Natural therapy aganist cancer

Under the guidance of:
MR. K. SUDHEER SIR
Dept of Pharmacognosy
Presented by:
K. SNEHA
13GD1R0002

INTRODUCTION:
Cancer is a group of diseases involving abnormal cell growth with the potential
to invade or spread to other parts of body.
CELL CYCLE:
Cell cycle is an ordered process of events that occur in 5 stages:-
• G0 Phase (Resting phase)
• G1 Phase (Presynthetic phase)
• S Phase (Synthetic phase)
• G2 Phase (Post Synthetic Phase)
• M Phase (Mitosis)

GENETICS OF CANCER:
Only a small number of the approximately 35,000 genes in the human
genome have been associated with cancer. Alterations in the same gene often are
associated with different forms of cancer.
These malfunctioning genes can be broadly classified into three groups.
• The first group, called proto-oncogenesThe mutated forms of these genes are
called oncogenes.
• The second group, called tumor suppressors
• The third group contains DNA repair genes.
MYC is a proto-oncogene that codes for a transcription factor.
RAS is another oncogene that normally functions as an “on-off” switch in the
signal cascade. About thirty percent of tumors — including lung, colon, thyroid,
and pancreatic carcinomas — have a mutation in RAS.

Sometimes a virus inserts its DNA in or near the proto-oncogene, causing it to
become an Oncogene. The result of any of these events is an altered form of the
gene, which contributes to cancer.
Major control switches of the cell cycle are cyclin-dependent kinasesThere
are specific cyclin-dependent kinase/cyclin complexes at the entry points into the
G1, S, and M phases of the cell cycle.

TUMOUR BIOLOGY:
Cancer cells behave as independent cells, growing without control to form
tumours.
Tumours grow in a series of steps.
• The first step is hyperplasia.
• The second step is dysplasia.
• The third step is called Anaphlasia. At this stage, because the tumour is still
contained within its original location (called in situ) and is not invasive, it is not
considered malignant.
• The last step occurs when the cells in the tumour metastasize
Non-invasive tumours are said to be benign.

There are five types of tumors:
• Carcinomas result from altered epithelial cells, which cover the surface of our skin
and internal organs. Most cancers are carcinomas.
• Sarcomas result from changes in muscle, bone, fat, or connective tissue.
• Leukemia results from malignant white blood cells.
• Lymphoma is a cancer of the lymphatic system cells that derive from bone marrow.
• Myelomas are cancers of specialized white blood cells that make antibodies.
REASONS FOR CANCER DEVELOPMENT:
We now know that 80 to 90% of all cancers are related to three major groups of
risk factors:
1. Nutrition – a high-fat, high-cholesterol, low-fibre, high-sugar diet.
2. Lifestyle – alcohol, smoking, stress, sedentary lifestyle.

3. Environment – industrial toxics, electromagnetic radiation, chemical
carcinogens, air and water pollution.
CHARECTERISTICS OF CANCER CELL:
These characteristics are:
• Cancer cells have greatly prolonged life spans compared to normal cells.
• Masses of cancer cells may become like parasites, developing their own
network of blood vessels and siphoning off key nutrients from the body.
• Cancer cells prefer sugar as source of energy as compared to normal cells which
favour oxygen.
• Cancer cells are more sensitive to heat and less able to tolerate high temperature
compared to normal cells.
• Cancer cells form a tumour, caused by the abnormal growth.The tumour can
invade adjacent normal tissue.

SIDE EFFECTS:
The list of side effects that accompany conventional cancer treatment is indeed
scary. They include;
• Bone marrow suppression .
•Weakness.
• Anaemia .
•Toxic overload.
• Diarrhoea.
• Hair loss.
7 STEPS TO BEAT CANCER NATURALLY:
1. Starving the cancer cell.
2. Oxygenate your body.
3. Avoid malnutrition.
4. Use nutritional supplements.
5. Balance your Internal terrain.
6. Balance your toxic load.
7. Balance your toxins.

Here are 10 cancer facts you must know to fight:
1.Mitochondria: The mitochondria is the energy factory of the cell. Cancer cells
prefer sugar as a source of energy as compared to normal cells which favour
oxygen.As a result, most cancer patients are weak and tired.

