This document discusses four main factors that can cause post-insertion problems with dentures: 1) adverse intra-oral anatomical factors such as sharp ridges on the denture surface or over-extended flanges, 2) clinical factors like poor denture stability from decreased retention or increased displacing forces, 3) technical factors related to the denture fabrication process, and 4) patient adaptation factors involving issues with wearing or adjusting to the new dentures. Specific examples are provided for each category along with potential treatments.