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Codeine detoxification.
By Nwanevu Sylvanus & Herman.
Introduction.
• Codeine - 3-methylmorphine is an opiate
which is a natural isomer of methylated
morphine.
• It was isolated in 1832 in France by Pierre
Robiquet.
• It is the most widely used opiate in the world.
Structure.
Applications of
codeine.
• It can be used as a pain killer in combination
with paracetamol, aspirin to enhance the
effect.
• Can also be used as a recreational drug.
• It is used to suppress premature labor
contractions, also in myocardial infarctions.
• As sedative & anti hypertensive drug.
Adverse effects.
• Drowsiness, constipation, euphoria, urinary
retention
• Rare effects include seizure & anaphylaxis.
Detoxification.
• Codeine is converted to morphine by enzyme
cytochrome p450 - CYP2D6
• It undergoes N-demethylation to form
Norcodeine by CYP3A4.
• UGT2B7 ( UDP- Glucuronosyltransferase-
2B7) conjugates codeine, norcodeine, &
morphine to corresponding 3- & 6-
glucuronides.
Codeine detoxification
Codeine detoxification
Codeine detoxification
Conclusion.
• Stay safe, don't abuse drugs!
• It is advised to only take drugs prescribed by
a Doctor.
Thanks for your
attention.

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Codeine detoxification

  • 2. Introduction. • Codeine - 3-methylmorphine is an opiate which is a natural isomer of methylated morphine. • It was isolated in 1832 in France by Pierre Robiquet. • It is the most widely used opiate in the world.
  • 4. Applications of codeine. • It can be used as a pain killer in combination with paracetamol, aspirin to enhance the effect. • Can also be used as a recreational drug. • It is used to suppress premature labor contractions, also in myocardial infarctions. • As sedative & anti hypertensive drug.
  • 5. Adverse effects. • Drowsiness, constipation, euphoria, urinary retention • Rare effects include seizure & anaphylaxis.
  • 6. Detoxification. • Codeine is converted to morphine by enzyme cytochrome p450 - CYP2D6 • It undergoes N-demethylation to form Norcodeine by CYP3A4. • UGT2B7 ( UDP- Glucuronosyltransferase- 2B7) conjugates codeine, norcodeine, & morphine to corresponding 3- & 6- glucuronides.
  • 10. Conclusion. • Stay safe, don't abuse drugs! • It is advised to only take drugs prescribed by a Doctor.