Difficulties in transradial intervention include failure to puncture the radial artery, radial artery spasm, tortuosity or loops in the radial or brachial arteries, use of smaller catheters, difficult coronary cannulation, and challenges during percutaneous coronary intervention. Proper catheter selection based on artery size and anatomy, use of adjunct devices like buddy wires, and deep intubation can help maximize support during difficult cases. Angiography may be needed to guide wiring and balloon crossing in tortuous vessels, and stenting can seal aortic dissections involving the coronary ostium.