Pseudomonas aeruginosa Transmigrates at Epithelial Cell-Cell Junctions, Exploiting Sites of Cell Division and Senescent Cell Extrusion
Fig 6
Model of P. aeruginosa transmigration across epithelial layers.
In resting epithelium, T2SS proteases or T3SS toxins are inefficient to disrupt the barrier formed by polarized epithelial cells provided with mature junctions. Bacteria may use cell division or dying cell extrusion to penetrate the epithelium. Once bacteria have access to the baso-lateral domain, they interact with cell membranes using their pili and inject their T3SS toxins, inducing cell retraction and facilitating their invasion of the basal compartment.
doi: https://doi.org/10.1371/journal.ppat.1005377.g006