Stress- The Unwanted Editor of Genes - An Oncologist  warning

Stress- The Unwanted Editor of Genes - An Oncologist warning

This article stirred thoughts, which I am penning hem now

https://www.nature.com/articles/s41380-024-02872-3?utm_source=chatgpt.com

When I walk into my clinic each morning as an oncologist, I know I’m not just seeing a person with cancer. I’m meeting the weight of a whole life—their struggles, their triumphs, their silent battles. Recently, I read about a remarkable scientific discovery: that stress, the very storms we carry inside, may leave a molecular “echo” in sperm, shaping not only us but the next generation.

It stopped me in my tracks.

Because in cancer care, stress is our constant shadow. The patient sits in front of me, trying to stay strong, but I see the flicker in their eyes—questions about survival, family, legacy. And beside them sits the spouse or child, carrying a different but equally heavy burden: what happens to us, if…?

Now science tells us that the echoes of this stress might outlive even the illness, whispering forward into the biology of our children and grandchildren. Imagine that—how the unspoken fears of today may ripple into tomorrow’s lives.

But here’s where empathy must rise higher than fear. If stress can leave its mark, perhaps love and resilience can too. I have watched families transform hospital corridors into sanctuaries of courage. A father, though frail, smiling as he helps his son with homework during chemo. A mother, in between infusions, reminding her daughter to chase her dreams. These moments are not just memories—they may be biological signatures of strength, hope, and connection.

To the patient, I say: Your body carries not just disease, but the imprints of everything you’ve survived. You are more than your diagnosis.

To the family, I whisper: Every hug, every laugh, every shared tear, is part of the healing story too.

And to myself, as a doctor: We are not just treating tumors; we are caretakers of legacies.

Perhaps one day, science will show us that resilience, like stress, can leave molecular fingerprints in our cells. Until then, I choose to believe that the love a patient and family share—through every trial—writes the strongest inheritance of all.

Srinivasu Vatti

Chief Technology Officer | Product Innovations | Medical & Consumer Products & Process Technology | Lean Six sigma & Operational Excellence| Ex Whirlpool | Ex Tech Mahindra.

3w

Well said Dr.Suresh 👏👏🙏

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Frank Michael Odia MBA MSHR

CEO & Executive Search Partner | Specialized in Oncology Leadership | Founder-Led, Personalized Search for Cancer Care Centers, Biotech & Pharmaceuticals

3w

Fascinating insights on how stress leaves epigenetic "fingerprints" that may increase cancer risk across generations! Your hopeful note about resilience and mindfulness rewriting our biological legacy is inspiring. Thanks for sparking this vital conversation!

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Dr. Alpesh Kikani

Founder & Director of Shashwat Hospitals | Consultant Medical Oncologist | Hematology Oncology Specialist | Compassionate, Evidence-Based Treatment | Advancing Patient-Centric Cancer Care

3w

🌟 Fascinating perspective, Dr. AVS Suresh. Your insights on the link between stress, epigenetics, and cancer risk highlight how deeply our lived experiences shape health outcomes — not just for us, but for future generations. At Shashwat Hospitals, we strongly believe in addressing mental health and preventive care alongside medical treatment, because resilience and compassion are as vital as science in rewriting our health legacy. 💙

Shashank Sherkar

Author of book 'The Drama of Burnout'| Burnout Survivor | Founder | 30 years experienced Civil Engineer at CADKEY Services | CAD Solutions provider | Solid Waste & eWaste Manager | Musician

3w
Deepak Sharma Lead/Manager QA CAR-T Cell and Gene Therapy

Lead/Manager QA (CART Cell and Gene Therapy) at Laurus Labs Pvt Ltd.

3w

Well said. Previously mutation was only considered as the factor for oncogenesis. Now, many studies are supporting the role of epigenetic factors for not only cancer, but for other metabolic disorders too. In women, PCOD is one of the example.

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