Evolving aseptic filling in biomanufacturing

Decades ago, laminar flow hoods and biosafety cabinets were the stalwarts of aseptic processing, providing controlled environments for fluid transfer tasks. However, as the demand for sterile drug products escalated and regulatory standards tightened, the industry embarked on a quest for more robust and efficient methods.

With advances in advanced therapies came the need to transfer small volumes in an aseptically closed system to reduce the risk of contamination. But it also led to reproducible aliquot consistency, filling accuracy and speed, resulting in improved efficiency in fluid management techniques.

The journey from laminar flow to automated fluid management has been nothing short of transformative. This evolution, marked by innovation and adaptability, has reshaped the way smaller volumes of biopharmaceuticals are handled and transferred with precision and sterility.

In this article, we review the success story of aseptic filling in the pharmaceutical industry and compare laminar flow, filling line isolators and automated filling platforms.

Full article: https://www.susupport.com/knowledge/fill-filtration/evolving-aseptic-filling-biomanufacturing

Automated filling platforms: https://www.susupport.com/solutions/platform-systems/fill