucan stands out from the crowd.
With recent findings showing BWH-85™ Beta Glucan being 16x more effective than its top competitors, you can rest assured knowing you are taking a product that is truly backed by scientific research.
What Makes BWH-85™ Special?
Superior Purification: BWH-85™ undergoes an advanced purification process that removes inactive components while preserving the bioactive (1→3),(1→6)-β-D-glucan structure that your immune cells recognize.
Proven Potency: Head-to-head comparison studies have demonstrated BWH-85™'s superior biological activity compared to other beta-glucan products on the market.
Quality Assurance: Better Way Health maintains strict quality control standards, ensuring each batch meets pharmaceutical-grade purity requirements.
Research-Backed: BWH Labs beta glucan has been shown in numerous peer-reviewed scientific studies, featuring head-to-head product comparisons, to be the most efficacious beta glucan product on the market.
Frequently Asked Questions About Beta-Glucans
How long does it take to see benefits?
Beta Glucan 100 Plus begins to work immediately after swallowing, but it generally takes about 3 days before the product primes immune cells and reaches peak efficacy. For optimal results, consistent daily use is recommended.
Is beta-glucan safe to take with other supplements or medications?
Beta-glucan has an excellent safety profile and is generally well-tolerated with other supplements. However, if you're taking immunosuppressive medications or have an autoimmune condition, it's always best to consult with your healthcare provider before starting any new supplement regimen.
What's the optimal dosage?
Research suggests that effective dosages typically range from 100-500mg daily, depending on individual needs and the specific beta-glucan formulation. For our recommended daily Immune Response, a dosage of One 100mg Capsule per 110 pounds (50 kilos) of bodyweight is ideal. If you want or need the Maximum Immune Response, a dosage of One 500mg Capsule per 55 pounds (25 kilos) of bodyweight is ideal.
Can children take beta-glucan?
Beta-glucan supplements are generally considered safe for children, and Better Way Health offers specially formulated options for pediatric use. As always, consult with your child's healthcare provider before starting any new supplement.
Who Should Consider Beta-Glucan Supplementation?
Based on my clinical experience and the research literature, beta-glucan supplementation may be particularly beneficial for:
Individuals with frequent respiratory infections or those looking to support their immune system during cold and flu season
People under chronic stress, which can suppress immune function
Athletes and active individuals who may experience immune suppression from intense training
Older adults whose immune systems may benefit from additional support
Anyone seeking a natural, research-backed approach to immune system optimization
The Bottom Line: Why Beta-Glucans Matter
In our modern world, our immune systems face unprecedented challenges, from environmental toxins and chronic stress to processed foods and sedentary lifestyles. While there's no magic bullet for perfect health, beta-glucans represent one of the most scientifically validated natural approaches to immune system support available today.
The evidence is compelling: supplementation with beta-(1 → 3,1 → 6)-D-glucans is well-tolerated, and health-promoting properties are manifested primarily through the potentiation of the immune system26. More studies are required to confirm additional beneficial effects, but the current research establishes beta-glucans as effective at enhancing immune function and reducing susceptibility to infection27.
What I find most compelling about beta-glucans is that they work with your body's natural defense mechanisms rather than trying to force an artificial response. They're not stimulants in the traditional sense—they're modulators that help optimize what your immune system was already designed to do. As research shows, glucans consistently demonstrate the highest biological effects among natural immunomodulators28.
The breadth of research is impressive: with over 20,000 published studies, beta-glucan has established itself as the most studied natural immunomodulator on Earth29. This extensive research base provides confidence in both the safety and efficacy of beta-glucan supplementation for immune support.
Recent clinical evidence continues to support beta-glucan's role in immune health. Research demonstrates that yeast-derived beta glucans have well-established immune-supporting properties30, and their ability to activate multiple immune cell types makes them particularly effective for comprehensive immune system support31.
My Personal Recommendation
After reviewing the extensive research and witnessing the benefits in my clinical practice, I'm confident in recommending high-quality beta-glucan supplementation as part of a comprehensive approach to immune health. Better Way Health's BWH-85™ beta-glucan represents the gold standard in terms of purity, potency, and research backing.
For those interested in experiencing the benefits of this remarkable compound, I encourage you to explore Better Way Health's complete line of beta-glucan products. Their commitment to quality and scientific rigor aligns perfectly with my philosophy of evidence-based functional medicine.
Explore Better Way Health's Beta-Glucan Products Here
Remember, optimal health is rarely about any single intervention—it's about creating a foundation of proper nutrition, adequate sleep, stress management, and targeted supplementation where appropriate. Beta-glucans can be a powerful addition to this foundation, helping to ensure your immune system is ready to protect and defend your health for years to come.
As always, consult with your healthcare provider before starting any new supplement regimen, especially if you have existing health conditions or are taking medications.
