This document provides guidance on selecting and installing surge protection devices (SPDs) for process control systems to protect sensitive electronics from electrical surges. It discusses SPD placement for different applications including hazardous areas, analog and digital I/O, high current signals up to 6A, 4-20mA loops, interposing relays, RTDs, HART communication, and RS232/RS485. SPDs should be installed at both ends of cable runs connecting PLCs, field instruments, and I/O to provide adequate protection from surges traveling on cables.