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Cerebrum internal features by DR.ARSHAD
• Each cerebral hemisphere includes a large
  volume of white matter, sometimes called the
  medullary center, that accommodates vast
  numbers of axons running to and from all
  parts of the cortex
• Axons that establish connections between the
  cortex and subcortical gray matter continue
  into the internal capsule.
Cerebral White Matter
• Three types of axons are present in the
  cerebral white matter
• Association fibers are confined to a
  hemisphere and connect one cortical area
  with another.
• Many of these fibers accumulate in named
  longitudinally running bundles that can be
  displayed by dissection.
• Most named association bundles (superior
  longitudinal, arcuate, inferior longitudinal,
  inferior occipitofrontal, uncinate, and superior
  occipitofrontal fasciculi) interconnect lobes.
• The cingulum, fornix, and stria terminalis are
  association bundles of the limbic system.
• The corpus callosum and anterior
  commissure, which interconnect symmetrical
  cortical regions, exchange information
  between the left and right sides.
• After transection of the commissures, a task
  that is newly learned with one hand cannot be
  performed by the other.
• Sensory data that enter only the right
  hemisphere cannot be put into words because
  of disconnection from the language areas in
  the left hemisphere.
• Commissural fibers connect the cortices of the
  two hemispheres; most are located in the
  corpus callosum, and the remainder are
  located in the anterior commissure.
• Projection fibers establish connections
  between the cortex and such subcortical
  structures as the corpus striatum, thalamus,
  brain stem, and spinal cord.
• They are afferent (corticopetal) or efferent
  (corticofugal) with respect to the cortex.
• Most corticopetal projection fibers originate
  in the thalamus; some ascend from nuclei in
  the hypothalamus and brain stem
ASSOCIATION FIBRES

• Association fibers are the most numerous of
  the three types of fiber noted.
• Operative procedures, vascular accidents,
  and lesions that transect the fasciculi may lead
  to dysfunction by disconnecting functionally
  related regions of the cerebral cortex.
Cerebrum internal features by DR.ARSHAD
• The cingulum, which is most easily displayed
  by dissection in the cingulate gyrus, is an
  association fasciculus of the limbic lobe.
• The axons in this longitudinal bundle run in
  both directions and interconnect the cingulate
  gyrus, parahippocampal gyrus of the temporal
  lobe, and septal area below the genu of the
  corpus callosum.
The cingulum
• easily displayed by dissection in the cingulate
  gyrus
• an association fasciculus of the limbic lobe.
• axons in this longitudinal bundle run in both
  directions and interconnect the cingulate
  gyrus, parahippocampal gyrus of the temporal
  lobe, and septal area below the genu of the
  corpus callosum.
Superior longitudinal fasciculus
• also known as the arcuate fasciculus
• runs in an anteroposterior direction above the
  insula, and many of the fibers turn downward
  into the temporal lobe.
• It is similar to the other large association
  bundles in that it consists of axons of various
  lengths that enter or leave the fasciculus at
  any point along its course.
• provides important communications between
  cortices of the parietal, temporal, and
  occipital lobes and the cortex of the frontal
  lobe.
• These provide a pathway whereby interpreted
  sensory signals (especially visual and
  proprioceptive) from the parietal cortex
  influence the formulation in the frontal lobe
  of neuronal programs for appropriate
  movements.
• provide a pathway whereby interpreted
  sensory signals (especially visual and
  proprioceptive) from the parietal cortex
  influence the formulation in the frontal lobe
  of neuronal programs for appropriate
  movements
• The arcuate fasciculus also includes fibers that
  connect the receptive (sensory) and
  expressive (motor) language areas
• An inferior longitudinal fasciculus, beneath
  the lateral and ventral surfaces of the occipital
  and temporal lobes, is difficult to demonstrate
  by dissection.
Cerebrum internal features by DR.ARSHAD
• The inferior occipitofrontal fasciculus and
  uncinate fasciculus are components of a single
  association system
• The fibers are compressed into a well-defined
  bundle below the insula and lentiform
  nucleus.
• The longer part of the fiber system, extending
  the length of the hemisphere, is the inferior
  occipitofrontal fasciculus.
• The uncinate fasciculus is the part that hooks
  around the stem of the lateral sulcus to
  connect the frontal lobe, especially cortex on
  its orbital surface, with cortex in the region of
  the temporal pole.
