Base Pair Bulletin

Highlights from Twist Bioscience, June 2025! We've rounded up the top news that happened this month from hot-off-the-press articles and collaboration updates to podcasts and publications. Read on for all the details and please subscribe and share with your network.

25th Anniversary of the Human Genome Project

Leading scientists, including our own Emily Leproust , reflect on the exponential acceleration in genomics, highlight the transformative impact of synthetic biology, rapid DNA synthesis and innovations in diagnostics and therapeutics— all made possible by the Human Genome Project.

Synthetic Biology Advances with Real Impact

The secret sauce of synthetic biology: DNA! This great SEQanswers article showcases how synthetic DNA helps researchers move faster from design to discovery. Read more about the endless possibilities for what can be done with synthetic DNA here.

Collaboration Updates:

Curio Genomics

Learn how Twist Bioscience + CURIO Genomics are working together to deliver focused, high-quality genomic insights for NGS customers in this great article: “Complete and Cost-effective Agrigenomics Genotyping Across Large Breeding Populations.”

KeyGene and Beckman Coulter

Twisters have been hard at work with KeyGene and Beckman Coulter Life Sciences to bring our customers the latest in plant exome workflows.Read more about how you can characterize more than 9,000 samples/day:

Oxford Nanopore Technologies

Check out how Oxford Nanopore Technologies + Twist Bioscience single-assay research workflow delivers comprehensive characterization of PGx targets without compromise.

Institute for Protein Innovation

The Institute for Protein Innovation and Harvard Medical School report a novel framework for making synthetic recombinant antibodies that can generate data specifically optimized for machine learning integration:

Recent Publications

• New work from National Institute of Standards and Technology (NIST), Microsoft, and Twist Bioscience ( James Diggans ) demonstrates that AIPD tools are not yet powerful enough for wholesale redesign. Read "Experimental Evaluation of AI-Driven Protein Design Risks Using Safe Biological Proxies" by clicking here.

• From our very own Linya Wang, PhD, her recent publication presents new potential for cancer immunotherapy strategies. "A multi-faceted discovery strategy identifies functional antibodies binding to cysteine-rich domain 1 of hDKK1 for cancer immunotherapy via Wnt non-canonical pathway."

• A new study from Philipp Rathert and team in Cell Reports Methods presents an innovative CRISPR screening platform (CRISPRgenee). They used high-quality, custom gRNA libraries from Twist to support this work ( Julian Jude, PhD ). Read "CRISPR GENome and epigenome engineering improves loss-of-function genetic-screening approaches" here.

Podcasts

The Grammar of RNA

Theral Timpson, host of Mendelspod , and Gavin Knott molecular biologist at Monash University and former postdoc in the Jennifer Doudna lab, discuss the “shapeshifting paradox” of RNA—and how structural biology is being upended by AI.

Can Math and AI Replace Some Biology in Drug Discovery?

Tune in to hear Theral Timpson and Aridni Shah of immunitoAI answer these questions and discuss the reinventing of how antibody therapies are developed on Mendelspod.

Promotions

Gene-ius Grants

Now accepting applications for our NGS Twist Gene‑ius Grant award program. One winner per region receives: $10,000 USD worth of Twist NGS products, and a free Apps Lab project valued at $20,000 USD. Apply by June 30th here.

Free DNA for iGEM teams

Every iGEM team receives complimentary synthesis of 20kb of Twist DNA, available as either Gene Fragments or Express Clonal Genes! Find all of the details here.

EMEA

Chu Liege (Pedriaticians) - 26, June. Belgium 🇧🇪

Microbial Engineering Symposium Cambridge 2025- 27, June. UK 🇬🇧

BioTrans 2025- 29 June - 3 July. Switzerland 🇨🇭

Ice Cream UK- 25 June UK/Oxford  AND 1 July UK/London 🇬🇧

Tabletop at Oxford University William Dunn School of Pathology- 2, July. UK 🇬🇧

Genome Science UK Newcastle 2025- 9. July. UK 🇬🇧

Dutch cfDNA Day- 4, July. Netherlands 🇳🇱

Utrecht conference, 2025- 4, July. Netherlands 🇳🇱

Paris Congress “Yeast 2025”- 23, July. France 🇫🇷

LIFE&BRAIN- 27, July. Germany 🇩🇪

Designer Biology- 29, July. UK 🇬🇧

APAC

The 15 International Workshop on Advanced Genomics- 2-4, July. Japan 🇯🇵

Twist Seminar @ NIBS, ChangPing Lab- 3, July. China 🇨🇳

The 32nd Annual Conference of The Japanese Society for Gene Diagnosis and Therapy- 7-11 July) - NGS

[Korea] Antibody Society of Korea (7-11 July) - Biopharma

[Japan] Kobe Biomedical innovation (Interphex week) (9-11 July) - Synbio/NGS

[Japan/Germany] IS-MPMI (13-17 July) -SynBio/NGS

[Korea] International Society for Animal Genomics (20-25 July) - NGS (AgBio)

[Taiwan} BioAsia Taiwan (23-27 July) - Biopharma

[China] Synthetic Biology Course Cold Spring Harbour Asia (24 July) - SynBio

[Singapore] Twist Bioscience: Pitch Your Idea (30 July) - Brand Awareness/Synbio