Insula monoaminergic deficits in idiopathic RBD - a new prodromal marker of α-synucleinopathies ?

We are thrilled to share our recent work investigating extranigrostriatal monominergic deficits in idiopathic REM sleep behavior disorder (#iRBD)—a potential early stage of #α-synucleinopathies, including #Parkinson’s disease and #Dementia with Lewy Bodies (#DLB) .

🔍 What makes this study significant?

• Identified insular monoaminergic deficits using an innovative imaging Voxel-wise application to standard Dat imaging
• Demonstrated that iRBD patients with these deficits face a significantly higher risk of phenoconversion to PD or DLB, independently from nigrostriatal deficits.

Check out our last paper published in Annals of Clinical and Translational Neurology

thanks to Alice Galli Silvia Paola Caminiti Cinzia Zatti Leandro Purin Andrea Rizzardi @bertagna @silvia lucchini Enrico Premi Daniela Perani Alessandro Padovani Claudio Liguori and the whole team of University of Brescia ASST Spedali Civili di Brescia University of Rome Tor Vergata Neurozentrum Kiel Libera Università Vita-Salute San Raffaele .. another important piece for a deeper understanding of #Neurodegeneration #ParkinsonsDisease #DementiaWithLewyBodies #iRBD #prodromalparkinson #InnovationInResearch #personalizedmedicine #SPECT #nuclearmedicine #striatal #insula #dopamine