Prostaglandins functions
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The prostaglandins are lipids produced during tissue damage or infection that regulate processes like inflammation, blood flow, blood clotting, and childbirth. They act as vasodilators to lower blood pressure, cause inflammation at sites of injury to initiate healing, regulate contraction of gastrointestinal and respiratory muscles, and influence immune function, renal function, metabolism, and female reproduction such as ovulation and inducing labor. High or low levels of prostaglandins can impact health, so herbs, drugs, and hormones are used to regulate their levels.
Prostaglandins functions
- 1. •The prostaglandins are a group of lipids mainly produce at sites of tissue damage or infection that are involved in dealing with injury and illness. •They control processes such as inflammation, blood flow, the formation of blood clots and the induction of labour.
- 2. REGULATION OF BLOOD PRESSURE Acts as vasodilator. Lower blood pressure by increasing blood flow. Agents for treatment of hypertension.
- 3. ROLE IN INJURY AND INFLAMMATION Causes inflammation at the site of injury and tissue damage. Initiate healing process by action of thromboxane and prostacyclin. Control the amount of blood flow and regulate response to injury and inflammation.
- 4. ROLE IN GUT Regulate contraction and relaxation of muscles in gut. Regulate gastric secretion. Stimulates pancreatic secretion and increase the motility of intestine. Used to treat gastric ulcers.
- 5. EFFECT ON RESPIRATORY FUNCTIONS Regulate air passage ways by acting as bronchodilator and constrictor of bronchial smooth muscles. Used in the treatment of Asthama.
- 6. INFLUENCE ON IMMUNE SYSTEM Secreted by macrophages. Decreases immunological functions of B and T lymphocytes.
- 7. INFLUENCE ON RENAL FUNCTION Increases rate of glomerular filtration and seretion of potassium under decreased circulating volume. Regulate sodium and water reabsorption . Useful to treat diabetes inspidus.
- 8. EFFECTS ON METABOLISM Influence certain metabolic reactions by mediation of cAMP. Prostaglandins: decreases lipolysis increases glycogen formation and promotes calcium mobilization
- 9. ROLE IN REPRODUCTION Regulate female reproductive system. Involved in : ovulation Menstural cycle Induction of labour by utrine contraction.
- 10. EFFECT OF LOW PRSTAGLANDINS LEVEL POSITIVE EFFECT: Low level deals with less inflammation. NEGTIVE EFFECT: Low level causes : Damage to the gut Heart rhythm disturbances Diabetic retinopathy(high blood sugar level causes damage in blood vessels of retina) To increase the level of prostaglandins, estrogen hormone is required.
- 11. EFFECT OF HIGH PROSTAGLANDIN LEVEL High prostaglandin level causes : Increase in allergies. Decreases the ability to fight cancer. Migraines and headaches. Menstural cramps. Deformation of nails and fingers(clubbing). Depression. Alzhemeimer’s disease. Kidney failure.
- 12. HOW TO DECREASE LEVEL OF PROSTAGLANDINS Herbs like green and black tea, ginger etc help to decrease the level of prostaglandins. Drugs like Aspirin etc. also decrease its level.