2.Free Radicals: Free radicals generated as a result of environmental toxins,
stress, processed food, and pollution are a direct cause of cellular mutation
and cancer
3.Matrix: Cancer cells spread locally by secreting enzymes that destroy the
interstitial collagen that forms the protective intercellular matrix.
Reinforcing of this matrix is akin to building a wall and preventing the
cancer cells from advancing.
4.Temperature : Cancer cells are more sensitive to heat and less able to tolerate
high temperature compared to normal cells.
5.Angiogenesis: Cancer cells spread to distant sites by angiogenesis
(formation of new blood vessel.Some non-toxic compounds have been shown to
retard this process.

6. Toxins: Many cancers come on because of an excess of toxins and a
compromised toxin clearance mechanism in the body. Detoxification is a
key to cancer control. The liver, skin, kidney, and lung are major
detoxification centers of the body.
7. Internal Terrain: Our body is an internal closed ecosystem. The proper
balance of this internal terrain by maintaining its equilibrium, for example
an optimum acid/base balance, is a key to preventing a buildup of unwanted
bacteria, fungus, and proteins (like prions) in the body which can bring on
cancer.
8. Immunity: Our first line of defense against assaults by external agents in
our body is our immune system. Those who are immunologically strong
have a better chance of surviving cancer.
9. Hormones :Most cancers have a hormonal component. The imbalance of our
hormones is a major cause of many cancers, including breast and prostate
cancer. Modulation and correction of hormonal imbalance naturally will
correct the systemic dysfunction upon which hormonal sensitive cancer is
kept under control.

10. Inflammation: Infections, poor dietary habit or high sugar and trans-fat are
potential carcinogens that leads to mutational changes .

NATURAL THERAPIES AGAINST CANCER:
Cancer inhibitory effect of most natural compounds does not directly cause
DNA damage ,as compared to drugs. They cause mutations in surviving cells &
act specifically on cancerous cells without affecting normal cells.
Specifically, natural compounds fight cancer by:
1.Strengthening the immune system.
2. Preventing the spread of cancer cells through inhibition of angiogenesis.
3.Creating an environment that is unfavourable for cancer growth.
4. Detoxifying the body and preventing further toxic build up in the body.
5.Fighting free radicals that cause mutational changes that lead to cancer
formation.

First of all Start daily with a good fundemental formula consisting of atleast
following:
•Vitamin A
•Vitamin C
•Vitamin E
•Selenium
•Magnesium
•Vitamin B9
• Vitamin B12
• Zinc
•Calcium
•Citrous Bioflavonoids.
Following Anti-cancer nutrients may be required:
•Vitamin E
•Niacinamide
•Fish oil
•Qercetin
•Beta carotene
•Pantothenic acid
•Grape seed extract

To boost immunity, following are considered:
•Turmeric extract
•Olive leaf extract
•Medical mushroom extract
SOME OF THE AGENTS HAVING ANTI-CANCER
ACTIVITY:

1.CURCUMIN:
The most potent Natural compound against cancers: curcumin appears to
be universally useful for just about every type of cancer.
It acts by:
a) Induction of p53/p21 Pathway
b) Release of Apoptosis-Inducing Factor
c) Cell Cycle Regulation

2. 6-SHOGAOL (Extract of GINGER):
The chemical, known as 6-shogaol, is produced when ginger roots are dried
or cooked.
• The researchers found that 6-shogaol targets breast cancer stem cells along
several different pathways, including altering the cell cycle to increase the rate of
cell death, inhibiting tumour formation, directly inducing programmed cell
death.
• The researchers then compared the cytotoxicity of 6-shogaol against human
breast cancer stem cells with that of the widely used chemotherapy drug Taxol.

3. BEC5 (Eggplant Extract):
The discovery of BEC5 - Solasidine Glycoside -extracted from eggplant and
Devil's Apple. This is the best available cure for malignant and non malignant skin
cancers.
• Stage III trials have confirmed that 8 weeks of topical application of BEC5 cream
cured 78% of the skin cancer.
• 12 weeks of topical use twice a day cured it 100%! without leaving any scar or
harming the surrounding normal skin
Now BEC is in trials for internal cancers and early results are promising.
4. SALINOMYCIN:
Salinomycin is made by a strain of streptomyces albus. Streptomyces is a
form of bacteria, usually found in soil.

Its a naturally occurring antibiotic. Salinomycin is not only able to kill
CSCs, but also regular tumor cells displaying resistance to cytotoxic drugs,
radiation, and induction of apoptosis hence salinomycin can be regarded as
a triple-edged sword against cancer.