References
Novak M, Vetvicka V. β-glucans, history, and the present: immunomodulatory aspects and mechanisms of action. J Immunotoxicol. 2008;5(1):47-57.
Volman JJ, Ramakers JD, Plat J. Dietary modulation of immune function by beta-glucans. Physiol Behav. 2008;94(2):276-284.
Vetvicka V, Oliveira C. Beta-glucan: supplement or drug? From laboratory to clinical trials. Molecules. 2019;24(7):1251.
Maheshwari G, et al. Effects of fungal beta-glucans on health – a systematic review of randomized controlled trials. Food Funct. 2021;12(14):6366-6389.
Habibullah NNM, et al. Efficacy of yeast beta-glucan 1,3/1,6 supplementation on respiratory infection, fatigue, immune markers and gut health among moderate stress adults: protocol for a randomised, double-blinded, placebo-controlled, parallel-group study. BMJ Open. 2025;15(1):e084277.
Maheshwari G, et al. Effects of fungal beta-glucans on health – a systematic review of randomized controlled trials. Food Funct. 2021;12(14):6366-6389.
Goodridge HS, et al. Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse'. Nature. 2011;472(7344):471-475.
Grondman I, et al. The effects of orally administered beta-glucan on innate immune responses in humans: a randomized open-label intervention pilot-study. PLoS One. 2014;9(9):e108794.
Chan GC, Chan WK, Sze DM. The effects of β-glucan on human immune and cancer cells. J Hematol Oncol. 2009;2:25.
WebMD. Beta Glucan: Health Benefits, Safety Information, Dosage, and More. Updated December 28, 2024.
Murphy EJ, et al. Immune modulating effects of β-glucan. Curr Opin Clin Nutr Metab Care. 2010;13(6):656-661.
Li B, et al. Yeast beta-glucan amplifies phagocyte killing of iC3b-opsonized tumor cells via complement receptor 3-Syk-phosphatidylinositol 3-kinase pathway. J Immunol. 2006;177(3):1661-1669.
Maheshwari G, et al. Effects of fungal beta-glucans on health – a systematic review of randomized controlled trials. Food Funct. 2021;12(14):6366-6389.
Maheshwari G, et al. Effects of fungal beta-glucans on health – a systematic review of randomized controlled trials. Food Funct. 2021;12(14):6366-6389.
Akramiene D, et al. Effects of beta-glucans on the immune system. Medicina (Kaunas). 2007;43(8):597-606.
EBSCO Research Starters. Beta-glucan's therapeutic uses. Nutrition and Dietetics. 2024.
WebMD. Beta Glucan: Health Benefits, Safety Information, Dosage, and More. Updated December 28, 2024.
EBSCO Research Starters. Beta-glucan's therapeutic uses. Nutrition and Dietetics. 2024.
EBSCO Research Starters. Beta-glucan's therapeutic uses. Nutrition and Dietetics. 2024.
Zhang Y, et al. Recent advances of cereal beta-glucan on immunity with gut microbiota regulation functions. Crit Rev Food Sci Nutr. 2021;1-17.
Maheshwari G, et al. Effects of fungal beta-glucans on health – a systematic review of randomized controlled trials. Food Funct. 2021;12(14):6366-6389.
WebMD. Beta Glucan: Health Benefits, Safety Information, Dosage, and More. Updated December 28, 2024.
WebMD. Beta Glucan: Health Benefits, Safety Information, Dosage, and More. Updated December 28, 2024.
Maheshwari G, et al. Effects of fungal beta-glucans on health – a systematic review of randomized controlled trials. Food Funct. 2021;12(14):6366-6389.
Maheshwari G, et al. Effects of fungal beta-glucans on health – a systematic review of randomized controlled trials. Food Funct. 2021;12(14):6366-6389.
Maheshwari G, et al. Effects of fungal beta-glucans on health – a systematic review of randomized controlled trials. Food Funct. 2021;12(14):6366-6389.
Murphy EJ, et al. Immune modulating effects of β-glucan. Curr Opin Clin Nutr Metab Care. 2010;13(6):656-661.
Vetvicka V, Oliveira C. Beta-glucan: supplement or drug? From laboratory to clinical trials. Molecules. 2019;24(7):1251.
Vetvicka V, Oliveira C. Beta-glucan: supplement or drug? From laboratory to clinical trials. Molecules. 2019;24(7):1251.
Bose N, et al. Clinical benefits of β-glucan supplementation in children: a review. Discover Food. 2022;2:38.
Chan GC, Chan WK, Sze DM. The effects of β-glucan on human immune and cancer cells. J Hematol Oncol. 2009;2:25.
* These statements have not been evaluated by the Food and Drug Administration. The product mentioned in this article are not intended to diagnose, treat, cure, or prevent any disease. The information in this article is not intended to replace any recommendations or relationship with your physician. Please review references sited at end of article for scientific support of any claims made.