The superior occipitofrontal
    fasciculus/subcallosal bundle
• located deep in the hemisphere
• Its fibers spread out to cortex of the frontal
  lobe and to cortex in the posterior part of the
  hemisphere
Cerebrum internal features by DR.ARSHAD
Arcuate fibers
• Connect adjacent gyri.
• Oriented at right angles to the gyri and bend
  sharply under the intervening sulci.
• Spread of activity along a gyrus or sulcus is
  provided by other subcortical association
  fibers and by axons within the cortex
COMMISSURES


 Corpus Callosum
• In laboratory animals, commissural fibers from
  an area of cortex in one hemisphere have
  been shown to terminate in the
  corresponding area and in cortex closely
  related functionally with that area, in the
  other hemisphere.
Cerebrum internal features by DR.ARSHAD
• In laboratory animals, commissural fibers from
  an area of cortex in one hemisphere have
  been shown to terminate in the
  corresponding area and in cortex closely
  related functionally with that area, in the
  other hemisphere.
• The hand areas of the primary somatosensory
  cortices and large parts of the primary visual
  areas are notable in that they are not directly
  connected by commissural fibers.
• They communicate functionally, however,
  through callosal fibers that connect the
  adjacent association areas..
Cerebrum internal features by DR.ARSHAD
• Much of the cortex of the temporal lobe
  makes its commissural connections by way of
  the anterior commissure rather than the
  corpus callosum
• The body/trunk of the corpus callosum is the
  compact part of the commissure in and near
  the midline.
• As they pass laterally, the callosal fibers
  intersect association bundles and projection
  fibers
• The trunk of the corpus callosum is
  considerably shorter than the hemispheres;
  this accounts for the enlargements of the
  ends, which are the splenium posteriorly and
  the genu anteriorly
• The splenium and the radiations that connect
  the occipital lobes constitute forceps major. a
• the genu and the radiations that connect the
  frontal lobes form the forceps minor.
• The genu tapers into the rostrum of the
  corpus callosum, which is continuous with the
  lamina terminalis forming the anterior wall of
  the third ventricle.
• Callosal fibers that form a thin sheet over the
  temporal horn of the lateral ventricle
  constitute the tapetum (see Fig. 16-6), which
  provides some of the communication
  between the cortices of the temporal lobes.
Cerebrum internal features by DR.ARSHAD
Projection fibres/internal capsule
• Interconnections between cerebral cortex and
  Subcortical structures travel through the
  Internal capsule
• compact bundle of fibres in the cleft between
  lenticular nucleus [laterally] and thalamus and
  head of the caudate nucleus [medially]
• Site for fibres leaving and entering thalamus
• Other fibres passing through are
  corticopontine, corticobulbar and
  corticospinal
• Also fibres going to parts of basal nuclei
• All fibres fan out as corona radiata and reach
  cortical destinations
Parts
• Based on relationship of each part to
  lenticular nucleus
• Anterior limb- between lenticular nucleus and
  head of caudate nucleus
• Posterior limb- between lenticular nucleus
  and thalamus
• Genu – junction between the two
• Retrolenticular- posterior to lentiform nucleus
• Sublentiform – inferior to the lenticular
  nucleus
• Curved sheet – not all parts seen in one
  section
Components
Anterior limb
• Fibres interconnecting anterior nucleus and
  the cingulate gyrus and most of those
  interconnecting the dorsomedial nucleus and
  prefrontal cortex
• Also frontopontine fibres- to ipsilateral
  pontine nuclei
Posterior limb
• Fibres connecting VA and VL with motor and
  premotor cortex
• Corticospinal and corticobulbar fibres
• Somatosensory fibres from VPL/VPM to
  postcentral gyrus
• Corticospinal fibres
Genu
• Transition zone between anterior and
  posterior limbs
• Frontopontine fibres
• Fibres interconnecting VA and VL with motor
  and premotor cortex
• Corticobulbar fibres to motor nuvlei of cranial
  nerves
Retrolenticular part
• Most fibres connecting thalamus with
  posterior portions of cerebral hemispheres
  [ bidirectional between parietal-occipital-
  temporal association cortex and the pulvinar/
  LP complex
• Also include optic radiation
• Corticopontine fibres [parietal lobe]
Sublenticular part
• Remainder of optic radiation
• Auditory radiation
Cerebrum internal features by DR.ARSHAD
Cerebrum internal features by DR.ARSHAD
• Most projection fibers pass through the
  internal capsule.
