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> it's an entirely reasonable question that needs to be asked when considering the potential for serious side effects

I agree about it being asked. A lot of times it isn’t being asked, but assumed.

I thought it was snake oil when announced. I’m now beginning to question if it’s closer to a weird vitamin that we face a systemic deficit of.





> I’m now beginning to question if it’s closer to a weird vitamin that we face a systemic deficit of.

There's some studies suggesting that a big part of what influences someone to naturally be fat or skinny is tied to natural production of the GLP-1 hormone. Post-prandial readings of serum level GLP-1 show significant differences in lean people vs. obese people, with obese people have much less.

We don't have an understood mechanism yet to determine if it's causative - maybe it's yet another feedback loop we have with gaining weight - but it seems very plausible that the natural level of production is a determinant factor in just how susceptible you are to packing on the pounds in today's food-rich world.




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