Objec n scope
- 1. _______________________________________________________Objective and Scope of Work 30 FORMULATION, DEVELOPMENT AND EVALUATION OF ROSUVASTATIN CALCIUM ORAL FLOATING TABLETS OBJECTIVE AND SCOPE OF WORK The main goal of pharmaceutical formulation is to achieve better therapeutic activity in the shortest possible time by using smallest quantity of drug administered by the most suitable route. Oral dosage forms in which mainly solid dosage forms are more popular than other dosage forms but suffer from problems like solubility, absorption viz. bioavailability, therefore patient compliance. Oral floating tablets dosage form is one of the advanced approach to achieve the above goal. FDDS have a bulk density lower than gastric fluid and thus remains buoyant in stomach for prolonged period of time without affecting gastric emptying time. Rosuvastatin calcium is a HMG-CoA reductase inhibitor used in the treatment of hyperlipidaemia. It is highly soluble in acidic pH and absorbed more in the upper part of the GIT12. In order to improve the absorption and its oral bioavailability, we have attempted to formulate a floating drug delivery systems using Rosuvastatin calcium as the model drug with HPMC K4M and Ethyl cellulose as polymers. FDDS are also referred to as hydro dynamically balanced systems (HBS) as they are able to maintain their low density.
- 2. _______________________________________________________Objective and Scope of Work 31 FORMULATION, DEVELOPMENT AND EVALUATION OF ROSUVASTATIN CALCIUM ORAL FLOATING TABLETS WORK PLAN 1. To develop spectrophotometeric method for the estimation of Rosuvastatin. 2. Formulation of oral floating tablets of Rosuvastatin Calcium tablets. 3. In vitro evaluation of tablets for hardness, friability, weight variation and thickness. 4. In vitro evaluation dissolution studies. 5. In vitro buoyancy studies and swelling mechanism. 6. To compare the four formulations and conclude the best formulation that showed sufficient release for prolonged period.