#ScienceWeek24 - Final Wrap-Up

Time for me to wrap-up #ScienceWeek24

Over the past 5 months, I’ve shed light weekly on one replay of this thought-stimulating event, focusing on #LifeSciences & #Healthcare.

A big THANK YOU to all the speakers who shared so compelling thoughts, with vibrant energy!

Suffering from FOMO? If you missed some of these replays, I’m listing all links & summaries in this single source of truth.

1- Science in the Age of Experience

This event featured, during 1.5 days, TED-style talks allowing attendees to hear firsthand how many organizations are leveraging Science to stay ahead of the innovation curve and change the world.

Two sections were of particular interest to me:

• Health for Life - Science for a Better Health

• Towards Healthcare

Here are links & short summaries of the sessions

Unlocking the Future of Drug Discovery with AI

Willem van Hoorn (Independent Consultant) shared insights on how artificial intelligence is revolutionizing drug discovery.

• How has AI changed the traditional process of drug discovery?

• What are the main challenges faced in drug discovery despite advancements in AI?

• What lessons has Willem learned from running an AI-focused drug discovery startup?

https://www.youtube.com/watch?v=5MYThafX2F8&list=PLMEjN73iIFkfWAVMF_MqeCqQPRv-nSU_5&index=7

Co-scientist & AI Automation for Discovery

Carnegie Mellon University's Dr. Gabe Gomes is revolutionizing the field of chemistry with groundbreaking research at the intersection of machine learning and organic synthesis.

• Faster drug development pipelines

• More efficient industrial processes

• Sustainable chemical solutions

https://youtu.be/O2jJ3V1yJ18?si=nCkqEdWyzJOMlIL9

Synthetic Data & The Power of Virtual Twins for Trials

I was thrilled to chair a thought-provoking panel with:

• Rui(Sammi) Tang, PhD, MBA , PhD, MBA (Servier)

• Ruthie Davi , PhD (Medidata Solutions)

• Pr. Benjamin Besse , MD, PhD (Institut Gustave Roussy)

• Shaun Rowark, MS (NICE)

These industry leaders shared invaluable insights on:

• Overcoming patient recruitment and retention hurdles

• Ethical considerations in clinical trials

• Innovative approaches to accelerate medical research and market access

https://youtu.be/ihWSdVhnYpQ?si=yi-ss9RO6G6_NXjp

Revolutionizing Production: the Key to Tomorrow’s Cell Therapies

Dr. David Sourdive , co-founder and EVP at Cellectis, shared groundbreaking insights on Next-Generation CAR T-Cells.

• How are cells being transformed into "living drones" within our bodies?

• What makes these new CAR T-cells "smart," and how could they revolutionize cancer treatment?

• How might off-the-shelf cell-based cancer drugs change the landscape of personalized medicine?

https://www.youtube.com/watch?v=24ITgJZU1CU&list=PLMEjN73iIFkfWAVMF_MqeCqQPRv-nSU_5&index=10

The future of medical diagnostics

Torrey Smith , CEO of Endiatx, gave an inspiring presentation on this incredible human and technological adventure, culminating in a live demonstration where he swallowed the PillBot on stage!

https://youtu.be/2jkDNfZlE48?si=cpaLjKjuC3VeWPhe

Innovation, Generative Technologies & Economics

Nobel Prize Laureate Pr. Jean Tirole brought his vast expertise in industrial organization, regulation, finance, and psychology-based economics to shed light on the intersection of AI and healthcare innovation.

• How might AI reshape the economics of healthcare delivery?

• What unique regulatory challenges does AI pose in the medical field?

• Can AI help address the rising costs of healthcare without compromising quality?

https://youtu.be/ZtK8mY3h_XE?si=iKCfr8lnRZhPRVRc

2- 10th Annual Virtual Human Twin Experience Symposium

The goal of this scientific symposium is to open the door to a new way of understanding, representing and simulating entire human bodies. It was built on deep-dive sessions led by experts, shedding light on how virtual twins of the human body can accelerate therapeutic innovation and trigger medical practice excellence.

3DS Keynote | Transformative Impact of Virtual Twins on Healthcare

 I was happy to open our 10th International Virtual Human Twin Experience Symposium!

• How are virtual twins set to enhance understanding of human body complexity?

• How can virtual twins advance scientific innovation through biorealistic simulations?

• How can virtual twins improve production processes in pharmaceuticals?

https://youtu.be/bAAOWKGQyko?si=IhZyo3poPwvBbmO9

Invited Keynote | the importance of Virtual Human Twins in Advancing Healthcare

Dr. Julien Vibert (李满山) from Institut Gustave Roussy presented on The Importance of Virtual Human Twins in Advancing Healthcare: Precision Oncology.

• How can virtual human twins transform the way we personalize cancer treatments and improve patient outcomes?

• What role do multi-scale biological, clinical, and environmental data play in the future of precision medicine?

• Could collaborative initiatives like MediTwin be the key to unlocking breakthroughs in oncology, cardiology, and neurology?

https://youtu.be/zJYURCHyIzw?si=Lx1RBwaud71OqN0Q

Panel Discussion | Journey of the Living Heart Project

This session gave an Overview Of The Living Human Project Expansion" featuring Cécile Bonnard and Dr. Nicolas Pécuchet from Dassault Systèmes.