• All parts of the internal capsule contain
  thalamocortical and corticothalamic fibers.
• Motor fibers, including those of the pyramidal
  system, descend in the posterior limb of the
  internal capsule.
• A small infarct in this area can cause
  contralateral hemiplegia.
Cerebrum internal features by DR.ARSHAD
Cerebrum internal features by DR.ARSHAD
Cerebrum internal features by DR.ARSHAD
Cerebrum internal features by DR.ARSHAD
Cerebrum internal features by DR.ARSHAD
Cerebrum internal features by DR.ARSHAD

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Cerebrum internal features by DR.ARSHAD

  • 2. • Each cerebral hemisphere includes a large volume of white matter, sometimes called the medullary center, that accommodates vast numbers of axons running to and from all parts of the cortex
  • 3. • Axons that establish connections between the cortex and subcortical gray matter continue into the internal capsule.
  • 4. Cerebral White Matter • Three types of axons are present in the cerebral white matter • Association fibers are confined to a hemisphere and connect one cortical area with another. • Many of these fibers accumulate in named longitudinally running bundles that can be displayed by dissection.
  • 5. • Most named association bundles (superior longitudinal, arcuate, inferior longitudinal, inferior occipitofrontal, uncinate, and superior occipitofrontal fasciculi) interconnect lobes.
  • 6. • The cingulum, fornix, and stria terminalis are association bundles of the limbic system. • The corpus callosum and anterior commissure, which interconnect symmetrical cortical regions, exchange information between the left and right sides.
  • 7. • After transection of the commissures, a task that is newly learned with one hand cannot be performed by the other. • Sensory data that enter only the right hemisphere cannot be put into words because of disconnection from the language areas in the left hemisphere.
  • 8. • Commissural fibers connect the cortices of the two hemispheres; most are located in the corpus callosum, and the remainder are located in the anterior commissure. • Projection fibers establish connections between the cortex and such subcortical structures as the corpus striatum, thalamus, brain stem, and spinal cord.
  • 9. • They are afferent (corticopetal) or efferent (corticofugal) with respect to the cortex. • Most corticopetal projection fibers originate in the thalamus; some ascend from nuclei in the hypothalamus and brain stem
  • 10. ASSOCIATION FIBRES • Association fibers are the most numerous of the three types of fiber noted. • Operative procedures, vascular accidents, and lesions that transect the fasciculi may lead to dysfunction by disconnecting functionally related regions of the cerebral cortex.
  • 12. • The cingulum, which is most easily displayed by dissection in the cingulate gyrus, is an association fasciculus of the limbic lobe. • The axons in this longitudinal bundle run in both directions and interconnect the cingulate gyrus, parahippocampal gyrus of the temporal lobe, and septal area below the genu of the corpus callosum.
  • 13. The cingulum • easily displayed by dissection in the cingulate gyrus • an association fasciculus of the limbic lobe. • axons in this longitudinal bundle run in both directions and interconnect the cingulate gyrus, parahippocampal gyrus of the temporal lobe, and septal area below the genu of the corpus callosum.
  • 14. Superior longitudinal fasciculus • also known as the arcuate fasciculus • runs in an anteroposterior direction above the insula, and many of the fibers turn downward into the temporal lobe. • It is similar to the other large association bundles in that it consists of axons of various lengths that enter or leave the fasciculus at any point along its course.
  • 15. • provides important communications between cortices of the parietal, temporal, and occipital lobes and the cortex of the frontal lobe. • These provide a pathway whereby interpreted sensory signals (especially visual and proprioceptive) from the parietal cortex influence the formulation in the frontal lobe of neuronal programs for appropriate movements.
  • 16. • provide a pathway whereby interpreted sensory signals (especially visual and proprioceptive) from the parietal cortex influence the formulation in the frontal lobe of neuronal programs for appropriate movements
  • 17. • The arcuate fasciculus also includes fibers that connect the receptive (sensory) and expressive (motor) language areas • An inferior longitudinal fasciculus, beneath the lateral and ventral surfaces of the occipital and temporal lobes, is difficult to demonstrate by dissection.
  • 19. • The inferior occipitofrontal fasciculus and uncinate fasciculus are components of a single association system • The fibers are compressed into a well-defined bundle below the insula and lentiform nucleus.
