Top 7 digital health trends to watch in 2025, a bold new reality

As we’re nearing 2025, the winds of change are blowing through health tech.

That’s exactly the feeling we got while speaking with our clients, exchanging knowledge with healthcare stakeholders, and interacting with healthcare leaders at recent HLTH USA, MEDICA, and Health Tech Forward conferences.

Couldn’t say we didn’t see that health tech reshuffle coming, considering that:

😮 In 2025, medical cost is expected to surge to its highest level in 13 years.

😲 In 2025, the U.S. healthcare industry is projected to face a significant shortage of 78,610 full-time registered nurses.

😲 Around 1 in every 10 patients is harmed in health care, and more than 3 million deaths occur annually due to unsafe care — half of this harm is attributed to medications.

Those are quite wake-up calls, right? And they are forcing the industry to seek innovative solutions. 

So we recapped the most important takeaways from the industry events, augmented them with our expertise, and presented a curated list of the top 7 digital health trends that will shape the future of healthcare…

…and probably, your product development efforts.

🤳 Remote patient monitoring and telehealth join forces

While the entire healthcare community is waiting for the waivers, RPM and telehealth technologies are chugging along into 2025, regardless of the obstacles in their path:

• Next year, RPM and telehealth will continue to merge, creating a seamless platform for both chronic and acute care monitoring with continuous, real-time data collection.
• An open ecosystem approach based on vendor-neutral interoperability is expected to dominate the remote and virtual care fields.
• Behavioral healthcare is likely to remain the most popular modality for telehealth, with large rounds flowing toward companies working on telehealth offerings, AI-enabled platforms, and services targeted to specific demographics.

And a sidenote: The average annual growth rate of U.S. health expenditures on home healthcare is projected to surpass other health sectors in the years ahead — between 2025 and 2026, this sector is expected to grow by 7.1%.

Innovators shaping the trend: Expressable, Grow Therapy, Equip, Doccla, CareYaya.

🧬 Personalized and genomic medicine looks to expand

In 2025, global personalized medicine is poised for rapid growth, accelerating at a predicted CAGR of 12% during 2025–2030.

Here’s what will propel it forward:

1️⃣ The increasing burden of chronic diseases and cancer across the globe.

2️⃣ The growing aging population worldwide and focus on longevity.

3️⃣ A shift towards prevention rather than treatment.

But tailoring treatments to an individual's unique genetic makeup, lifestyle, and health data requires a significant tech overhaul:

• The integration of EHRs with genetic information will be key to clearing hurdles inherent to genetic testing workflows.
• Wearable health technology and mobile health apps will be instrumental in enabling a more holistic understanding of a patient's health status.  
• The integration of the global health data network will empower clinicians and researchers to make more informed decisions.
• AI and big data analytics will remain a staple in genomics, delivering insights about population-level genetic variants, large-scale genomic rearrangements, and structural changes.

And those are likely the contours of the year to come.

Innovators shaping the trend: Zoe, Nucleai, Acrivon Therapeutics, CancerIQ.

🤖 AI, more AI

You know how it goes these days: it’s not health innovation unless it banks on AI. Jokes aside, AI and its offshoots have become an investment priority for 73% health system and health plan executives and will continue to be so in 2025.

But the modalities are changing:

• Generative AI is set to play a central role in healthcare, particularly in diagnostics, patient engagement, administration, and drug development.
• In a quest for healthcare data accessibility, more AI solutions will focus on the "picks and shovels" of healthcare.
• AI-powered training and staffing solutions are stepping in to address the healthcare staffing shortage.

Innovators shaping the field: Abridge, CodaMetrix, Artera, Atropos Health, Suki AI, Stepful.

💉 Clinical trials, unchained

Decentralized clinical trials (DCTs) are another trend the industry should save the date for in 2025 (courtesy of the new FDA guidance).

Over 24% of clinical trial studies now offer a home-based solution, and that number isn’t likely to stop there.

Unlike the “brick and mortar” site model, hybrid and fully decentralized trials allow patients to participate in clinical trials from their homes — a new chance for patient centricity and diversity.

But DCTs demand quite a toolbox to guarantee the accuracy of data collected, maintain data integrity, and overcome connectivity issues on both ends.

So, here’s what innovations we expect on a DCT tech bingo card in 2025:

• Advancements in analytical validation tools to promote data quality and centralization
• Focus on the usability of eConsent to improve the quality of the informed consent process
• Artificial intelligence to optimize trial design and participant engagement strategies
• Blockchain technology to enhance data security and de-risk the consent process

Innovators shaping the field: Curavit, Topography Health, Triomics, ResearchGrid.

👩🏻 Femtech is growing, and fast

A sector that’s long been under the funding radar, femtech saw a 15.1% year-over-year growth in funding in 2024. Femtech companies attracted around $1.1 billion, compared to $934.2 million in 2023.

Federal policies are also turning to women’s health. 

We project 2025 to be a pivotal year for this sector, influenced by the following trends:

• A new crop of femtech startups are focusing on increasing reproductive and sexual healthcare access to underserved communities.
• With maternal health (including postpartum depression and newborn well-being) in sharp focus, startups working on innovative care models and tech solutions that address maternal health disparities are in for potential growth.
• Wearable and monitoring devices, such as diagnostic tampons, CGM monitors, smart underwear, and others, continue to augment women’s health monitoring.

Innovators shaping the field: Qvin, Alloy, Willow, Persperity Health, Daye.

🧘🏻 Mental health solutions are getting leaner

In 2025, traditional teletherapy platforms won’t cut it.

The market, including investors, is expected to lean towards AI-driven behavioral health support and digital platforms.

• The prescription of digital mental health therapeutics can now be billed through Medicare and Medicaid, which will likely shape the future of mental healthcare delivery in 2025.
• Increasing regulatory attention indicates the importance of evidence-based practices for mental health applications.
• Artificial intelligence, and conversational AI interfaces in particular, have the potential to transform mental health care by making it more accessible, affordable, and personalized.
• The non-invasive neurotech market, though currently modest, is lined up for significant growth as the mental healthcare community is searching for innovative, accessible, drug-free ways to enhance mental health treatment. 

Innovators shaping the field: Happify Health, Rejoyn, Flow Neuroscience, DeepWell, Neurode.

⌚ No middleman for wearable health technology

The traditional model of wearable healthcare, the one incumbent on provider prescriptions, is shifting.

More direct-to-consumer offerings are on the horizon — and they’re getting smarter.

• Wearable health technology is getting more complicated as more tools are focusing on disease monitoring, chronic disease management, and early detection.
• AI-powered wearables are becoming the norm, enabling continuous, real-time, and advanced vitals monitoring.
• Startups are building wearables as therapeutics — and this trend is likely to gain traction in 2025.

Innovators shaping the field: Neurovalens, Metyos, Samphire Neuroscience, Oura.

So, that’s what the future of health technology holds for us. 

If you need a trusted tech team to implement one of those trends in your health tech product, drop us a line. Orangesoft is committed to helping you navigate the complex landscape of digital health. Let's build the future of healthcare, together.

More predictions for what’s to come:

Healthcare innovation at the turn of 2025 (Rock Health)

10 healthcare technology trends for 2025 (Philips)

Top healthcare trends of 2025 (Definitive Healthcare)

The most promising digital health startups of 2024 (CB Insights)

10 promising advanced healthcare technologies in practice (The Medical Futurist)