• Discover how the MediTwin project is revolutionizing healthcare through virtual twins

• Learn about multiscale, multisystem modeling for improved patient care

• Explore the power of collaborative innovation in medicine

https://youtu.be/TTpYx7ZNQ5o?si=2L7KE4qwJccvFUnm

Reflections on the Living Heart Project’s 10th Anniversary

With Steve Levine , we celebrated the 10th anniversary of the Living Heart Project - a decade of innovation and impact, a powerful reminder of how far we've come in transforming healthcare through virtual human modeling.

https://youtu.be/AIwE6rjBXgA?si=wkNfyFW2GUuN_rDa

3DS Keynote | Vision for a Global Community of the Virtual Twin for Humans

A groundbreaking keynote by Patrick JOHNSON , EVP Corporate Research & Sciences at Dassault Systèmes

• Did you know that virtual human twins can significantly accelerate drug development by allowing researchers to conduct in silico clinical trials?

• Did you know that digital twins can integrate vast amounts of patient data, including genetic information and lifestyle factors, to create personalized treatment plans?

• Did you know that the use of virtual twins in healthcare not only improves patient care but also enhances operational efficiency in hospitals?

https://youtu.be/xj6TwmhDMkA?si=u0ovqQCFkimcE_Pv

Invited Keynote | Redefining Preoperative Planning: Patient-Specific 3D Modeling, Virtual Surgery and Computational Fluid Dynamics.

A groundbreaking keynote by Dr. David Hoganson from Boston Children's Hospital

• How can patient-specific 3D modeling transform the way surgeons approach complex pediatric heart surgeries?

• What role does computational fluid dynamics play in preventing complications during cardiac procedures?

• Could virtual surgery simulations be the key to personalized cardiovascular care for children?

https://youtu.be/5Dsnockvkxc?si=_zglN6c81szbunwr

Patient Voice - Seeing The Journey Ahead: JJ’s Story

Katie Bales , Investor, Patient Advocate, and Mother, shared the moving journey of JJ, a young boy born with a complex congenital heart defect.

• Innovation in Action: See how cutting-edge technology is revolutionizing patient care.

• Impactful Stories: Discover the real-life impact of these advancements on patients and their families.

• Future of Healthcare: Learn how such transformative care can become accessible to every child and family.

https://youtu.be/PT2F1tf-Avk?si=GGvNHdIn24AQycsA

European views on Virtual Human Twins

Saila Rinne , Director of eHealth, Well-Being and Ageing at the EU Commission, unveiled their bold vision for Virtual Human Twins, with transformative potential to drive precision medicine, improve patient outcomes, and set a global standard for technological advancement in healthcare.

https://www.youtube.com/watch?v=is6f6OVfNqk

Liesbet Geris , Executive Director of the VPH Institute, introduced the EDITH project, which aims to create a Virtual Human Twin ecosystem.

https://youtu.be/FX_eoxQL_jk?si=yum_tV9n9AMvjbiw

Advancing Oncology Follow-Up With TwinOnco: Leveraging Ai And Virtual Human Twins For Precision Medicine

Laure Fournier, Professor of Radiology at Université Paris Cité, presented on the TwinOnco project, which is revolutionizing cancer follow-up through the integration of AI and virtual human twins.

• How might AI-powered virtual twins revolutionize the way we monitor and treat cancer?

• Could personalized digital models lead to more precise and effective cancer treatments?

• What if we could predict a patient's response to therapy before starting treatment?

https://youtu.be/ZPjvM-eiC3g?si=Xvh1V-DYLypWNr9F

MediTwin Ambition illustrated by it’s leaders

A team of experts including Baptiste DÉMURGER , Dassault Systèmes, Ninon Burgos , Paris Brain Institute, Dr. Nicolas Villain , AP-HP and Louise Moreau , Dassault Systèmes  presented on the MEDITWIN project, showcasing how virtual twins and AI are revolutionizing Alzheimer's diagnosis and care.

• How might virtual twins change the landscape of neurological diagnostics?

• Could this technology lead to breakthrough treatments for Alzheimer's?

• What ethical considerations arise from using AI in brain health assessments?

https://youtu.be/MO13qKpId6Y?si=3gzYc6HKZAYE9FO_

Clinical Applications and Regulatory & Ethical Considerations

A panel discussion led by Jean Colombel brought together experts Emmanuelle Voisin, PhD , Voisin Consulting, Pr. @Sharmila Anadasabapathy, Baylor College of Medicine, and Sébastien Rosset , Dassault Systèmes to explore the critical regulatory and ethical considerations surrounding the integration of virtual human twins in clinical applications.

• How might virtual human twins reshape clinical trials and patient care?

• What safeguards are needed to protect patient privacy in the digital twin era?

• How can we ensure equitable access to this groundbreaking technology?

https://youtu.be/387CDL_rMus?si=9r4Np1IbyEo2sUqH

ENRICHMENT In Silico Clinical Trial Playbook

A groundbreaking panel discussion led by Jean Colombel brought together experts Brent Craven , FDA; Kenneth Aycock , FDA; Pr. David Hoganson , Boston Children’s Hospital; Pr. Claudio Capelli , UCL; Steve Levine , Dassault Systèmes to explore the game-changing potential of in-silico clinical trials.

• How might virtual twins revolutionize the drug development pipeline?

• Could in silico trials significantly reduce the time and cost of bringing new treatments to patients?

• What ethical considerations arise from using virtual patients in clinical research?

https://youtu.be/ewPxWj-RkBw?si=TO6BtGnZDWaFML8x

What a Week!

I cannot wait until #ScienceWeek is back in 2025, in Boston on Oct 29-31.

See you there!