Epistatically Interacting Substitutions Are Enriched during Adaptive Protein Evolution
Figure 6
Epistasis in human NP occurs at sites enriched in CTL epitopes.
The number of CTL epitopes per site for the sites of the epistatically constrained substitutions in the human influenza NP versus (A) all sites or (B) the full set of sites that substituted along the evolutionary trajectory. The P-values shown on the plots represent the fraction of random subsets that contain as many total epitopes as the actual sites of the epistatically constrained substitutions. See http://jbloom.github.io/epitopefinder/example_NP_CTL_epitopes_H3N2_and_swine.html for code, input data, and detailed documentation.
doi: https://doi.org/10.1371/journal.pgen.1004328.g006