Ken Kesey's 'One Flew Over the Cuckoo’s Nest' is set in an Oregon psychiatric hospital and narrated by Chief Bromden, a patient suffering from hallucinations. The story revolves around Randle McMurphy, who challenges the authoritarian control of Nurse Ratched, symbolized by the oppressive 'combine.' The novel explores themes of mental illness, rebellion against authority, and the importance of individuality, using various literary devices such as symbolism, irony, and personification.