model organism cell signaling bacterial infections infectious disease viral infections c.elegans rnai arabidopsis rna interference immune regulation immune response massachusetts general hospital molecular genetics immunity phspho-amniacid analysis ip yth phospho-peptide mapping phoshorylation host-resistance yeast two hybrid biolistic bombardment engineering resistance kinase immunoprecipitation transgenic host-susceptibility viral diseases high-throughput screening host immunity trait mapping host resistance host susceptibility cell-cell interaction multi-directional control strategic positioning porter's five forces analysis swot astrazeneca business strategy coputational biology network biology infection emegence hypothesis bacterial pathogens systems biology meta-genomic studies infectious diseases bacterial diseases immune-compromised state cell-signaling nosocomial infections high-throughput screens system status change environment induced diseases multi-spectral screen novel anti-infectives emergence of disease avirulence proteins type iii secretion resistance genes
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