Codeine is a naturally occurring opiate that was isolated in 1832. It is widely used as a painkiller when combined with other drugs and can also be used recreationally. Codeine is metabolized in the liver by enzymes that convert it to morphine and norcodeine. Detoxification involves breaking down and removing codeine and its metabolites from the body through conjugation and excretion. The document cautions against drug abuse and recommends only taking medications under a doctor's supervision.