I would agree, personally - I won't go near DNP, and even the newer stuff like BAM15 that is supposed to be incredibly selective I am quite suspicious of.
But you still see people losing tons of weight on GLP-1s wanting it to go faster, drop more pounds, etc.
I'm a big proponent of them - and I have enough risk tolerance that I'm on grey market retatrutide - but I see a lot of people that want to just keep adding more and more chemicals to the equation to solve the issue. I've taken the time to significantly modify my food and exercise habits, and believe that I'll be able to maintain my weight loss if I were to go off of the GLP-1. But a lot of people haven't. They eat the same bad food, just in lower quantities, don't increase their protein and fiber intake, don't exercise, and just up the dose or add a new compound when their rate of weight loss doesn't satisfy them.
There's tons of interest in BAM15, clenbuterol, and all sorts of experimental substances. Tons of people taking things like tesamorelin and ipamorelin too.
I think the GLP-1s are basically miracle drugs that have allowed a lot of people, including myself, to totally revamp their approaches to diet and fitness. But there's a lot of people that are going to be more than happy to increase their cocktail with anything they think will get them skinny faster.
Uncouplers are particularly useful to make sure your metabolism doesn’t slow down, which makes getting off those drugs when reaching the right body fat percentage without regaining everything way easier
Losing weight through any method will make your metabolism slow down - fat is metabolically active. Uncouplers won't change this. Even if 100% of your weight loss is fat, your BMR is going to drop. The amount of metabolic adaptation from caloric deficits is grossly overstated by many people, and the "starvation mode" adaptation is temporary. Just reaching a maintenance level of calories for a relatively short period of time is enough to reset it - but this change is minor to begin with. The majority of any metabolism slowing will occur purely as a function of weight loss.
The issue with regaining weight after coming off these drugs is that people don't change their habits, and once they are off, they no longer have the limited appetite, and return to eating like they did before, which just results in the problem reoccurring. Uncouplers won't change this.
If people want to sustain their weight loss, they either need to change their lifestyle and eating habits, or they need to stay on the drugs, and potentially even both.
Let’s be real: both of us have no idea of how it would play out. Pharma companies will try to add them to their stack at some point, and then the real world data we currently lack will decide for everyone
