Concept Life Sciences

Congratulations Mary!

We’re excited to share that we will be exhibiting at EUROTOX Congress 2025 – Booth B04! Our experts Ritu Sharma, John McManus and Hayley Gooding are eager to meet industry peers, exchange insights, and discuss the latest advances in toxicology. We’ll also be presenting a poster at the event – stay tuned here on our LKD page for more details coming soon! See you there. #EUROTOX2025 #Toxicology #ECHA #Chemicals #ChemicalRegulations

We’re at the Biotech Vendor Services, Inc. event today at the Hayden Research Center in Lexington, MA. Come and meet the team Steven L. Holshouser, Ph.D. and Li Luo to discuss how our collaborative and flexible services can help you accelerate your discovery!

In vitro efficacy and safety studies are essential in CGT product development to establish cell-specificity, MoA, the ability to generate antigen specific immune responses, and to predict resistance mechanisms.     We develop and provide a range of assays to gain a deeper understanding of therapy interactions and responses with target and non-target cells including:    📈 Potency assays measuring immune cell activation  📈 Inflammatory response profiles measuring proinflammatory cytokines       Find out more about our services for in vitro efficacy and safety analysis for cell and gene therapies: https://lnkd.in/eAtKeU9h   #cellandgenetherapy #CGTs #autologouscelltherapy #allogeneiccelltherapy #immunotherapy #CRO #UKCRO

While summer is in full swing and many are taking a well-earned break, we’re already gearing up for an exciting and event-packed season ahead. Our teams are preparing to share cutting-edge science through a packed calendar of poster presentations, speaking engagements and conference appearances across the UK and beyond.   Want to know where you can meet us? Visit our website for the full events calendar : https://shorturl.at/ZOgRh Follow us here on LinkedIn — we’ll be spotlighting each event individually in the coming weeks Stay tuned – we’re just getting started. #ConceptLifeSciences #EventsSeason #DrugDiscovery #ScientificExcellence #MeetTheTeam #LifeSciencesEvents

With CADD being more critical than ever in driving innovation in drug discovery, our spotlight today is on Enrico Margiotta, Associate Director of Computational Chemistry. Enrico brings exceptional experience across both academic and CRO environments, and leads our cutting-edge team focused on projects requiring stand-alone or fully integrated drug discovery support. He holds a Ph.D. in Computational and Theoretical Chemistry through a joint program between the University of Padova and the Vrije Universiteit Amsterdam, under the mentorship of world-renowned experts in CADD and quantum chemistry. His postdoctoral work at the University of Cagliari contributed to an NIH-backed global effort targeting antibiotic resistance. Enrico also served as a Research Scientist at the Broad Institute of MIT and Harvard—ranked the 3rd top scientific research institute in the world—where he led computational chemistry efforts across multiple integrated drug discovery projects in collaboration with leading institutions such as Harvard Medical School, Dana-Farber Cancer Institute, and Novo Nordisk. He has a particular passion for ligand-protein interactions, structure-based drug design, and molecular dynamics simulations. Enrico’s in-depth expertise not only in computational chemistry, but also in medicinal chemistry and biology, makes him an invaluable asset for clients at every stage of their scientific programs. To find our more about our CADD services visit : https://lnkd.in/eSDpRgJF #Spotlight #CADD #DrugDiscovery #ComputationalChemistry #Charnwood #Welcome

[𝗦𝗽𝗼𝗻𝘀𝗼𝗿 𝗔𝗻𝗻𝗼𝘂𝗻𝗰𝗲𝗺𝗲𝗻𝘁] We’re excited to announce our Silver Sponsor for Discovery & Development US and Formulation & Delivery US 2025: Concept Life Sciences 𝗬𝗼𝘂𝗿 𝘁𝗿𝘂𝘀𝘁𝗲𝗱 𝗽𝗮𝗿𝘁𝗻𝗲𝗿 𝗳𝗿𝗼𝗺 𝗖𝗼𝗻𝗰𝗲𝗽𝘁 𝘁𝗼 𝗖𝗹𝗶𝗻𝗶𝗰 "We are your integrated drug discovery and development partner for complex challenges, renowned scientific knowledge and strategic execution across all modalities from small molecule and biologics to Cell & Gene Therapies (CGT)." Meet them this October in San Diego, California! https://hubs.la/Q03vTpf-0 #DiscoveryDevelopmentUS25 #drugdiscovery #drugdevelopment #pharma #biotech #formulation #drugdelivery #rna

We looked at the impact of refrigeration and freezing on mRNA-LNP formulations by assessing:    ❄️ The size distribution of mRNA-LNPs using single-angle dynamic light scattering (DLS)  ❄️ The encapsulation efficiency of mRNA-LNPs using the RiboGreen® assay   ❄️ The transfection efficiency by adding samples to HEK-293 cells and measuring GFP expression over 5 days     We found that for this formulation, refrigeration was the best method of storage for mRNA-LNPs as it resulted in the least distributed particle size, and the best encapsulation and transduction efficiencies.     Learn more about our biophysical, molecular, and cell-based services for cell and gene therapies: https://lnkd.in/ezewECBS      #cellandgenetherapy #CGTs #autologouscelltherapy #allogeneiccelltherapy #geneediting #genedelivery #CRO #UKCRO #CLS #Conceptlifesciences

This is an exciting time to work for Concept Life Sciences because July is the month where we welcome our new, fresh-out-of-the-box industrial placement students who come into our business and provide an outlet for us to innovate, develop new service lines and contribute to the wider drug discovery ecosystem. Over the last three years we have onboarded students in both chemistry (https://lnkd.in/eZ3wQ4rz) and biology – which has provided us with a platform to develop our expertise in 3D cell culture. Unfortunately, this is also the time of year when we say goodbye to our current crop of industrial placement students. This week we’ve had to bid farewell to Rosalba Craven, a third year biochemistry undergraduate from University of Bath. Rosie has developed a 3D co-culture model for MASH (metabolic associated steatohepatitis) using a fully synthetic peptide-based hydrogel. Her model enables testing of anti-MASH compounds by assessing key fibrotic markers such as collagen deposition, inflammation and lipid accumulation. Over the course of the year, Rosie has learned about the vital role of 3D co-culture models in drug development and the importance of continuous innovation in research. Along the way, she honed core lab skills like cell culture, assay optimisation & data analysis, while growing confident in designing and communicating scientific work. Reflecting on Rosie’s year-long journey with us, our Associate Director of Immunology, Dr Justyna Rzepecka had this to say: "The whole team at Concept Life Sciences enjoyed working with Rosie, who quickly became an integral part of the group. We’re incredibly proud of her undeniable growth as a scientist. I’ve been especially impressed by her ability to present complex data with clarity and confidence. We wish Rosie all the best in her next chapter and hope we played a meaningful role in her development. There’s no doubt she has a bright future ahead!" Thank you for all of your efforts Rosalba Craven, and good luck for the future!

Great to be working with all the team Fios Genomics