The document discusses a keynote speech given by Professor Mohan Munasinghe at an AMCHAM meeting in the Dominican Republic about restoring the Ozama River. It provides background on Professor Munasinghe and the Ozama River restoration project. It discusses some of the challenges facing sustainable development efforts, including climate change, growing inequality, and the need to address multiple interconnected threats. It emphasizes the importance of integrating social, economic and environmental considerations and involving diverse stakeholders. The document promotes applying the SUSTAINOMICS framework to guide sustainable development efforts in a balanced, innovative way.