Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map
Fig 6
CMAP queries for RNAi and CRISPR reagents.
(A) For all genes assessed by both CRISPR and RNAi technologies, the q-values for querying CMAP with the CRISPR CGS and its resulting connectivity to the RNAi CGS. See S7 Data. (B) Same as in (A), but only for genes passing holdout analysis (q-values < 0.25) by both technologies individually in a cell line, the q-values for connectivity. Holdout analysis q-values are plotted for each technology in the first 2 columns; connectivity q-values are plotted in the third column. See S7 Data. CGS, consensus gene signature; CMAP, Connectivity Map; CRISPR, clustered regularly interspaced short palindromic repeat; RNAi, RNA interference.
doi: https://doi.org/10.1371/journal.pbio.2003213.g006