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Breaking news: turns out acetaminophen has an active metabolite that acts on... sodium channels.

https://medicalxpress.com/news/2025-06-acetaminophen-discove...



AM404 really is the metabolite that keeps giving. The central nervous system system effects were fun too, acting on cannabinoid receptors and/or TRPV1 channels -- so either stony or spicy.


I can't say it ever made me feel high, but acetaminophen has been long shown to have significant behavioral effects

https://pubmed.ncbi.nlm.nih.gov/27217114/

https://pubmed.ncbi.nlm.nih.gov/32888031/

My primary care doc doesn't want me taking either NSAIDS or acetaminophen so when I get asked at the urgent care what I take for pain I say "Nothing".




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