"Zeaxanthin augments CD8 + effector T cell function"
Thus, could a dietary supplement augment the effects of "Keytruda" and other inhibitors of "don't kill me" signaling?
"The evolution of diet has played an essential role in shaping human physiology and pathology, including the development of the immune system and its responses to environmental stimuli.1–3 However, despite extensive epidemiological studies, the mechanistic understanding of how different diets impact the human immune system is very limited due to the intricate nature of the immune system, whole-organism metabolism, and the vast diversity of dietary components available."
"Hereby our findings reveal a previously unknown immunomodulatory function of ZEA, a carotenoid antioxidant known for its role in eye health. Dietary ZEA can be found in many fruits and green leafy vegetables such as kale, spinach, broccoli, peas, lettuce, durum wheat, and corn, as well as egg yolks, because common feeds for chickens contain grains such as corn and vegetables enriched with ZEA.32 It is widely recognized that plant-based or vegan diets can potentially benefit the human immune system.33 However, the underlying mechanistic link between plant-derived nutrients and human immunity remains largely unknown. Our strategy focusing on individual diet-derived nutrients despite the vast diversity of food and diet origins makes mechanistic studies feasible to explore nutritional influences on human health and the immune system. Using this approach, we successfully identified dietary TVA derived from animal-based diets5 and hereby ZEA as a plant-produced nutrient, both of which have direct yet mechanistically distinct effects on CD8+ effector T cells and anti-tumor immunity."