Functional Genomics on Point: Expert views, cutting-edge tech, and what’s shaping tomorrow
Precision meets scalability in functional genomics
From high-throughput CRISPRa screens to single-cell resolution tools, this edition explores how scientists are combining precision with flexibility to push their research forward. Whether you're refining assay design, optimizing your workflow, or scaling for discovery, we’ve gathered expert insights, application resources, and powerful new tools to support your next breakthrough.
Better together: Combining screening approaches for deeper insights
Looking to combine functional genomic screening with cell panel screening? Together, these orthogonal approaches create a powerful framework for discovering and validating novel therapeutic targets. Our experts share how this combination can generate rich, multi-dimensional datasets for stronger, independent confirmation. Read the blog.
Next-Gen Cocktails, Backed by six years of innovation
BioLegend, part of Revvity, is taking multiomics to the next level with newly refined TotalSeq™ reagents. Building on six years of close collaboration with researchers worldwide, our Human Universal Cocktails V2.0 and Essential Cocktails continue to set the gold standard. Compatible with 10x Genomics Chromium Single Cell Universal 3’, 5’, and Flex assays, these cocktails feature the most extensive antibody coverage available and come pre-titrated and fully optimized — ready to streamline your single-cell workflows Unlock the power of TotalSeq™. View cocktails now.
Scalable genome-wide CRISPRa screening starts here
Genome-wide CRISPRa screens don’t have to be complex or resource-intensive. This blog explores how synthetic sgRNA libraries offer a streamlined, scalable approach to gene activation studies—without the need for complex cloning or lentiviral production. Learn how researchers are using these libraries to uncover functional regulators of cell state, accelerate target discovery, and increase screening throughput. Streamline your activation screens. Read the blog.
CRISPR screening strategies: resistance vs. sensitivity - what’s right for your study?
Get practical guidance on choosing between resistance and sensitivity screens. This blog covers experimental design, analytical approaches, example datasets, and how Revvity’s functional genomic screening services can support your discovery journey. Read the blog.
Beyond the pool: Single-cell CRISPR screening for deeper phenotypic insights
Pooling has its power, but single-cell resolution takes functional genomics a step further. Learn how CRISPR-based single-cell screening can uncover hidden biological complexity and rare phenotypes that pooled screens might miss. Read the blog.
CRISPR in action: Mapping macrophage differentiation
What happens when you apply a focused CRISPR-Cas9 screen to the question of macrophage differentiation? This case study showcases how functional genomics can reveal critical regulators of immune cell development — combining arrayed CRISPR editing, targeted NGS, and in vitro differentiation assays to dissect key molecular pathways.
A must-read for anyone studying immune cell fate or applying functional genomics in immunology. See how CRISPR decodes immune cell fate.
Precision genome editing without phenotypic changes
Now available: AAVS1 and Rosa26 CRISPR cutting controls designed for safe-harbor targeting — giving you a clean genomic cut without affecting cell phenotype. Perfect for mismatch detection assays or confirming Cas9 activity during screens. Start editing with precision — Order now.
NGS library prep kits for pooled CRISPR Screening
Complete your CRISPR screen-to-sequence workflow with Dharmacon™ NGS library prep kits—now available for all pooled lentiviral sgRNA libraries, including Edit-R™, CRISPRmod™ CRISPRa and CRISPRi. Complete your workflow — Explore NGS-ready kits.
Bioprocessing Summit 2025 August 18–21 | Boston | Booth #504
We’ll be at the annual Bioprocessing Summit in Boston, the flagship event for decision-makers in the bioprocessing industry. Stop by our booth to meet the team, check out our latest posters, and join our presentation on gene editing. Revvity at BPS 2025.
On-Demand Webinar | Mastering RNA Interference: Essential Guidelines and Pro Tips
Discover key insights into RNAi, CRISPR, and functional genomics in this expert-led session. Learn practical strategies to accelerate your research and drug discovery efforts, with real-world tips to refine your RNAi techniques. Watch now.
