Looking Back: My Spectroscopy Learnings

When I think back to my postgraduate days in Pharmaceutical Chemistry (M.Pharm, 2019-2021), I’m filled with gratitude for the lessons I learned—especially about spectroscopy.

Now, in 2025, I see how these techniques have become invaluable in my professional journey, helping me solve complex problems and make better decisions.

Spectroscopy wasn’t just an academic subject; it became my way of understanding molecules, analyzing data, and contributing to science. Alongside these technical skills, I developed a love for reading, exploring, and reviewing research articles, which expanded my understanding of pharmaceuticals, medical devices, and the broader healthcare field.

Here are my key learnings, practical examples, and insights that might help professionals in pharmaceuticals, medical chemistry, or related fields.

The Spectroscopy Tools That Shaped My Learning

1. UV-Visible Spectroscopy: Quick and Effective Monitoring

This was my introduction to spectroscopy, one of the most valuable tools in my work. It allowed me to monitor drug reactions in real time, measure concentrations, and study dissolution profiles.

Example: In one of my projects, I used UV-Vis to track the release of active pharmaceutical ingredients (APIs) in drug formulations. I optimized the formulation process by analyzing the absorbance at specific wavelengths to ensure consistent and reliable results.

2. Fourier-Transform Infrared (FTIR) Spectroscopy: Molecular Fingerprinting

FTIR spectroscopy was a game-changer for identifying functional groups and studying molecular structures. It was beneficial for detecting impurities and ensuring compatibility between APIs and excipients.

Example: While developing a formulation, I noticed an unexpected peak in the FTIR spectrum. It turned out to be an impurity interacting with the excipient. This discovery helped me refine the formulation for better stability and performance.

3. Raman Spectroscopy: A Closer Look at Structural Details

Raman spectroscopy added another dimension to my analysis. It’s similar to FTIR but focuses on vibrational energy shifts caused by scattered light, which makes it excellent for studying crystalline forms and polymorphism.

Example: I used Raman spectroscopy to differentiate between two polymorphic forms of a drug compound. This insight was crucial in selecting the most stable and effective form for further development.

4. Nuclear Magnetic Resonance (NMR) Spectroscopy: The Structure Solver

NMR spectroscopy became my favorite tool for determining the structure of molecules. From elemental one-dimensional spectra to advanced 2D techniques like COSY and NOESY, it gave me the clarity I needed to tackle complex problems.

Example: In one project, I used NMR to identify the stereochemistry of a synthesized drug intermediate. This level of detail ensured that the compound met the required standards for biological activity.

5. Mass Spectrometry (MS): Pinpointing Molecular Weights and Fragmentation

Mass spectrometry helped me confirm molecular weights, study fragmentation patterns, and detect impurities at very low concentrations. It’s a highly versatile tool for both small molecules and complex formulations.

Example: During a stability study, I used MS to identify a degradation product caused by light exposure. This insight led to the development of better packaging to protect the drug.

The Power of Reading and Research

Beyond the lab, my journey involved constant learning through reading and exploring research articles. This habit expanded my understanding of:

• Pharmaceutical Innovations: Research papers helped me stay updated on emerging drug formulations, new excipients, and novel analytical methods.

• Medical Devices: I discovered how advanced technologies, like imaging systems and diagnostic tools, are revolutionizing healthcare.

• Regulatory Insights: Review articles often clarified global standards like ICH guidelines and FDA requirements.

Example: I remember studying a review article on spectroscopy applications in quality control, which introduced me to Process Analytical Technology (PAT). Later, I applied this knowledge to monitor real-time parameters during formulation development.

Pro Tip: Reading review articles is an excellent way to connect theoretical concepts with practical applications in the pharmaceutical and medical device industries.

Why This Matters to the Pharma and Medical Chemistry Community

1. Staying Ahead with Spectroscopy

Tools like FTIR, Raman, NMR, and MS are more than just instruments—they’re the bridge between understanding and innovation.

2. Broadening Perspectives Through Research

Reading and exploring articles is not just about gaining knowledge; it’s about asking questions, finding solutions, and contributing to advancements in pharmaceuticals and medical devices.

3. Encouraging Collaboration

The combination of spectroscopy skills and research knowledge fosters collaboration between R&D, regulatory teams, and production, ensuring better outcomes for patients and the industry.

Final Thoughts

Looking back, spectroscopy and research were not just academic subjects for me—they were tools to explore, question, and innovate. They shaped how I approach challenges in my work today and inspired me to keep learning.

To all professionals in pharma and medical chemistry: never stop exploring. Spectroscopy reveals the stories of molecules, and research articles broaden our horizons. Together, they help us create better drugs, advanced devices, and a healthier world.

Let’s keep learning, sharing, and innovating!