Institute of Metabolic Science-Metabolic Research Laboratories

Sharing for our colleagues at The University of Edinburgh who are carrying out a survey on weight loss drugs and pregnancy. Please help us learn more. Take the survey 👇👇👇👇 https://lnkd.in/ddFQkd5a

The gut's hidden messengers: unlocking the signalling pathways of human serotonin release. Research recently published as article in press at @Cellular and Molecular Gastroenterology and Hepatology (CMGH) and led by Dr Constanza Alcaino from the Fiona Gribble/Frank Reimann group, and colleagues at the Institute of Metabolic Science-Metabolic Research Laboratories and elsewhere, has for the first time, provided a complete expression and functional profile of human enterochromaffin cells which help control how our gut moves and feels. Read more 👉 https://lnkd.in/euPr9f5A Full paper ℹ️https://lnkd.in/eWs_bCdX

We are delighted to announce the launch of our Institute of Metabolic Science-Metabolic Research Laboratories Clinical Studies and PPI Opportunities Website ℹ️ https://lnkd.in/e9Df5Y7V   This platform will help promote research studies and public/patient involvement opportunities to a wider audience. It is designed to be clear and accessible for potential participants and collaborators alike, making it easier to engage with the exciting work happening across our Institute.

Fantastic celebration today of our 2024-25 Obesity, Endocrinology & Metabolism Taught MPhil cohort. 🍕 Posters and pizza - always a winner. https://lnkd.in/eKetVYAc #MPhil #obesity #metabolism #diabetes

Fantastic and well done 👏

🐁 The final paper from my PhD is out in The Journal of Physiology! ❤️ We studied the cardiovascular effects of prenatal metformin exposure in a mouse model of gestational glucose intolerance (a model of GDM). The oral drug metformin is increasingly used to treat diabetes in pregnancy, as it is cheaper and less invasive than insulin injections. Unlike insulin, metformin readily crosses the placenta, and long-term effects on offspring cardiovascular health remain unexplored. We show that offspring of GDM-like mice developed hypertension and diastolic cardiac dysfunction by the time they reached middle age. Maternal metformin treatment did not improve but worsened the cardiovascular phenotype, introducing independent cardiovascular alterations in offspring of both sexes. Male metformin-exposed mice had cardiac stiffening and vascular dysfunction while female mice developed obesity-induced hypertension, showing sexual dimorphism in metformin's prenatal effects. Our work highlights that long-term cardiovascular follow up in offspring (of both sexes!) from human metformin-treated pregnancies is crucial to make more informed decisions about metformin use in pregnancy - a tricky question that requires balancing mum and baby's health. The project was initiated (and most of the work was done) during my PhD at the Institute of Metabolic Science-Metabolic Research Laboratories, but it has been a four-year-long collaborative effort to get it over the finish line. I'm incredibly excited to finally share this work with you! Full paper (open access): https://lnkd.in/evV58fyd Funders: British Heart Foundation, Wellcome Trust and Medical Research Council I will present some of this (and other) work at the 13th DOHaD World Congress in Buenos Aires in September, so will be very glad to connect with anyone attending 👩🔬👨🔬

Opportunity to get involved in clinical research!!   Nutrition Research Study Are you eating around the clock? Do you have some extra weight?   Dr Maria Chondronikola, at the Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge is conducting a research study to determine the role of time-restricted eating in metabolic health. You may qualify if you fulfil the following criteria: ·     25-75 years old ·     Overweight or obesity (BMI 27-45) ·     No chronic disease (diabetes, heart disease, cancer, etc.) ·     Not smoking Participation includes: ·     Medical screening & body composition assessment ·     Following a prescribed heart-healthy diet for 14 weeks ·     Weekly visits with a Registered Dietitian or Nutritionist ·     Two 12-hour visits to assess sugar and fat metabolism ·     Two 36-hour visits (optional) ·     Continuous glucose monitoring ·     Fat and muscle biopsies ·     Reimbursement for time and effort will be provided.   CONTACT INFORMATION: Phone number: 07523268691 Email: cuh.nutritionrs@nhs.net So if you are in or close to Cambridge and want to find out more or get involved, please do get in touch (and do mention that you saw details here on LinkedIn)

For our next Institute of Metabolic Science - Metabolic Research Laboratories seminar, we look forward to welcoming Professor Robert Waterland from the Baylor College of Medicine, Houston to talk to us about ‘Epigenetic epidemiology: Time for a fresh start’.

We are delighted to welcome Professor ‪Brent Richards from McGill University, Montreal, Canada who is visiting the Institute of Metabolic Science-Metabolic Research Laboratories to talk to us today about ‘Causality, Calories, and COVID: Chasing Disease through the Human Genome’ 👇 👇 👇

📣 Final few days to apply for this great PA opportunity! Closes after this weekend!!! Take a look on the University of Cambridge jobs website! Details below 👇