CSS grids provide a layout system for web pages and applications, similar to tables, but defined entirely with CSS. Grids allow the creation of flexible layouts that can adapt to different screen sizes using media queries. Key grid terminology includes grid lines, tracks, cells, and areas. Grids are defined by specifying columns and rows, and items can then be placed onto the grid using line-based placement, spanning multiple cells, or defining named grid areas. Real-world examples show how grids can be used to build layouts for sites like those made with Foundation or Bootstrap.