A glimpse into SR-Tiget research at EHA 2025!

Oral presentations

12/06, 14:57 - Andrea Ditadi : Embryonic lymphocytes contribute to a genetic form of autoimmune inflammation

12/06, 15:15 - Maria Ester Bernardo : Mesenchymal stromal cells: Modification of MSC to enhance their therapeutic efficacy

12/06, 15:21 - Annamaria Aprile (Ferrari's lab): Targeting the bone marrow niche by FGF23 inhibition improves the engraftment of transduced hematopoietic stem cells in a preclinical model of gene therapy for beta-thalassemia

13/06, 17:00 - Martina Fiumara (Naldini's lab): Poisoning of hematopoiesis drives clonal dominance and bone marrow failure in VEXAS syndrome

Posters

13/06 Daniele Canarutto (Naldini's lab): HDR gene correction and selection of CD4+ T cells for the treatment of Hyper IGM1: moving toward an academic clinical trial

13/06 Valentina Capo (Villa's lab): Spontaneously circulating hematopoietic stem/progenitor cells at single cell resolution: lessons from a rare bone disease

13/06 Daniela Cesana Uncovering CAR-T therapy efficacy and toxicity through cell-free DNA profiling

13/06 Cristina Colleoni (Montini's lab): Adaptive immunity governs the clearance of oncogene-induced senescent HSPCS and controls inflammation

13/06 Anastasia Conti (Di Micco's lab): Senescence and inflammation are unintended adverse consequences of CRISPR-CAS9/AAV6 mediated gene editing in hematopoietic stem cells

13/06 Valeria Iannello (Villa's lab): Ex vivo expanded HSCS improve gene therapy outcome in autosomal recessive osteopetrosis

13/06 Michela Milani (Cantore's lab): In vivo lentiviral vector gene transfer into hematopoietic stem and progenitor cells

13/06 Gabriele Pedrazzani (Naldini's lab): Overcoming toxic conditioning in hematopoietic stem cell therapy leveraging mobilization-resistant CXCR4 variants

13/06 Serena Scala (Aiuti's lab): Biological properties and clonality of engineered hematopoietic stem/progenitor cells persisting long-term after gene therapy

13/06 Alessandra Zecchillo (Villa's lab): CXCR4-R334X mouse: a model to investigate the pathogenesis of WHIM syndrome and assess novel gene correction therapy

14/06 Giulia Chianella (Ferrari's lab): TNFα-NFKB deregulation is critical for controlling the HSC pool and commitment in beta-thalassemia

14/06 Scaramuzza Samantha (Ferrari's lab): Optimized transduction of MPB CD34+ cells increase transduction efficiency and VCN while preserving stemness: towards a phase IIb clinical trial of gene therapy for tdt beta-thalassemia

14/06 Alessandra Weber (Naldini's lab): Highly efficient and seamless in vivo selection of long-range gene-edited hspcs by targeting haploinsufficient genes