5. CRUCIFEROUS COMPOUNDS:
Cruciferous vegetables like brocolli, kale, brussels sprouts, arugula,
bokchoy, cabbage and cauliflower have not one but many powerful anti cancer
compounds like Indole-3-Carbinol, Sufurophanes, Crambene.
Scientific observational studies have shown that eating cruciferous
vegetables protects against cancer – here are a few examples
One of the important actions of cruciferous veggie compounds is
balancing hormones especially estrogen. They convert the dangerous forms of
estrogen to protective forms thereby preventing cancer from forming.

6. APIGENIN:
• A flavinoid found in many fruits.
• Apigenin treatment resulted in suppression of tumor necrosis factor (TNF)present
in umbilical vein.
• Apigenin treatment has been shown to decrease the levels of phosphorylated
EGFR tyrosine kinase and of other MAPK and their nuclear substrate c-myc, which
causes apoptosis in anaplastic thyroid cancer cells.
• Apigenin has been shown to inhibit the expression of casein kinase (CK)-2 in
both human prostate and breast cancer cells.

Oral administration of apigenin was shown to suppresses prostate and breast
cancer cell growth.
7. SANGRE DE GRADO:
This amazing compound has an unbelievable antioxidant.As a comparison
blueberry a favorite anti oxidant .SDG is almost 3,000% more potent than blueberries
and pomogranate.

8. LYCOPENE:
Is a pigment that helps give red fruits and vegetables their color. It is
most abundantly found on the skin of tomatoes. Cooking tomatoes multiplies the
available lycopene.

9. FUCOIDAN AND AHCC:
Fucoidan is a valuable substance that is obtained from the sliminess of most
brown seaweeds.
AHCC is a remarkable natural compound that is made from the roots of
Japanese medicinal mushrooms. AHCC is the most popular immune-supplement in
Japan. AHCC works by modulating the immune system so that the body can:
Increase the production and activity of immune cells to stimulate the suppressed
immune function.
Protect itself from the side effects of chemotherapy such as nausea and hair
loss.

10. HONEY, ROYAL JELLY, PROPOLIS AND BEE
POLLEN:
Studies have shown it has the following actions on cancer;
Its Apoptotic
Its Antiproliferative
It Effects Tumor Necrosis Factor (TNF)
Its Anti-Inflammatory and Immunomodulatory
Its Antioxidant
Its Antimutagenic
Estrogen Modulator

11. SELENIUM:
Is a trace mineral that has shown very potent cancer preventive action.
3 forms of Selinium are listed . The three forms of selenium most important in
cancer prevention are
sodium selenite
L-selenomethionine,
selenium-methyl L-selenocysteine.
The three selenium compounds complement one another in the ways
they affect your body's expression of important proteins involved in cancer
prevention and suppression.

12. GREEN TEAAND EGCG:
Multiple studies have shown the various benefits of green tea and its
polyphenols against cancer.

A new study conducted by food scientists at Penn State University shows
that green tea's primary compound — epigallocatechin-3-gallate (EGCG) —
may kill oral cancer cells and leave healthy cells unscathed.
Scientists believe that EGCG may trigger a process in the mitochondria of
cancer cells that leads to early cell death.

“It looks like EGCG causes the formation of reactive oxygen species in cancer
cells, which damages the mitochondria, and the mitochondria responds by
making more reactive oxygen species,” said Joshua Lambert.

CONLUSION:
Cancer is not simply localized lumps and bumps that we have been
programmed to accept through the years. We all have cancer cells in our
bodies. It is only when our body is unable to get rid of the cancer cells that a
disease process takes place.
The conventional treatment of surgery, radiation and chemotherapy
has been the cornerstone of cancer treatment over the past 50 years. Today, the
clinical success of these treatments has reached a ceiling.
• We need to break through this cure ceiling by trying fresh approaches.
The complete natural healing program should include a therapeutic
blend of vitamins, herbs, minerals and enzymes. Choosing the proper
combination and dosage of these natural compounds is an important key to
success.

REFERENCE:
1.Beating cancer with natural medicine by Michael,DM.
2. Bahls, C., and M. Fogarty. 2002. Reining in a killer disease. The Scientist
16[11]:16. An outline of several approaches to controlling cancer.
3.Gibbs, W. Wayt. 2003. Untangling the roots of cancer. Scientific American, July,
57–65. New evidence challenges old theories of how cancer develops.
4.Rayl, A. J. S., and Lewis, R. 2001. In cancer research, diet and exercise roles
strengthen. The Scientist 15[20]:17. Evidence for the importance of lifestyle in
preventing cancer.
5.Rang and Dales Pharmacology.

Natural therapy aganist cancer

Natural therapy aganist cancer

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Natural therapy aganist cancer