  • 20. • The longer part of the fiber system, extending the length of the hemisphere, is the inferior occipitofrontal fasciculus. • The uncinate fasciculus is the part that hooks around the stem of the lateral sulcus to connect the frontal lobe, especially cortex on its orbital surface, with cortex in the region of the temporal pole.
  • 21. The superior occipitofrontal fasciculus/subcallosal bundle • located deep in the hemisphere • Its fibers spread out to cortex of the frontal lobe and to cortex in the posterior part of the hemisphere
  • 23. Arcuate fibers • Connect adjacent gyri. • Oriented at right angles to the gyri and bend sharply under the intervening sulci. • Spread of activity along a gyrus or sulcus is provided by other subcortical association fibers and by axons within the cortex
  • 25. • In laboratory animals, commissural fibers from an area of cortex in one hemisphere have been shown to terminate in the corresponding area and in cortex closely related functionally with that area, in the other hemisphere.
  • 27. • In laboratory animals, commissural fibers from an area of cortex in one hemisphere have been shown to terminate in the corresponding area and in cortex closely related functionally with that area, in the other hemisphere.
  • 28. • The hand areas of the primary somatosensory cortices and large parts of the primary visual areas are notable in that they are not directly connected by commissural fibers. • They communicate functionally, however, through callosal fibers that connect the adjacent association areas..
  • 30. • Much of the cortex of the temporal lobe makes its commissural connections by way of the anterior commissure rather than the corpus callosum • The body/trunk of the corpus callosum is the compact part of the commissure in and near the midline.
  • 31. • As they pass laterally, the callosal fibers intersect association bundles and projection fibers • The trunk of the corpus callosum is considerably shorter than the hemispheres; this accounts for the enlargements of the ends, which are the splenium posteriorly and the genu anteriorly
  • 32. • The splenium and the radiations that connect the occipital lobes constitute forceps major. a • the genu and the radiations that connect the frontal lobes form the forceps minor.
  • 33. • The genu tapers into the rostrum of the corpus callosum, which is continuous with the lamina terminalis forming the anterior wall of the third ventricle. • Callosal fibers that form a thin sheet over the temporal horn of the lateral ventricle constitute the tapetum (see Fig. 16-6), which provides some of the communication between the cortices of the temporal lobes.
  • 35. Projection fibres/internal capsule • Interconnections between cerebral cortex and Subcortical structures travel through the Internal capsule • compact bundle of fibres in the cleft between lenticular nucleus [laterally] and thalamus and head of the caudate nucleus [medially]
  • 36. • Site for fibres leaving and entering thalamus • Other fibres passing through are corticopontine, corticobulbar and corticospinal • Also fibres going to parts of basal nuclei • All fibres fan out as corona radiata and reach cortical destinations
  • 37. Parts • Based on relationship of each part to lenticular nucleus • Anterior limb- between lenticular nucleus and head of caudate nucleus • Posterior limb- between lenticular nucleus and thalamus • Genu – junction between the two
  • 38. • Retrolenticular- posterior to lentiform nucleus • Sublentiform – inferior to the lenticular nucleus • Curved sheet – not all parts seen in one section
  • 39. Components Anterior limb • Fibres interconnecting anterior nucleus and the cingulate gyrus and most of those interconnecting the dorsomedial nucleus and prefrontal cortex • Also frontopontine fibres- to ipsilateral pontine nuclei
  • 40. Posterior limb • Fibres connecting VA and VL with motor and premotor cortex • Corticospinal and corticobulbar fibres • Somatosensory fibres from VPL/VPM to postcentral gyrus • Corticospinal fibres
  • 41. Genu • Transition zone between anterior and posterior limbs • Frontopontine fibres • Fibres interconnecting VA and VL with motor and premotor cortex • Corticobulbar fibres to motor nuvlei of cranial nerves
  • 42. Retrolenticular part • Most fibres connecting thalamus with posterior portions of cerebral hemispheres [ bidirectional between parietal-occipital- temporal association cortex and the pulvinar/ LP complex • Also include optic radiation • Corticopontine fibres [parietal lobe]
  • 43. Sublenticular part • Remainder of optic radiation • Auditory radiation
  • 46. • Most projection fibers pass through the internal capsule. • All parts of the internal capsule contain thalamocortical and corticothalamic fibers.
  • 47. • Motor fibers, including those of the pyramidal system, descend in the posterior limb of the internal capsule. • A small infarct in this area can cause contralateral hemiplegia.